A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
34 results in Replication Failure for "Mpro" · page 1 of 2
Ventura Simonovich, Leandro Daniel Burgos Pratx, Paula Scibona et al. · 2020 · New England Journal of Medicine
BACKGROUND: Convalescent plasma is frequently administered to patients with Covid-19 and has been reported, largely on the basis of observational data, to improve clinical outcomes. Minimal data are available from adequately powered…
Sanjit S. Jolly, John A. Cairns, Salim Yusuf et al. · 2015 · New England Journal of Medicine
BACKGROUND: During primary percutaneous coronary intervention (PCI), manual thrombectomy may reduce distal embolization and thus improve microvascular perfusion. Small trials have suggested that thrombectomy improves surrogate and clinical…
Manaf AlQahtani, Abdulkarim Abdulrahman, Abdulrahman Almadani et al. · 2021 · Scientific Reports
Convalescent plasma (CP) therapy in COVID-19 disease may improve clinical outcome in severe disease. This pilot study was undertaken to inform feasibility and safety of further definitive studies. This was a prospective, interventional and randomized open label pilot trial in patients with severe COVID-19. Twenty COVID-19 patients received two 200 ml transfusions of convalescent patient CP over 24-h compared with 20 who received standard of care. The primary outcome was the requirement for ventilation (non-invasive or mechanical ventilation). The secondary outcomes were biochemical parameters
Mikkael A. Sekeres, J. E. Lancet, Brent L. Wood et al. · 2012 · Haematologica
Improving outcomes in older adults with acute myeloid leukemia remains a formidable challenge. Lintuzumab (SGN-33; HuM195) is a humanized monoclonal antibody directed against CD33, which is expressed on the majority of myeloblasts in acute…
Kristen P. Lindgren, Reínout W. Wiers, Bethany A. Teachman et al. · 2015 · PLoS ONE
There is preliminary evidence that approach avoid training can shift implicit alcohol associations and improve treatment outcomes. We sought to replicate and extend those findings in US undergraduate social drinkers (Study 1) and at-risk drinkers (Study 2). Three adaptations of the approach avoid task (AAT) were tested. The first adaptation - the approach avoid training - was a replication and targeted implicit alcohol approach associations. The remaining two adaptations - the general identity and personalized identity trainings - targeted implicit drinking identity associations, which are rob
Ilker Uçkay, Benjamin Kressmann, Sarah Malacarne et al. · 2018 · BMC Infectious Diseases
BACKGROUND: An adjunctive topical therapy with gentamicin-sponges to systemic antibiotic therapy might improve the healing of infected diabetic foot ulcers (DFUI). METHODS: Single-center, investigator-blinded pilot study, randomizing (1:1) the gentamicin-sponge with systemic antibiotic versus systemic antibiotics alone for patients with DFUI. RESULTS: We included 88 DFUI episodes with 43 patients in the gentamicin-sponge arm and 45 in the control arm. Overall, 64 (64/88; 73%) witnessed total clinical cure, 13 (15%) significant improvement, and 46 (52%) showed total eradication of all pathogens
John Lowe, David Gillespie, Ali F. Aboklaish et al. · 2024 · The Lancet Respiratory Medicine
BACKGROUND: Systematic reviews have reported conflicting evidence on whether macrolide antibiotics reduce rates of chronic lung disease of prematurity (CLD) in at-risk preterm infants born at less than 30 weeks' gestation, including in those colonised with pulmonary Ureaplasma spp. Since an adequately powered trial has been lacking, we aimed to assess if the macrolide azithromycin improved survival without the development of physiologically defined moderate or severe CLD in preterm infants. METHODS: AZTEC was a multicentre, double-blind, randomised, placebo-controlled trial conducted in 28 ter
McMullin MP, Cadotte NB, Fuchs EM et al. · 2025 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Objectives We aimed to implement a post-cardiac arrest targeted temperature management (TTM) bundle to reduce the percent of time with a fever from 7% to 3.5%. Design A prospective, quality improvement (QI) initiative utilizing the Method…
Carra RB, Garcia LÁL, Menezes JR et al. · 2025 · Movement disorders : official journal of the Movement Disorder Society
Background Epidural electrical spinal cord stimulation has been studied for more than a decade for Parkinson's disease symptoms, but compelling evidence for its effectiveness is still lacking. Objective The aim of this study was to…
Bi X, Yu Y, Zhou S et al. · 2024 · Nephron
Introduction The renoprotective benefits of adding immunosuppressant therapy to corticosteroid (CS) treatment for immunoglobulin A nephropathy (IgAN) patients with less than 25% crescent formation (C1) remain uncertain, warranting further…
Ward E, Hanbury G, Possamai L et al. · 2025 · BMJ open quality
Background End-stage liver disease (ESLD) is a terminal diagnosis with a poor prognosis and an accelerating mortality rate in the UK. Limited research suggests that patients with ESLD have unmet palliative care (PC) needs, likely due to…
Panca M, Serfaty M, Satchell J et al. · 2025 · Preprint
Abstract Background : Crime has significant impact on older victims. High rates of anxiety and depression may be associated with crimes. Aims: This paper aims to evaluate the cost-effectiveness of a Victim Improvement Package (VIP) for the…
Moss AS, Nguyen QG, Iyer P · 2026 · Clinical rheumatology
Background Patient education materials are vital to health education and, according to the American Medical Association (AMA), should not be written above a 6th grade reading level (Weiss 2003). We aim to assess American College of…
