Negative / Null Result ReportMedicine
Stephen D. Silberstein, David W. Dodick, Joel R. Saper et al. · 2012 · Cephalalgia
BACKGROUND: Chronic migraine (CM) is a debilitating neurological disorder with few treatment options. Peripheral nerve stimulation (PNS) of the occipital nerves is a potentially promising therapy for CM patients. METHODS: In this…
View details →Negative / Null Result ReportBusiness, Management and Accounting
John Daniel Eshleman, Peng Guo · 2014 · Auditing A Journal of Practice & Theory
SUMMARY: Recent research suggests that Big 4 auditors do not provide higher audit quality than other auditors, after controlling for the endogenous choice of auditor. We re-examine this issue using the incidence of accounting restatements…
View details →Negative / Null Result ReportOpen accessMathematics
Olga Demler, Michael Pencina, Ralph B. D’Agostino · 2012 · Statistics in Medicine
The area under the receiver operating characteristics curve (AUC of ROC) is a widely used measure of discrimination in risk prediction models. Routinely, the Mann-Whitney statistics is used as an estimator of AUC, while the change in AUC…
View details →Negative / Null Result ReportOpen accessPsychology
Susan D. Cochran, Jack Drescher, Eszter Kismödi et al. · 2014 · Bulletin of the World Health Organization
The World Health Organization is developing the 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-11), planned for publication in 2017. The Working Group on the Classification of Sexual Disorders and Sexual Health was charged with reviewing and making recommendations on disease categories related to sexuality in the chapter on mental and behavioural disorders in the 10th revision (ICD-10), published in 1990. This chapter includes categories for diagnoses based primarily on sexual orientation even though ICD-10 states that sexual orientat
View details →Negative / Null Result ReportSocial Sciences
Idean Salehyan, David S. Siroky, Reed M. Wood · 2014 · International Organization
Abstract Although some rebel groups work hard to foster collaborative ties with civilians, others engage in egregious abuses and war crimes. We argue that foreign state funding for rebel organizations greatly reduces incentives to “win the…
View details →Negative / Null Result ReportOpen accessMedicine
Kathleen N. Moore, Amit M. Oza, Nicoletta Colombo et al. · 2021 · Annals of Oncology
•In platinum-resistant EOC MIRV did not significantly improve PFS over chemotherapy.•No unexpected toxicities were observed, and tolerability profiles were consistent with those observed in previous studies.•The most promising signals of…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Anup Karan, Winnie Yip, Ajay Mahal · 2017 · Social Science & Medicine
India launched the 'Rashtriya Swasthya Bima Yojana' (RSBY) health insurance scheme for the poor in 2008. Utilising 3 waves (1999-2000, 2004-05 and 2011-12) of household level data from nationally representative surveys of the National Sample Survey Organisation (NSSO) (N = 346,615) and district level RSBY administrative data on enrolment, we estimated causal effects of RSBY on out-of-pocket expenditure. Using 'difference-in-differences' methods on households in matched districts we find that RSBY did not affect the likelihood of inpatient out-of-pocket spending, the level of inpatient out of p
View details →Negative / Null Result ReportSocial Sciences
Aqeel Ahmed Soomro, Robert J. Breitenecker, Syed Afzal Shah · 2018 · South Asian Journal of Business Studies
Purpose People in both the developing and developed worlds now face issues like work-to-family and family-to-work conflicts. Accordingly, the purpose of this paper is to explore the relationships between work-life balance, work-family…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Patrick B. Hamilton, Elizabeth Nicol, Eliane S. R. De-Bastos et al. · 2014 · BMC Biology
BACKGROUND: Treated effluents from wastewater treatment works can comprise a large proportion of the flow of rivers in the developed world. Exposure to these effluents, or the steroidal estrogens they contain, feminizes wild male fish and…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
T. C. Peterson, Martin P. Hoerling, Peter A. Stott et al. · 2013 · Bulletin of the American Meteorological Society
Attribution of extreme events is a challenging science and one that is currently undergoing considerable evolution. In this paper are 19 analyses by 18 different research groups, often using quite different methodologies, of 12 extreme…
