Negative / Null Result ReportOpen accessHealth Professions
Allison Kufta, Ali R. Djalilian · 2025 · Journal of Clinical Medicine
Background/Objectives: Patient education materials (PEMs) in ophthalmology often exceed recommended readability levels, limiting accessibility for many patients. While organizations like the AAO provide relatively easy-to-read resources, topics remain limited, and other associations’ PEMs are too complex. AI chatbots could help clinicians create more comprehensive, accessible PEMs to improve patient understanding. This study aims to compare the readability of patient education materials (PEMs) written by the American Academy of Ophthalmology (AAO) with those generated by large language models
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Alfonz Kedves, Máté Balogh, Zoltán Kónya · 2026 · ACS ES&T Water
High Resolution Image Download MS PowerPoint Slide The increasing discharge of emerging contaminants (ECs) such as zinc oxide nanoparticles (ZnO NPs) and degradable microplastics (DMPs) into aquatic environments poses a growing challenge for next-generation wastewater treatment technologies. This study investigates the individual and combined effects of ZnO NPs, polylactic acid (PLA), and polycaprolactone (PCL) microplastics on microalgal-bacterial granular sludge (MBGS), a promising low-energy biotechnological system. Using photosequencing batch reactors, changes in extracellular polymeric su
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Alok Bharadwaj, R. de Bruin, Arjen J. Jakobi · 2026 · Nature Communications
Cryogenic sample electron microscopy (cryo-EM) maps often display uneven quality, with high-resolution features coexisting alongside weak or poorly ordered regions. Such variation complicates structural interpretation, especially for heterogeneous macromolecular assemblies. Here, we present LocScale-2.0, a context-aware map optimisation framework that operates without prior knowledge of molecular structure or composition. By leveraging general expectations of electron scattering by biological macromolecules, it enhances local detail and connectivity while preserving weak but biologically relev
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sevgi Kundu, Senem Akkoç, Yalçın Erzurumlu et al. · 2026 · Molecular and Cellular Biochemistry
Abstract Within the scope of this investigation, two novel compounds ( 3a and 3b ) were designed and synthesized in two steps. Compounds 3a and 3b were tested utilizing the MTT study to evaluate their in vitro cytotoxic activity against healthy human embryonic kidney, lung cancer, breast cancer, and human liver cancer cell lines. It was determined that compound 3b exhibited high levels of cytotoxic activity against both liver and breast cancer cell lines, with IC 50 values of 10.83 and 11.55 µM, respectively. Also, to elucidate the anticancer mechanism of compounds, pro-apoptotic BAX and BiD ,
View details →Negative / Null Result ReportOpen accessEnergy
Ahmed M. Khalil, Samir M. Kamel, Mohamed S. Mohy Eldin · 2026 · Scientific Reports
This work used a simple technique to prepare a novel cerium titanate nano-rods embedded in a cellulose-based hydrogel with high photo catalytic degradation activity. The composite hydrogel was prepared by embedding different amounts of cerium titanate nano-rods (Ce/Ti-NRs) into a crosslinked carboxymethyl cellulose/polyacrylamide polyelectrolyte complex (CMC/PAM) as a matrix material. The physico-chemical properties of the Ce/Ti-NRs, CMC/PAM, and cerium titanate nano-rods embedded in a cellulose-based hydrogel (Ce/Ti-NRs/CMC/PAM) were investigated by FT-IR, XRD, BET, TEM, SEM, and EDX techniqu
View details →Negative / Null Result ReportOpen accessChemical Engineering
Keying Wu, Weiyan Wu, Siyuan Liu et al. · 2026 · Angewandte Chemie International Edition
ABSTRACT Nitrate electroreduction reaction (NO 3 − RR) offers a promising solution to address excessive nitrate emissions by converting them into either environmentally benign dinitrogen or useful ammonia. Bimetallic catalysts, such as…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Richard E. Pratley, Douglas Scott Denham, Rupal Trivedi et al. · 2026 · Nature Medicine
