270 real negative results, null findings, and replication failures in Medicine · Replication Failure. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Fuse M, Rath KA, Riggs B et al. · 2026 · PloS one
Master of Science (MS) research training programs funded by organizations such as the NIH, the NSF as well as private corporations represent the potential for significant interventions for student success, especially for marginalized or…
View details →Zournatzidis P, Luyten P, Fonagy P et al. · 2026 · Attachment & human development
Children in institutions often develop insecure attachments. Although recovery is observed in childhood and adolescence, evidence in adulthood is limited. This pre-registered study compared adoptees with institutional experience and…
View details →Sawatpanich T, Innoi S, Chaiyamoon A et al. · 2026 · Life (Basel, Switzerland)
Morus alba L. fruit extract (MFE), which is rich in cyanidin 3-glucoside (C3G), demonstrates antioxidant properties and pharmacological effects, but its reproductive safety remains poorly understood. Polyphenols modulate steroidogenesis,…
View details →Jeremic M, Jovanovic-Tucovic M, Martinovic T et al. · 2026 · Neurotoxicology
The mechanistic target of rapamycin complex 2 (mTORC2), a key regulator of cellular metabolism, growth, and survival, remains poorly characterized in the context of dopaminergic neurotoxicity. In this study, we investigated the role of…
View details →Abdelmenam DS, Elshahawy WM, Ahmed RK · 2026 · Odontology
This study aimed to assess the effect of incorporating sodium fluoride (NaF) into an adhesive system on the microtensile bond strength of ceramic occlusal veneers. Eighty resin-dentin sticks (~ 1 mm 2 ) were obtained from 20 upper first…
View details →Kobayashi A, Kawashima S, Kimura T et al. · 2026 · The journal of medical investigation : JMI
Whether the difference in video laryngoscope view affects the success of endotracheal intubation in beginners is unknown. In the current study, we aimed to investigate whether the revision of the monitor program in a Macintosh-type video…
View details →Gálvez-García G, Romero-Arias T, Barramuño-Medina M et al. · 2026 · Behavioural brain research
This study examined the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on inhibitory control during motor tasks of varying complexity. Motor task complexity was manipulated in a Simon task using two approaches: (1)…
View details →Nguyen TT, Kanemoto Y, Sawada T et al. · 2026 · Bioscience, biotechnology, and biochemistry
Vitamin D (VD) and Wnt signaling both play important roles in bone metabolism and are targeted in osteoporosis therapy. Combination treatment with VD derivatives and anti-sclerostin antibodies that activate Wnt signaling improves clinical…
View details →Yang Y, Zeng L, Ren R et al. · 2026 · Veterinary sciences
Dental calculus is a highly prevalent oral condition in dogs and is widely recognized as an important risk factor for gingival inflammation and periodontal disease. Effective strategies for its prevention and treatment remain limited,…
View details →Gama de Matos D, de Santana JL, Aidar FJ et al. · 2026 · Journal of clinical medicine
Background : Frailty is a multifactorial condition that significantly impacts older adults' health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…
View details →Kroon E, Elsey JWB, Kuhns LN et al. · 2025 · Drug and alcohol dependence
Background and aims Many individuals aiming to reduce or quit cannabis use prefer self-guided interventions over formal treatment. In this pilot and feasibility randomized trial, we tested a two-week self-guided online intervention…
View details →Pinho RH, Reed M, Chapman K et al. · 2025 · Veterinary anaesthesia and analgesia
Objective To assess sedation following intramuscular (IM) administration of medetomidine versus medetomidine-vatinoxan in bearded dragons. Study design Prospective, randomized, experimental, crossover study. Animals A group of 10 (five…
View details →Connolly CE, Sgier BP, Masser R et al. · 2026 · International journal of breast cancer
Aims This study aimed to compare the performance of immunohistochemistry (IHC)-based luminal subtyping of breast cancer against gene expression panels at our institute and to evaluate a CE-certified artificial intelligence (AI) Ki67 image…
View details →Hyman AC, Albins MA, Curtis JS et al. · 2026 · Scientific reports
Biological invasions threaten ecosystems worldwide, with invasive predators such as lionfish (Pterois spp.) altering marine communities through predation, competition, and habitat disruption. Since their introduction to the western…
View details →Ludwig DR, Zhang F, Minor B et al. · 2026 · Academic radiology
Rationale and objectives To evaluate access to contrast-enhanced MRI among patients with acute or chronic renal failure after implementation of a more permissive contrast policy and determine whether any patients developed nephrogenic…
