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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

6 results in Replication Failure for "aging"

Replication FailureOpen accessNeuroscience

Reproducible brain-wide association studies require thousands of individuals

Scott Marek, Brenden Tervo‐Clemmens, Finnegan J. Calabro et al. · 2022 · Nature

Abstract Magnetic resonance imaging (MRI) has transformed our understanding of the human brain through well-replicated mapping of abilities to specific structures (for example, lesion studies) and functions 1–3 (for example, task functional MRI (fMRI)). Mental health research and care have yet to realize similar advances from MRI. A primary challenge has been replicating associations between inter-individual differences in brain structure or function and complex cognitive or mental health phenotypes (brain-wide association studies (BWAS)). Such BWAS have typically relied on sample sizes approp

View details →DOI: 10.1038/s41586-022-04492-9Cited by 2,026
Replication FailureMedicine

Imaging correlates of disease activity and patient-reported symptoms in primary Sjögren's disease: an ultrasonographic and scintigraphic study.

Vukšić J, Kustić D · 2026 · Rheumatology international

To examine whether salivary gland ultrasonography (SGUS) and scintigraphy (SGS) reflect systemic disease activity (ESSDAI) and patient-reported index (ESSPRI) in primary Sjögren's disease (PSD). We retrospectively enrolled 118 patients…

View details →DOI: 10.1007/s00296-026-06132-1
Replication FailureMedicine

Incisional Infiltration of Liposomal Bupivacaine in Geriatric Hip Fracture Surgery: A Randomized Parallel-Group Trial.

Yu X, Yuan Y, Zhao S et al. · 2026 · The Journal of bone and joint surgery. American volume

Background Hip fracture volumes are rising with population aging, and inadequate analgesia following hip fracture surgery has been shown to impede early mobilization and recovery. Liposomal bupivacaine (LB) may extend analgesia, but…

View details →DOI: 10.2106/jbjs.25.01498
Replication FailureMedicine

What's the Rush? Challenging the Early Surgery Paradigm for Older Adults in Emergency General Surgery.

Rice WM, Shaw AP, Britt RC et al. · 2026 · Journal of the American College of Surgeons

Background Rising patient volumes and an aging population are leading to difficulties in providing timely surgical intervention in emergency general surgery (EGS). With decreased resilience and greater comorbidity burden, we hypothesized…

View details →DOI: 10.1097/xcs.0000000000001749