View details →Negative / Null Result ReportOpen accessMedicine
Matthew J. Reilley, Patricia McCoon, Carl Cook et al. · 2018 · Journal for ImmunoTherapy of Cancer
BACKGROUND: The Janus kinase (JAK) and signal transduction and activation of transcription (STAT) signaling pathway is an attractive target in multiple cancers. Activation of the JAK-STAT pathway is important in both tumorigenesis and activation of immune responses. In diffuse large B-cell lymphoma (DLBCL), the transcription factor STAT3 has been associated with aggressive disease phenotype and worse overall survival. While multiple therapies inhibit upstream signaling, there has been limited success in selectively targeting STAT3 in patients. Antisense oligonucleotides (ASOs) represent a comp
View details →Negative / Null Result ReportOpen accessMedicine
Navneet Singh, Stephen J. Hopkins, Sharon Hulme et al. · 2014 · Journal of Neuroinflammation
BACKGROUND: Interleukin-1 (IL-1) is a key mediator of ischaemic brain injury induced by stroke and subarachnoid haemorrhage (SAH). IL-1 receptor antagonist (IL-1Ra) limits brain injury in experimental stroke and reduces plasma inflammatory mediators associated with poor outcome in ischaemic stroke patients. Intravenous (IV) IL-1Ra crosses the blood-brain barrier (BBB) in patients with SAH, to achieve cerebrospinal fluid (CSF) concentrations that are neuroprotective in rats. METHODS: A small phase II, double-blind, randomised controlled study was carried out across two UK neurosurgical centres
View details →Negative / Null Result ReportOpen accessNeuroscience
Jan Gläscher, David Rudrauf, Roberto Colom et al. · 2010 · Proceedings of the National Academy of Sciences
General intelligence (g) captures the performance variance shared across cognitive tasks and correlates with real-world success. Yet it remains debated whether g reflects the combined performance of brain systems involved in these tasks or…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Manjit Mehat, Venki Sundaram, Caterina Ripamonti et al. · 2018 · Ophthalmology
PURPOSE: Transplantation of human embryonic stem cell (hESC)-derived retinal pigment epithelial (RPE) cells offers the potential for benefit in macular degeneration. Previous trials have reported improved visual acuity (VA), but lacked detailed analysis of retinal structure and function in the treated area. DESIGN: Phase 1/2 open-label dose-escalation trial to evaluate safety and potential efficacy (clinicaltrials.gov identifier, NCT01469832). PARTICIPANTS: Twelve participants with advanced Stargardt disease (STGD1), the most common cause of macular degeneration in children and young adults. M
View details →Negative / Null Result ReportOpen accessMedicine
Maria Justine, Azliyana Azizan, Vally Hassan et al. · 2013 · Singapore Medical Journal
INTRODUCTION Although the benefits of physical activity and exercise are widely acknowledged, many middle-aged and elderly individuals remain sedentary. This cross-sectional study aimed to identify the external and internal barriers to…
View details →Negative / Null Result ReportOpen accessNeuroscience
Gilles Dutilh, Joachim Vandekerckhove, Birte U. Forstmann et al. · 2011 · Attention Perception & Psychophysics
People tend to slow down after they make an error. This phenomenon, generally referred to as post-error slowing, has been hypothesized to reflect perceptual distraction, time wasted on irrelevant processes, an a priori bias against the…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Matthias Fleckenstein, Francis A. Longstaff, Hanno Lustig · 2013 · The Journal of Finance
ABSTRACT We show that the price of a Treasury bond and an inflation‐swapped Treasury Inflation‐Protected Securities (TIPS) issue exactly replicating the cash flows of the Treasury bond can differ by more than $20 per $100 notional.…
View details →Negative / Null Result ReportOpen accessPsychology
Jeroen Borghuis, Jaap J. A. Denissen, Daniel L. Oberski et al. · 2017 · Journal of Personality and Social Psychology
Using data from 2 large and overlapping cohorts of Dutch adolescents, containing up to 7 waves of longitudinal data each (N = 2,230), the present study examined Big Five personality trait stability, change, and codevelopment in friendship…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Joris D. Veltman, Margaretha Lambers, Menno van Nimwegen et al. · 2010 · BMC Cancer
