11,287 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Jennifer L. Dearborn, Yiyi Zhang, Ye Qiao et al. · 2017 · Neurology
OBJECTIVE: To explore the association of intracranial atherosclerotic disease (ICAD) with mild cognitive impairment (MCI) and dementia. METHODS: From 2011 to 2013, 1,744 participants completed high-resolution vessel wall MRI from the…
View details →D. James Cooper, Jeffrey V. Rosenfeld, Lynnette Murray et al. · 2020 · Journal of Neurotrauma
Functional outcomes at 12 months were a secondary outcome of the randomized DECRA trial of early decompressive craniectomy for severe diffuse traumatic brain injury (TBI) and refractory intracranial hypertension. In the DECRA trial,…
View details →Daniel S. Thoma, Manuel Sancho‐Puchades, Dominik A. Ettlin et al. · 2011 · Journal Of Clinical Periodontology
AIM: To test whether a collagen matrix (CM) can improve early wound healing and aesthetics, and decrease wound sensitivity compared with spontaneous healing. METHODS: In 15 volunteers, 6-mm punch biopsies were harvested at both palatal…
View details →Shiu‐Dong Chung, Hsin‐Tzu Liu, Heng Lin et al. · 2011 · Neurourology and Urodynamics
AIMS: Chronic inflammation has been implicated in the development of overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS). An elevation of C-reactive protein (CRP) has been associated with chronic inflammation…
View details →Christopher T. Chan, Tom Greene, Glenn M. Chertow et al. · 2012 · Circulation Cardiovascular Imaging
BACKGROUND: An increase in left ventricular mass (LVM) is associated with mortality and cardiovascular morbidity in patients with end-stage renal disease. METHODS AND RESULTS: The Frequent Hemodialysis Network (FHN) Daily Trial randomized…
View details →Harrison G. Pope, Arthur M. Jacobs, Jean-Paul Mialet et al. · 2010 · Psychotherapy and Psychosomatics
BACKGROUND: In an exploratory study, we used a novel computerized battery of neuropsychological tests of attention to assess residual cognitive impairment in marijuana users. METHODS: We compared 25 college students who were heavy…
View details →E. Mahler, M. Blom, Nicol C. Voermans et al. · 2011 · Lara D. Veeken
OBJECTIVE: To assess the efficacy of rituximab on disease activity and muscle strength in patients with inflammatory myopathies refractory to conventional therapy. METHODS; Thirteen patients were treated with rituximab 1000 mg i.v., twice,…
View details →J. Vermorken, Pol Specenier · 2013 · Biologics
Head and neck cancer is the sixth most common cancer worldwide. At present, globally about 650,000 new cases of squamous cell carcinoma of the head and neck (SCCHN) are diagnosed each year. The epidermal growth factor receptor (EGFR) is…
View details →Martin Mynarek, Katja von Hoff, Torsten Pietsch et al. · 2020 · Journal of Clinical Oncology
PURPOSE The HIT-2000-BIS4 trial aimed to avoid highly detrimental craniospinal irradiation (CSI) in children < 4 years of age with nonmetastatic medulloblastoma by systemic chemotherapy, intraventricular methotrexate, and risk-adapted local radiotherapy. PATIENTS AND METHODS From 2001-2011, 87 patients received systemic chemotherapy and intraventricular methotrexate. Until 2006, CSI was reserved for nonresponse or progression. After 2006, local radiotherapy was introduced for nonresponders or patients with classic medulloblastoma (CMB) or large-cell/anaplastic medulloblastoma (LCA). DNA met
View details →Steven H. Kelder, Dale S. Mantey, Duncan Van Dusen et al. · 2020 · Public Health Reports
Objectives: From 2017 to 2018, electronic cigarette (e-cigarette) use increased 78% among high school students and 48% among middle school students in the United States. However, few e-cigarette prevention interventions have been…
View details →Sanjib Mohanty, Saroj K. Mishra, Rajyabardhan Patnaik et al. · 2011 · Clinical Infectious Diseases
BACKGROUND: Coma is a frequent presentation of severe malaria in adults and an important cause of death. The role of cerebral swelling in its pathogenesis, and the possible benefit of intravenous mannitol therapy to treat this, is…
View details →Hung-Yu Liu, Kun‐Hsien Chou, Pei‐Lin Lee et al. · 2016 · Cephalalgia
Objectives To investigate the structural changes of hippocampus and amygdala and their relationships with migraine frequency and prognosis. Methods Hippocampus and amygdala volumes were measured by 3-T brain magnetic resonance imaging…
View details →Edward I. Chang, Hong Zhang, Jun Liu et al. · 2015 · Head & Neck
BACKGROUND: Risk factors and techniques for free flap salvage in head and neck reconstruction are poorly described. METHODS: We conducted a retrospective review of all head and neck free flaps performed from 2000 to 2010. RESULTS: Overall,…
View details →Marco Marklewitz, Florian Zirkel, Innocent B. Rwego et al. · 2013 · Journal of Virology
Bunyaviruses are the largest known family of RNA viruses, infecting vertebrates, insects, and plants. Here we isolated three novel bunyaviruses from mosquitoes sampled in Côte d'Ivoire, Ghana, and Uganda. The viruses define a highly…
View details →Shujing Chen, Dingyu Zhang, Tianqi Zheng et al. · 2020 · Journal of Thrombosis and Thrombolysis
Few data are available on the incidence of deep vein thrombosis (DVT) in critically ill COVID-19 with thrombosis prophylaxis. This study retrospectively included 88 patients in the ICU with critically ill COVID-19 at Jinyintan Hospital in Wuhan, China. All patients underwent compression ultrasonography for identifying DVT. Firth logistic regression was used to examine the association of DVT with sex, age, hypoalbuminemia, D-dimer, and SOFA score. The median (interquartile range [IQR]) age and SOFA score of 88 patients were 63 (55-71) years old and 5 (4-6), respectively. Despite all patients re
View details →Marc A. Judson, Kristin B. Highland, Soon-Ho Kwon et al. · 2011 · PubMed