View details →Islam AM, Baldwin RB, Dyer BJ et al. · 2026 · Facial plastic surgery & aesthetic medicine
Background Patients with orbital floor fractures are frequently transferred between facilities for suspected clinical need, although many of these transfers may be unnecessary. Objective To compare the characteristics among patients with…
View details →Pentland DR, Treder N, Najjar S et al. · 2026 · Hearing research
WHRN gene mutations underlie several forms of deafness in humans and mice. It is not known whether WHRN-associated hearing loss can be reversed after its onset and we aimed to address this using a genetic approach. We show that a knockdown…
View details →Arslan B, Güdül KF · 2026 · BMC oral health
Aim The aim of this study is to assess whether coloured resin composites undergo greater colour changes following exposure to a colouring solution after the use of a whitening mouthwash. Materials and methods Sixty composite discs (2 × 8…
View details →Hamamoto Filho PT, Hafner MLMB, Ribeiro ZMT et al. · 2025 · PloS one
Background It has been proposed that the school origin of items for cross-institutional Progress Tests (PTs) may introduce a bias in favour of students from the same school, posing a potential threat to the validity and reliability of PT…
View details →Zhang J, Lyu Z, Huang J et al. · 2021 · Physical review letters
Light axion fields, if they exist, can be sourced by neutron stars due to their coupling to nuclear matter, and play a role in binary neutron star mergers. We report on a search for such axions by analyzing the gravitational waves from the…
View details →Li J, Lee P, Rafiee Y et al. · 2025 · Adaptive human behavior and physiology
Purpose People can judge others' ages from face images somewhat accurately and tend to rateyounger adults' faces as more attractive than older adults' faces. However, individual diff erences inthe strength of this preference for younger…
View details →Vander Zwalmen Y, Vrijsen JN, Meuleman B et al. · 2026 · Internet interventions
Background Late-life depression (LLD) is a prevalent and debilitating condition associated with a poor long-term prognosis and high rates of chronicity. Cognitive control impairments are common in LLD and contribute to symptom persistence,…
View details →Grischott T, Rachamin Y, Senn O et al. · 2023 · Journal of general internal medicine
Background Medication safety in patients with polypharmacy at transitions of care is a focus of the current Third WHO Global Patient Safety Challenge. Medication review and communication between health care professionals are key targets to…
View details →Guo G, Yan W, Zhou R et al. · 2026 · Frontiers in nutrition
Background Early-life nutritional factors play a crucial role in child health, but their association with palatine tonsil grading is not well understood. This study aimed to investigate the relationship between early-life nutrition and…
View details →Yi K, Zhan Y, Wei A et al. · 2026 · Drug design, development and therapy
Background The optimal analgesia regimen for patients undergoing laparoscopic gastrectomy is still unclear. This study evaluated the efficacy of ultrasound-guided rectus sheath block (RSB) with liposomal bupivacaine in providing sustained…
View details →Lopez DS, Polychronopoulou E, Abdelgadir O et al. · 2025 · Cancers
Background/Objectives: Metformin is one of the most frequently used concomitant medications among prostate cancer (PCa) patients. However, the effects of metformin on all-cause and PCa-specific mortality among men diagnosed with…
View details →Gass JC, Tonkin S, Maguin E et al. · 2024 · Translational behavioral medicine
Ecological Momentary Assessment (EMA) methods are increasingly used by translational scientists to study real-world behavior and experience. The ability to draw meaningful conclusions from EMA research depends upon participant compliance…
View details →Shelton RC, Pizzagalli DA, Cohen EA et al. · 2025 · The Journal of clinical psychiatry
Objective: To assess proof-of-concept (PoC) for efficacy, tolerability, and safety of TRPC4/5 inhibitor BI 1358894 vs placebo in patients with major depressive disorder (MDD) with inadequate response to ongoing antidepressants. Methods: In…
View details →Khan A, Khan H, Hughes GK et al. · 2024 · Cancer medicine
Objective This study aims to evaluate published clinical trials of ramucirumab to assess the risk/benefit profile and burden over time for patients. Background The burden of oncologic drug development on patients paired with increasing…
View details →Kendall C, Swaminathan A, Borichevsky GM et al. · 2026 · JGH open : an open access journal of gastroenterology and hepatology
Background Fecal calprotectin (fCal) and fecal myeloperoxidase (fMPO) have been proposed as biomarkers for monitoring inflammatory bowel disease (IBD); however, their reliability is not fully established. This study investigated clinical…
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