Negative / Null Result ReportOpen accessMedicine
Marianna Fontana, Steve K White, Sanjay M Banypersad et al. · 2012 · Journal of Cardiovascular Magnetic Resonance
BACKGROUND: Myocardial extracellular volume (ECV) is elevated in fibrosis or infiltration and can be quantified by measuring the haematocrit with pre and post contrast T1 at sufficient contrast equilibrium. Equilibrium CMR (EQ-CMR), using a bolus-infusion protocol, has been shown to provide robust measurements of ECV using a multibreath-hold T1 pulse sequence. Newer, faster sequences for T1 mapping promise whole heart coverage and improved clinical utility, but have not been validated. METHODS: Multibreathhold T1 quantification with heart rate correction and single breath-hold T1 mapping using
View details →DOI: 10.1186/1532-429x-14-88Cited by 265 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Federico Innocenti, Gregory M. Cooper, Ian B. Stanaway et al. · 2011 · PLoS Genetics
The discovery of expression quantitative trait loci ("eQTLs") can help to unravel genetic contributions to complex traits. We identified genetic determinants of human liver gene expression variation using two independent collections of primary tissue profiled with Agilent (n = 206) and Illumina (n = 60) expression arrays and Illumina SNP genotyping (550K), and we also incorporated data from a published study (n = 266). We found that ∼30% of SNP-expression correlations in one study failed to replicate in either of the others, even at thresholds yielding high reproducibility in simulations, and
View details →DOI: 10.1371/journal.pgen.1002078Cited by 210 Negative / Null Result ReportOpen accessMedicine
Ahmed M. Elkhatat · 2023 · International Journal for Educational Integrity
Abstract Academic plagiarism is a pressing concern in educational institutions. With the emergence of artificial intelligence (AI) chatbots, like ChatGPT, potential risks related to cheating and plagiarism have increased. This study aims to investigate the authenticity capabilities of ChatGPT models 3.5 and 4 in generating novel, coherent, and accurate responses that evade detection by text-matching software. The repeatability and reproducibility of both models were analyzed, showing that the generation of responses remains consistent. However, a two-sample t-test revealed insufficient evidenc
View details →DOI: 10.1007/s40979-023-00137-0Cited by 93 Negative / Null Result ReportOpen accessMedicine
Brit Mollenhauer, Frederick DuBois Bowman, Daniel Drake et al. · 2018 · Journal of Neurochemistry
Abstract α‐Synuclein is the major component of Lewy bodies and a candidate biomarker for neurodegenerative diseases in which Lewy bodies are common, including Parkinson's disease and dementia with Lewy bodies. A large body of literature suggests that these disorders are characterized by reduced concentrations of α‐synuclein in cerebrospinal fluid (CSF), with overlapping concentrations compared to healthy controls and variability across studies. Several reasons can account for this variability, including technical ones, such as inter‐assay and inter‐laboratory variation (reproducibility). We co
View details →DOI: 10.1111/jnc.14569Cited by 56 Negative / Null Result ReportOpen accessNeuroscience
Kenia Martínez, Sarah K. Madsen, Anand A. Joshi et al. · 2015 · Human Brain Mapping
People differ in their cognitive functioning. This variability has been exhaustively examined at the behavioral, neural and genetic level to uncover the mechanisms by which some individuals are more cognitively efficient than others.…
View details →DOI: 10.1002/hbm.22843Cited by 33 Negative / Null Result ReportOpen accessMedicine
Meryem A. Yücel, Robert Luke, Rickson C. Mesquita et al. · 2025 · Communications Biology
As data analysis pipelines grow more complex in brain imaging research, understanding how methodological choices affect results is essential for ensuring reproducibility and transparency. This is especially relevant for functional Near-Infrared Spectroscopy (fNIRS), a rapidly growing technique for assessing brain function in naturalistic settings and across the lifespan, yet one that still lacks standardized analysis approaches. In the fNIRS Reproducibility Study Hub (FRESH) initiative, we asked 38 research teams worldwide to independently analyze the same two fNIRS datasets. Despite using dif
View details →DOI: 10.1038/s42003-025-08412-1Cited by 24 Negative / Null Result ReportOpen accessMedicine
Lawrence Grierson, Samantha Winemaker, Alan Taniguchi et al. · 2020 · Perspectives on Medical Education
INTRODUCTION: The medical education community has implemented writing exercises that foster critical analysis and nurture reflective capacity. The REFLECT rubric (Wald et al. 2012) was developed to address the challenge of assessing these written reflections. The objective of this replication work is to explore the reproducibility of the reliability characteristics presented by the REFLECT developers. METHODS: Five raters evaluated narratives written by medical students and experienced clinicians using the REFLECT rubric. Reliability across rubric domains was determined via intraclass correlat
View details →DOI: 10.1007/s40037-020-00611-2Cited by 22 Negative / Null Result ReportOpen accessEnvironmental Science
Wei Li, Laura Germine, Samuel A. Mehr et al. · 2022 · Infant and Child Development
Widespread failures of replication and generalization are, ironically, a scientific triumph, in that they confirm the fundamental metascientific theory that underlies our field. Generalizable and replicable findings require testing large…
