Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Mohamed T. El‐Saadony, Ahmed Mohamed Saad, Mahmoud Zaki Sitohy et al. · 2026 · Frontiers in Immunology
Probiotics, defined as living microorganisms, are widely recognized for their ability to positively influence the gut microbiota, an effect increasingly linked to a wide array of health benefits. They are claimed to treat or prevent conditions ranging from infant colic to cardiovascular disease, respiratory infections, and certain cancers. Since the beginning of the 21st century, consumer demand for probiotic-enriched foods has risen significantly, propelled by these health assertions. The consumption of such products has been associated with the alleviation of disorders, including irritable b
View details →Negative / Null Result ReportOpen accessMedicine
Megan L. Uhelski, Mandee K. Schaub, Felipe Espinosa et al. · 2026 · Pain
ABSTRACT: Nonselective antagonists of voltage-gated sodium channels (VGSCs) provide effective local analgesia, but systemic administration is fraught with unwanted cardiovascular and central nervous system toxicity. The development of…
View details →Negative / Null Result ReportOpen accessMedicine
Florian Kahles, Andreas L. Birkenfeld, Nikolaus Marx · 2026 · Journal of Clinical Investigation
The incretin hormone glucagon-like peptide-1 (GLP-1) exerts potent effects on glucose metabolism, prompting the development of therapeutic strategies that enhance activity of the GLP-1 receptor (GLP-1R) pathway. Inhibitors of dipeptidyl peptidase 4 (DPP-4) prolong the half-life of endogenous GLP-1 and typically achieve reductions in HbA1c of 0.5%-0.8%. However, large-scale cardiovascular (CV) outcomes trials (CVOTs) with DPP-4 inhibitors demonstrated CV safety but did not show a reduction in CV events. A second incretin-based therapeutic approach was the development of GLP-1R agonists (GLP-1RA
View details →Negative / Null Result ReportOpen accessMedicine
Iñaki Eguren‐Santamaría, Ignacio Melero, Inmaculada Rodríguez et al. · 2025 · Journal for ImmunoTherapy of Cancer
Almost every successful anticancer treatment has been preceded by preclinical scientific breakthroughs that encouraged clinical development. However, therapeutic strategies showing promising preclinical results often fail to confirm…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Jung Ho Choi, Brandon Gipper, Shawn Shi · 2025 · Review of Accounting Studies
Early empirical evidence showed a lack of relative performance evaluation (RPE) for executive pay, a surprise given its theoretical appeal. We hypothesize that executive pay transparency can enhance the monitoring of pay practices and…
View details →Negative / Null Result ReportOpen accessMedicine
Youying Mao, Weidong Shen, Jiayao Shen et al. · 2025 · Kidney International Reports
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease and approximately 40% of patients with SLE progress to lupus nephritis (LN). The treatment of refractory SLE and LN remains challenging. This clinical study aimed to…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Sofience · 2026 · Zenodo (CERN European Organization for Nuclear Research)
This record provides SΔϕ-65 — Slop as Externalized Restabilization Cost: AI Slop, Human Slop, Authority Pollution, and the Cost of Re-entry (v1.0). SΔϕ-65 defines Slop not by whether it is produced by AI or humans, but by whether low execution or production cost externalizes high verification, rebuttal, correction, interpretation, cleanup, and restabilization cost onto others. The central proposition of this document is: Slop is not defined by the producer. Slop is defined by a cost asymmetry: low execution TCC on the producer side, high restabilization TCC on the receiver, platform, expert, p
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Xinyi Zhang, Liangjie Wang, Jian Wei et al. · 2026 · Nature Communications
Oxygen vacancies (Ov) on metal oxide surfaces exhibit high catalytic activity for activating peroxymonosulfate (PMS) in wastewater decontamination, yet their in-situ regeneration remains a significant challenge. This study successfully…
View details →Negative / Null Result ReportOpen accessChemical Engineering
Keying Wu, Weiyan Wu, Siyuan Liu et al. · 2026 · Angewandte Chemie International Edition
