Negative / Null Result ReportOpen accessEnvironmental Science
Kasper Skytte Andersen, Kai Zhao, Alexander de Linde Agerskov et al. · 2025 · Nature Communications
Understanding species-level abundance dynamics in complex microbial communities is key to managing microbial ecosystems, yet it remains a major challenge. In wastewater treatment plants (WWTPs), the presence and abundance of…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Shanwen Gu, Adil Javed · 2025 · Sustainability
The E-7 nations face significant challenges in harmonizing artificial intelligence (AI) adoption with sustainable economic and environmental goals. While AI holds transformative potential to revolutionize energy structures, modernize infrastructure, broaden financial inclusion, and reduce carbon emissions, its effective integration is frequently hindered by policy inertia, economic limitations, and long-standing institutional barriers. Using the multi-level perspective (MLP), this study employs the method of moments quantile regression (MMQREG) on panel data from 2004 to 2024 to investigate th
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Ali Ghasemi, Amaia Martínez-Usatorre, Yang Liu et al. · 2025 · Nature Communications
Cancer immunotherapy using dendritic cells (DC) pulsed ex vivo with tumour antigens is considered safe, but its clinical efficacy is generally modest. Here we engineer DC progenitors (DCP), which can replenish conventional type 1 DCs…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Yuliya Semenova, Ademi Yergaliyeva, Ainur Aimurziyeva et al. · 2024 · Antibiotics
BACKGROUND/OBJECTIVES: There has been a lack of a holistic approach to evaluating antibiotic consumption in Kazakhstan over the past few years using an internationally recognized methodology. Therefore, this study aimed to provide a nationwide evaluation of antibiotic consumption in Kazakhstan during the period 2019-2023. METHODS: Defined daily doses per 1000 inhabitants per day (DIDs) were calculated for systemic antibiotics (J01 code of the Anatomical Therapeutic Chemical Classification System (ATC)) following the methodology established by the Global Antimicrobial Resistance and Use Surveil
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Callum T. Donnan, Mark Dickinson, Anthony J. Taylor et al. · 2025 · The Astrophysical Journal
Abstract We present JWST/NIRSpec PRISM observations of three luminous ( M UV < −20) galaxies at z ∼ 10 observed with the CANDELS-Area Prism Epoch of Reionization Survey (CAPERS) Cycle 3 program. These galaxies exhibit extreme UV slopes compared to typical galaxies at z = 10. Of the three sources, two of them are a close pair (0 . ″ 22) of blue galaxies at z = 9.800 ± 0.003 and z = 9.808 ± 0.002 with UV slopes of β = −2.87 ± 0.15 and β = −2.46 ± 0.10, respectively, selected from PRIMER COSMOS NIRCam imaging. We perform spectrophotometric modeling of the galaxies, which suggests extre
View details →Negative / Null Result ReportOpen accessSocial Sciences
Jeremy Bowles, Kevin Croke, Horacio Larreguy et al. · 2025 · American Political Science Review
Exposure to misinformation can affect citizens’ beliefs, political preferences, and compliance with government policies. However, little is known about how to durably reduce susceptibility to misinformation, particularly in the Global South. We evaluate an intervention in South Africa that encouraged individuals to consume biweekly fact-checks—as text messages or podcasts—via WhatsApp for six months. Sustained exposure to these fact-checks induced substantial internalization of fact-checked content, while increasing participants’ ability to discern new political and health misinformation upon
View details →Negative / Null Result ReportOpen accessMedicine
Akram I. Ahmad, Samita Garg, Jeffrey Jacobs et al. · 2026 · JAMA Internal Medicine
Importance: Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are known to increase the risk of retained gastric contents. High-quality data are lacking to guide periprocedure management of GLP-1 and GIP agonists. Objective: To compare the risk of clinically significant residual gastric volume (RGV) in patients who continue vs hold 1 dose of weekly or daily GLP-1 and GIP agonists prior to sedation. Design, Setting, and Participants: This randomized, single-masked clinical trial conducted at 2 large tertiary referral centers in the US included patients under
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Jing Mai, Ying Ning, Zhonglong Lin et al. · 2025 · Industrial Crops and Products
Many bacteria such as Bacillus , Pseudomonas , and Lactobacillus are widely present in flue-cured tobacco leaves during the aging process, indicating they play important roles in improving tobacco quality. In this study, we aimed to screen…
View details →Negative / Null Result ReportOpen accessNeuroscience
