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19,815 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessEngineering

Bridging the missing middle in osseointegration: meso-scale topography between macro design and microroughness

Takahiro Ogawa, Rune Shibata, Keiji Komatsu et al. · 2025 · International Journal of Implant Dentistry

PURPOSE: Despite decades of clinical success with microrough implant surfaces, persistent challenges-particularly the biological trade-off between osteoblast proliferation and differentiation-highlight the need for novel surface design strategies. This review investigates the potential of meso-scale topography (10-500 μm) as a promising and underexplored dimension in implant surface engineering, situated between macro-level implant geometry and conventional microroughness. METHODS: A systematic review, supplemented by a targeted literature search, was conducted to evaluate the biological and m

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Negative / Null Result ReportOpen accessMedicine

NANO-LM: An updated scorecard for the clinical assessment of patients with leptomeningeal metastases

Émilie Le Rhun, Lakshmi Nayak, Mary Jane Lim-Fat et al. · 2024 · Neuro-Oncology

BACKGROUND: There are no validated tools for the clinical neurological assessment of patients with leptomeningeal metastases (LM). However, clinical examination during the course of the disease guides medical management and is part of response assessment in clinical trials. Because neuroimaging may not always be obtained owing to rapid clinical deterioration, clinical neurological assessment of LM is essential, and standardization is important to minimize rater disagreement. METHODS: The Response Assessment in Neuro-oncology-LM group launched a 2-step process, aiming at improving and standardi

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Negative / Null Result Report

A Refined Model of Stress–Diathesis Relationships in Mothers With Significant Depressive Symptom Severity

Yui Matsuda, Todd A. Schwartz, YunKyung Chang et al. · 2019 · Journal of the American Psychiatric Nurses Association

BACKGROUND: Mothers’ depressive symptoms affect their children’s growth as well as physical and mental well-being. Moreover, mothers of young children with developmental delay or disability (DD) tend to have higher depressive symptoms.…

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Negative / Null Result ReportOpen accessMedicine

Development of a tailored intervention targeting sedentary behavior and physical activity in people with stroke and diabetes: A qualitative study using a co-creation framework

Stefan Sjørslev Bodilsen, Mette Aadahl, Troels Wienecke et al. · 2023 · Frontiers in Rehabilitation Sciences

Purpose: Type 2 diabetes and sedentary behavior pose serious health risks in stroke survivors. Using a co-creation framework, this study aimed to develop an intervention in collaboration with stroke survivors with type 2 diabetes, relatives, and cross-sectoral health care professionals to reduce sedentary behavior and increase physical activity. Materials and methods: = 10) to develop the intervention. A content analysis was used to analyze data. Results: The developed "Everyday Life is Rehabilitation" (ELiR) intervention consisted of a tailored 12-week home-based behavior change intervention

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Negative / Null Result Report

Significant effect of information placebo on exercise test results in children with normal weight, overweight and obesity

Shira Fanti‐Oren, Daphna Birenbaum‐Carmeli, Dan Nemet et al. · 2019 · Acta Paediatrica

Abstract Aim The aim of the study was to examine the effect of information placebo on fitness test results in normal weight, overweight and obese children. Methods Twenty‐four pre‐pubertal children with overweight or obesity and 24 age and…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Use of Beauveria bassiana to control northern fowl mites (Ornithonyssus sylviarum) on roosters in an agricultural research facility.

Matthew S W Rassette, Elizabeth I. Pierpont, Tina Wahl et al. · 2011 · PubMed

Treatment of Northern fowl mite (Ornithonyssus sylviarum) infestation on poultry in research facilities can be challenging. The mite has a rapid reproductive cycle (egg to adult in 5 to 7 d), and chemical treatments can be toxic to birds,…

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Negative / Null Result Report

Nutraceutical and pharmaceutical cocktails did not improve muscle function or reduce histological damage in D2-mdx mice

Hannah R. Spaulding, Tiffany Quindry, Kayleen Hammer et al. · 2019 · Journal of Applied Physiology

Progressive muscle injury and weakness are hallmarks of Duchenne muscular dystrophy. We showed previously that quercetin (Q) partially protected dystrophic limb muscles from disease-related injury. As quercetin activates PGC-1α through…

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Negative / Null Result Report

No Significant Difference in Cognitive Decline and Mortality between Parkinson’s Disease Dementia and Dementia with Lewy Bodies: Naturalistic Longitudinal Data from the Swedish Dementia Registry

Seyed-Mohammad Fereshtehnejad, Johan Lökk, Anders Wimo et al. · 2018 · Journal of Parkinson’s Disease

Background: Whether dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) are distinct disorders or two subtypes of the same entity, is not yet fully understood. There is a dearth of knowledge on differences in…

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Negative / Null Result Report

Molecular phylogeny of Echinodera and Ruteria (Coleoptera:Curculionidae:Cryptorhynchinae) and the parallel speciation of Canary Island weevils along replicate environmental gradients

Jonas J. Astrin, Peter E. Stüben · 2010 · Invertebrate Systematics

A molecular phylogeny for the western Palaearctic weevil genus Echinodera Wollaston, 1863 and the former genus Ruteria Roudier, 1954 is presented, combining two mitochondrial genes (CO1 and 16S) in a Bayesian analysis. Special…

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Negative / Null Result Report

Flow Cytometry Method Analysis of Apoptosis

Xiao-yan Xu, Xiao-cui Nie, Hai-ying Ma et al. · 2014 · Technology in Cancer Research & Treatment

Flow cytometry method (FCM) is a generally accepted tool to analyze apoptosis. Although apoptosis assay kit was applied by many companies, the manufacturers were not consistent with whether using Trypsin with EDTA to collect the adherent…

