Negative / Null Result ReportOpen accessMedicine
Brahim Aı̈ssani, Kui Zhang, Howard W. Wiener · 2015 · Frontiers in Genetics
We evaluated the association of 56 candidate SNPs identified in two published genome-wide association studies (GWAS) of uterine leiomyoma (UL), or fibroids, with the risk and tumor size in the multi-ethnic uterine fibroid study (NIEHS-UFS). The selected SNPs were genotyped in 916 premenopausal women of African American (AA) and European American (EA) descents and their association with the outcomes was evaluated in race-stratified models and in meta-analysis of risk in NIEHS-UFS and discovery and replication GWAS in the Japanese population. We report moderate associations of variant rs4954368
View details →Negative / Null Result ReportPsychology
John G. McCabe, Daniel A. Krauss · 2011 · Behavioral Sciences & the Law
An intervention designed to correct affective and cognitive biases was tested in the context of a civil commitment hearing of a sexually violent predator. Potential differences between a college student mock jury sample and a more…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anna L. Guyatt, Kimberley Burrows, Philip A. I. Guthrie et al. · 2017 · Mitochondrion
The mitochondrial genome is present at variable copy number between individuals. Mitochondria are vulnerable to oxidative stress, and their dysfunction may be associated with cardiovascular disease. The association of mitochondrial DNA copy number with cardiometabolic risk factors (lipids, glycaemic traits, inflammatory markers, anthropometry and blood pressure) was assessed in two independent cohorts of European origin women, one in whom outcomes were measured at mean (SD) age 30 (4.3) years (N=2278) and the second at 69.4 (5.5) years (N=2872). Mitochondrial DNA copy number was assayed by qua
View details →Negative / Null Result ReportOpen accessPsychology
Lisanne S. Pauw, Hayley Medland, Sarah J. Paling et al. · 2022 · Affective Science
Abstract While emotion regulation often happens in the presence of others, little is known about how social context shapes regulatory efforts and outcomes. One key element of the social context is social support. In two experience sampling studies ( N s = 179 and 123), we examined how the use and affective consequences of two fundamentally social emotion-regulation strategies—social sharing and expressive suppression—vary as a function of perceived social support. Across both studies, we found evidence that social support was associated with variation in people’s use of these strategies, such
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anarkali Mahmood, Zdeněk Otruba, Alan W. Weisgerber et al. · 2023 · Biophysical Journal
When multivesicular endosomes (MVEs) fuse with the plasma membrane, exosomes are released into the extracellular space where they can affect other cells. The ability of exosomes to regulate cells nearby or further away depends on whether…
View details →Negative / Null Result ReportOpen accessEngineering
Michael Schütt, Connor O’Farrell, Konstantinos Stamatopoulos et al. · 2022 · Pharmaceutics
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic Colon Model; a physiologically representative in vitro model of the human proximal colon. Magnetic resonance imaging of the Dynamic Colon Model verified that the digital twin robustly replicated flow patterns under different physiological conditions (media viscosity, volume, and peristaltic wave speed). During local contractile activity, antegrade
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Rouven Doran, Daniel Hanss, Torvald Øgaard · 2017 · Sustainability
Two online experiments explored the effects of social comparison feedback on indicators of eco-friendly travel choices. It was tested whether the chosen indicators are sensitive to the information conveyed, and if this varies as a function of in-group identification. Study 1 (N = 134) focused on unfavourable feedback (i.e., being told that one has a larger ecological footprint than the average member of a reference group). People who received unfavourable feedback reported stronger intentions to choose eco-friendly travel options than those who received nondiscrepant feedback, when in-group id
View details →Negative / Null Result ReportOpen accessPsychology
Eike Kofi Buabang, Yannick Boddez, Oliver T. Wolf et al. · 2022 · Behavioral Neuroscience
People are more likely to engage in various suboptimal behaviors such as overeating, addictive behaviors, and short-sighted financial decision-making when they are under stress. Traditional dual-process models propose that stress can…
View details →Negative / Null Result ReportOpen accessMedicine
Helena Canhão, Ana Maria Rodrigues, María José Santos et al. · 2015 · BioMed Research International
BACKGROUND: The aim of our work was to replicate, in a Southern European population, the association reported in Northern populations between PTPRC locus and response to anti-tumor necrosis factor (anti-TNF) treatment in rheumatoid arthritis (RA). We also looked at associations between five RA risk alleles and treatment response. METHODS: We evaluated associations between anti-TNF treatment responses assessed by DAS28 change and by EULAR response at six months in 383 Portuguese patients. Univariate and multivariate linear and logistic regression analyses were performed. In a second step to con
View details →Negative / Null Result ReportOpen accessSocial Sciences
Jeni L. Burnette, Crystal L. Hoyt, Nicholas R. Buttrick et al. · 2021 · International Journal of Psychology
