Failed Experiment ReportOpen accessMedicine
Michael A. Castello, John D. Jeppson, Salvador Soriano · 2014 · BMC Neurology
BACKGROUND: High-profile Phase 3 clinical trials of bapineuzumab and solanezumab, antibodies targeted at amyloid-beta (Aβ) removal, have failed to meet their primary endpoints. Neither drug improves clinical outcomes in patients with late onset AD, joining a long list of unsuccessful attempts to treat AD with anti-amyloid therapies. DISCUSSION: These therapies are based on the assumption that Aβ accumulation is the primary pathogenic trigger of AD. Current evidence suggests that Aβ may actually accumulate as part of an adaptive response to long-term chronic brain stress stimuli that would make
View details →DOI: 10.1186/s12883-014-0169-0Cited by 80 Failed Experiment ReportOpen accessEnvironmental Science
Alban de Lavenne, Vazken Andréassian, Guillaume Thirel et al. · 2019 · Water Resources Research
Abstract In semidistributed hydrological modeling, sequential calibration usually refers to the calibration of a model by considering not only the flows observed at the outlet of a catchment but also the different gauging points inside the…
View details →DOI: 10.1029/2018wr024266Cited by 63 Failed Experiment ReportOpen accessMedicine
Darryl Falzarano, David Safronetz, Joseph Prescott et al. · 2015 · Emerging infectious diseases
The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.
View details →DOI: 10.3201/eid2106.150176Cited by 63 Failed Experiment ReportOpen accessEngineering
Kaustav A. Gopinathan, Avanish Mishra, Baris R. Mutlu et al. · 2023 · Nature
Abstract Microfluidics have enabled notable advances in molecular biology 1,2 , synthetic chemistry 3,4 , diagnostics 5,6 and tissue engineering 7 . However, there has long been a critical need in the field to manipulate fluids and suspended matter with the precision, modularity and scalability of electronic circuits 8–10 . Just as the electronic transistor enabled unprecedented advances in the automatic control of electricity on an electronic chip, a microfluidic analogue to the transistor could enable improvements in the automatic control of reagents, droplets and single cells on a microflui
View details →DOI: 10.1038/s41586-023-06517-3Cited by 61 Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kevin G. Shim, Shane Zaidi, Jill Thompson et al. · 2017 · Molecular Therapy
Systemic viroimmunotherapy activates endogenous innate and adaptive immune responses against both viral and tumor antigens. We have shown that therapy with vesicular stomatitis virus (VSV) engineered to express a tumor-associated antigen…
View details →DOI: 10.1016/j.ymthe.2017.01.023Cited by 24 Failed Experiment ReportOpen accessMedicine
Robert E. Coleman, Ying Zhou, Danielle Jandial et al. · 2021 · Advances in Therapy
INTRODUCTION: D-CARE, an international, phase 3, randomized, double-blind, placebo-controlled study in women with early-stage breast cancer at high risk of disease recurrence, failed to meet its primary endpoint-improvement in bone…
View details →DOI: 10.1007/s12325-021-01812-9Cited by 21 Failed Experiment ReportOpen accessMedicine
Maria Fortunata Lofiego, Francesca Piazzini, Francesca Pia Caruso et al. · 2024 · Journal of Translational Medicine
BACKGROUND: Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor, that is refractory to standard treatment and to immunotherapy with immune-checkpoint inhibitors (ICI). Noteworthy, melanoma brain metastases (MM-BM), that share the same niche as GBM, frequently respond to current ICI therapies. Epigenetic modifications regulate GBM cellular proliferation, invasion, and prognosis and may negatively regulate the cross-talk between malignant cells and immune cells in the tumor milieu, likely contributing to limit the efficacy of ICI therapy of GBM. Thus, manipulating the tumor
View details →DOI: 10.1186/s12967-024-05040-xCited by 19 Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Angeliki Argyriadou, Athanasios Ι. Gelasakis, Georgios Banos et al. · 2020 · Journal of the Hellenic Veterinary Medical Society
The objective of the study was twofold: (i) to review the genetics of production and resilience traits of indigenous Greek small ruminant breeds as well as the evolution of national breeding programs, and (ii) explore innovative and…
View details →DOI: 10.12681/jhvms.22967Cited by 15 Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Deanna Schmitt, Dawn M. O’Dee, Joseph Horzempa et al. · 2012 · PLoS ONE