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Negative / Null Result Report

Stroke Volume Variation-Guided Goal-Directed Fluid Therapy Did Not Significantly Reduce the Incidence of Early Postoperative Complications in Elderly Patients Undergoing Minimally Invasive Esophagectomy: A Randomized Controlled Trial

Wei Tang, Yuwei Qiu, Huijie Lu et al. · 2021 · Frontiers in Surgery

Study Objective: This study aimed to investigate whether stroke volume variation (SVV)-guided goal-directed therapy (GDT) can improve postoperative outcomes in elderly patients undergoing minimally invasive esophagectomy (MIE) compared…

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Negative / Null Result Report

Ultrasonography-Guided Core Needle Biopsy Did Not Reduce Diagnostic Lobectomy for Thyroid Nodules Diagnosed as Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance

Jung Hyun Yoon, Jin Young Kwak, Hee Jung Moon et al. · 2019 · Ultrasound Quarterly

Abstract In this study, we evaluated the role of ultrasonography-guided core needle biopsy (US-CNB) in deciding upon management for prior atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS)…

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Negative / Null Result ReportMedicine

Significant effects of lymph and blood vascular invasion on the prognosis of early‐stage cervical squamous cell carcinoma

Yanna Zhang, Ming Yan, Jiehua He et al. · 2010 · Journal of obstetrics and gynaecology research

AIM: In the past 10 years, therapeutic advances have led to improved short-term efficacy for cervical carcinoma; however, the 5-year survival rate was not significantly enhanced. To investigate the effects of blood vessel invasion (BVI)…

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Negative / Null Result ReportOpen accessMedicine

Lack of benefit from hospitalization in patients with syncope: A propensity analysis

Padma Kaul, Dat T. Tran, Roopinder K. Sandhu et al. · 2020 · Journal of the American College of Emergency Physicians Open

STUDY OBJECTIVE: Patients with syncope are frequently admitted to the hospital, but whether this improves outcome is unknown. We tested whether hospitalization reduced mortality in patients who presented to emergency departments (EDs) with…

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Negative / Null Result ReportOpen accessMedicine

Effect of the index of cardiac electrophysiological balance on major adverse cardiovascular events in patients with diabetes complicated with coronary heart disease

Yuan Lin, Fang Zhou, Xihui Wang et al. · 2023 · PeerJ

Purpose: To investigate the prognostic value of the index of cardio-electrophysiological balance (ICEB) and its association with major adverse cardiac events (MACE) and cardiovascular death in diabetic patients complicated with coronary heart disease. Methods: A total of 920 diabetic patients were enrolled in this longitudinal study. Participants were categorized into three groups based on their ICEB levels: normal ICEB, low ICEB, and high ICEB. The primary outcome was the occurrence of MACE, and secondary outcomes included cardiovascular death, coronary heart disease (CHD), heart failure (HF)

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Negative / Null Result ReportOpen accessMedicine

Chemoradiation ± Atezolizumab in Limited-Stage Small Cell Lung Cancer: Results of NRG Oncology/Alliance LU005

Kristin A. Higgins, Chen Hu, Helen J. Ross et al. · 2026 · Journal of Clinical Oncology

PURPOSE NRG Oncology/Alliance LU005 (ClinicalTrials.gov identifier: NCT03811002 ) tested the addition of atezolizumab to concurrent chemoradiation (CRT) in this open-label, phase III international trial. METHODS Patients with limited-stage…

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Negative / Null Result ReportOpen accessMedicine

On the Rapid Calculation of Binding Affinities for Antigen and Antibody Design and Affinity Maturation Simulations

Simone Conti, Edmond Y. Lau, Victor Ovchinnikov · 2022 · Antibodies

The accurate and efficient calculation of protein-protein binding affinities is an essential component in antibody and antigen design and optimization, and in computer modeling of antibody affinity maturation. Such calculations remain challenging despite advances in computer hardware and algorithms, primarily because proteins are flexible molecules, and thus, require explicit or implicit incorporation of multiple conformational states into the computational procedure. The astronomical size of the amino acid sequence space further compounds the challenge by requiring predictions to be computed

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Negative / Null Result Report

Combining biological and psychosocial baseline variables did not improve prediction of outcome of a very‐low‐energy diet in a clinic referral population

P. Sumithran, K. Purcell, S. Kuyruk et al. · 2017 · Clinical Obesity

Summary Consistent, strong predictors of obesity treatment outcomes have not been identified. It has been suggested that broadening the range of predictor variables examined may be valuable. We explored methods to predict outcomes of a…

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Negative / Null Result Report

Did the use of open invitations in place of timed appointment invitations reduce the uptake of breast screening in the London region during the COVID-19 recovery?

Sue M Hudson, Kathie Binysh, Stephen W Duffy · 2022 · Journal of Medical Screening

Objective The Covid-19 pandemic created a backlog of women awaiting an invitation for breast screening in the UK. To recover in a timely fashion, the National Health Service programme opted to issue open invitations (OI) to women rather…

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Negative / Null Result Report

Significant association of urinary alpha‐1‐microglobulin compared to urinary neutrophil gelatinase‐associated lipocalin with renal insufficiency in patients with type 2 diabetes

Guangming Chen, Xiaoyun Shan, Huabin Wang · 2021 · Nephrology

Abstract Aim Various studies have reported that urinary neutrophil gelatinase‐associated lipocalin (NGAL), an indicator of tubular damage, may be an effective biomarker of renal impairment in patients with diabetes. This study aimed to…

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