Communications about the Coronavirus Disease 2019 (COVID-19) often employ metaphors, which can help people understand complex issues. For example, public health messages may focus on "fighting" the disease, attempting to rouse people to…
View details →Negative / Null Result ReportMathematics
Kevin D. Floate, Paul C. Coghlin · 2010 · The Canadian Entomologist
Abstract Fluctuating asymmetries (FAs) are small random deviations between left- and right-side measurements of normally symmetrical traits in a given organism. Changes in FA have frequently been proposed as biomarkers for organisms…
View details →Negative / Null Result ReportOpen accessMedicine
Liv Cecilie Vestrheim Thomsen, Nina S. McCarthy, Phillip E. Melton et al. · 2016 · Journal of Hypertension
OBJECTIVE: Preeclampsia is a complex heterogeneous disease commonly defined by new-onset hypertension and proteinuria in pregnancy. Women experiencing preeclampsia have increased risk for cardiovascular diseases (CVD) later in life.…
View details →Negative / Null Result ReportOpen accessMedicine
Antonija Perović, Nora Nikolac, Marina Njire Bratičević et al. · 2017 · Biochemia Medica
INTRODUCTION: Scuba diving represents a combination of exercise and changes in environmental conditions. This study aimed to evaluate changes in haematological parameters after recreational scuba diving in order to identify clinically significant changes. MATERIALS AND METHODS: The study included males, 17 recreational divers, median age (range) 41 (30-52) years. Blood samples were taken before diving, immediately after diving to 30 meters for 30 minutes, 3 hours and 6 hours after diving. Complete blood counts were analyzed on the Cell Dyn Ruby haematology analyzer. Statistical significance be
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Sascha Otto · 2011 · International Journal of Economics and Finance
We analyze the speculative efficiency of the six base metals traded at the London Metal Exchange (LME) for the post-Tin Crisis period from 1991-2008. Especially the influence of different futures contracts on the one side and different underlyings on the other side provides economic insights for market participants like hedgers and speculators. We focus on the 3-month and 15-month futures contracts for all six base metals and conduct single-contract test for every base metal applying an ARMA process. This system is expanded to the multi-contract case, modeling the forecast error as an ARMAX pr
View details →Negative / Null Result ReportOpen accessNeuroscience
Klára Marečková, Amy Miles, Zhijie Liao et al. · 2022 · NeuroImage Clinical
BACKGROUND: Prenatal stress influences brain development and mood disorder vulnerability. Brain structural covariance network (SCN) properties based on inter-regional volumetric correlations may reflect developmentally-mediated shared…
View details →Negative / Null Result ReportEngineering
John Keane, Wei Zhang, Chris H. Kim · 2010
We present an array-based system to accurately study variations in ROSC aging. Microsecond measurements for minimal BTI recovery, and frequency shift measurement resolution ranging down to the error floor of 0.07% are achieved with three…
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
E. M. Dunne, Lindsay Lee, Carly Reddington et al. · 2012 · Atmospheric chemistry and physics
Abstract. Observed correlations between short-term decreases in cosmic ray ionisation and cloud and aerosol properties have been attributed to short-term decreases in the ion-induced nucleation rate. We use a global aerosol microphysics model to determine whether a 10 day reduction of 15% in the nucleation rate could generate a statistically significant response in aerosol concentrations and optical properties. As an upper limit to the possible effect of changes in ion-induced nucleation rate, we perturb the total nucleation rate, which has been shown to generate particle concentrations and nu
View details →Negative / Null Result ReportOpen accessMedicine
Freija Verdoodt, Susanne K. Kjær, Christian Dehlendorff et al. · 2018 · British Journal of Cancer
BACKGROUND: Increasing data suggest that aspirin use may improve cancer survival; however, the evidence is sparse for ovarian cancer. METHODS: We examined the association between postdiagnosis use of low-dose aspirin and mortality in a…
View details →Negative / Null Result ReportOpen accessMedicine
Ping‐Hong Yeh, Sara M. Lippa, Tracey A. Brickell et al. · 2022 · Brain Communications
Abstract The purpose of this study was to analyze quantitative diffusion tensor imaging measures across the spectrum of traumatic brain injury severity and evaluate their trajectories in military service members. Participants were 96 U.S. military service members and veterans who had sustained a mild traumatic brain injury [including complicated mild traumatic brain injury (n = 16) and uncomplicated mild traumatic brain injury (n = 68)], moderate-severe traumatic brain injury (n = 12), and controls (with or without orthopaedic injury, n = 39). All participants had been scanned at least twice,
View details →Negative / Null Result ReportOpen accessMedicine
Tae‐Young Pak, Susana Ferreira, Gregory Colson · 2016 · Population Health Metrics
BACKGROUND: Because people care about their weight relative to peers and society, obesity inequality plays a role in explaining obesity incidence and the impacts of being obese on subjective well-being. While the increase in obesity prevalence and mean body mass index (BMI) is well documented, the measurement of distributional changes and corresponding obesity inequality is yet to be fully explored. METHODS: The present study analyzed BMI data for adults aged 20 to 74 from the National Health and Nutritional Examination Survey (NHANES) I (1971-1974), II (1976-1980), III (1988-1994), and contin
