Negative / Null Result ReportOpen accessEngineering
S. M. Abd Elazim, M.H. Elkholy, Abdelrahman Elgarhy et al. · 2025 · Scientific Reports
Growing integration of renewable energy sources (RESs) into power grids has several advantages, including reduced greenhouse gas emissions and improved energy sustainability. Despite the related benefits, RES integration also poses actual…
View details →DOI: 10.1038/s41598-025-14143-4Cited by 29 Negative / Null Result ReportOpen accessMedicine
Francisco Llavero, Adrián Castillo‐García, Carmen Fiuza‐Luces et al. · 2026 · PubMed
BACKGROUND: Regular exercise, particularly moderate-intensity continuous training (MICT), can improve immune function. Natural killer (NK) cells, a subset of lymphocytes that react to infections, are the most responsive innate immune cells…
View details →DOI: 10.22029/eir.2021.1745Cited by 29 Negative / Null Result ReportOpen accessPsychology
Chun-Yu Kuo, Yang-Ming Huang, Yei‐Yu Yeh · 2018 · Frontiers in Psychology
Cognitive training and social engagement are two of the routes that potentially improve cognitive functions in older adults. The former targets specific functions so that an intervention can trigger the plasticity and efficiency of the underpinning neural systems, and the latter also provides an environment supportive of social and emotional needs. We investigated whether an integration of the two routes could enhance cognitive functions related to executive control, because no prior research has adopted a theory-driven approach to design a group-based cognitive training program for executive
View details →DOI: 10.3389/fpsyg.2018.02482Cited by 29 Negative / Null Result ReportMedicine
Amy Thomas, Khaled Dajani, John P. Neoptolemos et al. · 2010 · Digestive Diseases
Pancreatic cancer is one of the major causes of cancer death in Europe with a 5-year survival rate of less than 5%. Although surgery cannot guarantee a cure, the 5-year survival does improve to around 10% following resection and increases…
View details →DOI: 10.1159/000320099Cited by 29 Negative / Null Result ReportOpen accessEngineering
Marwa Radwan, Abdelhameed Ibrahim, M. A. Abdelsalam et al. · 2026 · Scientific Reports
Deep learning models often encounter two key challenges in developing intelligent and scalable forecasting frameworks for renewable energy systems: input feature space dimensionality and sensitivity to hyperparameter settings. These limitations increase computational cost and compromise generalization and robustness. This paper presents a hybrid deep learning-optimization framework that leverages cognitively inspired metaheuristics to address these challenges, employing the Binary iHow Optimization Algorithm (biHOW) for feature selection and its continuous counterpart, iHOW, for hyperparameter
View details →DOI: 10.1038/s41598-026-39632-yCited by 29 Negative / Null Result ReportOpen accessImmunology and Microbiology
D. Beaujean, Fedor Gassner, A Wong et al. · 2016 · BMC Public Health
BACKGROUND: Lyme disease or Lyme borreliosis (LB) is the most common tick-borne disease both in the United States and Europe. Children, in particular, are at high risk of contracting LB. Since child-specific educational tools on ticks, tick bites and LB are lacking, we developed an online educational video game. In this study, we compared the effectiveness of an online educational video game versus a newly developed leaflet aimed to improve prevention of tick bites and LB among Dutch schoolchildren. METHODS: A total of 887 children, aged 9-13 years and attending the two final years of primary
View details →DOI: 10.1186/s12889-016-3811-5Cited by 28 Negative / Null Result Report
Leon Deutsch, Damjan Osredkar, Janez Plavec et al. · 2021 · Metabolites
Spinal muscular atrophy (SMA) is a genetically heterogeneous group of rare neuromuscular diseases and was until recently the most common genetic cause of death in children. The effects of 2-month nusinersen therapy on urine, serum, and…
View details →DOI: 10.3390/metabo11040206Cited by 28 Negative / Null Result ReportOpen accessMedicine
Maria L.V. Dizon, Rakesh Rao, Shannon E. G. Hamrick et al. · 2019 · BMC Pediatrics
