Negative / Null Result ReportOpen accessEngineering
H. Fu, Xiong Zhou, Pengfei Xu et al. · 2025 · Materials
Predicting the compressive strength of concrete is essential for engineering design and quality assurance. Traditional empirical formulas often fall short in capturing complex multi-factor interactions and nonlinear relationships. This study employs an interpretable machine learning framework using Gradient Boosting Trees, Random Forest, and Backpropagation Neural Networks to predict concrete compressive strength. Bayesian optimization was employed for hyperparameter tuning, and SHAP analysis was used to quantify feature contributions. Based on 223 sets of compression test data, this study sys
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Bálint Soczó, Ildikó Pethes · 2025 · Journal of Molecular Liquids
Describing the interactions of water molecules is one of the most common, yet critical, tasks in molecular dynamics simulations . Because of its unique properties, hundreds of attempts have been made to construct an ideal interaction potential model for water. In various studies, the models have been evaluated based on their ability to reproduce different properties of water. This work focuses on the atomic-scale structure in the liquid phase of water. Forty-four classical water potential models are compared to identify those that can accurately describe the structure in alignment with experim
View details →Negative / Null Result ReportOpen accessMedicine
Sabrina Gloria Giulia Testoni, Guglielmo Albertini Petroni, Maria Laura Annunziata et al. · 2025 · Diagnostics
Inflammatory bowel diseases (IBDs), comprising Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated inflammatory diseases of the gastrointestinal (GI) tract with still-elusive etiopathogeneses and an increasing prevalence worldwide. Despite the growing availability of more advanced therapies in the last two decades, there are still a number of unmet needs. For example, the achievement of mucosal healing has been widely demonstrated as a prognostic marker for better outcomes and a reduced risk of dysplasia and cancer; however, the accuracy of endoscopy is crucial for bo
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Amalie Kjær Andresen, Mathilde Sophie Felding, Margarida M. A. Sacramento et al. · 2025 · Journal of Controlled Release
Bacterial biofilms pose a significant clinical challenge due to their intrinsic resistance to antibiotics and immune clearance. Traditional systemic antibiotic therapies are often ineffective against the structured microbial communities, emphasizing the urgent need for localized and targeted drug delivery systems. Hydrogels are three-dimensional, water-rich polymeric networks, and have emerged as a versatile platform for localized delivery of antimicrobial agents, offering controlled release, biocompatibility and the potential for functionalization with bioactive components. This review explor
View details →Negative / Null Result ReportOpen accessEngineering
Bianca Menzani, Priscille De Gea, Xavier Gidrol et al. · 2026 · Lab on a Chip
models for studying human physiology, development and disease. Their potential is very important and they have broad applications, but their impact is currently limited by persistent challenges such as incomplete maturation, batch…
View details →Negative / Null Result ReportOpen accessPsychology
Marielle Demarais, Melissa Fisher, Anne Williams-Wengerd et al. · 2024 · BMC Psychiatry
BACKGROUND: Coordinated specialty care (CSC) programs for first episodes of psychosis are increasingly offered in the United States. A component of CSC programs is active family engagement in treatment, though research on the impact of…
View details →Negative / Null Result ReportOpen accessNursing
Lea Klein, Claudia Lenz, Karsten Krüger et al. · 2025 · Lipids in Health and Disease
BACKGROUND: Different dietary choices can influence blood fatty acid profiles, which are crucial for maintaining physiological health and reducing disease risk. In particular, the exclusion of animal foods in vegetarian diets is associated with a higher risk of undersupply of long-chain omega (n)-3 fatty acids, which could, potentially, have a negative effect on inflammation. This study aimed to examine differences in plasma and erythrocyte fatty acid profiles as well as inflammation-related biomarkers between various plant-based diets and a regular omnivores diet. METHODS: The Nutritional Eva
View details →Negative / Null Result ReportOpen accessEngineering
M. A. Huque, Leon M. Tolbert, Benjamin J. Blalock et al. · 2026 · IMAPSource Proceedings
High-temperature power conversion modules (DC-DC converters, inverters, etc.) have enormous potential in extreme environment applications, including automotive, aerospace, geothermal, nuclear, and well logging. Power-to-volume and…
View details →Negative / Null Result ReportOpen accessMedicine
Solveigh C. Koeberle, Maria Thürmer, Fengting Su et al. · 2025 · Theranostics
: Our study deciphers the structural features of silybin contributing to hepatic lipid remodeling and suggests that silymarin/silybin protects the liver in individuals with mild metabolic dysregulation, involving a lipid class switch from triglycerides to phospholipids, whereas it may be less effective in disease states associated with severe metabolic dysregulation.
