A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
25 results in Replication Failure for "randomized controlled trial"
F.G.R. Fowkes · 2010 · JAMA
CONTEXT: A low ankle brachial index (ABI) indicates atherosclerosis and an increased risk of cardiovascular and cerebrovascular events. Screening for a low ABI can identify an asymptomatic higher risk group potentially amenable to…
Amelia Averitt, Chunhua Weng, Patrick Ryan et al. · 2020 · npj Digital Medicine
Randomized controlled trials (RCTs) are regarded as the most reputable source of evidence. In some studies, factors beyond the intervention itself may contribute to the measured effect, an occurrence known as heterogeneity of treatment effect (HTE). If the RCT population differs from the real-world population on factors that induce HTE, the trials effect will not replicate. The RCTs eligibility criteria should identify the sub-population in which its evidence will replicate. However, the extent to which the eligibility criteria identify the appropriate population is unknown, which raises conce
Manaf AlQahtani, Abdulkarim Abdulrahman, Abdulrahman Almadani et al. · 2021 · Scientific Reports
Convalescent plasma (CP) therapy in COVID-19 disease may improve clinical outcome in severe disease. This pilot study was undertaken to inform feasibility and safety of further definitive studies. This was a prospective, interventional and randomized open label pilot trial in patients with severe COVID-19. Twenty COVID-19 patients received two 200 ml transfusions of convalescent patient CP over 24-h compared with 20 who received standard of care. The primary outcome was the requirement for ventilation (non-invasive or mechanical ventilation). The secondary outcomes were biochemical parameters
Clark DuMontier, Hajime Uno, Tammy Hshieh et al. · 2022 · PubMed
We conducted a randomized controlled trial in older adults with hematologic malignancies to determine the impact of geriatrician consultation embedded in our oncology clinic alongside standard care. From February 2015 to May 2018,…
Brian Chin, Andrea Copeland, Lucas Gallo et al. · 2019 · Plastic & Reconstructive Surgery
Background: The fragility index has been proposed as a metric to evaluate the robustness of statistically significant findings in randomized controlled trials. It measures the number of events that a trial result relies on to maintain…
Anthony T.�C. Chan, Edwin P. Hui, Roger K.C. Ngan et al. · 2017 · Journal of Clinical Oncology
6002 Background: The benefit of adjuvant CT in NPC is unclear. Post-RT EBV DNA predicts poor survival and may be a biomarker of subclinical residual disease. We conducted a biomarker driven RCT using post-RT EBV DNA to select high risk NPC…
Jason Smith, Rebecca Cardigan, Emily Sanderson et al. · 2026 · New England Journal of Medicine
BACKGROUND: Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. METHODS: We conducted a pragmatic,…
Cristina Expósito-Álvarez, Manuel Roldán-Pardo, Gail Gilchrist et al. · 2024 · Psychosocial Intervention
Objective: Intimate partner violence (IPV) perpetrators with alcohol and/or other drug use problems (ADUPs) have been identified as one of the main high-risk and highly resistant groups of perpetrators requiring special attention in…
Minkhorst K, Munn A, MacDermid J et al. · 2025 · Archives of physical medicine and rehabilitation
Objective To evaluate whether the addition of an orthosis improved the efficacy of cortisone injection for the nonoperative management of trigger finger. Design Block randomized controlled trial. Setting Outpatient hand clinic.…
Takeda Y, Nakai T, Okamoto T et al. · 2026 · The Journal of arthroplasty
Background Mirogabalin, a selective α2δ-1 ligand, has been proposed to exhibit potent analgesic effects with fewer central nervous system (CNS) side effects than prior gabapentinoids. Its effectiveness for acute postoperative pain after…
Bhardwaj A, Jain A, Jain N et al. · 2026 · Indian pediatrics
Objective To evaluate whether epinephrine nebulization, when used in addition to standard care, reduces extubation failure (EF) in term and preterm neonates. Methods A parallel, randomized controlled superiority trial was conducted in a…
Khadanga S, Yant B, Savage PD et al. · 2026 · Journal of cardiopulmonary rehabilitation and prevention
Purpose Despite the benefits, cardiac rehabilitation (CR) is underutilized, particularly in women. Case management (CM) has been shown to reduce the risk of cardiovascular disease and improve health outcomes. The purpose of this study was…
Cardon de Lichtbuer P, Declerck W, Rosseel Q et al. · 2026 · Journal of cataract and refractive surgery
