19,814 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Barton J. Mann, Taco Gosens, Stephen Lyman · 2012 · The American Journal of Sports Medicine
Treatment outcome researchers in orthopaedics frequently report only tests of statistical significance between group means to evaluate the effectiveness of a given intervention. Although important in establishing that mean differences are…
View details →Haoran Zhou, Jung-Min Ji, Min Kim et al. · 2018 · Nanomaterials
The rational design of porphyrin sensitizers is always crucial for dye-sensitized solar cells (DSSCs), since the change of only a single atom can have a significant influence on the photovoltaic performance. We incorporated the…
View details →Joshua Fisher, Poonam Arora, Sophia Rhee · 2018 · Sustainability
The viability of conservation efforts, including protected areas and buffer zones, depends on finding ways to make those strategies more attractive and viable for local populations. This paper presents a pilot study utilizing a rapid rural…
View details →Geoffrey L. Dickens, Laura E. O'Shea · 2017 · International Journal of Forensic Mental Health
Outcomes measures are commonly derived from post-discharge recidivism, readmission, and mortality rates but information about common outcomes across admission is scant. We determined whether reliable and clinically significant change in…
View details →Seo-Ha Jeong, Yeon Gyo Nam · 2024 · Healthcare
Background/Objectives: Globally, life expectancy has been increasing with South Korea focusing on improving health to enhance quality of life. The COVID-19 pandemic further emphasized the need for digital transformation in healthcare,…
View details →Wenhua Wan, Petra Döll, Hang Zheng · 2022 · Water Resources Research
Abstract To support the implementation of China's carbon neutrality target, this study assesses the impact of future climate change on hydroelectricity production (HP) in China. We developed a hydropower database for mainland China, which…
View details →Joon Young Choi, Jeong Uk Lim, Ho Jung Jeong et al. · 2020 · BMC Pulmonary Medicine
Abstract Background We investigated the association between a combination of two markers, peripheral (PEC) and bronchoalveolar lavage (BAL) eosinophil percentage (BEP), and oxygen requirements in patients with acute eosinophilic pneumonia…
View details →Dhyani Mehta · 2024 · Carbon Research
Abstract The current research investigates the impact of financial development, digitalization, green trade, manufacturing, and national income on carbon dioxide (CO 2 ) emissions of six Mediterranean countries (MEDIT-6). The study uses a nonlinear panel quantile regression model with panel data of MEDIT-6 countries from 1994 to 2022. The study asserts that higher financial development will reduce CO 2 emissions for MEDIT-6 countries, as it provides more financing options to invest in green energy and potentially curb excessive energy consumption which in turn reduces CO 2 emissions. The study
View details →Giacomo Mutti, Eduard Ocaña‐Pallarès, Toni Gabaldón · 2025 · Molecular Biology and Evolution
Recent developments in protein structure prediction have allowed the use of this previously limited source of information at genome-wide scales. It has been proposed that the use of structural information may offer advantages over…
View details →Jinbiao Huo, Ziyuan Gu, Zhiyuan Liu et al. · 2025 · Transportation Science
This study focuses on simulation-based optimization (SBO) in transportation systems considering the pervasive and influential heteroscedastic noise. Existing studies rarely consider the effects of such heteroscedasticity on the solution…
View details →Chao Jiang, Yingying Dai, Yunheng Ding et al. · 2024 · Brain Sciences
Electroencephalography (EEG)-based emotion recognition is increasingly pivotal in the realm of affective brain-computer interfaces. In this paper, we propose TSANN-TG (temporal-spatial attention neural network with a task-specific graph), a novel neural network architecture tailored for enhancing feature extraction and effectively integrating temporal-spatial features. TSANN-TG comprises three primary components: a node-feature-encoding-and-adjacency-matrices-construction block, a graph-aggregation block, and a graph-feature-fusion-and-classification block. Leveraging the distinct temporal sca
View details →Wen Sun, Pan Zhang, Miaomiao Hu et al. · 2025 · Radiology
= .39). Conclusion In patients with VBAO admitted with an NIHSS score of 10 or less, early EVT (DPT ≤ 120 minutes) combined with BMM outperformed BMM alone, whereas late EVT (DPT > 120 minutes) combined with BMM did not outperform BMM…