Vaccination is a proven strategy to mitigate morbidity and mortality of infectious diseases. The methodology of identifying and testing new vaccine candidates could be improved with rational design and in vitro testing prior to animal experimentation. The tularemia vaccine, Francisella tularensis live vaccine strain (LVS), does not elicit complete protection against lethal challenge with a virulent type A Francisella strain. One factor that may contribute to this poor performance is limited stimulation of antigen-presenting cells. In this study, we examined whether the interaction of genetical
View details →DOI: 10.1371/journal.pone.0031172Cited by 14 Failed Experiment Report
Abubakar Aminu Mu’azu, Kauthar Kabir · 2023 · WSEAS TRANSACTIONS ON COMPUTERS
The Security of confidential communication is protected using the most popular type of carrier to hold information known as Image steganography. The Least Significant Bit (LSB) algorithm and the Most Significant Bit (MSB) algorithm are…
View details →DOI: 10.37394/23205.2023.22.29Cited by 1 Failed Experiment ReportOpen accessMathematics
Anh-Huy Phan, Petr Tichavský, Andrzej Cichocki · 2017 · arXiv
In CANDECOMP/PARAFAC tensor decomposition, degeneracy often occurs in some difficult scenarios, e.g., when the rank exceeds the tensor dimension, or when the loading components are highly collinear in several or all modes, or when CPD does not have an optimal solution. In such the cases, norms of some rank-1 terms become significantly large and cancel each other. This makes algorithms getting stuck in local minima while running a huge number of iterations does not improve the decomposition. In this paper, we propose an error preservation correction method to deal with such problem. Our aim is
Failed Experiment ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Nenonen Arja, Rinne Marjo, Groundstroem Kaj et al. · 2007 · Cardiovascular Ultrasound
Abstract Background Myocardial diastolic tissue velocities are reduced already in newly onset Type 2 diabetes mellitus (T2D). Poor disease control may lead to left ventricular (LV) systolic dysfunction and heart failure. The aim of this study was to assess the effects of exercise training on myocardial diastolic function in T2D patients without ischemic heart disease. Methods 48 men (52.3 ± 5.6 yrs) with T2D were randomized to supervised training four times a week and standard therapy (E), or standard treatment alone (C) for 12 months. Glycated hemoglobin (HbA 1c ), oxygen consumption (VO 2max
View details →DOI: 10.1186/1476-7120-5-32 Failed Experiment ReportMedicine
Lertwiram P, Fuangfa P, Kijkunasathian C et al. · 2026 · Scientific reports
Arthroscopic rotator cuff repair (ARCR) generally improves clinical outcomes, but the impact of pre-existing glenohumeral osteoarthritis (GHOA) severity on these outcomes remains unclear. This study aims to evaluate the correlation between…
View details →DOI: 10.1038/s41598-026-58506-x Failed Experiment ReportMedicine
Lapner P · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Rotator cuff retears remain the most frequently observed complication after arthroscopic cuff repair, with tendon nonhealing rates reported between 20% and 68%. Biological solutions to improve healing rates are needed, and bone marrow…
View details →DOI: 10.1016/j.arthro.2025.03.025 Failed Experiment ReportOpen accessPublic aspects of medicine
Jacqueline A. Benson MPH, Matthew Wilson MS, Aidan J. Flynn MS et al. · 2025 · Inquiry: The Journal of Health Care Organization, Provision, and Financing
The strongest risk factor for readmission to the hospital is impaired physical function. We sought to determine the usability and feasibility of a post-hospital behavioral intervention to improve mobility in older adults with significant morbidity and functional impairment. We conducted a two-arm pragmatic pilot randomized trial of a behavioral economics-informed intervention to increase daily steps in Veterans, age 60 or older, receiving home health (HH) services post-discharge. The intervention group received a multicomponent behavioral economics-informed intervention, including daily step c
View details →DOI: 10.1177/00469580251384787 Failed Experiment ReportOpen accessComputer Science
Henrique K. Miyamoto, Sheng Yang · 2026 · arXiv