BACKGROUND: Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and have a critical role in immune suppression. MDSC suppress T and NK cell function via increased expression of arginase I and production of reactive oxygen species (ROS) and nitric oxide (NO). Immune suppression by MDSC was found to be one of the main factors for immunotherapy insufficiency. Here we investigate if the in vivo immunoregulatory function of MDSC can be reversed by in
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Gabriella Andreotti, Stella Koutros, Jonathan N Hofmann et al. · 2017 · JNCI Journal of the National Cancer Institute
Background: Glyphosate is the most commonly used herbicide worldwide, with both residential and agricultural uses. In 2015, the International Agency for Research on Cancer classified glyphosate as "probably carcinogenic to humans," noting…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Timothy D. Brandt · 2021 · The Astrophysical Journal Supplement Series
Abstract We present a cross-calibration of Hipparcos and Gaia EDR3 intended to identify astrometrically accelerating stars and to fit orbits to stars with faint, massive companions. The resulting catalog, the EDR3 edition of the…
View details →Negative / Null Result ReportPsychology
Andrew T. Jebb, Mike Morrison, Louis Tay et al. · 2020 · Psychological Science
Using representative cross-sections from 166 nations (more than 1.7 million respondents), we examined differences in three measures of subjective well-being over the life span. Globally, and in the individual regions of the world, we found…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Peter Aaby, Cesário Martins, M.‐L. Garly et al. · 2010 · BMJ
OBJECTIVE: To examine in a randomised trial whether a 25% difference in mortality exists between 4.5 months and 3 years of age for children given two standard doses of Edmonston-Zagreb measles vaccines at 4.5 and 9 months of age compared…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Thorsten Beck, Asli Demirgüç‐Kunt, María Soledad Martínez Pería · 2010 · Journal of Financial Services Research
Using data for 91 large banks from 45 countries, this paper finds that foreign, domestic private, and government-owned banks use different lending technologies and organizational structures for SME financing. The extent, type, and pricing…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Colter Mitchell, John Hobcraft, Sara McLanahan et al. · 2014 · Proceedings of the National Academy of Sciences
Disadvantaged social environments are associated with adverse health outcomes. This has been attributed, in part, to chronic stress. Telomere length (TL) has been used as a biomarker of chronic stress: TL is shorter in adults in a variety…
View details →Negative / Null Result ReportOpen accessMedicine
Huijuan Wu, Christopher P. Larsen, Cesar F. Hernandez-Arroyo et al. · 2020 · Journal of the American Society of Nephrology
Significance Statement Kidney involvement may occur in coronavirus disease 2019 (COVID-19), and can be severe among Black individuals. In this study of collapsing glomerulopathy in six Black patients with COVID-19, the authors found that…
View details →Negative / Null Result ReportOpen accessMedicine
Gaurav Aggarwal, Giuseppe Lippi, Brandon Michael Henry · 2020 · International Journal of Stroke
INTRODUCTION: There is an urgent need to identify patients at high risk during the ongoing coronavirus disease (COVID-19) pandemic. Whether a history of stroke is associated with increased severity of disease or mortality is unknown.…
View details →Negative / Null Result ReportPsychology
Trevor J. Egli, Helen W. Bland, Bridget F. Melton et al. · 2011 · Journal of American College Health
OBJECTIVE: The authors examined differences in exercise motivation between age, sex, and race for college students. PARTICIPANTS: Students from 156 sections of physical activity classes at a midsize university were recruited (n = 2,199;…
View details →Negative / Null Result ReportOpen accessMedicine
Felipe Lobelo, Isabel Garcia de Quevedo · 2014 · American Journal of Lifestyle Medicine
Physical inactivity constitutes the fourth leading cause of death worldwide. Health care providers (HCPs) should play a key role in counseling and appropriately referring their patients to adopt physical activity (PA). Previous reports…
View details →Negative / Null Result ReportSocial Sciences
Maxim Pinkovskiy, Xavier Sala-i-Martín · 2016 · The Quarterly Journal of Economics
Abstract GDP per capita and household survey means present conflicting pictures of the rate of economic development in emerging countries. One of the areas in which the national accounts–household surveys debate is key is the measurement…
View details →