View details →DOI: 10.1002/icd.2348Cited by 20 Negative / Null Result ReportOpen accessComputer Science
Joshua K. Hartshorne, Lauren Skorb, Sven L. Dietz et al. · 2019 · Collabra Psychology
We report the first set of results in a multi-year project to assess the robustness – and the factors promoting robustness – of the adult statistical word segmentation literature. This includes eight total experiments replicating six different experiments. The purpose of these replications is to assess the reproducibility of reported experiments, examine the replicability of their results, and provide more accurate effect size estimates. Reproducibility was mixed, with several papers either lacking crucial details or containing errors in the description of method, making it difficult to ascert
View details →DOI: 10.1525/collabra.181Cited by 16 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Waylon J. Hastings, Laura Etzel, Christine M. Heim et al. · 2022 · Aging
Various approaches exist to assess population differences in biological aging. Telomere length (TL) is one such measure, and is associated with disease, disability and early mortality. Yet, issues surrounding precision and reproducibility are a concern for TL measurement. An alternative method to estimate TL using DNA methylation (DNAmTL) was recently developed. Although DNAmTL has been characterized in adult and elderly cohorts, its utility in pediatric populations remains unknown. We examined the comparability of leukocyte TL measurements generated using qPCR (absolute TL; aTL) to those esti
View details →DOI: 10.18632/aging.203849Cited by 14 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Rasit Dinc, Nurittin Ardıç · 2026 · Cells
Exosomes and other extracellular vesicles (EVs) carry microRNAs, proteins, and lipids that reflect cardiovascular pathophysiology and can enable minimally invasive biomarker discovery. However, EV datasets are highly dimensional and heterogeneous, strongly influenced by pre-analytic variables and non-standardized isolation/characterization workflows, limiting reproducibility across studies. Artificial intelligence (AI), including machine learning (ML), deep learning (DL), and network-based approaches, can support EV biomarker development by integrating multi-omics profiles with clinical metada
View details →DOI: 10.3390/cells15030304Cited by 14 Negative / Null Result ReportOpen accessMaterials Science
Chitra Yadav, Alexander S. Evtushenko, Andrea Bistrović et al. · 2025 · npj Biomedical Innovations.
3D spheroid culture has emerged as a valuable tool for studying complex intratumoral processes and screening novel therapeutics in vitro. However, spheroids face reproducibility and data interpretation issues, which limit their utility. This work describes a simple and reproducible co-culture spheroid model compatible with high-throughput screening designed to study pancreatic ductal adenocarcinoma (PDAC), a highly therapy-resistant cancer. These spheroids, composed of both cancer and stromal cells, recapitulate key features of PDAC which are difficult to study in traditional 2D cell culture,
View details →DOI: 10.1038/s44385-025-00041-xCited by 11 Negative / Null Result ReportOpen accessHealth Professions
Nasser Lubega, Abigail Anderson, Nicole Nelson · 2023 · PLoS ONE
High rates of irreproducibility and of poor mental health in graduate students have been reported in the biomedical sciences in the past ten years, but to date, little research has investigated whether these two trends interact. In this study, we ask whether the experience of failing to replicate an expected finding impacts graduate students' mental health. Using an online survey paired with semi-structured qualitative interviews, we examined how often biomedical science doctoral students at a large American public university experienced events that could be interpreted as failures to replicat
View details →DOI: 10.1371/journal.pone.0293584Cited by 10 Negative / Null Result Report
Jack W. O’Sullivan, John P. A. Ioannidis · 2021 · Scientific Reports
Abstract With the establishment of large biobanks, discovery of single nucleotide variants (SNVs, also known as single nucleotide polymorphisms (SNVs)) associated with various phenotypes has accelerated. An open question is whether…
View details →DOI: 10.1038/s41598-021-97896-yCited by 9 Negative / Null Result Report
Tümay Capraz, Wolfgang Huber · 2024 · Bioinformatics
Abstract Motivation A fundamental step in many analyses of high-dimensional data is dimension reduction. Two basic approaches are introduction of new synthetic coordinates and selection of extant features. Advantages of the latter include…
View details →DOI: 10.1093/bioinformatics/btae548Cited by 3 Negative / Null Result Report
Caetano Souto-Maior · 2025 · PeerJ
Reports of crises of reproducibility have abounded in the scientific and popular press, and are often attributed to questionable research practices, lack of rigor in protocols, or fraud. On the other hand, it is a known fact that—just like…
View details →DOI: 10.7717/peerj.18972Cited by 2 Negative / Null Result Report
Ke Xiao, Rongxin Zhang, Jing Tu · 2025 · International Journal of Molecular Sciences
G-quadruplex (G4) ChIP-Seq data are critical for studying the roles of G4 structures in various biological processes, yet their reproducibility remains systematically uncharacterized. In this study, we evaluated the consistency of in vivo…