Abstract Loss of lean mass in proportion to total weight loss is observed with incretin mimetic therapies such as tirzepatide and has the potential to adversely affect health and function. Apitegromab is an investigational, fully human monoclonal antibody that selectively inhibits myostatin activation and is, thereby, capable of increasing muscle mass. In the randomized, double-blind, placebo-controlled phase 2 EMBRAZE study, adults with overweight or obesity ( n = 102) were randomized 1:1 to receive tirzepatide plus apitegromab (10 mg kg −1 ) or tirzepatide plus placebo. At week 24, apitegrom
View details →Negative / Null Result ReportOpen accessEngineering
Lorenzo Tamboia, Giorgio Montinaro, Elisa Ravesio et al. · 2026 · Journal of Cleaner Production
The growing demand for sustainable energy solutions has highlighted the crucial role of lithium-ion batteries (LIBs) in the global energy transition. However, the conventional use of polyvinylidene fluoride (PVDF) binders combined with…
View details →Negative / Null Result ReportOpen accessHealth Professions
Andrew Hughes, Daniel J. Taylor, P D Morris et al. · 2026 · European Heart Journal
Wearable devices are transforming cardiovascular medicine by enabling continuous monitoring of physiologic and behavioural measures outside of traditional clinical settings. Smartwatches and activity trackers, the most widely used wearables, employ motion and biometric sensors to measure physical activity, sleep quality, heart rate, and rhythm. By converting health goals into objective, quantifiable measures, wearable devices empower patients to assume a more active role in their health while providing clinicians with novel opportunities for longitudinal, real-world assessment. Clinical applic
View details →Negative / Null Result ReportOpen accessMedicine
A. Giordano, Cristina Romero-Mascarell, Begoña González-Suárez et al. · 2025 · Digestive Diseases and Sciences
The integration of artificial intelligence (AI) into capsule endoscopy is transforming gastrointestinal diagnostics by enhancing lesion detection and optimizing reading efficiency. This review focuses on the clinical applications of…
View details →Negative / Null Result ReportOpen accessMedicine
Robin Murray, Alice Egerton, Yueming Gao et al. · 2025 · Biological Psychiatry
Much is known about the use, benefits, and side-effects, of clozapine in treatment resistant schizophrenia (TRS). However, why clozapine is more effective than other antipsychotics in TRS remains unclear. This paper addresses this question. TRS patients show glutamate abnormalities, and clozapine has widespread effects on glutamate. However, these actions have not been proven different to those of other antipsychotics. Immune dysfunction is also reported in TRS, and clozapine has anti-inflammatory actions, but these have not been correlated with clinical improvement. Currently, there is much i
View details →Negative / Null Result ReportOpen accessNeuroscience
Madhur Mangalam · 2025 · European Journal of Applied Physiology
The Bayesian brain hypothesis-the idea that neural systems implement or approximate Bayesian inference-has become a dominant framework in cognitive neuroscience over the past two decades. While mathematically elegant and conceptually unifying, this paper argues that the hypothesis occupies an ambiguous territory between useful metaphor and testable, biologically plausible mechanistic explanation. We critically examine the key claims of the Bayesian brain hypothesis, highlighting issues of unfalsifiability, biological implausibility, and inconsistent empirical support. The framework's remarkabl
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Gabriel Baldanzi, Anna Larsson, Sergi Sayols-Baixeras et al. · 2026 · Nature Medicine
Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gut microbiome. In multivariable confounder-adjusted regression models, antibiotic use <1 year before fecal sampling was associated with the greatest reduction in species diversity, but significant asso
View details →Negative / Null Result ReportOpen accessSocial Sciences
Ingvild Almås, Alexander W. Cappelen, Erik Ø. Sørensen et al. · 2026 · The Quarterly Journal of Economics
Abstract This article provides the first comprehensive global evidence on people’s fairness and efficiency preferences, beliefs about the sources of inequality and the efficiency cost of redistribution, and policy attitudes toward redistribution. Using a globally harmonized consequential experiment with more than 65,000 individuals across 60 countries, we show that the source of inequality plays a substantially larger role for inequality acceptance than the efficiency cost of redistribution. At the global level, implemented inequality increases by 85% when inequality is caused by merit rather
