11,287 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Gus A. Baker, Rebecca Bromley, Maria Briggs et al. · 2014 · Neurology
OBJECTIVE: To delineate the risk to child IQ associated with frequently prescribed antiepileptic drugs. METHODS: Children born to women with epilepsy (n = 243) and women without epilepsy (n = 287) were recruited during pregnancy and…
View details →Didier Keh, Evelyn Trips, Gernot Marx et al. · 2016 · JAMA
Importance: Adjunctive hydrocortisone therapy is suggested by the Surviving Sepsis Campaign in refractory septic shock only. The efficacy of hydrocortisone in patients with severe sepsis without shock remains controversial. Objective: To…
View details →Marianna Fontana, Steve K White, Sanjay M Banypersad et al. · 2012 · Journal of Cardiovascular Magnetic Resonance
BACKGROUND: Myocardial extracellular volume (ECV) is elevated in fibrosis or infiltration and can be quantified by measuring the haematocrit with pre and post contrast T1 at sufficient contrast equilibrium. Equilibrium CMR (EQ-CMR), using a bolus-infusion protocol, has been shown to provide robust measurements of ECV using a multibreath-hold T1 pulse sequence. Newer, faster sequences for T1 mapping promise whole heart coverage and improved clinical utility, but have not been validated. METHODS: Multibreathhold T1 quantification with heart rate correction and single breath-hold T1 mapping using
View details →Ludmila Danilova, Won Jin Ho, Qingfeng Zhu et al. · 2019 · Cancer Immunology Research
Abstract Immune-checkpoint therapy has failed to demonstrate meaningful clinical benefit in unselected cases of pancreatic adenocarcinoma (PDAC), but a subset of PDACs are known to upregulate pathways involved in acquired immune…
View details →C. Schilder, Caroline Seynaeve, L.V.A.M. Beex et al. · 2010 · Journal of Clinical Oncology
PURPOSE: To evaluate the influence of adjuvant tamoxifen and exemestane on cognitive functioning in postmenopausal patients with breast cancer (BC). PATIENTS AND METHODS: Neuropsychological assessments were performed before the start (T1)…
View details →Giorgio V. Scagliotti, Joachim von Pawel, Silvia Novello et al. · 2015 · Journal of Clinical Oncology
PURPOSE: Tivantinib, a MET receptor tyrosine kinase inhibitor, demonstrated increased anticancer activity in preclinical and early clinical studies when combined with erlotinib. Our study aimed to confirm efficacy and safety of the…
View details →US Preventive Services Task Force, Kirsten Bibbins‐Domingo, David C. Grossman et al. · 2017 · JAMA
IMPORTANCE: Preeclampsia affects approximately 4% of pregnancies in the United States. It is the second leading cause of maternal mortality worldwide and may lead to serious maternal complications, including stroke, eclampsia, and organ…
View details →Corita R. Grudzen, Lynne D. Richardson, Pauline N. Johnson et al. · 2016 · JAMA Oncology
IMPORTANCE: The delivery of palliative care is not standard of care within most emergency departments (EDs). OBJECTIVE: To compare quality of life, depression, health care utilization, and survival in ED patients with advanced cancer…
View details →Shitao Rao, Alexandria Lau, Hon‐Cheong So · 2020 · Diabetes Care
OBJECTIVE COVID-19 has become a major public health problem. There is good evidence that ACE2 is a receptor for SARS-CoV-2, and high expression of ACE2 may increase susceptibility to infection. We aimed to explore risk factors affecting…
View details →Margie E. Lachman, Stefan Agrigoroaei, Patricia A. Tun et al. · 2013 · Assessment
Assessment of cognitive functioning is an important component of telephone surveys of health. Previous cognitive telephone batteries have been limited in scope with a primary focus on dementia screening. The Brief Test of Adult Cognition…
View details →Carole Clair, Nancy A. Rigotti, Bianca Porneala et al. · 2013 · JAMA
IMPORTANCE: Smoking cessation reduces the risks of cardiovascular disease (CVD), but weight gain that follows quitting smoking may weaken the CVD benefit of quitting. OBJECTIVE: To test the hypothesis that weight gain following smoking…
View details →Bharat Randive, Vishal Diwan, Ayesha De Costa · 2013 · PLoS ONE