View details →Witat Fakcharoenphol, T. Stelzer · 2014 · Physical Review Special Topics - Physics Education Research
In this clinical study on helping students prepare for an exam, we compared three different treatments. All students were asked to take a practice exam. One group was then given worked-out solutions for that exam, another group was given the solutions and targeted exercises to do as homework based on the result of their practice exam, and the third group was given the solutions, homework, and also an hour of one-on-one tutoring. Participants from all three conditions significantly outperformed the control group on the midterm exam. However, participants that had one-on-one tutoring did not out
View details →Hae Won Kim, Jee In Kang, Eunhee Hwang et al. · 2018 · PLoS ONE
Accumulating evidence suggests that the glutamatergic system plays a major role in the pathophysiology of obsessive compulsive disorder (OCD) and empathic processing. Particularly, genetic influence of glutamate transporter gene (SLC1A1) on OCD has been frequently replicated in previous studies, but several studies did not replicate the result. Therefore, we aimed to replicate the associations between the SLC1A1 and OCD in a Korean population. In addition, we investigated the influence of SLC1A1 on trait empathy, impairments in which are characteristic of OCD. Six single-nucleotide polymorphis
View details →Chitra Priyadarshani, Ranjan Laik, Sumit Sow et al. · 2025 · Archives of Agronomy and Soil Science
Integrated crop residue management with micronutrient application can effectively addresses dual challenges of maintaining productivity while enhancing grain nutritional quality of rice in calcareous soils. This study evaluated the role of different soil properties for enhancing yield and grain quality of rice under 29 years of long-term effects of crop residue incorporation and zinc (Zn) fertilization in calcareous Typic Haplaquepts soils. Results showed 100% crop residue incorporation significantly enhanced soil organic carbon (SOC), available nitrogen, available Zn, soil respiration, and we
View details →Athina Trachalaki, Anna Lindahl, Simone Petrarulo et al. · 2025 · Breathe
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with limited treatment options. Despite the approval of pirfenidone and nintedanib that slow disease progression, IPF remains a disease with poor survival. Promising therapeutic…
View details →Zhendong Zhao, Huiwang Dai, Tiantian Nie et al. · 2025 · Nature Communications
High-valent iron-oxo species (FeIV=O) have garnered increasing attention for water purification, while the selective generation of FeIV = O in Fenton-like reactions still lacks an effective control protocol at the atomic level. Here, we…
View details →Yadong Yang, Lei Xu, Yongdong Li et al. · 2025 · Journal of Extracellular Vesicles
ABSTRACT Bacterial outer membrane vesicles (OMVs) are emerging as promising platforms for drug delivery and immunotherapy. However, bacteria only secrete a small amount of OMVs during the growth process, which seriously restricts their…
View details →Bilal A. Siddiqui, Sumit K. Subudhi, Padmanee Sharma · 2022 · Cell Reports Medicine
The addition of atezolizumab (anti-PD-L1) to enzalutamide (androgen receptor antagonist) did not prolong survival in metastatic prostate cancer.1Powles T. Yuen K.C. Gillessen S. Kadel 3rd, E.E. Rathkopf D. Matsubara N. Drake C.G. Fizazi K.…
View details →Pinar Sargin, Mark F. Roethle, Shuang Jia et al. · 2022 · Gut Microbes
The increasing incidence of Type 1 diabetes has coincided with the emergence of the low-fiber, high-gluten Western diet and other environmental factors linked to dysbiosis. Since Lactiplantibacillus plantarum 299 v (Lp299v) supplementation improves gut barrier function and reduces systemic inflammation, we studied its effects in spontaneously diabetic DRlyp/lyp rats provided a normal cereal diet (ND) or a gluten-free hydrolyzed casein diet (HCD). All rats provided ND developed diabetes (62.5±7.7 days); combining ND with Lp299v did not improve survival. Diabetes was delayed by HCD (72.2±9.4 day
View details →Malte L Schmieding, Marvin Kopka, Myrto Bolanaki et al. · 2025 · Journal of Medical Internet Research
BACKGROUND: Symptom checker apps (SCAs) are layperson-facing tools that advise on whether and where to seek care, or possible diagnoses. Previous research has primarily focused on evaluating the accuracy, safety, and usability of their recommendations. However, studies examining SCAs' impact on clinical care, including the patient-physician interaction and satisfaction with care, remain scarce. OBJECTIVE: This study aims to evaluate the effects of an SCA on satisfaction with the patient-physician interaction in acute care settings. Additionally, we examined its influence on patients' anxiety a