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Alina Marculetiu, Çiğdem Ataseven, Injazz J. Chen · 2025 · Business Ethics the Environment & Responsibility
ABSTRACT This study investigates the effectiveness of institutional pressures in motivating two contrasting sustainability strategies, symbolic and substantive, and their subsequent impact on the triple bottom line (TBL). Using data from…
View details →Negative / Null Result ReportOpen accessMedicine
Émilie Le Rhun, Lakshmi Nayak, Mary Jane Lim-Fat et al. · 2024 · Neuro-Oncology
BACKGROUND: There are no validated tools for the clinical neurological assessment of patients with leptomeningeal metastases (LM). However, clinical examination during the course of the disease guides medical management and is part of response assessment in clinical trials. Because neuroimaging may not always be obtained owing to rapid clinical deterioration, clinical neurological assessment of LM is essential, and standardization is important to minimize rater disagreement. METHODS: The Response Assessment in Neuro-oncology-LM group launched a 2-step process, aiming at improving and standardi
View details →Negative / Null Result ReportOpen accessNursing
Clara Barnés-Calle, P. Gou, E. Fulladosa et al. · 2026 · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
Fourier transform infrared spectroscopy (FTIR) combined with Amide I band deconvolution has been used to investigate protein structural changes occurring during high moisture extrusion processing (HMEP). However, it is a sensitive,…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
W. V. Jacobson-Galán, Luc Dessart, Kyle W. Davis et al. · 2025 · The Astrophysical Journal
Abstract We present analysis of the plateau and late-time phase properties of a sample of 39 Type II supernovae (SNe II) that show narrow, transient, high-ionization emission lines (i.e., “IIn-like”) in their early-time spectra from interaction with confined, dense circumstellar material (CSM). Originally presented by W. V. Jacobson-Galán et al., this sample also includes multicolor light curves and spectra extending to late-time phases of 35 SNe with no evidence for IIn-like features at <2 days after first light. We measure photospheric phase light-curve properties for the distance-correct
View details →Negative / Null Result ReportOpen accessMedicine
Ruben P. A. van Eijk, Daphne N. Weemering, Sarah Opie-Martin et al. · 2025 · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Objective To characterize the natural history of the revised ALS functional rating scale (ALSFRS-R) over a 24-month period following initial assessment, and to assess its associations with survival.Methods Longitudinal ALSFRS-R…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Nina Martino, Erin Sanders, Ramon Bossardi Ramos et al. · 2025 · Journal of Clinical Investigation
Severe systemic inflammatory reactions, including sepsis, often lead to shock, organ failure, and death, in part through an acute release of cytokines that promote vascular dysfunction. However, little is known about the vascular endothelial signaling pathways regulating the transcriptional profile in failing organs. Our work focused on signaling downstream of IL-6, due to its clinical importance as a biomarker for disease severity and predictor of mortality. Here, we show that loss of endothelial expression of the IL-6 pathway inhibitor SOCS3 promoted a type I IFN-like (IFNI-like) gene signat
View details →Negative / Null Result ReportOpen accessPsychology
Gerui Xu, Shruthi Venkatesha Murthy, Bochen Jia · 2025 · Informatics
As AI decision support systems play a growing role in high-stakes decision making, ensuring effective integration of human intuition with AI recommendations is essential. Despite advances in AI explainability, challenges persist in fostering appropriate reliance. This review explores AI decision support systems that enhance human intuition through the analysis of 84 studies addressing three questions: (1) What design strategies enable AI systems to support humans’ intuitive capabilities while maintaining decision-making autonomy? (2) How do AI presentation and interaction approaches influence
