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Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Harnessing Fear and Promoting Self-Efficacy in Response to Mass Casualty Scenarios: Evaluating Stop the Bleed at an Urban University.

Tong ST, Phillips K, Gomez J et al. · 2026 · Journal of prevention (2022)

Emergency situations range from everyday traffic accidents to incidents of mass gun violence and require individuals to be prepared and willing to act in times of crisis. To encourage people to help one another during such emergencies, the…

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Negative / Null Result ReportMedicine

Persistence of pulmonary hypertension in patients with ventricular septal defect after intracardiac repair: insights from a long-term follow-up study.

Wakisaka Y, Inai K, Harada G et al. · 2025 · Cardiology in the young

Background Ventricular septal defect is the most common CHD and is complicated by pulmonary hypertension in about 5% of cases. Although long-term outcomes after repair are generally good, persistent pulmonary hypertension has been…

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Negative / Null Result ReportMedicine

Subjective well-being mediates the longitudinal effect of insomnia symptoms on internalizing symptoms in community-dwelling older adults.

Ying Y, Meng R, Xu J et al. · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives The associations between insomnia symptoms and internalizing symptoms are well-established, particularly in older adults; however, the mediating factors remain inconsistent. This study seeks to explore the longitudinal…

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Negative / Null Result ReportMedicine

Clinical impact of TP53 classifications in previously treated advanced driver-negative non-small cell lung cancer: A biomarker analysis of the OAK and POPLAR randomized clinical trials.

Zhou DD, Lord SJ, Lin FP et al. · 2026 · Lung cancer (Amsterdam, Netherlands)

Background In NSCLC, TP53 mutations are heterogeneous with varied effects on protein synthesis, function and clinical outcomes. We hypothesize that a refined classification of TP53 mutations, beyond binary categorization, could improve…

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Negative / Null Result ReportMedicine

Computed Tomography Measurement of Optic Nerve Sheath Diameter in Thrombolysis-Treated Ischemic Stroke: Association with Post-Thrombolytic Intracranial Hemorrhage.

Coşkun Yaş S, Üçöz Kocaşaban D, Güler S et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Optic nerve sheath diameter (ONSD) measurement is a non-invasive marker of intracranial pressure. Its role in predicting post-thrombolytic intracranial hemorrhage in acute ischemic stroke patients remains unclear. This study aimed to…

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Negative / Null Result ReportMedicine

Expression of CD226 on γδ T cells is lower in advanced chronic lymphocytic leukemia and correlates with IgA, IgG and LDH levels.

Zarobkiewicz MK, Lehman N, Kowalska W et al. · 2025 · Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Background Gamma-delta (γδ) T cells comprise an important subset of human T cells, responding to viral and bacterial infections, and are significant for cancer immunosurveillance. Human γδ T cells are divided into 5 major subsets, namely…

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Negative / Null Result ReportMedicine

Exploring fonts as retrieval cues in text-based learning.

Krieglstein F, Jansen S, Meusel F et al. · 2024 · Acta psychologica

A growing body of research focuses on optimizing retrieval processes to help learners recall information from memory. The context-dependent memory effect suggests that information retrieval is more effective when the retrieval context…

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Negative / Null Result ReportOpen accessMedicine

Combining Endoscopic Submucosa Dissection and Endoscopic Full-Thickness Resection for Resection of a Gastric Schwannoma Mimicking Gastrointestinal Stroma Tumor.

Kormann S, Semadeni GM, Weber M et al. · 2024 · ACG case reports journal

Subepithelial gastric tumors are a diagnostic challenge. Endoscopic ultrasound allows differentiation. Lesions originating from the submucosal layer can be resected using endoscopic submucosal dissection (ESD). Surgery or endoscopic…

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Negative / Null Result ReportMedicine

Multi-parametric magnetic resonance imaging of the prostate in Victoria, Australia; unintended consequences of changing Medicare Benefits Schedule access.