View details →Negative / Null Result ReportOpen accessMedicine
Marta Młodawska, Anna Zmelonek-Znamirowska, Grzegorz Świercz et al. · 2026 · Journal of Clinical Medicine
Background and Objectives: Placenta accreta spectrum (PAS) complicating placenta praevia is associated with increased maternal morbidity; however, neonatal respiratory burden may be underappreciated. We compared neonatal outcomes between pregnancies complicated by placenta praevia with and without histopathologically confirmed PAS, with additional adjustment of respiratory outcomes for gestational age at delivery. Materials and Methods: We conducted a retrospective single-centre cohort study (n = 82). Based on placental histopathology, women were classified as PAS (n = 37; accreta/increta/perc
View details →Negative / Null Result ReportOpen accessDecision Sciences
Yuan Tao, Yu Z, Tianxue Chen et al. · 2026 · iScience
Phytomedicine extraction-process optimization often relies on regression or machine learning models, but model choice is commonly judged by goodness of fit alone. Here, we assembled 1,148 structurally eligible extraction datasets from…
View details →Negative / Null Result ReportOpen accessArts and Humanities
Yongliang Wang, Han Shi · 2026 · Discover Computing
Abstract The role of generative artificial intelligence (GenAI) affordance in specific task teaching, particularly the continuation writing task, remains insufficiently theorized and empirically underexplored. To bridge this research gap, a repeated-measures intervention study was conducted within the framework of Dynamic Systems Theory (DST) to investigate the implementation of GenAI-assisted continuation task instruction and its associations with the development of English as a Foreign Language (EFL) students’ writing performance. Twenty-five Chinese EFL high school students participated in
View details →Negative / Null Result ReportOpen accessMedicine
Sherry S. Y. Nyeo, Erin M. Cumming, Oliver S. Burren et al. · 2026 · Nature
Abstract Epstein–Barr virus (EBV) is an endemic herpesvirus implicated in autoimmunity, cancer and neurological disorders. Although primary infection is often subclinical, persistent EBV infection can drive immune dysregulation and long-term complications. Despite the ubiquity of infection, the determinants of EBV persistence following primary exposure remain poorly understood, although human genetic variation partially contributes to this phenotypic spectrum 1–3 . Here we demonstrate that existing whole genome sequencing (WGS) data of human populations can be used to quantify persistent EBV D
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Sad Abu alim, Marwan Mansour · 2026 · Sustainability
FinTech adoption is increasingly viewed as a catalyst for sustainable finance, yet empirical evidence on how and under what conditions it enhances environmental, social, and governance (ESG) performance remains mixed, particularly in emerging economies. This study examines the relationship between FinTech adoption and ESG performance in MENA banks, explicitly modeling corruption risk as an internal governance transmission channel. Using a panel of 152 listed banks across 11 MENA countries over the period 2013–2023 and a novel bank-level FinTech Adoption Index constructed through textual analys
View details →Negative / Null Result ReportOpen accessMedicine
Ashley I. Martinez, Sarah C. MacDonald, Sruthi Adimadhyam et al. · 2026 · JAMA Network Open
Importance: Respiratory syncytial virus (RSV) is a leading cause of infant hospitalizations. In August 2023, the US Food and Drug Administration approved a bivalent RSV prefusion F subunit-based vaccine (RSVpreF) for maternal immunization…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Saimum Hossain, Faruque Ahmed · 2026 · Dhaka University Journal of Business Studies
The study investigates the relationship between bank profitability and a comprehensive list of bank-specific, industry-specific and macroeconomic variables using unique panel data from 23 Bangladeshi banks with large market shares from…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Ioannis Tsomidis, A. Tsakou, Argyro Voumvouraki et al. · 2026 · Biomedicines