BACKGROUND: While intercenter variation (ICV) in anti-epileptic drug (AED) use in neonates with seizures has been previously reported, variation in AED practices across regional NICUs has not been specifically and systematically evaluated. This is important as these centers typically have multidisciplinary neonatal neurocritical care teams and protocolized approaches to treating conditions such as hypoxic ischemic encephalopathy (HIE), a population at high risk for neonatal seizures. To identify opportunities for quality improvement (QI), we evaluated ICV in AED utilization for neonates with H
View details →DOI: 10.1186/s12887-019-1441-7Cited by 28 Negative / Null Result ReportOpen accessMedicine
Natalie Kashefi, Jonathan I. Nathan, Sharmila Dissanaike · 2014 · Plastic & Reconstructive Surgery Global Open
BACKGROUND: Smoke inhalation is a major source of morbidity and mortality. Heparin and N-acetylcysteine treatment has potential efficacy in inhalation injury. We investigated the impact of a heparin/N-acetylcysteine/albuterol nebulization…
View details →DOI: 10.1097/gox.0000000000000121Cited by 28 Negative / Null Result ReportMedicine
Shahar Shelly, Pritikanta Paul, Hong‐Yan Bi et al. · 2020 · Neurology
OBJECTIVE: To improve myasthenia gravis (MG) autoantibody testing. METHODS: MG serologic tests with confirmatory or refuting clinical-electrodiagnostic (EDX) testing and cancer evaluations were reviewed over 4 years (2012-2015). All…
View details →DOI: 10.1212/wnl.0000000000010910Cited by 28 Negative / Null Result Report
Ronnie Detrich, Teri Lewis · 2012 · Journal of Positive Behavior Interventions
It has been 10 years since No Child Left Behind (NCLB), with its emphasis on scientifically based instruction as a means for improving the educational outcomes of students, was signed into law. In this article, we review the basic tenets…
View details →DOI: 10.1177/1098300712460278Cited by 27 Negative / Null Result ReportMedicine
Ryan G. Overmayer, Matthew Driller · 2017 · International Journal of Sports Physiology and Performance
PURPOSE: To examine the efficacy of intermittent sequential pneumatic compression (ISPC) on exercise recovery and subsequent performance, when implemented between a 20-min cycling bout (simulated scratch race) and a 4-min cycling test…
View details →DOI: 10.1123/ijspp.2017-0207Cited by 27 Negative / Null Result ReportOpen accessArts and Humanities
Taro Oshikiri, 押切, 太郎, オシキリ, タロウ et al. · 2023 · Kobe University Repository Kernel (Kobe University)
Objective: To clarify whether routine thoracic duct (TD) resection improves the prognosis of patients with esophageal cancer after radical esophagectomy. Summary Background Data: Although TD resection can cause nutritional disadvantage and…
Negative / Null Result ReportMedicine
Cynthia Ciwei Lim, Chieh Suai Tan, Manish Kaushik et al. · 2014 · Nephrology
AIM: Optimal timing for acute renal replacement therapy (ARRT) initiation in critically ill patients with acute kidney injury (AKI) is unclear. We aimed to evaluate outcomes in patients who initiated ARRT for traditional indications versus…
View details →DOI: 10.1111/nep.12364Cited by 27 Negative / Null Result ReportOpen accessNeuroscience
Alba Di Pardo, Elena Ciaglia, Monica Cattaneo et al. · 2020 · Cell Death and Disease
Abstract The longevity-associated variant (LAV) of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) has been found significantly enriched in long-living individuals. Neuroinflammation is a key player in Huntington’s disease (HD), a neurodegenerative disorder caused by neural death due to expanded CAG repeats encoding a long polyglutamine tract in the huntingtin protein (Htt). Herein, we showed that striatal-derived cell lines with expanded Htt (STHdh Q 111/111 ) expressed and secreted lower levels of BPIFB4, when compared with Htt expressing cells (STHdh Q 7/
View details →DOI: 10.1038/s41419-020-02754-wCited by 27 Negative / Null Result ReportOpen accessMedicine
Fortunato Giustra, Francesco Bosco, Giorgio Cacciola et al. · 2022 · Journal of Clinical Medicine