BACKGROUND: India accounts for 19% of global maternal deaths, three-quarters of which come from nine states. In 2005, India launched a conditional cash transfer (CCT) programme, Janani Suraksha Yojana (JSY), to reduce maternal mortality ratio (MMR) through promotion of institutional births. JSY is the largest CCT in the world. In the nine states with relatively lower socioeconomic levels, JSY provides a cash incentive to all women on birthing in health institution. The cash incentive is intended to reduce financial barriers to accessing institutional care for delivery. Increased institutional
View details →Yuhei Kobayashi, Hiroyuki Okura, Teruyoshi Kume et al. · 2014 · Circulation Journal
BACKGROUND: Stent underexpansion remains a concern as a cause of drug-eluting stent (DES) failure. Although coronary calcification is considered to be a contributing factor in stent underexpansion, previous intravascular ultrasound studies…
View details →Haresh Kirpalani, Edward F. Bell, Susan R. Hintz et al. · 2020 · New England Journal of Medicine
BACKGROUND: Limited data suggest that higher hemoglobin thresholds for red-cell transfusions may reduce the risk of cognitive delay among extremely-low-birth-weight infants with anemia. METHODS: We performed an open, multicenter trial in…
View details →Lyna Z. Schieber, Gery P. Guy, Puja Seth et al. · 2019 · JAMA Network Open
Importance: Risk of opioid use disorder, overdose, and death from prescription opioids increases as dosage, duration, and use of extended-release and long-acting formulations increase. States are well suited to respond to the opioid crisis through legislation, regulations, enforcement, surveillance, and other interventions. Objective: To estimate temporal trends and geographic variations in 6 key opioid prescribing measures in 50 US states and the District of Columbia. Design, Setting, and Participants: Population-based cross-sectional analysis of opioid prescriptions filled nationwide at US r
View details →Elizabeth DiNenno, Joseph Prejean, Kathleen L. Irwin et al. · 2017 · MMWR Morbidity and Mortality Weekly Report
CDC's 2006 recommendations for human immunodeficiency virus (HIV) testing state that all persons aged 13-64 years should be screened for HIV at least once, and that persons at higher risk for HIV infection, including sexually active gay,…
View details →Jane W. Newburger, Lynn A. Sleeper, J. William Gaynor et al. · 2018 · Circulation
Background: In the SVR trial (Single Ventricle Reconstruction), 1-year transplant-free survival was better for the Norwood procedure with right ventricle-to-pulmonary artery shunt (RVPAS) compared with a modified Blalock–Taussig shunt in…
View details →NiCole A. Finch, Minerva M. Carrasquillo, Matthew Baker et al. · 2010 · Neurology
OBJECTIVES: To determine whether TMEM106B single nucleotide polymorphisms (SNPs) are associated with frontotemporal lobar degeneration (FTLD) in patients with and without mutations in progranulin (GRN) and to determine whether TMEM106B…
View details →Brian O’Sullivan, Anthony M. Griffin, Colleen Dickie et al. · 2013 · Cancer
BACKGROUND: This study sought to determine if preoperative image-guided intensity-modulated radiotherapy (IG-IMRT) can reduce morbidity, including wound complications, by minimizing dose to uninvolved tissues in adults with lower extremity…
View details →Katherine M.W. Pisters, Eric Vallières, John J. Crowley et al. · 2010 · Journal of Clinical Oncology
PURPOSE Patients with early-stage non-small-cell lung cancer (NSCLC) have a poor prognosis even after complete resection. Earlier studies of preoperative (induction) chemotherapy in resectable NSCLC demonstrated feasibility and encouraging…
View details →Michael A. Yassa, L. Tugan Muftuler, Craig E.L. Stark · 2010 · Proceedings of the National Academy of Sciences
The perforant path (PP) undergoes synaptic changes in the course of aging and dementia. Previous studies attempting to assess the integrity of the PP in humans using diffusion tensor imaging (DTI) were limited by low resolution and the…
View details →Alessandro Tarozzi, Aprajit Mahajan, Brian G. Blackburn et al. · 2014 · American Economic Review