View details →Negative / Null Result ReportOpen accessEngineering
Yaser Maddahi, Kourosh Zareinia, Liu Shi Gan et al. · 2016 · BioMed Research International
The use of robotic technology in the surgical treatment of brain tumour promises increased precision and accuracy in the performance of surgery. Robotic manipulators may allow superior access to narrow surgical corridors compared to freehand or conventional neurosurgery. This paper reports values and ranges of tool-tissue interaction forces during the performance of glioma surgery using an MR compatible, image-guided neurosurgical robot called neuroArm. The system, capable of microsurgery and stereotaxy, was used in the surgical resection of glioma in seven cases. neuroArm is equipped with for
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Bart de Boer · 2010 · Journal of Evolutionary Psychology
This paper investigates the effect of larynx position on the articulatory abilities of a human-like vocal tract. Previous work has investigated models that were built to resemble the anatomy of existing species or fossil ancestors. This…
View details →Negative / Null Result ReportOpen accessNeuroscience
Sean Coulborn, Howard Bowman, R. Chris Miall et al. · 2020 · Frontiers in Human Neuroscience
Mind-wandering is associated with switching our attention to internally directed thoughts and is by definition an intrinsic, self-generated cognitive function. Interestingly, previous research showed that it may be possible to modulate its propensity externally, with transcranial direct current stimulation (tDCS) targeting different regions in the default mode and executive control networks. However, these studies used highly heterogeneous montages (targeting the dorsolateral prefrontal cortex (DLPFC), the right inferior parietal lobule (IPL), or both concurrently), often showed contradicting
View details →Negative / Null Result ReportOpen accessComputer Science
Christian Bock, Thomas Gumbsch, Michael Moor et al. · 2018 · Bioinformatics
Motivation: Most modern intensive care units record the physiological and vital signs of patients. These data can be used to extract signatures, commonly known as biomarkers, that help physicians understand the biological complexity of…
View details →Negative / Null Result ReportOpen accessMedicine
Minghua Wu, Shervin Assassi, Gloria A. Salazar et al. · 2016 · Arthritis Research & Therapy
BACKGROUND: Systemic sclerosis (SSc)-related interstitial lung disease (ILD) has phenotypic similarities to lung involvement in idiopathic interstitial pneumonia (IIP). We aimed to assess whether genetic susceptibility loci recently identified in the large IIP genome-wide association studies (GWASs) were also risk loci for SSc overall or severity of ILD in SSc. METHODS: A total of 2571 SSc patients and 4500 healthy controls were investigated from the US discovery GWAS and additional US replication cohorts. Thirteen IIP-related selected single nucleotide polymorphisms (SNPs) were genotyped and
View details →Negative / Null Result ReportPsychology
Samantha J. Heintzelman, Jason Trent, Laura A. King · 2014 · The Journal of Positive Psychology
Growing popular interest in positive psychology may have important implications for the measurement of well-being. Five studies tested the prediction that well-being ratings are influenced by desirability bias. In Study 1, participants (N…
View details →Negative / Null Result ReportOpen accessHealth Professions
Shane J. J. McCrea · 2017 · International Journal of Dentistry
Here we present an analysis of patient perceptions and expectations to dental implant placement and their prosthetic reconstruction, to then consider whether they have an effect on long-term satisfaction levels. A Post-Treatment Completion Questionnaire was designed to analyse whether patient satisfaction is influenced by age and/or gender; has an effect on patient-reported self-confidence levels; contributes to increased levels of oral hygiene; provides further insight into the average pain levels during and after the surgical intervention; or influences further acceptance of dental implant s
View details →Negative / Null Result ReportComputer Science
Qingyu Shi, Fang Wang, Dan Feng · 2020 · IEEE Transactions on Network and Service Management
Datacenter network load balancing schemes handle network traffic generated by massive different applications. Some packet-based or flowlet-based schemes capture traffic bursts for load balancing. But frequent rerouting within a flow can…
View details →Negative / Null Result ReportMedicine
Jason M. Schon, Jacob D. Mikula, Jonathon D. Backus et al. · 2016 · Foot & Ankle International
BACKGROUND: The effect of ankle positioning during suture-button fixation for syndesmosis repair on range of motion (ROM) and anatomic reduction has yet to be investigated. The purpose of this cadaveric study was to compare the effects of…
View details →Negative / Null Result ReportOpen accessMedicine
Yuli Wang · 2019 · UNC Libraries
The human small intestinal epithelium possesses a distinct crypt-villus architecture and tissue polarity in which proliferative cells reside inside crypts while differentiated cells are localized to the villi. Indirect evidence has shown…
View details →