Replication FailureOpen accessNeuroscience
Scott Marek, Brenden Tervo‐Clemmens, Finnegan J. Calabro et al. · 2022 · Nature
Abstract Magnetic resonance imaging (MRI) has transformed our understanding of the human brain through well-replicated mapping of abilities to specific structures (for example, lesion studies) and functions 1–3 (for example, task functional MRI (fMRI)). Mental health research and care have yet to realize similar advances from MRI. A primary challenge has been replicating associations between inter-individual differences in brain structure or function and complex cognitive or mental health phenotypes (brain-wide association studies (BWAS)). Such BWAS have typically relied on sample sizes approp
View details →DOI: 10.1038/s41586-022-04492-9Cited by 2,026 Replication FailureOpen accessHealth Professions
Dian Zhu, Jianan Zhao, Tong Wu et al. · 2025 · JMIR mhealth and uhealth
Background: Exercise is a primary recommended treatment for knee osteoarthritis (KOA), as it helps alleviate symptoms and improves joint functionality. Personalized exercise programs, tailored to individual patient needs, have demonstrated promising results in maintaining physical fitness and enhancing overall well-being. In recent years, digital health applications have emerged as innovative tools for supervising and facilitating rehabilitation programs. Leveraging computer vision (CV) technology, these applications offer the potential to provide precise feedback and support personalized exer
View details →DOI: 10.2196/63022Cited by 11 Replication FailureOpen accessMedicine
Nick Woznitza, Lesley Smith, Janette Rawlinson et al. · 2026 · Nature Medicine
Prioritizing artificial intelligence (AI)-detected imaging findings may reduce the time to diagnosis of lung cancer. This prospective, multicentre, randomized controlled trial tested whether immediate AI prioritization of primary care-requested chest X-rays (CXR) influenced time to computed tomography (CT) and lung cancer diagnosis, the primary outcomes. Secondary outcomes included the number of urgent suspected lung cancer referrals, incidence and stage of lung cancer, times to urgent referral and treatment, concordance between AI and radiology reports, and algorithm accuracy. AI was availabl
View details →DOI: 10.1038/s41591-026-04253-5Cited by 9 Replication FailureMedicine
Nissi L, Elseragy A, Wahab A et al. · 2026 · American journal of otolaryngology
Background Depth of invasion (DOI) is a well-established prognostic factor in oral cavity squamous cell carcinoma (OSCC). Incorporating DOI into the OSCC staging system has substantially refined T-classification and now informs key…
View details →DOI: 10.1016/j.amjoto.2026.104869 Replication FailureMedicine
Rodrigue JR, Fleishman A, Fitzpatrick S et al. · 2015 · Progress in transplantation (Aliso Viejo, Calif.)
Context Since nearly all registered organ donors in the United States signed up via a driver's license transaction, motor vehicle (MV) offices represent an important venue for organ donation education. Objective To evaluate the impact of…
View details →DOI: 10.7182/pit2015166 Replication FailureMedicine
Rice WM, Shaw AP, Britt RC et al. · 2026 · Journal of the American College of Surgeons
Background Rising patient volumes and an aging population are leading to difficulties in providing timely surgical intervention in emergency general surgery (EGS). With decreased resilience and greater comorbidity burden, we hypothesized…
View details →DOI: 10.1097/xcs.0000000000001749 Replication FailureMedicine
Yu X, Yuan Y, Zhao S et al. · 2026 · The Journal of bone and joint surgery. American volume
Background Hip fracture volumes are rising with population aging, and inadequate analgesia following hip fracture surgery has been shown to impede early mobilization and recovery. Liposomal bupivacaine (LB) may extend analgesia, but…
View details →DOI: 10.2106/jbjs.25.01498 Replication FailureMedicine
Vukšić J, Kustić D · 2026 · Rheumatology international
To examine whether salivary gland ultrasonography (SGUS) and scintigraphy (SGS) reflect systemic disease activity (ESSDAI) and patient-reported index (ESSPRI) in primary Sjögren's disease (PSD). We retrospectively enrolled 118 patients…
View details →DOI: 10.1007/s00296-026-06132-1 