Negative / Null Result ReportOpen accessMedicine
Ángela Lamarca, Paul J. Ross, Harpreet Wasan et al. · 2019 · JNCI Journal of the National Cancer Institute
BACKGROUND: The incidence of intrahepatic cholangiocarcinoma (iCCA) is increasing. The aim of the study was to provide reference survival data for patients with advanced iCCA treated with first-line cisplatin-gemcitabine chemotherapy (current standard of care). METHODS: Individual data from patients with iCCA recruited into the prospective, random assignment Advanced Biliary Tract Cancer (ABC)-01, -02, and -03 studies were retrieved. The prevalence and survival of liver-only iCCA was also assessed. Survival analysis was performed using univariate and multivariable Cox regression. All statistic
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Carol A. Langford, David Cuthbertson, Steven R. Ytterberg et al. · 2017 · Arthritis & Rheumatology
Objective To compare the efficacy of abatacept to that of placebo for the treatment of Takayasu arteritis (TAK). Methods In this multicenter trial, patients with newly diagnosed or relapsing TAK were treated with abatacept 10 mg/kg…
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Hendrikus J. A. van Os, Lucas A. Ramos, Adam Hilbert et al. · 2018 · Frontiers in Neurology
Background: Endovascular treatment (EVT) is effective for stroke patients with a large vessel occlusion (LVO) of the anterior circulation. To further improve personalized stroke care, it is essential to accurately predict outcome after EVT. Machine learning might outperform classical prediction methods as it is capable of addressing complex interactions and non-linear relations between variables. Methods: We included patients from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN) Registry, an observational cohort of LVO
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Jake Dunning, Foday Sahr, Amanda Rojek et al. · 2016 · PLoS Medicine
BACKGROUND: TKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated. METHODS AND FINDINGS: In this single-arm phase 2 trial, adults with laboratory-confirmed EVD received 0.3 mg/kg of TKM-130803 by intravenous infusion once daily for up to 7 d. On days when trial enrolment capacity was reached, patients were enrolled into a concurrent observational cohort. The primary outcome was survival to day 14 after admission, excluding patients who died within 48 h of ad
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Vivek Iyer, Karen L. Swanson, Rodrigo Cartin‐Ceba et al. · 2012 · Hepatology
UNLABELLED: Hepatopulmonary syndrome (HPS) is a pulmonary vascular disorder occurring as a consequence of advanced liver disease, characterized by hypoxemia due to intrapulmonary vascular dilatations. HPS independently increases mortality,…
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Efrem S. Lim, Cynthia Rodríguez, Lori R. Holtz · 2018 · Microbiome
Recent studies have conflicting data regarding the presence of intra-amniotic microbiota. Viral communities are increasingly recognized as important although overlooked components of the human microbiota. It is unknown if the developing fetus is exposed to a community of viruses (virome). Given the debate over the existence of an intra-amniotic microbial community and the importance of understanding how the infant gut is populated, we characterized the virome and bacterial microbiota of amniotic fluid from 24 uncomplicated term pregnancies using next-generation sequencing methods. Contrary to
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Martina Ulrich, T. Braunmuehl, Hjalmar Kurzen et al. · 2015 · British Journal of Dermatology
BACKGROUND: The diagnostic criteria for basal cell carcinoma (BCC) using optical coherence tomography (OCT) have been described previously, but the clinical value of these findings remains unknown. OBJECTIVES: To investigate the diagnostic…
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Murray B. Stein, Ronald C. Kessler, Steven G. Heeringa et al. · 2015 · American Journal of Psychiatry
OBJECTIVE: Traumatic brain injury (TBI) is increasingly recognized as a risk factor for deleterious mental health and functional outcomes. The purpose of this study was to examine the strength and specificity of the association between…
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David J. Dorer, Ronald K. Knickerbocker, Michele Baccarani et al. · 2016 · Leukemia Research
Ponatinib is approved for adults with refractory chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia, including those with the T315I BCR-ABL1 mutation. We pooled data from 3 clinical trials (N=671) to…
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Jhanelle E. Gray, Rebecca S. Heist, Alexander Starodub et al. · 2017 · Clinical Cancer Research
Abstract Purpose: We evaluated a Trop-2–targeting antibody conjugated with SN-38 in metastatic small cell lung cancer (mSCLC) patients. Experimental Design: Sacituzumab govitecan was studied in patients with pretreated (median, 2; range,…