ABSTRACT Nitrate electroreduction reaction (NO 3 − RR) offers a promising solution to address excessive nitrate emissions by converting them into either environmentally benign dinitrogen or useful ammonia. Bimetallic catalysts, such as…
View details →Negative / Null Result ReportOpen accessMedicine
Van Nguyen, Sreenidhi Iyengar, Haroon Rasheed et al. · 2025 · Ophthalmology Science
Purpose Develop and test a deep learning (DL) algorithm for detecting referable glaucoma. Design Retrospective cohort study. Participants A total of 6116 patients from the Los Angeles County (LAC) Department of Health Services (DHS) were…
View details →Negative / Null Result ReportOpen accessMedicine
Janine Kutzsche, Nicoleta Carmen Cosma, Gunther Kauselmann et al. · 2025 · Nature Communications
Self-replicating amyloid beta (Aβ) oligomers are considered as one of the major drivers for disrupted synaptic function and plasticity, leading to impaired neuronal viability and progression of Alzheimer's disease (AD). Here, we investigated the safety, tolerability and pharmacokinetics of the anti-oligomeric peptide PRI-002, which was developed to disassemble toxic Aβ oligomers into non-toxic monomers. In a randomized, double-blind, single-center phase 1b trial, 20 patients aged between 50 and 80 years, with mild neurocognitive impairment (MCI) or mild dementia due to AD were recruited. Eligi
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Anna Carolina Bruno Ferreira, Ygor Velloso Tavares, Nina Rezende Fontana et al. · 2026 · Molecules
The widespread utilization of synthetic dyes within the textile industry, driven by their chemical recalcitrance and diverse chromatic spectra, constitutes a significant global environmental challenge. Improper discharge of these highly stable effluents into natural water bodies leads to severe ecological imbalances, affecting aquatic life and soil integrity while posing indirect risks to human health due to their mutagenic potential. Conventional physicochemical treatment methods are often hindered by prohibitive operational costs and the frequent generation of hazardous secondary pollutants.
View details →Negative / Null Result ReportOpen accessComputer Science
Dunigan Parker Folk, Elizabeth Dunn · 2026 · Psychological Science
Advances in AI have enabled chatbots to provide warm, personalized support. Yet little is known about the long-term consequences of AI companionship. Across a 12-month longitudinal study with more than 2,000 adults from four Western…
View details →Negative / Null Result ReportOpen accessMedicine
Vesna Bjelic‐Radisic, Fátima Cardoso, Joachim Weis et al. · 2025 · The Breast
BACKGROUND: The EORTC QLQ-BR23, published in 1996, was one of the first disease-specific questionnaires to assess health-related quality of life (HRQoL) in patients with breast cancer (BC). In the last decades, major changes in BC…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Ali Derakhshan, Gurpinder Singh Lalli, Yujong Park · 2026 · Language Testing in Asia
While Artificial Intelligence (AI) has significantly transformed L2 testing and assessment, empirical research into how EFL practitioners perceive the specific opportunities and challenges of these tools remains limited. To address this…
View details →Negative / Null Result ReportOpen accessNeuroscience
Madhur Mangalam · 2025 · European Journal of Applied Physiology
The Bayesian brain hypothesis-the idea that neural systems implement or approximate Bayesian inference-has become a dominant framework in cognitive neuroscience over the past two decades. While mathematically elegant and conceptually unifying, this paper argues that the hypothesis occupies an ambiguous territory between useful metaphor and testable, biologically plausible mechanistic explanation. We critically examine the key claims of the Bayesian brain hypothesis, highlighting issues of unfalsifiability, biological implausibility, and inconsistent empirical support. The framework's remarkabl
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Richard E. Pratley, Douglas Scott Denham, Rupal Trivedi et al. · 2026 · Nature Medicine
Abstract Loss of lean mass in proportion to total weight loss is observed with incretin mimetic therapies such as tirzepatide and has the potential to adversely affect health and function. Apitegromab is an investigational, fully human monoclonal antibody that selectively inhibits myostatin activation and is, thereby, capable of increasing muscle mass. In the randomized, double-blind, placebo-controlled phase 2 EMBRAZE study, adults with overweight or obesity ( n = 102) were randomized 1:1 to receive tirzepatide plus apitegromab (10 mg kg −1 ) or tirzepatide plus placebo. At week 24, apitegrom
