Negative / Null Result ReportOpen accessSocial Sciences
Tyler Colasante, Katie Faulkner, Dana Kharbotli et al. · 2024 · Affective Science
Abstract Public discourse and empirical studies have predominantly focused on the negative repercussions of social media on adolescents’ mental health. However, pervasive social media use is a relatively new phenomenon—its apparent harms have been widely accepted before sufficient longitudinal and experimental research has been conducted. The present study used an intensive longitudinal design (four assessments/day × 14 days; N = 154 12- to 15-year-olds ( M age = 13.47, SD = 0.58); N = 6,240 valid measurement occasions) to test the directionality of social media–negative emotion links in early
View details →Negative / Null Result ReportNeuroscience
Nathan Leggett, Nicole A. Thomas, Michael E. R. Nicholls · 2015 · Cognition & Emotion
Approach motivation leads to greater left hemisphere activation, whereas an avoidant motivational state activates the right hemisphere. Recent research, which served as the basis for the current experiment, suggests line bisection provides…
View details →Negative / Null Result ReportOpen accessMedicine
Sarah N. Rigby, Lorna S. Jakobson, Pauline M. Pearson et al. · 2020 · Frontiers in Psychology
Alexithymia is a personality trait characterized by difficulties identifying and describing feelings (DIF and DDF) and an externally-oriented thinking style (EOT). The primary aim of the present study was to investigate links between alexithymia and the evaluation of emotional scenes. We also investigated whether viewers’ evaluations of emotional scenes were better predicted by specific alexithymic traits or by individual differences in sensory processing sensitivity (SPS). Participants (N = 106) completed measures of alexithymia and SPS along with a task requiring speeded judgments of the ple
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Sreeram V Ramagopalan, Andrew P. Skingsley, Lahiru Handunnetthi et al. · 2015 · F1000Research
Background : We and others have shown a significant proportion of interventional trials registered on ClinicalTrials.gov have their primary outcomes altered after the listed study start and completion dates. The objectives of this study…
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Rui Perdigão · 2018 · Entropy
The information shared among observables representing processes of interest is traditionally evaluated in terms of macroscale measures characterizing aggregate properties of the underlying processes and their interactions. Traditional…
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Giannis Penloglou, Alexandros Pavlou, Costas Kiparissides · 2023 · Fermentation
The intended circular economy for plastics envisages that they will be partially replaced by bio-based polymers in the future. In this work, the natural polyester polyhydroxybutyrate (PHB) was produced by Azohydromonas lata using cheese…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kristin Köppen, Diana Fatykhova, Gudrun Holland et al. · 2023 · Frontiers in Cellular and Infection Microbiology
Introduction Tularemia is mainly caused by Francisella tularensis ( Ft ) subsp. tularensis ( Ftt ) and Ft subsp. holarctica ( Ftt ) in humans and in more than 200 animal species including rabbits and hares. Human clinical manifestations depend on the route of infection and range from flu-like symptoms to severe pneumonia with a mortality rate up to 60% without treatment. So far, only 2D cell culture and animal models are used to study Francisella virulence , but the gained results are transferable to human infections only to a certain extent. Method In this study, we firstly established an ex
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Pilar Fernández‐Martín, Rocío Rodríguez‐Herrera, Rosa Cánovas et al. · 2023 · European Child & Adolescent Psychiatry
In the past two decades, the traditional nosology of attention-deficit/hyperactivity disorder (ADHD) has been criticized for having insufficient discriminant validity. In line with current trends, in the present study, we combined a data-driven approach with the advantages of virtual reality aiming to identify novel behavioral profiles of ADHD based on ecological and performance-based measures of inattention, impulsivity, and hyperactivity. One hundred and ten Spanish-speaking participants (6-16 years) with ADHD (medication-naïve, n = 57) and typically developing participants (n = 53) complete
View details →Negative / Null Result ReportPsychology
Casey LaDuke, Benjamin Locklair, Kirk Heilbrun · 2018 · Journal of Forensic Psychology Research and Practice
Neuroscientific evidence is assuming an increasingly prominent role in criminal law, where it has considerable potential for affecting legal decision making. Our understanding of this effect is currently limited. Research initially…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Natalia Ristic, Mario P. S. Chin · 2010 · Retrovirology
BACKGROUND: The viral genome of HIV-1 contains several secondary structures that are important for regulating viral replication. The stem-loop 1 (SL1) sequence in the 5' untranslated region directs HIV-1 genomic RNA dimerization and packaging into the virion. Without SL1, HIV-1 cannot replicate in human T cell lines. The replication restriction phenotype in the SL1 deletion mutant appears to be multifactorial, with defects in viral RNA dimerization and packaging in producer cells as well as in reverse transcription of the viral RNA in infected cells. In this study, we sought to characterize SL
View details →Negative / Null Result ReportPsychology