Meenakshi Khosla, Leila Wehbe · 2026 · Nature Communications
Neuroscientific studies rely heavily on a-priori hypotheses, which can bias results toward existing theories. Here, we use a hypothesis-neutral approach to study category selectivity in higher visual cortex. Using only stimulus images and their associated fMRI activity, we constrain randomly initialized neural networks to predict voxel activity. Despite no category-level supervision, units in the trained networks act as detectors for semantic concepts like 'faces' or 'words', providing solid empirical support for categorical selectivity. Importantly, this selectivity is mostly maintained when
View details →Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Sadek Ahmed, Khaled M. Attallah, Marwa Eid Sayyed · 2026 · AAPS PharmSciTech
Abstract This research focuses on creating a novel Brijaluronic-based terpesomal system capable of transporting quercetin (QER) efficiently to the brain. The vesicles were fabricated through an ethanol-injection method and then refined using a structured optimization approach in Design-Expert® software. The influence of three main formulation parameters: terpene-to-drug ratio, surfactant type, and hyaluronic acid amount were evaluated. The optimization process was designed to maximize EE%, minimize VS, and maintain ZP within an acceptable stability range. The optimal formula hit a desirability
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Leah Zuroff, Vista Farkhondeh, Riley Bove et al. · 2025 · Drugs
Despite major advances in multiple sclerosis (MS) treatment, disability accumulation independent of relapse activity remains a significant challenge. Chronic demyelination is a key driver of neurodegeneration and disease progression,…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Nikola Pavlović, Petar Todorović, Mirko Maglica et al. · 2025 · Biomolecules
The heart’s relentless contractile activity depends critically on mitochondrial function to meet its extraordinary bioenergetic demands. Mitochondria, through oxidative phosphorylation, not only supply ATP but also regulate metabolism, calcium homeostasis, and apoptotic signaling, ensuring cardiomyocyte viability and cardiac function. Mitochondrial dysfunction is a hallmark of cardiomyopathies and heart failure, characterized by impaired oxidative phosphorylation, excessive production of reactive oxygen species (ROS), dysregulated calcium handling, and disturbances in mitochondrial dynamics an
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Anwar Zahid, Md. Aminur Rahman, M. Rashidul Hassan et al. · 2026 · BRAC University Journal
The study area lies on the coastal belt of the Bengal Delta, southern Bangladesh. This study bas been condocted to deteonine salinity sources in the multi-layered aquifers of the Bengal Delta. Dissolved major ions including chloride (Cr) and brontide (Br) were measured in groundwater of the coastal areas of Bangladesh to assess the source(s) of salinity. Ionic concentrations of 48 groundwater samples were analyzed for this study; samples were collected from observation wells installed at different depths down to 336 m. The major ion trends of the upper (<200 m deep) Sodium (Na')-Chloride (C
View details →Negative / Null Result ReportOpen accessMedicine
Atul Malhotra, R GRUNSTEIN, Ali Azarbarzin et al. · 2026 · Nature Medicine
Obstructive sleep apnea (OSA) is associated with obesity and cardiovascular risk. The SURMOUNT-OSA master protocol comprised two, 52-week, randomized, double-blind, placebo-controlled phase 3 studies (study 1 and study 2) and demonstrated…
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Gabriela Yamazaki de Campos, Raquel Amorim Oliveira, Patrícia Kellen Martins Oliveira-Brito et al. · 2020 · PeerJ
Background The macrophage lineage is characterized by plasticity due to the acquisition of distinct functional phenotypes, and two major subsets are evaluated; classical M1 activation (strong microbicidal activity) and alternative M2…
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Joshua Hascher, Nitisha Desai, Ian Krajbich · 2021 · Judgment and Decision Making
Abstract A core principle in decision science is that people choose according to their subjective values. These values are often measured using unincentivized scales with arbitrary units (e.g., from 0 to 10) or using incentivized…
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Behrooz Ghorbani, Song Mei, Theodor Misiakiewicz et al. · 2021 · Journal of Statistical Mechanics: Theory and Experiment
Abstract For a certain scaling of the initialization of stochastic gradient descent (SGD), wide neural networks (NN) have been shown to be well approximated by reproducing kernel Hilbert space (RKHS) methods. Recent empirical work showed…
View details →Negative / Null Result Report