This paper studies random-coding error exponents of randomised list decoding, in which the decoder randomly selects $L$ messages with probabilities proportional to the decoding metric of the codewords. The exponents (or bounds) are given for mismatched, and then particularised to matched and universal decoding metrics. Two regimes are studied: for fixed list size, we derive an ensemble-tight random-coding error exponent, and show that, for the matched metric, it does not improve the error exponent of ordinary decoding. For list sizes growing exponentially with the block-length, we provide a no
Failed Experiment ReportOpen accessComputer Science
J. A. Casas, A. Lleyda, C. Muñoz · 1996 · arXiv
The general constraints on the parameter space of soft-breaking terms, in order to avoid dangerous charge and color breaking minima, are applied to the four-dimensional string scenario where the dilaton is the source of supersymmetry breaking (dilaton-dominated limit). The results indicate that the whole parameter space is excluded on these grounds after imposing the present experimental data on the top mass. The inclusion of a non-vanishing cosmological constant does not improve essentially the prospects. Possible way-outs to this situation are briefly discussed.
Failed Experiment ReportOpen accessComputer Science
V. Vedral · 1999 · arXiv
We investigate asymptotic distillation of entanglement in the presence of an unlimited amount of bound entanglement for bi-partite systems. We show that the distillability is still bounded by the relative entropy of entanglement. This offers a strong support to the fact that bound entanglement does not improve distillation of entanglement.
Failed Experiment ReportOpen accessPhysics
Nicolas Tancogne-Dejean, Martin Lüders, Carsten A. Ullrich · 2023 · arXiv
We extend some of the well established self-interaction correction (SIC) schemes of density-functional theory to the case of systems with noncollinear magnetism. Our proposed SIC schemes are tested on a set of molecules and metallic clusters in combination with the widely used local spin-density approximation. As expected from the collinear SIC, we show that the averaged-density SIC works well for improving ionization energies but fails to improve more subtle quantities like the dipole moments of polar molecules. We investigate the exchange-correlation magnetic field produced by our extension
Failed Experiment ReportOpen accessComputer Science
Frits de Nijs, Daan Wilmer · 2012 · arXiv
The goal of this paper is to critically evaluate a heuristic algorithm for the Inverse Banzhaf Index problem by Laruelle and Widgrén. Few qualitative results are known about the approximation quality of the heuristics for this problem. The intuition behind the operation of this approximation algorithm is analysed and evaluated. We found that the algorithm can not handle general inputs well, and often fails to improve inputs. It is also shown to diverge after only tens of iterations. We present three alternative extensions of the algorithm that do not alter the complexity but can result in up t
Failed Experiment ReportOpen accessComputer Science
Zixian Huang, Kaichen Yang, Xu Huang et al. · 2026 · arXiv
A widely adopted strategy for model enhancement is to use synthetic data generated by a stronger model for supervised fine-tuning (SFT). However, for emerging reasoning models like Qwen3-8B, this approach often fails to improve reasoning capabilities and can even lead to a substantial drop in performance. In this work, we identify substantial stylistic divergence between teacher generated data and the distribution of student as a major factor impacting SFT. To bridge this gap, we propose a Teacher-Student Cooperation Data Synthesis framework (TESSY), which interleaves teacher and student model
Failed Experiment ReportMedicine
Baier, Miao, Schirrmacher et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background : Zirconium-89 ( 89 Zr) is a key PET radionuclide and the limited in vivo stability of its clinically used 89 Zr-DFO complexes has driven the pursuit of improved chelator architectures. Among these, DFO* has attracted particular…
View details →DOI: 10.3390/ph19060813 Failed Experiment ReportOpen accessPhysics
Ying-Dan Wang, Xiao-Bo Yan, Stefano Chesi · 2016 · arXiv
Using a perturbative treatment, we quantify the influence of non-adiabatic leakage and system dissipation on the transfer fidelity of a stimulated Raman adiabatic passage (STIRAP) process. We find that, optimizing transfer time rather than coupling profiles, leads to a significant improvement of the transfer fidelity. The upper bound of the fidelity has been found as a simple analytical function of system cooperativities. We also provide a systematic approach to reach this upper bound efficiently.