In the last decades, several surgical techniques, such as medial pivot (MP) philosophy and kinematic alignment (KA), have been introduced in total knee arthroplasty (TKA) to improve patients’ outcomes. This retrospective study aims to evaluate the clinical, radiographic, and functional results of PCL preservation or sacrifice in KA MP-TKA. A consecutive series of 147 patients older than 60, with a minimum follow-up of two years, were treated with TKA for severe primary knee osteoarthritis (OA) at the Department of Orthopedics and Traumatology between 1 January 2019, and 1 July 2020. After excl
View details →DOI: 10.3390/jcm11216569Cited by 27 Negative / Null Result ReportOpen accessEnvironmental Science
Anthony Laybros, Daniel Schläpfer, Jean‐Baptiste Féret et al. · 2019 · Remote Sensing
Imaging spectroscopy is a promising tool for airborne tree species recognition in hyper-diverse tropical canopies. However, its widespread application is limited by the signal sensitivity to acquisition parameters, which may require new training data in every new area of application. This study explores how various pre-processing steps may improve species discrimination and species recognition under different operational settings. In the first experiment, a classifier was trained and applied on imaging spectroscopy data acquired on a single date, while in a second experiment, the classifier wa
View details →DOI: 10.3390/rs11070789Cited by 26 Negative / Null Result ReportOpen accessComputer Science
David Graber, Peter Stockinger, Fabian Meyer et al. · 2025 · Nature Machine Intelligence
The field of computational drug design requires accurate scoring functions to predict binding affinities for protein-ligand interactions. However, train-test data leakage between the PDBbind database and the Comparative Assessment of Scoring Function benchmark datasets has severely inflated the performance metrics of currently available deep-learning-based binding affinity prediction models, leading to overestimation of their generalization capabilities. Here we address this issue by proposing PDBbind CleanSplit, a training dataset curated by a new structure-based filtering algorithm that elim
View details →DOI: 10.1038/s42256-025-01124-5Cited by 26 Negative / Null Result ReportOpen accessMedicine
Sunita Padman, Robert Padbury, Carol Beeke et al. · 2013 · Acta Oncologica
BACKGROUND: Metastatectomy in colorectal cancer (CRC) is now a standard of care with improved survival reported. Conversion chemotherapy has increased the population who are suitable for surgery. Here we assess patterns of care and…
View details →DOI: 10.3109/0284186x.2013.831473Cited by 26 Negative / Null Result Report
Mélusine Boon-Falleur, Adrien Bouguen, Axelle Charpentier et al. · 2022 · Scientific Reports
Abstract Recent empirical research has shown that improving socio-emotional skills such as grit, conscientiousness and self-control leads to higher academic achievement and better life outcomes. However, both theoretical and empirical…
View details →DOI: 10.1038/s41598-021-04046-5Cited by 26 Negative / Null Result Report
Sang Jun Song, Se Gu Kang, Yeon Je Lee et al. · 2018 · Knee Surgery, Sports Traumatology, Arthroscopy
Abstract Purpose In the present study, the early results of sensor‐assisted versus manually balanced posterior‐stabilized total knee arthroplasty (TKA) for osteoarthritis with varus deformities were prospectively compared. Methods Fifty…
View details →DOI: 10.1007/s00167-018-5314-7Cited by 26 Negative / Null Result Report
Jean-Philippe Hauzeur, Chantal Lechanteur, Etienne Baudoux et al. · 2019 · Clinical Orthopaedics & Related Research
Abstract Background In patients with nontraumatic osteonecrosis of the femoral head (ONFH), implantation of bone marrow aspirate concentrate (BMAC) could delay the progression of osteonecrosis and improve symptoms in pre-fracture ONFH.…
View details →DOI: 10.1097/corr.0000000000001107Cited by 26 Negative / Null Result ReportOpen accessMedicine
Xiaozhun Huang, Lin Xu, Teng Ma et al. · 2021 · Frontiers in Oncology
BACKGROUND: Nivolumab and pembrolizumab disrupt the programmed cell death-1 immune checkpoint and display promising efficacy and safety results in advanced hepatocellular carcinoma (HCC). However, the benefits remain limited. The preliminary results of lenvatinib (LEN) combined with immune checkpoint inhibitors (ICIs) reveal that the combinations were well-tolerated and encouraging. This study aimed to analyze the safety and efficacy of LEN plus ICIs in a real-world cohort of patients with advanced HCC. METHOD: Between June 4, 2017, and June 30, 2019, 16 patients received LEN plus nivolumab, a