View details →Steven D. Nathan, Victoria Lacasse, Heidi Bell et al. · 2024 · Pulmonary Circulation
The PERFECT study, a randomized, controlled, double-blind study of inhaled treprostinil in patients with COPD and associated pulmonary hypertension (PH-COPD) was a negative trial that was terminated early. The reason(s) for the negative…
View details →Jason E. Pope, Ajay Antony, Erika Petersen et al. · 2024 · Pain and Therapy
INTRODUCTION: Drawbacks of fixed-output spinal cord stimulation (SCS) screening trials may lead to compromised trial outcomes and poor predictability of long-term success. Evoked compound action potential (ECAP) dose-controlled closed-loop…
View details →Sandra Heskamp, Otto C. Boerman, Janneke D.M. Molkenboer‐Kuenen et al. · 2014 · Molecular Pharmaceutics
Bevacizumab and cetuximab are approved for the treatment of cancer. However, in advanced colorectal cancer, addition of cetuximab to chemotherapy with bevacizumab did not improve survival. The reason for the lack of activity remains…
View details →Takahiro Ogawa, Rune Shibata, Keiji Komatsu et al. · 2025 · International Journal of Implant Dentistry
PURPOSE: Despite decades of clinical success with microrough implant surfaces, persistent challenges-particularly the biological trade-off between osteoblast proliferation and differentiation-highlight the need for novel surface design strategies. This review investigates the potential of meso-scale topography (10-500 μm) as a promising and underexplored dimension in implant surface engineering, situated between macro-level implant geometry and conventional microroughness. METHODS: A systematic review, supplemented by a targeted literature search, was conducted to evaluate the biological and m
View details →Özgür Atılgan, Franz W. Kellermanns · 2025 · Family Business Review
We investigate how negative types of intra-family conflicts (i.e., status conflict and relationship conflict) influence the family firm leader’s socioemotional wealth importance (SEWi). Based on 159 matched responses from family firm…
View details →Bekir Enes Koca, Sümeyye Sarıtaş, Mikhaël Bechelany et al. · 2025 · International Journal of Molecular Sciences
Polyphenols are bioactive molecules that occur naturally in plants and exhibit a diverse array of properties, including antioxidant, anti-inflammatory, and anti-obesity effects, all of which have been supported by numerous studies. They are categorized into four main groups: flavonoids, phenolic acids, stilbenes, and lignans. Polyphenols demonstrate a wide range of health-promoting effects throughout human life, from the womb to old age. They can exert these effects by modulating signaling pathways, regulating gut microbiota, influencing gene expression, and regulating epigenetic pathways. Thi
View details →Haisheng Zhang, Jiawei Li, Haijing Yan et al. · 2025 · Advanced Materials
Proton exchange membrane water electrolysis (PEMWE) is a promising blueprint for the industrial production of green hydrogen in the short term, but its large-scale deployment is extremely constrained by the high cost and low storage of…
View details →Yohsuke Ohtsubo, Miyu Higuchi · 2022 · Letters on Evolutionary Behavioral Science
This study aimed at replicating a previously reported pattern: costly apologies are perceived as more sincere than non-costly apologies even when the transgression was unintentional, while costly apologies do not foster forgiveness more than non-costly apologies when the transgression was unintentional. We conducted a vignette study with a 2 (apology cost: costly vs. non-costly) × 3 (intention: no vs. ambiguous vs. malicious intention) between-participants factorial design. We failed to replicate the aforementioned pattern. Instead, we found that costly apologies promote not only perceived sin
View details →Gustavo Jimenez‐Maggiora, Arndt‐Peter Schulz, Michael Donohue et al. · 2024 · The Journal of Prevention of Alzheimer s Disease
BACKGROUND: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) studies were conducted between 2014 and 2023, with enrollment completed in 2017 and final study results reported in 2023. The study screening process involved the collection of initial clinical, cognitive, neuroimaging, and genetic measures to determine eligibility. Once randomized, enrolled participants were assessed every four weeks over a 4.5-year follow-up period during which longitudinal clinical, cognitive, and neuroimaging measures wer
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