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Failure-mode index

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A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

7 results in Abandoned Hypothesis for "Mpro"

Abandoned HypothesisOpen accessComputer Science

Adaptive estimation of a time-varying phase with coherent states: smoothing can give an unbounded improvement over filtering

Kiarn T. Laverick, Howard M. Wiseman, Hossien T. Dinani et al. · 2017 · arXiv

The problem of measuring a time-varying phase, even when the statistics of the variation is known, is considerably harder than that of measuring a constant phase. In particular, the usual bounds on accuracy - such as the $1/(4\bar{n})$ standard quantum limit with coherent states - do not apply. Here, restricting to coherent states, we are able to analytically obtain the achievable accuracy - the equivalent of the standard quantum limit - for a wide class of phase variation. In particular, we consider the case where the phase has Gaussian statistics and a power-law spectrum equal to $κ^{p-1}/|ω

Abandoned Hypothesis

How can I find my own voice through my instrument

Julia Casañas Cast · 2020 · Royal Conservatoire Research Portal

Many classical musicians can suffer from tension and nervousness during solo performance. This research looks at how practicing improvisation and creative body movement, as well as creating one’s own performance together with a dancer, can…

View details →DOI: 10.22501/koncon.792184
Abandoned HypothesisOpen accessMedicine

Emotion regulation skills training for adolescents and parents in a clinical setting: a randomised controlled trial.

Holmqvist Larsson K, Falkenström F, Andersson G et al. · 2026 · Child and adolescent psychiatry and mental health

Background Emotion dysregulation is a transdiagnostic construct associated with psychiatric symptomatology. Improving strategies to regulate emotions is an important focus in several psychological treatments. In the current study we…

View details →DOI: 10.1186/s13034-026-01098-1
Abandoned HypothesisOpen accessMedicine

Implantation of a Continuous-Flow Left Ventricular Assist Device During Cardiopulmonary Bypass Is Associated with a Significant and Transient Acute Thromboinflammatory Response.

Gerogianni A, Sørensen G, Hoel TN et al. · 2026 · International journal of molecular sciences

Left ventricular assist device (LVAD) implantation is a life-saving therapy for end-stage heart failure but may compromise immune integrity. Mechanical shear stress and surface-induced innate immune activation can trigger bleeding and…

View details →DOI: 10.3390/ijms27104594
Abandoned HypothesisMedicine

We need to start thinking about thinking: The impact of rumination on OCD symptom improvement in exposure and response prevention.

McNamara ME, Becker MS, Nota JA et al. · 2026 · Journal of anxiety disorders

While rumination has been recognized in clinical settings as prevalent and problematic for individuals with obsessive compulsive disorder (OCD), its relationship to OCD symptom trajectories has been understudied. In a large sample of N =…

View details →DOI: 10.1016/j.janxdis.2026.103170
Abandoned HypothesisOpen accessMedicine

Ugi multicomponent reactions of optically active aldehydes and chiral aminoindanols: diastereoselective synthesis of bisamides relevant to SARS-CoV-2 Mpro inhibitors.

Ghosh AK, Bhattacharjee A, Jayashankar U et al. · 2026 · Organic & biomolecular chemistry

We have investigated diastereoselective Ugi-multicomponent reactions (Ugi-MCR) relevant to bis-amide scaffolds related to SARS-CoV-2 main protease (Mpro) inhibitors. The studies were mainly focussed on development of diastereoselective…

View details →DOI: 10.1039/d5ob01897h