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20,201 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Low-Cost Airlines: A Failed Business Model?

Kenneth Button · 2012 · Transportation Journal

Abstract The article examines the sustainability of the low-cost, or no-frills, airline business model. It looks at the background to the development of this managerial approach within the context of some prevailing business theories and…

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Negative / Null Result ReportOpen accessMedicine

Significant association between polymorphism of the erythropoietin gene promoter and myelodysplastic syndrome

Wanlong Ma, Hagop M. Kantarjian, Ke Zhang et al. · 2010 · BMC Medical Genetics

BACKGROUND: Myelodysplastic syndrome (MDS) may be induced by certain mutagenic environmental or chemotherapeutic toxins; however, the role of susceptibility genes remains unclear. The G/G genotype of the single-nucleotide polymorphism (SNP) rs1617640 in the erythropoietin (EPO) promoter has been shown to be associated with decreased EPO expression. We examined the association of rs1617640 genotype with MDS. METHODS: We genotyped the EPO rS1617640 SNP in 189 patients with MDS, 257 with acute myeloid leukemia (AML), 106 with acute lymphoblastic leukemia, 97 with chronic lymphocytic leukemia, 353

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Negative / Null Result Report

Defining the Minimal Clinically Important Difference for Patients With Vestibular Schwannoma: Are all Quality-of-Life Scores Significant?

Panagiotis Kerezoudis, Kathleen J Yost, Nicole M Tombers et al. · 2018 · Neurosurgery

Abstract BACKGROUND The diagnosis of vestibular schwannomas (VS) is associated with reduced patient quality of life (QOL). Minimal clinically important difference (MCID) was introduced as the lowest improvement in a patient-reported…

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Negative / Null Result Report

Dissimilarity–Overlap analysis of replicate enrichment communities

Jean C C Vila, Yang-Yu Liu, Alvaro Sanchez · 2020 · The ISME Journal

Abstract The taxonomic composition of microbial communities can vary substantially across habitats and within the same habitat over time. Efforts to build quantitative and predictive models of microbial population dynamics are underway,…

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Negative / Null Result Report

Does integrating nonurgent, clinically significant radiology alerts within the electronic health record impact closed-loop communication and follow-up?

Stacy D O’Connor, Anuj K Dalal, V Anik Sahni et al. · 2015 · Journal of the American Medical Informatics Association

Abstract Objective To assess whether integrating critical result management software—Alert Notification of Critical Results (ANCR)—with an electronic health record (EHR)-based results management application impacts closed-loop…

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Negative / Null Result Report

Assessment of T-History Method Variants to Obtain Enthalpy–Temperature Curves for Phase Change Materials With Significant Subcooling

Katherine D’Avignon, Michaël Kummert · 2015 · Journal of Thermal Science and Engineering Applications

To assess the potential of thermal energy storage systems using phase change materials (PCMs), numerical simulations rely on an enthalpy–temperature curve (or equivalent specific heat curve) to model the PCM thermal storage behavior. The…

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Negative / Null Result Report

‘Virtual Parrots’ Confirm Mating Preferences of Female Budgerigars

Marin L. Moravec, Georg F. Striedter, Nancy T. Burley · 2010 · Ethology

Abstract Parrots comprise one of the several taxa in which life‐long learning of new vocal signals used in intraspecific communication is known to occur routinely. The functions and evolutionary bases of this ability are largely unknown.…

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Negative / Null Result ReportOpen accessMedicine

Inflammation-Related Gene Variants as Risk Factors for Pancreatic Cancer

Kaye M. Reid–Lombardo, Brooke L. Fridley, William R. Bamlet et al. · 2011 · Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: Recent reports support an association between chronic inflammation and progression to pancreatic cancer (PC). METHODS: This case-control, candidate gene association study evaluated 1,354 Caucasian patients with pancreatic…

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Negative / Null Result ReportEconomics, Econometrics and Finance

A new test for analysing hysteresis in European unemployment

Fumitaka Furuoka · 2016 · Applied Economics Letters

This article proposes a new unit root test to analyse unemployment hysteresis. The test is able to incorporate cross-sectional dependence, unattended nonlinearity and unknown structural breaks in the time-series data. This study used data…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of GWAS candidate susceptibility loci for uterine leiomyoma in the multi-ethnic NIEHS uterine fibroid study

