490 real negative results, null findings, and replication failures in Medicine · Failed Experiment Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Napora Z, Griffith O, Slobounov S · 2026 · Frontiers in neurology
The transition to active rehabilitation in concussion care requires precise tools to identify patients at risk of persistent post-concussive symptoms (PPCS). While machine learning (ML) offers the potential to personalize prognosis,…
View details →Das UN · 2026 · Nutrition (Burbank, Los Angeles County, Calif.)
The failed regimens for sepsis include but are not limited to steroids, antibiotic coverage for gram-negatives, and activated protein C. Reports of dramatic successes with vitamin C, its low cost and virtual absence of side effects in…
View details →Dalbeni A, Vicardi M, Natola LA et al. · 2026 · Oncology research
Objectives The combination of atezolizumab plus bevacizumab (A+B) represents one of the standards first-line treatments for unresectable hepatocellular carcinoma (HCC). Metformin has garnered attention for its potential antitumour and…
View details →Lapner P · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Rotator cuff retears remain the most frequently observed complication after arthroscopic cuff repair, with tendon nonhealing rates reported between 20% and 68%. Biological solutions to improve healing rates are needed, and bone marrow…
View details →Elattar S, Basha NR, Salem A et al. · 2025 · Cardiology in review
Pulmonary arterial hypertension (PAH), a subset of pulmonary hypertension (PH), remains a progressive and debilitating disease marked by vascular remodeling and elevated pulmonary vascular resistance. Tadalafil, a phosphodiesterase type 5…
View details →Connacher, Hu, Roden et al. · 2026 · RNA biology
Brain tumor (Brat) is a Drosophila TRIM-NHL protein required for embryogenesis and neural stem cell differentiation. Although structural and biochemical studies established that the Brat NHL domain specifically binds RNA, the in vivo…
View details →Ellis, Perry, Tabbara et al. · 2026 · Journal of vascular surgery cases and innovative techniques
Renovascular hypertension can be clinically challenging to diagnose. The most common etiology remains atherosclerotic disease. When medical management fails, renal artery revascularization is considered. Since the advent of endovascular…
View details →Montagud-Martínez R, Ruiz R, Baldanta S et al. · 2026 · Nature communications
Cas9 can process poly(T) single-stranded DNA molecules upon activation in an RNA-guided manner. Here, we uncover key determinants underlying this function. First, we show that unflanked R-loops in the RNA 5' side favor trans-cleavage…
View details →Justyna Zielińska-Turek, Grzegorz Turek, Dominika Jakubowicz-Lachowska et al. · 2016 · Aktualności Neurologiczne
Objectives: No widely available, adequately sensitive diagnostic test to establish prognosis in stroke patients has been developed thus far. The aim of this study was to analyse changes in plasma levels of MMP-9 and MMP-2 as potential prognostic factors in patients with ischaemic stroke. Methods: The study included 56 patients presenting with the signs of ischaemic stroke for less than 24 hours, and 60 healthy controls without a history of neurological and/or inflammatory disorders. Plasma concentrations of MMP-2 and MMP-9 were determined immunoenzymatically at admission (i.e. within 24 hours
View details →Shetty PMV, Matzen A, Hille S et al. · 2026 · Scientific reports
Marfan syndrome (MFS) is a connective tissue disorder caused by FBN1 mutations, characterised by aortic aneurysms leading to life-threatening dissections. Asprosin is the C-terminal propeptide of fibrillin-1 that was shown to function as a…
View details →Wei W, Chen W, Peng R et al. · 2026 · Frontiers in cellular and infection microbiology
Background Helicobacter pylori ( H. pylori ) infection affects approximately half of the global population and has been linked to oral microbiota dysbiosis, while eradication therapies may further disrupt microbial balance. This…
View details →Sung K, Park M, Kweon O et al. · 2026 · Food Microbiology.
Campylobacter jejuni is a foodborne pathogen with limited ability to thrive at low temperatures. This study investigated the survival and proteomic responses of C. jejuni NCTC 11168 during prolonged storage at 4 °C, with specific focus on…
View details →Lertwiram P, Fuangfa P, Kijkunasathian C et al. · 2026 · Scientific reports
Arthroscopic rotator cuff repair (ARCR) generally improves clinical outcomes, but the impact of pre-existing glenohumeral osteoarthritis (GHOA) severity on these outcomes remains unclear. This study aims to evaluate the correlation between…
View details →Bagińska M, Morawska-Tota M, Pałka T et al. · 2026 · Journal of clinical medicine
Background/Objectives : Bone tissue undergoes continuous remodelling processes that are closely controlled by mechanical stimuli and metabolic as well as inflammatory factors. Although the beneficial effects of regular physical activity on…
View details →Tahar Gargah, Majda Cherif, Rim Goucha-Louzir et al. · 2012 · Saudi Journal of Kidney Diseases and Transplantation
The hemolytic uremic syndrome (HUS), characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure, represents one of the major causes of acute renal failure in infancy and childhood. The typical form occurring after an episode of diarrhea caused by Escherichia coli is the most frequent in children. Other microorganisms also may be responsible for HUS, such as Streptococcus pneumoniae, which causes more severe forms of the disease. We report an 8-month-old girl who presented with pneumonia and subsequently developed HUS. Renal biopsy showed characteristic lesion
View details →Holden A, Burns P, Devenny A et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Background Improved survival in cystic fibrosis (CF) has shifted clinical focus toward late complications, including altered body composition, bone health and cardiopulmonary fitness. The effects of Elexacaftor/Tezacaftor/Ivacaftor (ETI)…