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Pengfei Fu, Xijie Li, Zhongxiang Sun et al. · 2025 · Evolutionary Applications
As a migratory agricultural pest, the fall armyworm has been in the spotlight since it invaded Africa in 2016. Invasive populations have now colonized much of the Eastern Hemisphere, causing severe damage to a wide range of crops. However, there is still disagreement internationally on the origin and mode of invasion of fall armyworm populations, especially from the Americas to China. In this study, we provided an in-depth insight into the invasion of the fall armyworm in the Eastern hemisphere based on genome-wide data from 124 fall armyworm individuals collected from 14 sites across three co
View details →Negative / Null Result ReportOpen accessMedicine
Golan Carmi · 2025 · Education Sciences
Generative AI technologies are rapidly permeating higher education as innovative tools that support teaching and learning processes. This study investigates the integration of GenAI tools into academic learning and examines their influence on students’ learning effectiveness, attitudes, and satisfaction. A quantitative survey was administered to 485 college students. The findings indicate that students’ attitudes, satisfaction, and accumulated experience with GenAI constitute the most influential factors in promoting effective learning. Perceived advantages and disadvantages also play a substa
View details →Negative / Null Result ReportOpen accessMedicine
Qi Sun, Yanping Zhao, Simiao Qiao et al. · 2026 · Nature Communications
Radiotherapy can both activate and suppress immunity, making it difficult to predict or modulate these opposing effects for better cancer treatment. Boron neutron capture therapy (BNCT), a cellular-level radiotherapy, has demonstrated…
View details →Negative / Null Result ReportOpen accessEngineering
Bin Liu, Changfeng Yan, Ming Lv et al. · 2026 · Computers in Industry
Domain adaptation-based methods are extensively applied to predict the Remaining Useful Life (RUL) of rolling bearings under complex operating conditions. However, the nonlinear degradation process of bearings gives rise to markedly…
View details →Negative / Null Result ReportOpen accessDentistry
Chen Ding, Dize Li, Linzhu Su et al. · 2026 · International Journal of Oral Science
Nanotechnology has provided thousands of novel nano-antimicrobials possessing features uncommon in clinically available antimicrobials. Here, nanocarriers loaded with conventional antimicrobials and responding to environmental changes upon…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Michael Korenjak, Nuri A. Temiz, Stéphane Keïta et al. · 2026 · Genome Medicine
BACKGROUND: Tobacco use is linked to multiple cancer types and a quarter of cancer deaths. Tobacco smoke contains numerous mutagenic chemicals such as polycyclic aromatic hydrocarbons (PAH), however, the mutagenicity of many chemicals in…
View details →Negative / Null Result ReportOpen accessEngineering
Cao Zhengzheng, Guo Fangxu, Rong Tao et al. · 2026 · Scientific Reports
Floor aquifers are responsible for approximately 55% of water inrush incidents in coal mines. As mining depths increase, the risk posed by confined floor aquifers becomes more severe. Grouting reinforcement and the sealing of water…
View details →Negative / Null Result ReportOpen accessPsychology
E. G. J. M. Arts, Bram Orobio de Castro, Ellen Luteijn et al. · 2024 · Social Development
Abstract This study investigated whether interactive virtual reality (VR) training of social and emotional abilities (InterAction) improves socio‐emotional functioning of youth with developmental language disorders (DLD). To this end we conducted a multiple baseline intervention study, comparing participants’ social abilities during a baseline phase with their changes in abilities during the intervention and posttest phase. The training group consisted of 29 adolescents ( 20 boys, 9 girls ) with DLD from the Netherlands. The training consisted of nine, weekly (45–50 min) individual sessions wi