We describe findings from the first large-scale cluster randomized controlled trial in a developing country that evaluates the uptake of a health-protecting technology, insecticide-treated bednets (ITNs), through micro-consumer loans, as…
View details →Brian A. Walker, Christopher P. Wardell, Lorenzo Melchor et al. · 2012 · Blood
We have used whole exome sequencing to compare a group of presentation t(4;14) with t(11;14) cases of myeloma to define the mutational landscape. Each case was characterized by a median of 24.5 exonic nonsynonymous single-nucleotide…
View details →Leonard B. Saltz, Stephen Clarke, Eduardo Díaz‐Rubio et al. · 2023 · Journal of Clinical Oncology
Purpose To evaluate the efficacy and safety of bevacizumab when added to first-line oxaliplatin-based chemotherapy (either capecitabine plus oxaliplatin [XELOX] or fluorouracil/folinic acid plus oxaliplatin [FOLFOX-4]) in patients with…
View details →Paulina Aleksandrowicz, Andrea Marzi, Nadine Biedenkopf et al. · 2011 · The Journal of Infectious Diseases
Virus entry into host cells is the first step of infection and a crucial determinant of pathogenicity. Here we show that Ebola virus-like particles (EBOV-VLPs) composed of the glycoprotein GP(1,2) and the matrix protein VP40 use…
View details →Gillian C. Barnett, Charlotte E. Coles, Rebecca Elliott et al. · 2011 · The Lancet Oncology
BACKGROUND: Several studies have reported associations between radiation toxicity and single nucleotide polymorphisms (SNPs) in candidate genes. Few associations have been tested in independent validation studies. This prospective study aimed to validate reported associations between genotype and radiation toxicity in a large independent dataset. METHODS: 92 (of 98 attempted) SNPs in 46 genes were successfully genotyped in 1613 patients: 976 received adjuvant breast radiotherapy in the Cambridge breast IMRT trial (ISRCTN21474421, n=942) or in a prospective study of breast toxicity at the Chris
View details →Frederic T. Billings, Patricia A. Hendricks, Jonathan S. Schildcrout et al. · 2016 · JAMA
IMPORTANCE: Statins affect several mechanisms underlying acute kidney injury (AKI). OBJECTIVE: To test the hypothesis that short-term high-dose perioperative atorvastatin would reduce AKI following cardiac surgery. DESIGN, SETTING, AND…
View details →David T. Levy, Kenneth E. Warner, K. Michael Cummings et al. · 2018 · Tobacco Control
BACKGROUND: The 2018 National Academies of Sciences, Engineering, and Medicine Report found substantial evidence that electronic cigarette use (vaping) by youth is strongly associated with an increased risk of ever using cigarettes…
View details →Noémie Travier, Miranda J. Velthuis, Charlotte N. Steins Bisschop et al. · 2015 · BMC Medicine
BACKGROUND: Exercise started shortly after breast cancer diagnosis might prevent or diminish fatigue complaints. The Physical Activity during Cancer Treatment (PACT) study was designed to primarily examine the effects of an 18-week exercise intervention, offered in the daily clinical practice setting and starting within 6 weeks after diagnosis, on preventing an increase in fatigue. METHODS: This multi-centre controlled trial randomly assigned 204 breast cancer patients to usual care (n = 102) or supervised aerobic and resistance exercise (n = 102). By design, all patients received chemotherapy
View details →Weimin Cai, Jun Xu, Xiao Wu et al. · 2023 · Cardiovascular Diabetology
Abstract Background The triglyceride-glucose (TyG) index was significantly associated with insulin resistance (IR). Several studies have validated the effect of TyG index on cerebrovascular disease. However, the value of TyG index in patients with severe stroke requiring ICU admission remains unclear. The aim of this study was to investigate the association between the TyG index and clinical prognosis of critically ill patients with ischemic stroke (IS). Methods This study identified patients with severe IS requiring ICU admission from the Medical Information Mart for Intensive Care (MIMIC-IV)
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