Brahim Aı̈ssani, Kui Zhang, Howard W. Wiener · 2015 · Frontiers in Genetics

We evaluated the association of 56 candidate SNPs identified in two published genome-wide association studies (GWAS) of uterine leiomyoma (UL), or fibroids, with the risk and tumor size in the multi-ethnic uterine fibroid study (NIEHS-UFS). The selected SNPs were genotyped in 916 premenopausal women of African American (AA) and European American (EA) descents and their association with the outcomes was evaluated in race-stratified models and in meta-analysis of risk in NIEHS-UFS and discovery and replication GWAS in the Japanese population. We report moderate associations of variant rs4954368

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Cardiometabolic phenotypes and mitochondrial DNA copy number in two cohorts of UK women

Anna L. Guyatt, Kimberley Burrows, Philip A. I. Guthrie et al. · 2017 · Mitochondrion

The mitochondrial genome is present at variable copy number between individuals. Mitochondria are vulnerable to oxidative stress, and their dysfunction may be associated with cardiovascular disease. The association of mitochondrial DNA copy number with cardiometabolic risk factors (lipids, glycaemic traits, inflammatory markers, anthropometry and blood pressure) was assessed in two independent cohorts of European origin women, one in whom outcomes were measured at mean (SD) age 30 (4.3) years (N=2278) and the second at 69.4 (5.5) years (N=2872). Mitochondrial DNA copy number was assayed by qua

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Negative / Null Result ReportOpen accessPsychology

Social Support Predicts Differential Use, but not Differential Effectiveness, of Expressive Suppression and Social Sharing in Daily Life

Lisanne S. Pauw, Hayley Medland, Sarah J. Paling et al. · 2022 · Affective Science

Abstract While emotion regulation often happens in the presence of others, little is known about how social context shapes regulatory efforts and outcomes. One key element of the social context is social support. In two experience sampling studies ( N s = 179 and 123), we examined how the use and affective consequences of two fundamentally social emotion-regulation strategies—social sharing and expressive suppression—vary as a function of perceived social support. Across both studies, we found evidence that social support was associated with variation in people’s use of these strategies, such

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Exosome secretion kinetics are controlled by temperature

Anarkali Mahmood, Zdeněk Otruba, Alan W. Weisgerber et al. · 2023 · Biophysical Journal

When multivesicular endosomes (MVEs) fuse with the plasma membrane, exosomes are released into the extracellular space where they can affect other cells. The ability of exosomes to regulate cells nearby or further away depends on whether…

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Negative / Null Result ReportOpen accessEngineering

Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model

Michael Schütt, Connor O’Farrell, Konstantinos Stamatopoulos et al. · 2022 · Pharmaceutics

The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic Colon Model; a physiologically representative in vitro model of the human proximal colon. Magnetic resonance imaging of the Dynamic Colon Model verified that the digital twin robustly replicated flow patterns under different physiological conditions (media viscosity, volume, and peristaltic wave speed). During local contractile activity, antegrade

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Negative / Null Result ReportOpen accessEnvironmental Science

Can Social Comparison Feedback Affect Indicators of Eco-Friendly Travel Choices? Insights from Two Online Experiments

Rouven Doran, Daniel Hanss, Torvald Øgaard · 2017 · Sustainability

Two online experiments explored the effects of social comparison feedback on indicators of eco-friendly travel choices. It was tested whether the chosen indicators are sensitive to the information conveyed, and if this varies as a function of in-group identification. Study 1 (N = 134) focused on unfavourable feedback (i.e., being told that one has a larger ecological footprint than the average member of a reference group). People who received unfavourable feedback reported stronger intentions to choose eco-friendly travel options than those who received nondiscrepant feedback, when in-group id

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Negative / Null Result ReportOpen accessPsychology

The role of goal-directed and habitual processes in food consumption under stress after outcome devaluation with taste aversion.