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Charly Gaul, Christina van Doorn, Nadine Webering et al. · 2011 · The Journal of Headache and Pain
This study investigated the outcome of a 5-day headache-specific multidisciplinary treatment program (MTP) and the adherence to treatment recommendations in 295 prospectively recruited consecutive headache patients [210 migraine, 17 tension-type headache (TTH), 68 combination headache, including 56 medication-overuse headache (MOH)]. Headache frequency decreased from 13.4 (±8.8) to 8.8 (±8.0) days per month after 12-18 months. Forty-three percent of the participants fulfilled the primary outcome (reduction of headache frequency of ≥50%), which was less likely in patients with combination of mi
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Sandy R. Shultz, David Wright, Ping Zheng et al. · 2015 · Brain
Traumatic brain injury is a common and serious neurodegenerative condition that lacks a pharmaceutical intervention to improve long-term outcome. Hyperphosphorylated tau is implicated in some of the consequences of traumatic brain injury…
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Hawazin Faruki, Gregory M. Mayhew, Jonathan S. Serody et al. · 2017 · Journal of Thoracic Oncology
INTRODUCTION: Molecular subtyping of lung adenocarcinoma (AD) and lung squamous cell carcinoma (SCC) reveal biologically diverse tumors that vary in their genomic and clinical attributes. METHODS: Published immune cell signatures and…
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Rachel Saunders‐Pullman, Anat Mirelman, Roy N. Alcalay et al. · 2018 · JAMA Neurology
Importance: Few prospective longitudinal studies have evaluated the progression of Parkinson disease (PD) in patients with the leucine-rich repeat kinase 2 (LRRK2 [OMIM 609007]) mutation. Knowledge about such progression will aid clinical…
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Allison Bond, Heather Mason, Chelsey Lemaster et al. · 2013 · Medical Education Online
OBJECTIVE: An effective career in medicine requires empathy and compassion, yet the demands of a medical education increase stress and decrease students' ability to connect with patients. However, research suggests mind-body practices improve psychological well-being. This study aimed to evaluate the psychological effects on medical students of an 11-week elective course, Embodied Health or EH, which combines yoga and meditation with neuroscience didactics. METHODS: The effects on 27 first- and second-year medical students were evaluated via surveys in four areas: empathy, perceived stress, se
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Gerrit Fischer, Axel Stadie, Róbert Reisch et al. · 2011 · Operative Neurosurgery
BACKGROUND: Improvements in preoperative imaging and intraoperative visualization have led to a refinement in surgical techniques. OBJECTIVE: Report of a 20-year experience with application of the keyhole technique as a contribution to the…
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Moira Strand Hutchinson, Guri Grimnes, Ragnar M. Joakimsen et al. · 2010 · European Journal of Endocrinology
OBJECTIVE: Ecologic and observational studies have suggested an association between serum 25-hydroxyvitamin D (25(OH)D) levels and cardiovascular disease (CVD) risk factors, CVD mortality, and cancer mortality. Based on this, low serum…
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Aletta P. I. Houwink, Saskia Rijkenberg, Rob J. Bosman et al. · 2016 · Critical Care
BACKGROUND: During resuscitation in severe sepsis and septic shock, several goals are set. However, usually not all goals are equally met. The aim of this study is to determine the relative importance of the different goals, such as mean arterial pressure (MAP), lactate, central venous oxygen saturation (ScvO2) and central to forefoot temperature (delta-T), and how they relate to intensive care unit (ICU) and hospital mortality. METHODS: In a retrospective cohort study in a 20-bed mixed medical and surgical ICU of a teaching hospital we studied consecutive critically ill patients who were admi
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Adam C. Naj, Gary W. Beecham, Eden R. Martin et al. · 2010 · PLoS Genetics
Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of association with polymorphisms in APOE. However, until recently, variants at few other loci with statistically significant associations have replicated across studies. The present study combines data on 483,399 single nucleotide polymorphisms (SNPs) from a previously reported GWAS of 492 LOAD cases and 496 controls and from an independent set of 439 LOAD cases and 608 controls to strengthen power to identify novel genetic association signals. Associations exceeding the ex
