Negative / Null Result ReportOpen accessMedicine
Fereshteh Baygi, Theis Bitz Trabjerg, Lars Henrik Jensen et al. · 2025 · JMIR Formative Research
BackgroundEnhancing care coordination and sharing information in cancer care improves patient experiences by promoting clarity and satisfaction. ObjectiveThis study aims to assess the impact of cross-sectoral video consultation on patient perceptions of care coordination and satisfaction with received information compared to usual care. MethodsThis study presents secondary outcomes on patient perceptions of care coordination and satisfaction with received information from a 7-month follow-up of the Partnership Project. In this randomized controlled trial, patients with cancer were allocated to
View details →DOI: 10.2196/76910 Negative / Null Result ReportOpen accessPublic aspects of medicine
Éva Bíró, Ferenc Vincze, Gabriella Mátyás et al. · 2021 · Frontiers in Public Health
Background: The public health relevance of health literacy is highlighted by the fact that its higher levels can improve health outcomes and reduce health inequities. In order to design effective interventions for improving health literacy, the relationship between health literacy and other factors such as sociodemographic variables, subjective health and social support must be understood.Objective: Our aim was to test a socioecological model of the determinants of health literacy with a special focus on the effect of residence. Our study investigated geographical differences regarding the lev
View details →DOI: 10.3389/fpubh.2021.724995 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Michael Christian Leitner, Michael Christian Leitner, Michael Christian Leitner et al. · 2023 · Frontiers in Neurology
IntroductionA significant number of Restitution Training (RT) paradigms claim to ameliorate visual field loss after stroke by re-activating neuronal connections in the residual visual cortex due to repeated bright light-stimulation at the border of the blind and intact fields. However, the effectiveness of RT has been considered controversial both in science and clinical practice for years. The main points of the controversy are (1) the reliability of perimetric results which may be affected by compensatory eye movements and (2) heterogeneous samples consisting of patients with visual field de
View details →DOI: 10.3389/fneur.2023.1114718 Negative / Null Result ReportOpen accessOtorhinolaryngology
Iqra Zakir, Ahmad Ahmad, Hamdan Pasha et al. · 2022 · Iranian Journal of Otorhinolaryngology
Introduction:Tympanoplasty is a common surgery for chronic otitis media and has conventionally been performed with a microscope for decades. The trend of endoscopic minimally invasive surgeries has been increasing worldwide for the last few decades. Few studies have discussed the outcomes of microscopic and endoscopic tympanoplasty. This study aims to compare results of tympanoplasty done with microscope vs endoscope in terms of graft take rate and improvement in conductive hearing loss.Materials and Methods:We did a retrospective review of 120 patients (54 male and 66 female) who underwent Ty
View details →DOI: 10.22038/ijorl.2022.61234.3104 Negative / Null Result ReportOpen accessBiotechnology
Katja Oberhofer, Patrick D. Wettenschwiler, Navrag Singh et al. · 2018 · Applied Bionics and Biomechanics
The introduction of hip belts to backpacks has caused a shift of loading from the spine to the hips with reported improvements in musculoskeletal comfort. Yet the effects of different hip belt tensions on gait biomechanics remain largely unknown. The goal of this study was to assess the influence of backpack weight and hip belt tension on gait biomechanics. Data from optical motion capture and ground reaction forces (GRF) during walking were acquired in nine healthy male subjects (age 28.0 ± 3.9 years). Six configurations of a commercial backpack were analyzed, that is, 15 kg, 20 kg, and 25 kg
View details →DOI: 10.1155/2018/4671956 Negative / Null Result ReportOpen accessMining engineering. Metallurgy
Yutaka ITO, Masato TAKEUCHI, Shuto MIKAMI et al. · 2020 · Journal of MMIJ
Productivity, safety and its improvement is also an integral part of a good mining operation. In recent times, due to constraints on time and cost, it has become increasingly harder to conduct training and safety inductions at mine sites. For the purpose of overcoming these limitations, the use of virtual reality (VR) is proposed for mining education and training. VR has already been introduced in the education and training of miners overseas, and quantitative studies on the effects of using VR for miner's education and training have been made. However, Japan has only one such application
View details →DOI: 10.2473/journalofmmij.136.33 Negative / Null Result Report
Abebe GM, Demissie WM, Zewdie MC · 2026 · Preprint
Abstract Mechanization has immense potential to improve agricultural productivity and overall production, while crop–livestock diversification plays a crucial role in enhancing nutrition security; however, the combined effects of…
View details →DOI: 10.21203/rs.3.rs-10046750/v1 Negative / Null Result Report
Whitmore N, Kim M, Chua P et al. · 2026 · Preprint
Abstract Interoception–the capacity to sense and process internal bodily signals–is strongly linked to emotional experience and mental health, but whether amplifying access to bodily signals causally improves mental well-being remains…
View details →DOI: 10.21203/rs.3.rs-9918164/v1 Negative / Null Result ReportMedicine
Clemens NH, Boucher AN, Vaughn S et al. · 2026 · Journal of learning disabilities
Students in grades 2 through 4 with significant word reading difficulties were randomly assigned to one of two 10-week interventions. In the Dual Treatment condition, decoding instruction emphasized regularity in spelling-sound…
View details →DOI: 10.1177/00222194261417589 Negative / Null Result Report
Ofori I · 2026 · Preprint
Abstract In the current dynamic and competitive business landscape, firms are under increasing pressure to improve their cost efficiency while simultaneously embracing sustainable supply chain practices. The main objective of the study was…
View details →DOI: 10.21203/rs.3.rs-9580593/v1 Negative / Null Result ReportOpen accessMedicine
Layton KL, Edwards TL, Foster TM · 2026 · Journal of the experimental analysis of behavior