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a continuum of hepatic pathological manifestations of the metabolic syndrome. Pathogenesis is not clearly understood despite recent progress, but Kupffer cells and bone marrow-derived macrophages (BMDMs) have a fundamental role. In this review, the multiple pathophysiological aspects of MASLD are presented, including genetics, insulin resistance, lipotoxicity, and inflammation. The participation of innate and adaptive immunity, as well as the implications of the recently described trained immunity, is presented. The interplay
View details →Negative / Null Result ReportOpen accessEngineering
Prabhu Gurunathappa Sheelavantar, Poornachandra Pandit, Shreelaxmi Prashant · 2026 · Scientific Reports
Abstract The need for sustainable, practical alternatives to Portland cement and two-part alkali-activated systems has led to the development of one-part alkali-activated concrete (OPAAC), which efficiently reuses industrial by-products like fly ash and ground granulated blast furnace slag (GGBS). This study evaluates the fresh (workability) and hardened properties (compressive, tensile, and flexural strengths) of FA-GGBS-based OPAAC, along with durability indicators including sorptivity and chloride ion permeability. A performance-based multi-response optimization using a Taguchi L 9 array an
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Cailin Plunkett, S. Vitale, T. A. Callister et al. · 2026 · Physical Review Letters
Repeated black-hole mergers in dense stellar clusters are a plausible mechanism to populate the predicted gap in black hole masses due to the pair-instability supernova process. These hierarchical mergers carry distinct spin…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jennifer L. Havens, Sergei L. Kosakovsky Pond, Jordan D. Zehr et al. · 2026 · Cell
Using a phylogenetic framework to characterize natural selection, we investigate the hypothesis that zoonotic viruses require adaptation prior to zoonosis to sustain human-to-human transmission. Examining the zoonotic emergence of Ebola…
View details →Negative / Null Result ReportOpen accessMedicine
Joe M. Butler, Hessel Peters Sengers, Tom D. Y. Reijnders et al. · 2025 · EBioMedicine
BACKGROUND: Knowledge of the contribution of the pathogen to the heterogeneity of the host response to infection is limited. We aimed to compare the host response in critically ill patients with a bloodstream infection (BSI). METHODS: RNA profiles were determined in blood obtained between one day before and after a positive blood culture. Differential expression and pathway analyses were performed on independent patients' samples by RNA sequencing (discovery) or microarray (validation). Additional patients were included for the discovery and validation of transcriptome classifiers of pathogen-
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Victoria Bae‐Jump, Michael W. Sill, Paola A. Gehrig et al. · 2025 · Gynecologic Oncology
INTRODUCTION: We evaluated the efficacy of the addition of the anti-diabetic drug metformin to standard-of-care paclitaxel and carboplatin (PC) in patients with advanced and recurrent endometrial cancer (EC). METHODS: In this phase II/III…
View details →Negative / Null Result ReportOpen accessMedicine
Iñaki Eguren‐Santamaría, Ignacio Melero, Inmaculada Rodríguez et al. · 2025 · Journal for ImmunoTherapy of Cancer
Almost every successful anticancer treatment has been preceded by preclinical scientific breakthroughs that encouraged clinical development. However, therapeutic strategies showing promising preclinical results often fail to confirm…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Vania Stavrakeva, JENNY TANG · 2026 · The Journal of Finance
ABSTRACT Conventional wisdom holds that lowering a home country's interest rate relative to another's will depreciate the domestic currency. We document that, at business‐cycle frequencies, U.S. forward guidance monetary policy easings had…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Jessica Coria, Jūratė Jaraitė · 2025 · Research Policy
This paper examines whether the EU Emissions Trading Scheme (EU ETS) and innovation subsidies interact to enhance green innovation at the firm level. Using staggered difference-in-differences and matched samples, we find no evidence of synergetic effects: firms subject to both the EU ETS and innovation subsidies do not outperform those subject only to subsidies in terms of green patenting outcomes. By contrast, subsidies alone have a clear positive impact on green innovation. Firms receiving subsidies generate more green patents, receive more citations, and develop technologies with greater te
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