Failed Experiment ReportMedicine
Gauci, Millet, Jacquot et al. · 2026 · Journal of shoulder and elbow surgery
The efficacy of patient-specific guides (PSGs) in improving accuracy and reducing the number of outliers in glenoid implant positioning in anatomic total shoulder arthroplasty has been clearly shown. However, long-term clinical benefit in…
View details →DOI: 10.1016/j.jse.2026.06.018 Failed Experiment Report
Omar S. Aljitawi, Jeff Radel, Bruce Kimler et al. · 2011 · Blood
Abstract Abstract 4695 Introduction: UCB is also an attractive stem cell source for transplantation because of the ease of procurement, the absence of donor risks, and reduced risk of transmissible infections. Unfortunately, outcomes of…
View details →DOI: 10.1182/blood.v118.21.4695.4695 Failed Experiment ReportOpen accessPublic aspects of medicine
Susan C. Wright, Titilayo T. Biya, Majapi E. Chokwe · 2014 · Health SA Gesondheid: Journal of Interdisciplinary Health Sciences
Background: Pregnancy-related health education conveys basic information regarding healthy lifestyle choices and preventive healthcare in order to promote the health of the mother and foetus. Verbal education is supplemented frequently by means of healthpromotion leaflts. A pregnancy-related leaflt used in primary care clinics in Tshwane, South Africa titled: ‘Are you pregnant or planning to have a baby?’ was the focus of this research. Objectives: The study had two objectives, the fist of which was to explore whether the English pregnancy leaflt improved the knowledge of young female adults w
View details →DOI: 10.4102/hsag.v19i1.764 Failed Experiment ReportOpen accessEngineering
Ramin Babaee, Shahab Oveis Gharan, Martin Bouchard · 2025 · arXiv
We propose a novel digital-to-analog converter (DAC) weighting architecture that statistically minimizes the distortion caused by random timing mismatches among current sources. To decode the DAC input codewords into corresponding DAC switches, we present three algorithms with varying computational complexities. We perform high-level Matlab simulations to illustrate the dynamic performance improvement over the segmented structure.
Failed Experiment ReportOpen accessPlant culture
Laura Cabero-Moreno, Ignacio Landeras-López, María Victoria Bravo-Navas et al. · 2025 · Frontiers in Plant Science
Abies pinsapo is an endangered species, endemic to southern Spain. Somatic embryogenesis and cryopreservation constitute important biotechnological tools, which can be used in order to improve the management and conservation of threatened species. The objective of this work was to develop somatic embryogenesis and cryopreservation protocols for A. pinsapo. Somatic embryogenesis was induced from mature zygotic embryos of A. pinsapo cultured on solid MS medium with macroelements at half-strength and supplemented with 20 g L-1 sucrose and 5 mg L-1 6-benzylaminopurine (BA). Embryogenic cultures su
View details →DOI: 10.3389/fpls.2025.1535113 Failed Experiment Report
· 2024 · Multimedia Manual of Cardio-Thoracic Surgery
The Ross procedure provides young patients with unrepairable aortic valve disease with a living pulmonary autograft that confers significant survival benefit and improved quality of life. However, the procedure is complicated, and surgeons…
View details →DOI: 10.1510/mmcts.2024.095 Failed Experiment Report
Liudmila Zakharova, Hikmet Nural, James R Nimlos et al. · 2013 · Circulation Research
A pilot clinical study using autologous c-Kit+ cells showed improvement in cardiac functions in congestive heart failure (CHF), however, it is unclear if c-Kit+ cells isolated from CHF hearts are equally as potent as cells from controls.…
View details →DOI: 10.1161/res.113.suppl_1.a131 