Purpose To evaluate the effectiveness and usability of a safety-first, clinician-validated conversational artificial intelligence (AI) chatbot for cataract surgery education compared with standard brochures. Setting University Hospital (UZ…
Ramasubbu D, Lewney J · 2025 · Evidence-based dentistry
Design The Brushing RemInder 4 Good oral HealTh (BRIGHT) multi-centre randomized controlled trial was based in state-funded secondary schools in England, Wales and Scotland. It had two arms, aiming to assess the clinical and cost…
Wang L, Wang X, Zhang R et al. · 2025 · The American journal of clinical nutrition
Background Gestational diabetes mellitus (GDM) affects millions of females and their children. Effective dietary strategies for early prevention are controversial. Objectives This study aims to investigate whether an individualized…
Wongkraisri C, Chusuwanrak K, Laocharoenkeat A et al. · 2025 · BMC cancer
Background Hand-foot syndrome (HFS) is a common adverse event of capecitabine causing treatment modifications. Topical urea cream can reduce sorafenib-induced hand-foot skin reaction. However, its benefit in preventing…
Lee CT, Tran D, Tsukiboshi Y et al. · 2023 · Journal of clinical periodontology
Aim This randomized controlled trial aimed to investigate the efficacy of soft-tissue augmentation (STA) with a subepithelial connective tissue graft (SCTG) or an acellular dermal matrix (ADM) on reducing tissue alterations at an immediate…
Vander Zwalmen Y, Vrijsen JN, Meuleman B et al. · 2026 · Internet interventions
Background Late-life depression (LLD) is a prevalent and debilitating condition associated with a poor long-term prognosis and high rates of chronicity. Cognitive control impairments are common in LLD and contribute to symptom persistence,…
Grischott T, Rachamin Y, Senn O et al. · 2023 · Journal of general internal medicine
Background Medication safety in patients with polypharmacy at transitions of care is a focus of the current Third WHO Global Patient Safety Challenge. Medication review and communication between health care professionals are key targets to…
Yi K, Zhan Y, Wei A et al. · 2026 · Drug design, development and therapy
Background The optimal analgesia regimen for patients undergoing laparoscopic gastrectomy is still unclear. This study evaluated the efficacy of ultrasound-guided rectus sheath block (RSB) with liposomal bupivacaine in providing sustained…
Mirsharifi MS, Shirdel S, Ghaderi E et al. · 2026 · Reproductive sciences (Thousand Oaks, Calif.)
OBJECTIVE: This study aimed to evaluate the effect of vitamin D supplementation on in vitro fertilization (IVF) outcomes in poor responder women with vitamin D deficiency, focusing on fertilization rates, oocyte quality, and pregnancy…
Rymaszewska J, Szcześniak D, Maciaszek J et al. · 2026 · Journal of affective disorders
The exploration of Theta Burst Stimulation (TBS) in Obsessive-compulsive disorder (OCD) treatment is still in its nascent stages, and these initial findings underscore the need for further research to optimize stimulation parameters and…
Pieracci FM, Doben A, Eriksson E et al. · 2026 · The journal of trauma and acute care surgery
Abstract The use of surgical stabilization of rib fractures (SSRF) for non-flail fracture patterns continues to rise. However, multiple, recent randomized controlled trials in this patient population have failed to show a clear benefit to…
Ben-Gang Zhou, Ming-Wen Guo, Li-Juan Zhang et al. · 2024 · Therapeutic Advances in Gastroenterology
Background: The efficacy of the 14-day esomeprazole–amoxicillin (EA) dual therapy in eradicating Helicobacter pylori ( H. pylori ) has been widely discussed previously. Vonoprazan, a novel potassium-competitive acid blocker, presents rapid, potent, and long-lasting acid inhibitory effects compared to esomeprazole. However, there is currently a scarcity of direct comparisons between the 10-day vonoprazan–amoxicillin (VA) and the 14-day EA dual therapy for H. pylori eradication. Objectives: This study aimed to compare the efficacy and safety of the 10-day VA and the 14-day EA dual therapy for H.
Karina da Silva, Cristino Carneiro Oliveira, Leandro Ferracini Cabral et al. · 2023 · PLoS ONE
Pulmonary expansion manoeuvres are therapeutic techniques used to prevent and reverse atelectasis; however, no randomized controlled trials have provided evidence supporting the use of this intervention among individuals on mechanical ventilation. Objective To evaluate the effects of chest compression-decompression and chest block manoeuvres compared to usual care among patients on mechanical ventilation. Methods The current study was a randomized clinical trial of adult subjects on mechanical ventilation for 12 to 48 hours. The control group received usual care (passive or active mobilization