Translational research investigating traditional differential reinforcement of alternative behavior (DRA) suggests that such procedures increase the persistence of target behavior relative to when the alternative behavior is first…
View details →DOI: 10.1002/jeab.70117 Negative / Null Result ReportOpen accessVocational rehabilitation. Employment of people with disabilities
Uzair Ahmad, Babar Ali, Seema Gul et al. · 2025 · Journal Riphah College of Rehabilitation Sciences
Background: Regular physical activity has a positive impact on brain function, improves perception, and significantly influences academic achievement. Objective: This study aimed to determine the association of physical activity, motor skills, and academic performance in high school students in Hayatabad, Peshawar. Methodology: A total of 349 students were recruited using stratified random sampling from both public and private high schools within the Hayatabad region, Peshawar, Pakistan from December 2020 to May 2021. Only students in 9th and 10th grades from public and private schools who met
Negative / Null Result ReportOpen accessDentistry
Mohammad Tavakoli, Ensiyeh Bateni, Mansour Rismanchian et al. · 2012 · Dental Research Journal
Background: The greater surface of bioactive glass nanoparticles presents an incomparable and promising feature similar to the biological apatite. Nanoparticles improve cellular adhesion, enhance osteoblast proliferation and differentiation, and increase biomineralization for periodontal regeneration and dental implants. Considering the fact that interaction between periodontal cells and bone graft materials are important for periodontal lesion regeneration, the present study was undertaken to investigate the genotoxicity of a novel synthesized nanoscale bioactive glass and compared it with No
View details →DOI: 10.4103/1735-3327.99831 Negative / Null Result ReportOpen accessMedicine
Hall, Natalie J, Berry, Sameer K, Aguilar, Jack et al. · 2021 · JMIR Formative Research
BackgroundA potential benefit of electronic health records (EHRs) is that they could potentially save clinician time and improve documentation by auto-generating the history of present illness (HPI) in partnership with patients prior to the clinic visit. We developed an online patient portal called AEGIS (Automated Evaluation of Gastrointestinal [GI] Symptoms) that systematically collects patient GI symptom information and then transforms the data into a narrative HPI that is available for physicians to review in the EHR prior to seeing the patient. ObjectiveThis study aimed to compare whether
View details →DOI: 10.2196/23599 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Rathi N. Pillai, MD, Suresh S. Ramalingam, MD, Meena Thayu, MD et al. · 2021 · JTO Clinical and Research Reports
Introduction: The programmed death-ligand 1 inhibitor atezolizumab improves progression-free survival (PFS) and overall survival (OS) for patients with previously treated advanced NSCLC. Preclinical studies indicate that targeting CD38-positive cells with daratumumab may synergistically enhance atezolizumab’s antitumor activity by increasing the effector T-cell activity. Methods: This phase 1b-2 study included a safety run-in (one cycle of daratumumab plus atezolizumab) and randomized phases (daratumumab plus atezolizumab versus atezolizumab alone). The primary objective of the randomized phas
View details →DOI: 10.1016/j.jtocrr.2020.100104 Negative / Null Result ReportOpen accessPsychiatry
Esther-Sevil Eigl, Laura Krystin Urban-Ferreira, Manuel Schabus et al. · 2023 · Frontiers in Psychiatry
BackgroundApproximately one-third of the healthy population suffer from sleep problems, but only a small proportion of those affected receive professional help. Therefore, there is an urgent need for easily accessible, affordable, and efficacious sleep interventions.ObjectiveA randomized controlled study was conducted to investigate the efficacy of a low-threshold sleep intervention consisting of either (i) sleep data feedback plus sleep education or (ii) sleep data feedback alone in comparison with (iii) no intervention.Material and methodsA total of 100 employees of the University of Salzbur
View details →DOI: 10.3389/fpsyt.2023.1117645 Negative / Null Result ReportOpen accessEducation
Lam D. Pham · 2022 · AERA Open
Turnaround interventions often require or encourage low-performing schools to replace teachers, assuming that schools will recruit high-performing teachers who remain effective after transferring. However, teacher effectiveness may change after transferring, which could explain why some teacher replacement efforts do not improve student achievement. This paper contributes new information on the stability of teacher effectiveness by examining teachers who transfer into turnaround schools relative to teachers who transfer into low-performing but non-turnaround schools. I examine this issue by us
View details →DOI: 10.1177/23328584221139763 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Katrin Abram, Silvia Bohne, Peter Bublak et al. · 2016 · Dementia and Geriatric Cognitive Disorders Extra
Background/Aims: Postural instability in patients with normal pressure hydrocephalus (NPH) is a most crucial symptom leading to falls with secondary complications. The aim of the current study was to evaluate the therapeutic effect of spinal tap on postural stability in these patients. Methods: Seventeen patients with clinical symptoms of NPH were examined using gait scale, computerized dynamic posturography (CDP), and neuropsychological assessment. Examinations were done before and after spinal tap test. Results: The gait score showed a significant improvement 24 h after spinal tap test in al
View details →DOI: 10.1159/000450602 Negative / Null Result ReportOpen accessGeriatrics
Lars Donath, Sebastian Ludyga, Daniel Hammes et al. · 2017 · BMC Geriatrics
Abstract Background Aging is accompanied by a decline of executive function. Aerobic exercise training induces moderate improvements of cognitive domains (i.e., attention, processing, executive function, memory) in seniors. Most conclusive data are obtained from studies with dementia or cognitive impairment. Confident detection of exercise training effects requires adequate between-day reliability and low day-to-day variability obtained from acute studies, respectively. These absolute and relative reliability measures have not yet been examined for a single aerobic training session in seniors.