View details →Negative / Null Result ReportOpen accessMedicine
Sathish Babu Vasamsetti, Samreen Sadaf, Mohammad A. Uddin et al. · 2026 · Nature Communications
How cellular metabolism facilitates tissue-resident macrophage maintenance remains elusive. Here we show that visceral adipose tissue (VAT)-resident macrophages, unlike monocyte-derived macrophages, are enriched with mitochondrial-specific antioxidant enzymes restraining inflammation and promoting VAT homeostasis and insulin sensitivity. Additionally, VAT resident macrophages express high levels of plasminogen activator inhibitor type 2, encoded by SerpinB2, which is involved in the blood coagulation cascade. SerpinB2 promotes adipose resident macrophage survival by regulating mitochondrial ox
View details →Negative / Null Result ReportOpen accessMedicine
Yi Zhang, Yanqi Han, Ying Sun et al. · 2026 · Signal Transduction and Targeted Therapy
Osteoarthritis (OA) is a debilitating joint disorder that causes chronic pain, inflammation, and detrimental bone alterations. Despite significant advances in understanding OA pathogenesis, current therapeutic strategies remain inadequate in halting disease progression or providing effective pain relief, highlighting unmet clinical needs. Recent insights into OA nociceptive pathways, inflammatory mediators, and organelle dysfunction have revealed promising therapeutic targets. Specifically, OA progression is driven by mitochondrial dysfunction (marked by accumulated damaged mitochondria with e
View details →Negative / Null Result ReportOpen accessComputer Science
Sterling Williams-Ceci, Maurice Jakesch, Advait Bhat et al. · 2026 · Science Advances
Artificial intelligence (AI) writing assistants powered by large language models (LLMs) are increasingly used to make autocomplete suggestions to people as they write text. Can these AI writing assistants affect people’s attitudes in this…
View details →Negative / Null Result ReportOpen accessSocial Sciences
John M. Carey, Brian J. Fogarty, Marília Gehrke et al. · 2025 · Science Advances
We investigate how to counter misinformation about voter and election fraud using data from the US and Brazil. Our study first compares two types of messages countering claims of widespread fraud: (i) retrospective corrections from…
View details →Negative / Null Result ReportOpen accessMedicine
F Visalli, Matteo Capobianco, F. Cappellani et al. · 2026 · International Journal of Molecular Sciences
Mitochondrial dysfunction represents a central hallmark of aging and a broad spectrum of chronic diseases, ranging from metabolic to neurodegenerative and ocular disorders. Nicotinamide riboside (NR), a vitamin B3 derivative and efficient precursor of NAD+ (nicotinamide adenine dinucleotide), and berberine (BBR), an isoquinoline alkaloid widely investigated in metabolic regulation, have independently emerged as promising mitochondrial modulators. NR enhances cellular NAD+ pools, thereby activating sirtuin-dependent pathways, stimulating PGC-1α–mediated mitochondrial biogenesis, and triggering
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Chunmei Cai, Guohua Ni, Lei Chen et al. · 2026 · Signal Transduction and Targeted Therapy
At high altitudes, which typically exceed 2500 m, approximately 80 million people reside permanently, with over a million visitors annually. The primary effect of high altitude is hypobaric hypoxia, which leads to decreased oxygen availability and a cascade of physiological responses. However, inadequate or excessive responses can lead to malacclimatization, resulting in hypoxemia and various high-altitude illnesses, including acute mountain sickness (AMS), high-altitude cerebral edema (HACE), high-altitude pulmonary edema (HAPE), chronic mountain sickness (CMS), and high-altitude pulmonary hy
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