BACKGROUND: Sarcoidosis associated pulmonary hypertension (SAPH) is associated with significant morbidity and mortality. There is a paucity of information concerning therapy for this condition. METHODS: We performed a prospective,…
View details →Ashfaq Shuaib, Natan M. Bornstein, Hans‐Christoph Diener et al. · 2011 · Stroke
BACKGROUND AND PURPOSE: Fewer than 5% of patients with acute ischemic stroke are currently treated, and there is need for additional treatment options. A novel catheter treatment (NeuroFlo) that increases cerebral blood flow was tested to…
View details →N. de Korte, Johan P. Kuyvenhoven, Donald L. van der Peet et al. · 2011 · Colorectal Disease
AIM: Conservative treatment of mild colonic diverticulitis usually consists of observation, restriction of oral intake, intravenous fluids and antibiotics. The beneficiary effect of antibiotics remains unclear. The aim of this study is to…
View details →Jason R. Conn, Elizabeth Catchpoole, Naomi Runnegar et al. · 2017 · PLoS ONE
Febrile neutropenia (FN) is a medical emergency and can represent a life-threatening complication for hematology patients treated with intensive chemotherapy regimens. In clinical practice, the diagnostic yield of blood cultures and other investigations which aim to identify a causative organism or site of infection is low. We have retrospectively examined all blood cultures collected in a "real world" cohort of patients receiving chemotherapy for acute leukemia and patients with aggressive lymphoma treated with Hyper-CVAD/MTX-cytarabine, at a single tertiary center over a five-year period. In
View details →David Gaist, Ellen Garde, Morten Blaabjerg et al. · 2016 · Brain
A small number of population-based studies reported an association between migraine with aura and risk of silent brain infarcts and white matter hyperintensities in females. We investigated these relations in a population-based sample of…
View details →Marie Louise Tørring, Peter Murchie, William Hamilton et al. · 2017 · British Journal of Cancer
BACKGROUND: The benefits from expedited diagnosis of symptomatic cancer are uncertain. We aimed to analyse the relationship between stage of colorectal cancer (CRC) and the primary and specialist care components of the diagnostic interval.…
View details →Patrick J. Leavey, Nadia N. Laack, Mark D. Krailo et al. · 2021 · Journal of Clinical Oncology
PURPOSE The primary aim of this phase III randomized trial was to test whether the addition of vincristine, topotecan, and cyclophosphamide (VTC) to interval compressed chemotherapy improved survival outcomes for patients with previously…
View details →Manesh R. Patel, Richard C. Becker, Daniel Wojdyla et al. · 2014 · European Journal of Preventive Cardiology
AIMS: To determine the effect of ticagrelor compared to clopidogrel in patients with peripheral artery disease (PAD) and acute coronary syndromes (ACS). METHODS AND RESULTS: PLATO (n = 18,624) was a multicentre, double-blind, randomized…
View details →Thomas Tu, William S. Mason, Andrew D. Clouston et al. · 2015 · Journal of Viral Hepatitis
Hepatocyte clone size was measured in liver samples of 21 patients in various stages of chronic hepatitis B virus (HBV) infection and from 21 to 76 years of age. Hepatocyte clones containing unique virus-cell DNA junctions formed by the…
View details →Gianluca Tognon, Lauren Lissner, Ditte Sæbye et al. · 2013 · British Journal Of Nutrition
The aim of the present study was to determine whether the Mediterranean Diet Score (MDS) is associated with reduced total mortality, cardiovascular incidence and mortality in a Danish population. Analyses were performed on 1849 men and…
View details →Wendy Y. Craig, Walter C. Allan, Edward M. Kloza et al. · 2011 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Lower neurocognitive development scores at age 2 yr have been reported in association with euthyroid hypothyroxinemia during early pregnancy. OBJECTIVE: The objective of this study was to further explore this association with…
View details →Anahita Mostaghim, Hoi Yee Annie Lo, N.M. Khardori · 2017 · SAGE Open Medicine
Objective: This study aims to define risk factors as well as their association with microbiology and clinical outcomes in a large US infective endocarditis population. Methods: Hospital records were searched for appropriate infective…
View details →Tina Wong, Lei Zhou, Jing Li et al. · 2011 · Investigative Ophthalmology & Visual Science
PURPOSE: To identify the tear proteins associated with the long-term use of glaucoma medication by using proteomic analysis and to compare these proteins to those previously reported in primary dry eye disease. METHODS: Eighteen patients…
View details →Danielle S. Gruen, Joshua B. Brown, Francis X. Guyette et al. · 2020 · JCI Insight
BACKGROUNDPrehospital plasma improves survival in severely injured patients transported by air ambulance. We hypothesized that prehospital plasma would be associated with a reduction in immune imbalance and endothelial damage.METHODSWe sampled blood from 405 trauma patients enrolled in the Prehospital Air Medical Plasma (PAMPer) trial upon hospital admission (0 hours) and 24 hours post admission across 6 U.S. sites. We assayed samples for 21 inflammatory mediators and 7 markers associated with endothelial function and damage. We performed hierarchical clustering analysis (HCA) of these biomark
View details →Nuala J. Meyer, John P. Reilly, Brian J. Anderson et al. · 2017 · Critical Care Medicine
OBJECTIVE: Plasma interleukin-1 beta may influence sepsis mortality, yet recombinant human interleukin-1 receptor antagonist did not reduce mortality in randomized trials. We tested for heterogeneity in the treatment effect of recombinant…
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