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Zvinka Z. Zlatar, Martha C. Muniz, Douglas Galasko et al. · 2016 · The Journals of Gerontology Series B
Objectives: Subjective cognitive decline (SCD) is common in older adults; however, its utility in clinic-based samples remains controversial given its strong associations with mood symptoms. Methods: Five hundred nineteen individuals aged…
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Anja Laschkolnig, Barbara Kollerits, Claudia Lamina et al. · 2014 · Cardiovascular Research
AIMS: The relevance of lipoprotein(a) [Lp(a)] concentrations and low-molecular-weight (LMW) apo(a) phenotypes in peripheral arterial disease (PAD) has only been investigated by few studies. Therefore, we analysed this association in three…
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Vijayvel Jayaprakash, Mihai Merzianu, Graham Warren et al. · 2013 · Head & Neck
BACKGROUND: The survival rates and prognostic factors for salivary duct carcinoma (SDC) are not clear. METHODS: Survival estimates and prognostic factors were evaluated for 228 patients with SDC identified from the Surveillance,…
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Daniel Gelfond, Sonya L. Heltshe, Chang‐Xing Ma et al. · 2017 · Clinical and Translational Gastroenterology
OBJECTIVES: A defect in bicarbonate secretion contributes to the pathophysiology of gastrointestinal complications in patients with cystic fibrosis (CF). We measured gastrointestinal pH, clinical outcomes, and intestinal transit profiles…
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Laurence Lepage, A Dufour, Jessica Doiron et al. · 2015 · Clinical Journal of the American Society of Nephrology
BACKGROUND AND OBJECTIVES: Hyperkalemia affects up to 10% of patients with CKD. Sodium polystyrene sulfonate has long been prescribed for this condition, although evidence is lacking on its efficacy for the treatment of mild hyperkalemia…
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Mary Dankbaar, Jelmer Alsma, Els E. H. Jansen et al. · 2015 · Advances in Health Sciences Education
Simulation games are becoming increasingly popular in education, but more insight in their critical design features is needed. This study investigated the effects of fidelity of open patient cases in adjunct to an instructional e-module on students' cognitive skills and motivation. We set up a three-group randomized post-test-only design: a control group working on an e-module; a cases group, combining the e-module with low-fidelity text-based patient cases, and a game group, combining the e-module with a high-fidelity simulation game with the same cases. Participants completed questionnaires
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Padhma Ranganathan, Paul A. Clark, John S. Kuo et al. · 2011 · Journal of Virology
Viruses are appreciated as etiological agents of certain human tumors, but the number of different cancer types induced or exacerbated by viral infections is unknown. Glioblastoma multiforme (GBM)/astrocytoma grade IV is a malignant and…
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Zhongheng Zhang, Gensheng Zhang, Hemant Goyal et al. · 2018 · Critical Care
BACKGROUND AND OBJECTIVE: Sepsis is a heterogeneous disease and identification of its subclasses may facilitate and optimize clinical management. This study aimed to identify subclasses of sepsis and its responses to different amounts of fluid resuscitation. METHODS: This was a retrospective study conducted in an intensive care unit at a large tertiary care hospital. The patients fulfilling the diagnostic criteria of sepsis from June 1, 2001 to October 31, 2012 were included. Clinical and laboratory variables were used to perform the latent profile analysis (LPA). A multivariable logistic regr
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Nicholas J. Short, Naval Daver, Courtney D. DiNardo et al. · 2024 · Journal of Clinical Oncology
PURPOSE Azacitidine plus venetoclax is a standard of care for patients with newly diagnosed AML who are unfit for intensive chemotherapy. However, FLT3 mutations are a common mechanism of resistance to this regimen. The addition of…
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Ignacio Illán‐Gala, Alberto Lleó, Anna Karydas et al. · 2020 · Neurology
OBJECTIVE: To test the hypothesis that plasma total tau (t-tau) and neurofilament light chain (NfL) concentrations may have a differential role in the study of frontotemporal lobar degeneration syndromes (FTLD-S) and clinically diagnosed…
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Xiaoyi Huang, Jian Zhao, Jinyi Bai et al. · 2019 · Journal of bone oncology
Osteosarcoma is the most common primary sarcoma of the bone. Lung osteosarcoma metastases at diagnosis have a significantly poor prognosis, even when surgery plus chemotherapy are performed. Our goal was to analyze clinical and sarcoma…
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