Eike Kofi Buabang, Yannick Boddez, Oliver T. Wolf et al. · 2022 · Behavioral Neuroscience

People are more likely to engage in various suboptimal behaviors such as overeating, addictive behaviors, and short-sighted financial decision-making when they are under stress. Traditional dual-process models propose that stress can…

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Negative / Null Result ReportOpen accessMedicine

TRAF1/C5but NotPTPRCVariants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy

Helena Canhão, Ana Maria Rodrigues, María José Santos et al. · 2015 · BioMed Research International

BACKGROUND: The aim of our work was to replicate, in a Southern European population, the association reported in Northern populations between PTPRC locus and response to anti-tumor necrosis factor (anti-TNF) treatment in rheumatoid arthritis (RA). We also looked at associations between five RA risk alleles and treatment response. METHODS: We evaluated associations between anti-TNF treatment responses assessed by DAS28 change and by EULAR response at six months in 383 Portuguese patients. Univariate and multivariate linear and logistic regression analyses were performed. In a second step to con

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Negative / Null Result ReportOpen accessSocial Sciences

Well‐being in the time of COVID‐19: Do metaphors and mindsets matter?

Jeni L. Burnette, Crystal L. Hoyt, Nicholas R. Buttrick et al. · 2021 · International Journal of Psychology

Communications about the Coronavirus Disease 2019 (COVID-19) often employ metaphors, which can help people understand complex issues. For example, public health messages may focus on "fighting" the disease, attempting to rouse people to…

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Negative / Null Result ReportOpen accessMedicine

The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia

Liv Cecilie Vestrheim Thomsen, Nina S. McCarthy, Phillip E. Melton et al. · 2016 · Journal of Hypertension

OBJECTIVE: Preeclampsia is a complex heterogeneous disease commonly defined by new-onset hypertension and proteinuria in pregnancy. Women experiencing preeclampsia have increased risk for cardiovascular diseases (CVD) later in life.…

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Negative / Null Result ReportOpen accessMedicine

Does recreational scuba diving have clinically significant effect on routine haematological parameters?

Antonija Perović, Nora Nikolac, Marina Njire Bratičević et al. · 2017 · Biochemia Medica

INTRODUCTION: Scuba diving represents a combination of exercise and changes in environmental conditions. This study aimed to evaluate changes in haematological parameters after recreational scuba diving in order to identify clinically significant changes. MATERIALS AND METHODS: The study included males, 17 recreational divers, median age (range) 41 (30-52) years. Blood samples were taken before diving, immediately after diving to 30 meters for 30 minutes, 3 hours and 6 hours after diving. Complete blood counts were analyzed on the Cell Dyn Ruby haematology analyzer. Statistical significance be

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

A Speculative Efficiency Analysis of the London Metal Exchange in a Multi-Contract Framework

Sascha Otto · 2011 · International Journal of Economics and Finance

We analyze the speculative efficiency of the six base metals traded at the London Metal Exchange (LME) for the post-Tin Crisis period from 1991-2008. Especially the influence of different futures contracts on the one side and different underlyings on the other side provides economic insights for market participants like hedgers and speculators. We focus on the 3-month and 15-month futures contracts for all six base metals and conduct single-contract test for every base metal applying an ARMA process. This system is expanded to the multi-contract case, modeling the forecast error as an ARMAX pr

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Negative / Null Result ReportOpen accessEarth and Planetary Sciences

No statistically significant effect of a short-term decrease in the nucleation rate on atmospheric aerosols

E. M. Dunne, Lindsay Lee, Carly Reddington et al. · 2012 · Atmospheric chemistry and physics

Abstract. Observed correlations between short-term decreases in cosmic ray ionisation and cloud and aerosol properties have been attributed to short-term decreases in the ion-induced nucleation rate. We use a global aerosol microphysics model to determine whether a 10 day reduction of 15% in the nucleation rate could generate a statistically significant response in aerosol concentrations and optical properties. As an upper limit to the possible effect of changes in ion-induced nucleation rate, we perturb the total nucleation rate, which has been shown to generate particle concentrations and nu

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Negative / Null Result ReportOpen accessMedicine

Aspirin use and ovarian cancer mortality in a Danish nationwide cohort study

Freija Verdoodt, Susanne K. Kjær, Christian Dehlendorff et al. · 2018 · British Journal of Cancer

BACKGROUND: Increasing data suggest that aspirin use may improve cancer survival; however, the evidence is sparse for ovarian cancer. METHODS: We examined the association between postdiagnosis use of low-dose aspirin and mortality in a…

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