View details →Negative / Null Result ReportOpen accessMedicine
Robin Murray, Alice Egerton, Yueming Gao et al. · 2025 · Biological Psychiatry
Much is known about the use, benefits, and side-effects, of clozapine in treatment resistant schizophrenia (TRS). However, why clozapine is more effective than other antipsychotics in TRS remains unclear. This paper addresses this question. TRS patients show glutamate abnormalities, and clozapine has widespread effects on glutamate. However, these actions have not been proven different to those of other antipsychotics. Immune dysfunction is also reported in TRS, and clozapine has anti-inflammatory actions, but these have not been correlated with clinical improvement. Currently, there is much i
View details →Negative / Null Result ReportOpen accessMedicine
Linjie Luo, Yan Wang, Tuyen Bui et al. · 2026 · Nature Communications
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are the standard first-line treatment for hormone receptor-positive, HER2−negative (HR+/HER2−) metastatic breast cancer, but resistance inevitably develops.…
View details →Negative / Null Result ReportOpen accessNeuroscience
Jorge Escudero, Judit Gonzalvo, Maria-Dolors Piulachs et al. · 2025 · PLoS Genetics
Insect metamorphosis occurs in two main forms, hemimetaboly (simple) and holometaboly (complete), both regulated by hormonal and genetic pathways involving the transcription factors Krüppel homolog 1 (Kr-h1), Broad-Complex (BR-C), and Ecdysone-induced protein 93F (E93). The BTB-zinc finger protein Chronologically inappropriate morphogenesis (Chinmo), recently identified in the fruit fly Drosophila melanogaster, an holometabolan, as a larval state maintainer, was studied here in the German cockroach, Blattella germanica, an hemimetabolan. We also examined another BTB transcription factor, Abrup
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Victoria Bae‐Jump, Michael W. Sill, Paola A. Gehrig et al. · 2025 · Gynecologic Oncology
INTRODUCTION: We evaluated the efficacy of the addition of the anti-diabetic drug metformin to standard-of-care paclitaxel and carboplatin (PC) in patients with advanced and recurrent endometrial cancer (EC). METHODS: In this phase II/III…
View details →Negative / Null Result ReportOpen accessMedicine
Jacopo Conti, Nicholas Geremia, Stefano Di Bella et al. · 2025 · European Journal of Clinical Microbiology & Infectious Diseases
PURPOSE: To describe the epidemiology, diagnosis, microbiological findings, clinical features, and outcomes of infectious spondylodiscitis (IS). METHODS: Retrospective analysis of 98 IS patients (2010-2023 - Trieste Hospital). Clinical, radiological, and microbiological data analysed, multivariate logistic regression assessed risk factors for poor outcomes. RESULTS: The incidence of IS was 3 cases per 100,000 inhabitants per year. Pyogenic infections accounted for 54% of cases, tuberculosis for 10%, while 35% remained of unknown etiology. Back pain (79%) and fever (72%) were the most common sy
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Richard Stiskalek, Harry Desmond, Julien Devriendt et al. · 2025 · Monthly Notices of the Royal Astronomical Society
ABSTRACT The peculiar velocity field of the local Universe provides direct insights into its matter distribution and the underlying theory of gravity, and is essential in cosmological analyses for modelling deviations from the Hubble flow. Numerous methods have been developed to reconstruct the density and velocity fields at $z \lesssim 0.05$, typically constrained by redshift-space galaxy positions or by direct distance tracers such as the Tully–Fisher relation, the Fundamental Plane, or Type Ia supernovae. We introduce a validation framework to evaluate the accuracy of these reconstructions
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Koen H.M. Prange, Gemma Bel-Bordes, MAC Depuydt et al. · 2026 · European Heart Journal