Gangeri L, Alfieri S, Anselmi V et al. · 2025 · Tumori
Background As part of the improvement plan of the Organisation of European Cancer Institutes at the Fondazione IRCCS Istituto Nazionale dei Tumori of Milan (INT) a Committee composed of patients, caregivers, and representatives of patient…
Khadanga S, Yant B, Savage PD et al. · 2026 · Journal of cardiopulmonary rehabilitation and prevention
Purpose Despite the benefits, cardiac rehabilitation (CR) is underutilized, particularly in women. Case management (CM) has been shown to reduce the risk of cardiovascular disease and improve health outcomes. The purpose of this study was…
Chau IJ, Dixon PR, Lin V et al. · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Objective To identify patient characteristics associated with improvements in speech recognition scores (SRS) and Cochlear Implant Quality of Life (CIQOL-35) scores following cochlear implantation. Study design Multi-institutional…
Ho CB, Tran TT, Ngo LT · 2026 · Preprint
Background: /Objectives: Glass-hybrid and high-viscosity glass-ionomer systems aim to improve conventional glass-ionomer performance. This in vitro study compared Vickers hardness and microleakage of a coated glass-hybrid system and a…
Nguyen TT, Kanemoto Y, Sawada T et al. · 2026 · Bioscience, biotechnology, and biochemistry
Vitamin D (VD) and Wnt signaling both play important roles in bone metabolism and are targeted in osteoporosis therapy. Combination treatment with VD derivatives and anti-sclerostin antibodies that activate Wnt signaling improves clinical…
Gama de Matos D, de Santana JL, Aidar FJ et al. · 2026 · Preprint
Background: Frailty is a multifactorial condition that significantly impacts older adults' health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…
Gama de Matos D, de Santana JL, Aidar FJ et al. · 2026 · Journal of clinical medicine
Background : Frailty is a multifactorial condition that significantly impacts older adults' health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…
Gass JC, Tonkin S, Maguin E et al. · 2024 · Translational behavioral medicine
Ecological Momentary Assessment (EMA) methods are increasingly used by translational scientists to study real-world behavior and experience. The ability to draw meaningful conclusions from EMA research depends upon participant compliance…
Hajkowicz K, Woodford J, Pillai ES et al. · 2025 · Emerging infectious diseases
Using metatranscriptomics, we identified Trubanaman virus in cerebrospinal fluid from a severely immunocompromised man who died of encephalitis in Queensland, Australia. Virus sequences were related to orthobunyaviruses previously detected…
Hölscher C · 2026 · Journal of Alzheimer's disease : JAD
BackgroundSemaglutide is a glucagon-like peptide-1 analog that is on the market to treat type 2 diabetes and weight loss (Ozempic, Wegovy). Two phase 3 clinical trials have been conducted, Evoke and Evoke+, testing the drug in patients…
Supriyo Maji · 2017 · arXiv
Spin transfer torque oscillators (STOs) based on magnetic tunnel junction (MTJ) devices are emerging as a possible replacement for complementary metal-oxide semiconductors for radio-frequency (RF) signal generation. Advantages include low power consumption, small device area, and large frequency tunability. But such a single device cannot achieve the necessary noise performance for RF applications. It has been reported lately that a network of globally coupled STOs achieves significant improvement in phase noise. The study here is to propose use of such coupled STOs as self-oscillating RF mixe
Xiqi Hao, Zengqing Wu, Yu-Xuan Qiu et al. · 2026 · arXiv
Multi-agent debate (MAD) is a promising strategy for improving LLM reasoning, but when agents converge on a shared answer, it is unclear whether that convergence reflects genuine deliberation or social compliance. We show that the conventional answer flip rate conflates three distinct mechanisms: spontaneous instability, stance-induced conformity, and reasoning-induced persuasion. Our three-source decomposition framework isolates each through controlled counterfactual conditions. In the primary MMLU-Pro setting, 37% of agent-question observations change under self-reflection alone, while robus
John H. Strickler · 2018
Abstract Summary: Anti-EGFR therapies have failed to improve survival for unselected patients with metastatic gastroesophageal cancer, but in a subset of patients, EGFR amplification may predict treatment benefit. Maron and colleagues…
Glynatsis MN, Economou M, Papadopoulou K et al. · 2024 · Cureus
This report presents a rare case of a central retinal artery occlusion in an eight-year-old girl attributed to an undiagnosed patent ductus arteriosus (PDA). Despite intensive treatment, the patient's eyesight failed to improve. Cases of…
Appleman LJ, Kim SE, Harris WB et al. · 2024 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Purpose Patients with no evidence of disease (NED) after metastasectomy for renal cell carcinoma are at high risk of recurrence. Pazopanib is an inhibitor of vascular endothelial growth factor receptor and other kinases that improves…
Frank Meier, Hans Walliser · 1996 · arXiv
We present a procedure to calculate 1-loop graphs in the soliton sector of chiral Lagrangians and use it to calculate quantum corrections to certain baryon observables in Skyrme-type models. Results generally show an improvement over the values obtained in tree approximation except for the case of the axial coupling g_A.
Ye C, Sheng Y, Zhang X et al. · 2026 · Plant Science.
Gene editing has emerged as a powerful tool in crop breeding, particularly for rice, enabling the creation of germplasm and trait improvement. A thorough understanding of gene functions is essential for precise and efficient crop…