View details →DOI: 10.3390/ijms26199769Cited by 1 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Alexandre Pereira Tognon, Murilo Foppa, Vivian Cristine Luft et al. · 2015 · Arquivos Brasileiros de Cardiologia
Background: Echocardiography, though non-invasive and having relatively low-cost, presents issues of variability which can limit its use in epidemiological studies. Objective: To evaluate left ventricular mass reproducibility when assessed at acquisition (online) compared to when assessed at a reading center after electronic transmission (offline) and also when assessed by different readers at the reading center. Methods: Echocardiographers from the 6 ELSA-Brasil study investigation centers measured the left ventricular mass online during the acquisition from 124 studies before transmitting to
View details →DOI: 10.5935/abc.20140183 Negative / Null Result ReportOpen accessMedicine
Stapleton JR, Heilmann NZ, Cattell K et al. · 2026 · JBMR plus
As HR-pQCT increases in popularity for studying bone dynamics, it becomes increasingly important to quantify the factors that impact rigor and reproducibility in research, particularly for longitudinal studies. Previously reported data for…
View details →DOI: 10.1093/jbmrpl/ziag097 Negative / Null Result Report
Bauer L, Laumer T · 2026 · Preprint
Abstract Fused layer modelling (FLM) is an additive manufacturing technique of growing relevance. Therefore, quality requirements regarding component properties, reproducibility and waste reduction are also rising. To achieve this, process…
View details →DOI: 10.21203/rs.3.rs-8721830/v1 Negative / Null Result ReportMedicine
Chen Y, Deng M, Xie L et al. · 2026 · Journal of translational medicine
Background The rarity of right heart masses challenges diagnostic proficiency, while reproducibility is affected by the echocardiography operator. Artificial intelligence (AI)-based imaging tools may help address these limitations. Methods…
View details →DOI: 10.1186/s12967-026-08322-8 Negative / Null Result ReportMedicine
Herrera-Torres OA, Flores-Zapata J, Ferreyro-Bravo F · 2026 · Nutricion hospitalaria
Introduction Introduction: the estimation of body fat mass (FM) can be performed using different methods. Although Dual-Energy X-ray Absorptiometry (DXA) is considered the reference technique due to its precision and reproducibility, its…
View details →DOI: 10.20960/nh.06323 Negative / Null Result ReportMedicine
Cuspidi C, Facchetti R, Tadic M et al. · 2026 · Journal of hypertension
Background The long-term reproducibility of the nighttime blood pressure (BP) phenotypes, namely, dipping (D) and nondipping (ND) has never been described in population-based studies. We investigated this issue in the participants to the…
View details →DOI: 10.1097/hjh.0000000000004276 Negative / Null Result ReportOpen accessMedicine
Ashburn-Nardo L, Moss-Racusin CA, Smith JL et al. · 2022 · Frontiers in psychology
The reproducibility movement in psychology has resulted in numerous highly publicized instances of replication failures. The goal of the present work was to investigate people's reactions to a psychology replication failure vs. success,…
View details →DOI: 10.3389/fpsyg.2022.823147 Negative / Null Result ReportOpen accessMedicine
Kawamoto S, Horiguchi H, Torigoe D et al. · 2026 · EMBO reports
The discovery of the senescence-associated secretory phenotype (SASP) has reshaped our understanding of cellular senescence, shifting its role from a solely tumor-suppressive mechanism to a potential driver of chronic inflammation and…
View details →DOI: 10.1038/s44319-026-00740-5 Negative / Null Result ReportOpen accessMedicine
Harada Y · 2026 · Cureus
Introduction Large language models are increasingly discussed as tools for patient-facing symptom assessment, but safe self-triage depends on the concrete next action recommended to the user rather than on generic urgency language alone.…
View details →DOI: 10.7759/cureus.105878 Negative / Null Result ReportMedicine
Hudec J, Prokopova T, Hulkova M et al. · 2026 · Anesthesia and analgesia
Background Anesthetic agents or some pathophysiological conditions can affect transcranial motor evoked potentials (TcMEP) monitoring. However, the influence of depth of anesthesia on TcMEP reproducibility in youth remains unclear due to…
View details →DOI: 10.1213/ane.0000000000008158 Negative / Null Result Report
Wiechert S, de Groot E, Rutjens BT et al. · 2026 · Preprint
Over the past decade, psychology has embraced transparency and reproducibility reforms to address the replication crisis, raising the question of whether these signals help legal decision-makers identify which psychological evidence is…
View details →DOI: 10.31234/osf.io/g6zhw_v1 Negative / Null Result ReportMedicine
Badran PM, Stecca CM, de Souza de Castro JT et al. · 2025 · Clinical radiology
Aim Ovarian cancer is the most lethal gynecologic malignancy, with prognosis linked to stage at diagnosis. Ultrasonography is the first-line tool for adnexal mass evaluation, while computed tomography (CT) supports staging and surgical…
View details →DOI: 10.1016/j.crad.2025.107088 Negative / Null Result ReportOpen accessMedicine
Errington TM, Mathur M, Soderberg CK et al. · 2021 · eLife
Replicability is an important feature of scientific research, but aspects of contemporary research culture, such as an emphasis on novelty, can make replicability seem less important than it should be. The Reproducibility Project: Cancer…
View details →DOI: 10.7554/elife.71601 