BACKGROUND AND AIMS: Atherosclerosis is a chronic lipid-driven inflammatory disease and one of the leading underlying causes of cardiovascular morbidity and mortality in Western society. Macrophages are key players in atherosclerotic development. Although the cellular composition of carotid atherosclerotic lesions has been determined, macrophage population definitions lack granularity and lineage data. Moreover, to date no direct link has been established between cellular content of atherosclerotic lesions and secondary clinical outcome. This study is aimed at characterization of atherosclerot
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mathilde Bourdon, Chloé Maignien, Marion Ouazana et al. · 2025 · Reproductive BioMedicine Online
Oestradiol plays a crucial role in reproduction, particularly in assisted reproductive technology (ART), where it can reach supraphysiological concentrations. These fluctuations occur during ovarian stimulation in fresh embryo transfer cycles and during endometrial preparation for frozen embryo transfer, potentially impacting implantation and perinatal outcomes. Oestradiol influences endometrial proliferation, receptivity, implantation and placentation, with the sensitivity of the endometrium to systemic oestrogen emerging as a key determinant of reproductive success. In fresh embryo transfer
View details →Negative / Null Result ReportOpen accessMedicine
Shabnam Santos, Ivonne Salinas, Nicolás Almeida et al. · 2025 · Engineering Microbiology
ABSTRACT Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder characterized by debilitating motor and non-motor symptoms. Its etiology is multifactorial, with no single definitive cause identified, although aging…
View details →Negative / Null Result ReportOpen accessMedicine
Joseph R. Winer, Hillary Vossler, Christina B. Young et al. · 2024 · Brain Communications
Abstract Co-pathology is frequent in Lewy body disease, which includes clinical diagnoses of both Parkinson’s disease and dementia with Lewy bodies. Measuring concomitant pathology in vivo can improve clinical and research diagnoses and prediction of cognitive trajectories. Tau PET imaging may serve a dual role in Lewy body disease by measuring cortical tau aggregation as well as assessing dopaminergic loss attributed to binding to neuromelanin within substantia nigra. We sought to characterize 18F-PI-2620, a next generation PET tracer, in individuals with Lewy body disease. We recruited 141 p
View details →Negative / Null Result ReportOpen accessComputer Science
Qiuhan Zhu, Xiangnan Li, Yiang Dong et al. · 2026 · Frontiers in Psychology
Generative AI tools such as ChatGPT now perform core cognitive operations—reasoning, synthesis, evaluation, and creative generation—on users' behalf, raising urgent questions for educational psychology about how AI use relates to cognitive development. Yet research on cognitive offloading has largely treated AI use as a unidimensional phenomenon, obscuring a theoretically consequential distinction: whether AI substitutes for the user's own thinking or scaffolds it. Drawing on the autonomous–dependent help typology and self-determination theory, the present study introduces and examines a disti
View details →Negative / Null Result ReportOpen accessMedicine
Şafak Kılıç · 2025 · PLoS ONE
BACKGROUND AND OBJECTIVE: Male fertility assessment through sperm morphology analysis remains a critical component of reproductive health evaluation, as abnormal sperm morphology is strongly correlated with reduced fertility rates and poor assisted reproductive technology outcomes. Traditional manual analysis performed by embryologists is time-intensive, subjective, and prone to significant inter-observer variability, with studies reporting up to 40% disagreement between expert evaluators. This research presents a novel deep learning framework combining Convolutional Block Attention Module (CB
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jong Won Shin, Minh Nguyen Thien, Sun Ha Jee · 2025 · Healthcare
Background: Bilirubin is a potent endogenous antioxidant that plays a key role in regulating oxidative stress and inflammation, both closely linked to lung carcinogenesis. This study reinterprets the ALBI (Albumin–Bilirubin) and PALBI (Platelet–Albumin–Bilirubin) indices as composite markers of antioxidant and inflammatory status and evaluates their associations with lung cancer risk by sex, including stratified analyses by major lifestyle factors such as smoking and alcohol use. Methods: This study utilized data from the Korean Cancer Prevention Study-II (KCPS-II) cohort, which included 133,6
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