Kärt Simre, Oivi Uibo, Aleksandr Peet et al. · 2019 · Acta Paediatrica
Abstract Aim Our aim was to compare the presence of various common viruses (rhinovirus, enterovirus, adenovirus, Epstein–Barr virus, cytomegalovirus, norovirus, parechovirus) in stool and nasal swab samples as well as virus‐specific…
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Heido Trofimov, Nicolas Bellouin, Velle Toll · 2020 · Journal of Geophysical Research: Atmospheres
Abstract Aerosols offset a poorly quantified fraction of anthropogenic greenhouse gas warming, and the aerosol impact on clouds is the most uncertain mechanism of anthropogenic climate forcing. Here observations of a relatively weak…
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Yumeng Zhang, Premsai Kumar, Jacob J. Adashek et al. · 2022 · Cells
Modulating the cyclooxygenase 2 (COX-2) pathway has improved responses to immune checkpoint inhibitors (ICIs) in certain solid tumors, such as melanoma. Little is known about COX-2 inhibition in response to ICIs in metastatic renal cell…
View details →Negative / Null Result Report
Howard Cooke, Rianne Appel-Meulenbroek, Theo Arentze · 2019 · International Journal of Strategic Property Management
This paper seeks to understand whether the alignment process between business strategy and Corporate Real Estate (CRE) between 2007 and 2014 was dynamic. It investigated the financial data of 230 UK companies by means of a distributed time…
View details →Negative / Null Result Report
Vikram Sharma, Tanujit Dey, Kesavan Sankaramangalam et al. · 2019 · Journal of the American Heart Association
Background Troponin elevation occurs commonly in the setting of transcatheter aortic valve replacement (TAVR). There is a lack of information on the extent of troponin elevation post TAVR that is prognostically significant. We assessed the…
View details →Negative / Null Result Report
Robin-Tobias Jauss, Sophia Schließke, Rami Abou Jamra · 2022 · Genes
Routine diagnostics is biased towards genes and variants with satisfactory evidence, but rare disorders with only little confirmation of their pathogenicity might be missed. Many of these genes can, however, be considered relevant,…
View details →Negative / Null Result Report
Paul C. Moorehead, Nicholas J. Barrowman, Janelle Cyr et al. · 2017 · Pediatric Critical Care Medicine
Objective: There are no proven methods to predict the risk of clinically significant bleeding in the PICU. A retrospective study identified platelet count as a risk marker for clinically significant bleeding. We conducted a study to…
View details →Negative / Null Result Report
Rui Guan, Xueyuan Li, Per Hofvander et al. · 2015 · Lipids
Abstract The aim of this study was to evaluate the importance of three enzymes, LPCAT, PDCT and PDAT, involved in acyl turnover in phosphatidylcholine in order to explore the possibility of further increasing erucic acid (22:1) content in…
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CHARLOTTA GRUNEWALD, STELLAN HÅKANSSON, SISSEL SALTVEDT et al. · 2010 · Acta Obstetricia et Gynecologica Scandinavica
Abstract Objective. To evaluate the effects on neonatal morbidity of a regional change in induction policy for post‐term pregnancy from 43 +0 to 42 +0 gestational weeks (GWs). Design and setting. Nationwide retrospective register study…
View details →Negative / Null Result ReportEarth and Planetary Sciences
David John Gagne, Amy McGovern, Jeffrey B. Basara et al. · 2012 · Journal of Applied Meteorology and Climatology
Abstract Oklahoma Mesonet surface data and North American Regional Reanalysis data were integrated with the tracks of over 900 tornadic and nontornadic supercell thunderstorms in Oklahoma from 1994 to 2003 to observe the evolution of…
View details →Negative / Null Result ReportComputer Science
Subrata Datta, Kalyani Mali · 2021
Traditional support-confidence framework based association rule mining approaches often generate huge number of rules including the insignificant ones. These insignificant association rules are useless in knowledge discovery. One of the…
View details →Negative / Null Result ReportOpen accessMedicine
Brian Hitsman, George D. Papandonatos, Jackie K. Gollan et al. · 2023 · Addiction
BACKGROUND AND AIMS: Treatment of depression-related psychological factors related to smoking behavior may improve rates of cessation among adults with major depressive disorder (MDD). This study measured the efficacy and safety of 12…
View details →Negative / Null Result ReportOpen accessComputer Science
Vincent Adegoke, Daqing Chen, Ebad Banissi et al. · 2017
In this paper, several ensemble cancer survivability predictive models are presented and tested based on three variants of AdaBoost algorithm. In the models we used Random Forest, Radial Basis Function Network and Neural Network algorithms…
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