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490 real negative results, null findings, and replication failures in Medicine · Failed Experiment Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportOpen accessMedicine

Lupeol and pristimerin do not inhibit activation of the human sperm CatSper Ca(2+)-channel [version 2; peer review: 2 approved, 1 approved with reservations]

Christian Marcus Pedersen, Anders Rehfeld · 2022 · F1000Research

Opposing findings have been published on the regulation of the sperm-specific Ca2+ channel CatSper (cation channel of sperm) in human sperm cells by the plant triterpenoids lupeol and pristimerin. While the original study on this topic found these triterpenoids to act as potent inhibitors of human CatSper, subsequent studies have failed to replicate such an inhibitory effect. It has been suggested that these issues could in part be due to purity issues and/or batch variation between the plant-derived extracts of lupeol and pristimerin obtained for the studies. The aim of this study was to eluc

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Failed Experiment ReportOpen accessMedicine

Postoperative drainage after pancreatoduodenectomy: a randomized controlled trial among patients with intermediate and low risks for pancreatic fistula-DRAIN1.

Wallon S, Williamsson C, Karlsson V et al. · 2026 · Trials

Background Routine use of surgical drains after abdominal operations has largely been abandoned over the past decades. Studies have failed to demonstrate benefits of routine drainage following liver, gallbladder, gastric, and colorectal…

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Failed Experiment ReportMedicine

Defining a natural killer cell-enriched molecular rejection-like state in lung transplant transbronchial biopsies.

Gauthier PT, Mackova M, Hirji A et al. · 2023 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

In lung transplantation, antibody-mediated rejection (AMR) diagnosed using the International Society for Heart and Lung Transplantation criteria is uncommon compared with other organs, and previous studies failed to find molecular AMR…

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Failed Experiment ReportMedicine

Clinical trials targeting tau should be halted.

Olluri A · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Experimental drugs lowering brain tau are heralded as improvements in the treatment of Alzheimer's disease. However, the outcomes in clinical trials testing these agents have consistently failed to improve patient outcomes, i.e. slow down…

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Failed Experiment ReportMedicine

Association of primary and secondary hemostasis biomarkers with acute ischemic stroke outcome in patients undergoing thrombectomy, with or without thrombolytics: post hoc analysis of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands-NO IV.

Barakzie A, Jansen AJG, Cavalcante F et al. · 2025 · Journal of thrombosis and haemostasis : JTH

Background Intravenous thrombolysis (IVT) using recombinant tissue plasminogen activator prior to endovascular thrombectomy treatment (EVT) failed to improve treatment effect in acute ischemic stroke (AIS) patients compared with EVT alone.…

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Failed Experiment ReportMedicine

Candida auris screening positivity after discontinuation of cohort units and enhanced nursing engagement: An interrupted time series.

Turner D, DeMaet MA, Bundage D et al. · 2026 · American journal of infection control

During an 87-week interrupted time series, we evaluated screening positivity after de-escalating dedicated cohort units for Candida auris and later implementing enhanced nursing engagement. Discontinuing cohort units did not increase…

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Failed Experiment ReportMedicine

Safety and efficacy of autologous haematopoietic stem-cell transplantation with low-dose cyclophosphamide mobilisation and reduced intensity conditioning versus standard of care in refractory Crohn's disease (ASTIClite): an open-label, multicentre, randomised controlled trial.

Lindsay JO, Hind D, Swaby L et al. · 2024 · The lancet. Gastroenterology & hepatology

Background A previous controlled trial of autologous haematopoietic stem-cell transplantation (HSCT) in patients with refractory Crohn's disease did not meet its primary endpoint and reported high toxicity. We aimed to assess the safety…

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Failed Experiment ReportOpen accessMedicine

Variation of rabbit serum IgA in relation to RHDV vaccination and infection: implications for serological diagnosis and epidemiological investigations.

Capucci L, Di Giovanni V, Schiavitto M et al. · 2026 · Veterinary research

Rabbit haemorrhagic disease (RHD) is a highly pathogenic and contagious disease caused by RHD virus (RHDV) and RHDV type 2 (RHDV2), two distinct Lagovirus europaeus belonging to the Caliciviridae family. Serological investigations have…

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Failed Experiment ReportMedicine

[Prokaryotic expression of Echinococcus granulosus Polo-like kinase 2 and immunoprotective efficacy of its recombinant protein].

Wang, Yan, Qi et al. · 2026 · Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control

To prepare the recombinant Echinococcus granulosus Polo-like kinase 2 (rEgPLK2) protein and evaluate its immunoprotective efficacy against cystic echinococcosis, so as to provide insights into research and development of novel vaccines…

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Failed Experiment ReportMedicine

Endovascular management of a ruptured pancreaticoduodenal artery pseudoaneurysm using a stent-graft: a case report and literature review.

Abukhalaf, Al-Ihribat, Sabarna et al. · 2026 · International journal of surgery case reports

Pancreaticoduodenal artery (PDA) pseudoaneurysms are rare vascular complications, accounting for approximately 2% of all visceral artery aneurysms. They are often associated with chronic pancreatitis and have a high risk of rupture, which…

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Failed Experiment ReportMedicine

Failed air enema reduction leading to the diagnosis of small-bowel intussusception secondary to Meckel's diverticulum with ectopic gastric mucosa in a 5-month-old infant: A case report.

Wang, Yu · 2026 · SAGE open medical case reports

A 5-month-old infant presented with paroxysmal crying and vomiting for more than 4 h. Ultrasonography confirmed intussusception in the right abdomen, but intraluminal gas limited precise classification. On the assumption of…

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Failed Experiment ReportMedicine

Transposition of the right renal artery to gastroduodenal artery for management of acute, symptomatic renovascular hypertension.

Ellis, Perry, Tabbara et al. · 2026 · Journal of vascular surgery cases and innovative techniques

Renovascular hypertension can be clinically challenging to diagnose. The most common etiology remains atherosclerotic disease. When medical management fails, renal artery revascularization is considered. Since the advent of endovascular…

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Failed Experiment ReportMedicine

Managing post-laminoplasty deformity after resection in of a cervical intramedullary hemangioblastoma in a 36-year-old male: a case report.

Versyck, Tollenaere, Schelfaut et al. · 2026 · Journal of spine surgery (Hong Kong)

Cervical kyphotic deformity is a recognized complication following posterior cervical spine surgery, particularly after laminectomy. However, post-laminoplasty kyphosis remains an underreported entity. We present a case of progressive…

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Failed Experiment ReportMedicine

Loureirin B Attenuates Methotrexate-Induced Liver Injury Associated with Oxidative Stress, SIRT1 Alterations, and TGF-β/SMAD3-Related Profibrotic Responses.

Hengirmen Acu, Erbaş · 2026 · Pharmaceuticals (Basel, Switzerland)

Background: Methotrexate-induced oxidative stress is mechanistically linked not only to hepatocellular injury but also to DNA damage, indicating that oxidative stress, hepatotoxicity, and genotoxicity represent interconnected…

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