Gordon P, Urquhart E, Oad S et al. · 2024 · Australian health review : a publication of the Australian Hospital Association

Objective To assess whether prostate biopsy rates have altered with the July 2018 change in Australian Medicare Benefits Schedule (MBS) rebates supporting multiparametric magnetic resonance imaging (mpMRI) for diagnosing prostate cancer.…

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Negative / Null Result ReportOpen accessMedicine

A Case of Unexpected Peritoneal Carcinomatosis From Colon Cancer Detected After Robot-Assisted Radical Cystectomy for Advanced Bladder Cancer.

Ito K, Yamashita R, Kasai S et al. · 2026 · IJU case reports

Introduction Peritoneal carcinomatosis in patients with advanced bladder cancer is a rare but lethal event following robot-assisted radical cystectomy (RARC). We report a case of an unusual clinical course in which peritoneal dissemination…

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Negative / Null Result ReportMedicine

Integrating vision and somatosensation does not improve the accuracy and response time when estimating area and perimeter of rectangles in primary school.

Leukel C, Loibl K, Leuders T · 2024 · Trends in neuroscience and education

Background Problem-solving and learning in mathematics involves sensory perception and processing. Multisensory integration may contribute by enhancing sensory estimates. This study aims to assess if combining visual and somatosensory…

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Negative / Null Result ReportMedicine

Icotinib plus chemotherapy as neoadjuvant treatment for resectable stage II-IIIB EGFR-mutant lung adenocarcinoma: a phase II study (NEOIPOWER).

Lu F, Lv C, Yang X et al. · 2025 · Lung cancer (Amsterdam, Netherlands)

Background EGFR tyrosine kinase inhibitors (EGFR-TKIs) have shown activity in the neoadjuvant setting of EGFR-mutant (EGFRm) non-small cell lung cancer; however, data on the combination of neoadjuvant EGFR-TKIs plus chemotherapy are…

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Negative / Null Result ReportMedicine

Efficacy and safety of intravenous prasinezumab in individuals with early-stage Parkinson's disease on stable symptomatic monotherapy (PADOVA): a phase 2b, multicentre, randomised, double-blind, placebo-controlled study.

Nikolcheva T, Pagano G, Anzures-Cabrera J et al. · 2026 · Lancet (London, England)

Background Prasinezumab has previously shown potential for reducing the progression of motor signs (Movement Disorder Society-sponsored Revision of the Unified Parkinson's Disease Rating Scale [MDS-UPDRS] Part III) in patients with…

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Negative / Null Result ReportMedicine

Safety and efficacy of the anti-α-synuclein monoclonal antibody amlenetug for the treatment of patients with multiple system atrophy (AMULET): a phase 2, randomised, double-blind, multicentre trial.

Kjærsgaard L, Wiedemann J, Singer W et al. · 2026 · The Lancet. Neurology

Background Pathological aggregation and propagation of α-synuclein species drive disease progression in multiple system atrophy (MSA). We assessed the efficacy and safety of amlenetug, a monoclonal antibody targeting aggregated…

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Negative / Null Result ReportMedicine

Hepatectomy Plus Chemotherapy or Chemotherapy Alone for Resectable Liver and Unresectable Lung Metastases from Colorectal Adenocarcinoma (LUNA): A Randomized Phase II Trial.

Folkert IW, Mehran R, Sun R et al. · 2026 · Annals of surgical oncology

Background Hepatectomy for isolated colorectal liver metastases is associated with 5 year overall survival (OS) of 58% and is accepted as standard of care. However, the role of liver resection with unresectable low-volume lung metastases…

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Negative / Null Result ReportMedicine

Intercalated Avelumab plus platinum-based chemotherapy in patients with Extensive-Stage Small-Cell Lung cancer (PAVE): Final outcome, immunophenotypic and biomarker analysis of a multi-center phase II Hellenic Cooperative Oncology Group study.

Linardou H, Papadopoulou K, Korfiatis N et al. · 2025 · European journal of cancer (Oxford, England : 1990)

Background Extensive stage small cell lung cancer (ES-SCLC) has poor prognosis, and first-line chemo-immunotherapy is now the standard-of-care. We hypothesized that intercalated immunotherapy administration in-between chemotherapy cycles,…

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