Massimo Salgaro · 2015 · Scientific Study of Literature
In literary theory, there are two common proposals about the nature of literature: that literariness is a distinctive characteristic of literary texts and that literariness is mostly characterized by highly foregrounded textual features.…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Y C Shih · 2026 · Frontiers in Environmental Science
To assess the systematic integration of Marine Spatial Planning (MSP) and Other Effective Area-Based Conservation Measures (OECMs) into Taiwan’s coastal and marine governance frameworks to balance marine conservation and coastal development. The study adopts a comparative mixed-methods design that combines quantitative statistical analysis of spatial and ecological-economic data with qualitative policy analysis of the two selected governance frameworks. The comparative aspect of the research design explores the performance of multiple hub cases across temporal, spatial and multimodal aspects,
View details →Negative / Null Result ReportOpen accessSocial Sciences
Junhua Dang, Zeynep E. Ekim, Sarah Ohlsson et al. · 2020 · BMC Psychology
BACKGROUND: Previous studies showed that anger, rather than sadness, created automatic intergroup bias in a minimal group context. METHODS: The current research reports a single study (N = 99) aiming to replicate this finding and further to test whether the intergroup bias manifests as ingroup favoritism, outgroup derogation, or both. RESULTS: Our results failed to replicate the effect of anger on automatic bias. Intriguingly, participants across all emotion conditions exhibited high level of ingroup favoritism, but there was little evidence of outgroup derogation. CONCLUSION: These results su
View details →Negative / Null Result ReportOpen accessMedicine
Fiona McPhee, Joseph Ueland, Vincent Vellucci et al. · 2019 · Antimicrobial Agents and Chemotherapy
[tested DAAs] of >5,000 nM) and were detected in evaluated GT-6b and -6f sequences. NS5A-L28A-R30A, observed in GT-6r, did not replicate. In conclusion, HCV GT-6b, GT-6f, and GT-6r sequences harbored highly resistant RASs to all evaluated…
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Han Sang Kim, Jung Yong Hong, Jaekyung Cheon et al. · 2020 · Journal of Clinical Oncology
4584 Background: Previously, two phase III clinical trials of immune checkpoint inhibitors (ICI) failed to meet their primary endpoints, leading to doubts regarding the clinical activity of ICI monotherapy in patients with aHCC. Here, we…
View details →Negative / Null Result ReportMedicine
Mélissa De Regge, Koenraad G. Monsieurs, K. Vandewoude et al. · 2012 · PubMed
Automated external defibrillators (AEDs) have shown to improve survival after cardiopulmonary arrest (CPA) in many, but not all clinical settings. A recent study reported that the use of AEDs in-hospital did not improve survival. The…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Fanzhuo Xu, Yu Xie, Weiwei Yu et al. · 2026 · Frontiers in Microbiology
Multidrug resistance in Gram-negative bacteria has become a significant global public health challenge, threatening human health and clinical treatment outcomes. The unique outer membrane structure of these pathogens greatly limits antibiotic penetration, serving as the core mechanism of resistance. This paper systematically analyses antimicrobial strategies targeting the outer membrane of Gram-negative bacteria, mainly including: (1) directly disrupting the outer membrane structure and enhancing drug permeability; (2) inhibiting the biosynthesis or transport pathways of key outer membrane com
View details →Negative / Null Result ReportOpen accessNeuroscience
Astrid Feiten, Kilian Dahm, Kai Schlepckow et al. · 2026 · Nature Communications
Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and loss-of-function coding variants are major risk factors for late onset Alzheimer's disease (LOAD). To better understand the molecular and functional changes associated with TREM2 signalling in microglia, we generated a TREM2 reporter mouse. In APP transgenic animals, bulk RNA-sequencing of isolated microglia sorted based on reporter expression highlighted TREM2 level-related changes in major immunometabolic pathways, and enrichment of genes in oxidative phosphorylation and cholesterol met
View details →Negative / Null Result ReportOpen accessMedicine
Martin G Schultz, Petr Otahal, Philip Roberts-Thomson et al. · 2025 · European Heart Journal
BACKGROUND AND AIMS: A hypertensive response to exercise is independently associated with cardiovascular disease (CVD), but clinical interpretation may be confounded by aerobic capacity (fitness). The aim of this study was to determine the relationship between exercise blood pressure (BP) relative to fitness and CVD events. METHODS: Clinical exercise test records were analysed from 12 743 people (aged 53 ± 13 years, 60% male) who completed a standard exercise stress test (Bruce treadmill protocol, stages 1-4) at six Australian hospitals. Records were linked to administrative datasets (hospital
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Marcello Candelli, Marta Sacco Fernandez, Gloria Rozzi et al. · 2025 · Diagnostics
Background and Objectives: Despite major advances in medical science and critical care, sepsis remains a leading cause of morbidity and mortality worldwide: it arises from dysregulated host response to infections and may culminate in organ dysfunction. A hallmark of its pathogenesis is the cytokine storm, in which interleukins (ILs) serve as central mediators of both protective and deleterious immune responses. This review summarizes the current knowledge on the role of ILs in sepsis, emphasizing their potential as biomarkers and therapeutic targets. Material and Methods: We analyzed recent cl