View details →DOI: 10.3389/fonc.2021.751159Cited by 26 Negative / Null Result ReportOpen accessMedicine
Joshua A. Beckman, Allison B. Goldfine, Alison Goldin et al. · 2010 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Antagonism of protein kinase Cbeta (PKCbeta) restores endothelial function in experimental models of diabetes and prevents vascular dysfunction in response to hyperglycemia in healthy humans. OBJECTIVE: We tested the hypothesis…
View details →DOI: 10.1210/jc.2010-0286Cited by 26 Negative / Null Result ReportOpen accessMedicine
Lucius S. Fekonja, Ziqian Wang, Dogu Baran Aydogan et al. · 2021 · Frontiers in Oncology
Tumors infiltrating the motor system lead to significant disability, often caused by corticospinal tract injury. The delineation of the healthy-pathological white matter (WM) interface area, for which diffusion magnetic resonance imaging (dMRI) has shown promising potential, may improve treatment outcome. However, up to 90% of white matter (WM) voxels include multiple fiber populations, which cannot be correctly described with traditional metrics such as fractional anisotropy (FA) or apparent diffusion coefficient (ADC). Here, we used a novel fixel-based along-tract analysis consisting of cons
View details →DOI: 10.3389/fonc.2020.622358Cited by 25 Negative / Null Result ReportOpen accessMedicine
Garth Funston, Gary Abel, Emma J. Crosbie et al. · 2021 · Cancers
CA125 is widely used as an initial investigation in women presenting with symptoms of possible ovarian cancer. We sought to develop CA125-based diagnostic prediction models and to explore potential implications of implementing model-based thresholds for further investigation in primary care. This retrospective cohort study used routinely collected primary care and cancer registry data from symptomatic, CA125-tested women in England (2011-2014). A total of 29,962 women were included, of whom 279 were diagnosed with ovarian cancer. Logistic regression was used to develop two models to estimate o
View details →DOI: 10.3390/cancers13122886Cited by 25 Negative / Null Result ReportOpen accessMedicine
Marta Celorrio, Kirill Shumilov, Camryn Payne et al. · 2022 · Acta Neuropathologica Communications
Clinical trials of therapeutics for traumatic brain injury (TBI) demonstrating preclinical efficacy for TBI have failed to replicate these results in humans, in part due to the absence of clinically feasible therapeutic windows for administration. Minocycline, an inhibitor of microglial activation, has been shown to be neuroprotective when administered early after experimental TBI but detrimental when administered chronically to human TBI survivors. Rather than focusing on the rescue of primary injury with early administration of therapeutics which may not be clinically feasible, we hypothesiz
View details →DOI: 10.1186/s40478-022-01310-1Cited by 25 Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kevin G. Shim, Shane Zaidi, Jill Thompson et al. · 2017 · Molecular Therapy
Systemic viroimmunotherapy activates endogenous innate and adaptive immune responses against both viral and tumor antigens. We have shown that therapy with vesicular stomatitis virus (VSV) engineered to express a tumor-associated antigen…
View details →DOI: 10.1016/j.ymthe.2017.01.023Cited by 24 Negative / Null Result Report
Tsai‐Ling Liao, Ching‐Heng Lin, Hsin‐Hua Chen et al. · 2017 · Journal of the American Heart Association
Background Accumulating evidence suggests an increased risk of stroke after herpes zoster ( HZ ). This risk is elevated in immunocompromised patients. The incidence of HZ in Asia is higher than in Western countries. However, the…
View details →DOI: 10.1161/jaha.117.006304Cited by 24 Negative / Null Result Report
Panagiotis Kerezoudis, Kathleen J Yost, Nicole M Tombers et al. · 2018 · Neurosurgery
Abstract BACKGROUND The diagnosis of vestibular schwannomas (VS) is associated with reduced patient quality of life (QOL). Minimal clinically important difference (MCID) was introduced as the lowest improvement in a patient-reported…
View details →DOI: 10.1093/neuros/nyy467Cited by 23 