View details →Luca G Valente, Ngoc Dung Le, Melissa Pitton et al. · 2022 · PLoS ONE
Background Treatment failure in pneumococcal meningitis due to antibiotic resistance is an increasing clinical challenge and alternatives to antibiotics warrant investigation. Phage-derived endolysins efficiently kill gram-positive bacteria including multi-drug resistant strains, making them attractive therapeutic candidates. The current study assessed the therapeutic potential of the novel endolysin PlyAZ3aT in an infant rat model of ceftriaxone-resistant pneumococcal meningitis. Methods Efficacy of PlyAZ3aT was assessed in a randomized, blinded and controlled experimental study in infant Wis
View details →Celik M, Polat ME, Ceviz K et al. · 2026 · World journal of urology
Purpose Vasculogenic erectile dysfunction (ED) is associated with endothelial dysfunction and oxidative stress. This study evaluated the clinical efficacy of radial-type low-intensity extracorporeal shockwave therapy (Li-ESWT) and its…
View details →Kuruppu J, Purdy JB, Pauls C et al. · 2026 · Open forum infectious diseases
Background Some people with HIV (PWH) have a poor immunologic response to antiretroviral therapy (ART). Such immunologic nonresponders are at increased risk for HIV and non-HIV related complications. Immune exhaustion may contribute to…
View details →Celik F, Gungor IH, Uslug M et al. · 2026 · Parasitology research
Cystic echinococcosis (CE) is a chronic zoonotic disease caused by Echinococcus granulosus, primarily affecting the liver and lungs of livestock but also capable of inducing systemic alterations through oxidative stress and metabolic…
View details →Wang, Yu · 2026 · SAGE open medical case reports
A 5-month-old infant presented with paroxysmal crying and vomiting for more than 4 h. Ultrasonography confirmed intussusception in the right abdomen, but intraluminal gas limited precise classification. On the assumption of…
View details →Reuter AK, Deschner J, Schütz L et al. · 2026 · BMC medical education
Introduction The inverted classroom model (ICM) is a learner-centred approach that aims to promote engagement, independence and deeper understanding by shifting knowledge acquisition to self-directed learning before class and using class…
View details →Clark M, Wuennenberg J, Maghfour J et al. · 2026 · Clinical and experimental dermatology
Background Reflectance confocal microscopy (RCM) criteria for the in vivo diagnosis of superficial basal cell carcinoma (sBCC) lesions have been validated, with studies indicating a high level of diagnostic sensitivity. However, there…
View details →Yıldız V, Batur M, Yıldız S et al. · 2026 · Current eye research
Purpose To evaluate the effect of acute insulin treatment on retinal layers in patients with diabetes mellitus using spectral domain optical coherence tomography (SD-OCT). Methods This study included 44 eyes of 44 patients with diabetes.…
View details →Se-Hee Min, Suk Hyung Choe, Won Shik Kim et al. · 2022 · Scientific Reports
Abstract Flap failure after microvascular reconstructive surgery is a rare but devastating complication caused by reperfusion injury and tissue hypoperfusion. Remote ischemic conditioning (RIC) provides protection against ischemia/reperfusion injury and reduces tissue infarction. We hypothesized that RIC would enhance flap oxygenation and exert organ-protective effects during head and neck free flap reconstructive surgery. Adult patients undergoing free flap transfer surgery for head and neck cancer were randomized to receive either RIC or sham-RIC during surgery. RIC consisted of four cycles
View details →Al-Quraan LT, Al-Trad B, Alomari G et al. · 2026 · Current molecular medicine
Introduction This study aimed to address the effects of 1,8-cineole on diabetic muscular atrophy in streptozotocin (STZ)-induced diabetic rats. Materials and methods Adult male rats were divided into three groups (n = 15): nondiabetic…
View details →Sayın O, Çalım Sİ, Çigel A et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives: Green tea is known for its powerful antioxidant properties. However, the effects of green tea consumption during pregnancy on neonatal development and the mechanisms of these effects are not fully understood. The…
View details →Van Overmeiren T, de Alaiza Ortega SG, Calle S et al. · 2026 · Progress in cardiovascular diseases
Background Mavacamten is a cardiac myosin inhibitor used for patients with obstructive hypertrophic cardiomyopathy (oHCM). The efficacy and safety of this negative inotropic agent in oHCM and concomitant left bundle branch block (LBBB)…
View details →Yi Zhan, Huiming Yang, Jiangtao Wang et al. · 2024 · Scientific Reports
Abstract Based on the characteristics of Kummell’s disease (KD) and related anatomical structures of the thoracolumbar spine, a novel bone cement screw system has been designed to effectively avoid the cement loosening and displacement. This experiment aimed to assess the biological effects of the novel bone cement screw system in KD on fresh cadaveric thoracolumbar spine specimens, thereby discussing its potential application value and providing a foundation for clinical implementation. This study employed a total of 50 fresh female adult cadaver specimens. Each specimen underwent extraction
View details →Omole-ohonsi A, Ashimi AO · 2008 · Ibom Medical Journal
Objective: To evaluate the feasibility and outcome of caesarean myomectomy. Patients and Methods: A retrospective study of cases of caesarean myomectomy at the Aminu Kano Teaching Hospital, Kano, Nigeria, a tertiary health facility in a developing country between January 1998 and December 2004. Outcome Measures: Age and parity of the women, number, size and location of fibroids, duration of operation, estimated blood loss, postoperative complications and duration of hospital stay. Results: Sixteen cases of caesarean myomectomy were done during the study period using the tourniquet method. It i
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