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Xinyi Chen, Mu Yang, Yongbiao Huang et al. · 2025 · Therapeutic Advances in Medical Oncology
Abscopal immunity—the regression of distant, non-irradiated lesions after localized radiotherapy (RT)—signals conversion of focal DNA damage into systemic antitumor immunity. This review advances a unifying three-stage…
View details →Negative / Null Result ReportOpen accessNeuroscience
Eric A. Finkel, Yi-Ting Chang, Rajan Dasgupta et al. · 2024 · Cell Reports
The brain receives constant tactile input, but only a subset guides ongoing behavior. Actions associated with tactile stimuli thus endow them with behavioral relevance. It remains unclear how the relevance of tactile stimuli affects…
View details →Negative / Null Result ReportOpen accessNeuroscience
James Downar, James Downar, Julie Lapenskie et al. · 2024 · Palliative Medicine
Background: Psychological and existential suffering affects many people with advanced illness, and current therapeutic options have limited effectiveness. Repetitive transcranial magnetic stimulation (rTMS) is a safe and effective therapy…
View details →Negative / Null Result ReportOpen accessNeuroscience
Olivier Senn, Florian Hoesl, Toni Bechtold et al. · 2024 · PLoS ONE
There is a broad consensus in groove research that the experience of groove, understood as a pleasurable urge to move in response to music, is to some extent related to the complexity of the rhythm. Specifically, music with medium rhythmic complexity has been found to motivate greater urge to move compared to low or high complexity music (inverted-U hypothesis). Studies that confirmed the inverted-U hypothesis usually based their measure of complexity on the rhythmic phenomenon of syncopation, where rhythms with more and/or stronger syncopation are considered to be more complex than less synco
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Alexandra Irma Gabriela Bauşic, Francesca Scurtu, Andrei Manu et al. · 2025 · International Journal of Molecular Sciences
Endometriosis is a complex gynaecological disorder characterised by the presence of endometrial-like tissue outside the uterus, leading to chronic inflammation, pain, and infertility. Recent research suggests that gut microbiota may play a crucial role in the pathogenesis and progression of endometriosis by modulating immune responses and oestrogen metabolism. This study investigates the intestinal microbiota composition in women with endometriosis and its potential as a disease diagnosis and severity biomarker. Stool samples from nine patients diagnosed with endometriosis were analysed using
View details →Negative / Null Result ReportOpen accessSocial Sciences
Untung Rahardja · 2025 · Journal of Digital Market and Digital Currency.
This study investigates the effectiveness of various digital marketing campaign types—Awareness, Conversion, and Retention—on conversion rates and engagement levels. Using a dataset of 8,000 records, we conducted a comprehensive analysis through ANOVA, Chi-Square tests, and OLS regression to understand the impact of these campaign types. The ANOVA results indicated no significant differences in conversion rates across the campaign types, with an F-statistic of 0.4752 and a p-value of 0.6218. Similarly, the analysis for engagement levels, measured by website visits, yielded an F-statistic of 0.
View details →Negative / Null Result ReportOpen accessSocial Sciences
Roddy Theobald, Zeyu Xu, Allison F. Gilmour et al. · 2025 · Educational Evaluation and Policy Analysis
We study the impact of a bonus policy in Hawai‘i Public Schools that raised the salaries of all special education teachers by $10,000. We estimate that this policy reduced the proportion of vacant special education teaching positions…
View details →Negative / Null Result ReportOpen accessEngineering
Zhaowei Yang, Wenqi Liu, Miwei Li et al. · 2025 · Energy Engineering
Accurate short-term wind power forecast technique plays a crucial role in maintaining the safety and economic efficiency of smart grids. Although numerous studies have employed various methods to forecast wind power, there re... | Find, read and cite all the research you need on Tech Science Press
View details →Negative / Null Result ReportOpen accessMaterials Science
Rosalie Cresswell, Parveen Kumar Deralia, Yoshihisa Yoshimi et al. · 2025 · Journal of the American Chemical Society
High Resolution Image Download MS PowerPoint Slide The structure of plant cellulose microfibrils remains elusive, despite the abundance of cellulose and its utility in industry. Using 2D solid-state NMR of 13 C-labeled never-dried plants, six major glucose environments are resolved, which are common to the cellulose of softwood, hardwood, and grasses. These environments are maintained in isolated holocellulose nanofibrils, allowing more detailed microfibril characterization. We show that there are only two glucose environments that reside within the microfibril core. These have the same NMR 13
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Matthew MacLachlan, Michael K. Adjemian, Xiaoli Etienne et al. · 2025 · Nature Communications
The advent of COVID-19 ended an era of stable US retail food prices that followed the world food price crisis of 2010–2012. Pandemic-related disruptions, avian influenza outbreaks, and the Russia-Ukraine war drove 2022 food-at-home…
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