View details →DOI: 10.1186/s12877-017-0634-x Negative / Null Result ReportOpen accessMedicine
Niroshica Mohanathas, Lianna Montanari, Rachel Downey et al. · 2026 · PLoS ONE
Background Multitasking, such as listening while balancing, relies on integrated processing in the sensory, cognitive, and motor systems; systems that often decline with age. Hearing loss is linked to increased risks of both falls and cognitive decline. Improving cognitive processing through executive function (EF) training may support balance, especially in older adults with hearing loss. This randomized controlled study conducted across age groups and hearing abilities, examined the effects of a 12-week EF training program on postural outcomes (center of pressure (COP)) using an auditory-cog
View details →DOI: 10.1371/journal.pone.0331276 Negative / Null Result ReportMedicine
Janz C, Timpka J, Storch A et al. · 2026 · Journal of Parkinson's disease
BackgroundThe Parkinson's Disease (PD) Home Diary (HD) is a common clinical outcome measure, but studies show only fair agreement between clinical observer and patient assessments, with no significant improvement after patient…
View details →DOI: 10.1177/1877718x261461073 Negative / Null Result ReportMedicine
Diprose W, Fahed R, Volders D et al. · 2026 · Journal of neurointerventional surgery
Background Randomized trials showed that endovascular thrombectomy (EVT) did not improve outcomes in medium vessel occlusion (MeVO) stroke compared with usual care. We investigated whether patients randomized to EVT who achieved…
View details →DOI: 10.1136/jnis-2025-024733 Negative / Null Result ReportMedicine
Yamaguchi T, Akai S, Uozumi N et al. · 2026 · Gan to kagaku ryoho. Cancer & chemotherapy
A 53-year-old male patient presented with dyspnea and was admitted with the diagnosis of bacterial pneumonia.His respiratory condition did not improve despite the resolution of fever with antibiotic therapy, and he was eventually diagnosed…
Negative / Null Result ReportOpen accessMedicine
Sanabria A, Rodrigo JP, Araújo ALD et al. · 2025 · Cancers
Background/Objectives : Oropharyngeal squamous cell carcinoma (OPSCC) management has shifted following recognition of HPV-driven disease. Neoadjuvant chemotherapy (NAC) has historically failed to improve overall survival (OS) in mixed head…
View details →DOI: 10.3390/cancers18010023 Negative / Null Result ReportOpen accessScience
NATALIA C. SILVA, KAREN M. LEÃO, JOÃO T. PÁDUA et al. · 2021 · Anais da Academia Brasileira de Ciências
Abstract To evaluate the addition of antioxidants in extenders on post-thaw bovine semen quality and in vitro embryo production efficiency. Six semen samples were collected from five Holstein bulls. In the experiment I, the samples were diluted with AndroMed® and Bovimix® and added antioxidants glutathione (1.5 and 2.5 mM) and melatonin (0.5 and 1.0 mM). In the experiment II, the best treatments obtained in experiment I were used for in vitro fecundation. Glutathione did not improve sperm viability. Melatonin had a negative effect on semen characteristics. Andromed® showed better results in sp
View details →DOI: 10.1590/0001-3765202120191229 Negative / Null Result ReportOpen accessChemistry
Yu Jia, Cao Yu, Song Hang et al. · 2012 · Journal of the Serbian Chemical Society
Ab initio Hartree-Fock (HF) method and Density Functional Theory (DFT) were used to calculate the optical rotation of 26 chiral compounds. The effects of theory and basis sets used for calculation, solvents influence on the geometry and values of calculated optical rotation were all discussed. The polarizable continuum model, included in the calculation, did not improve the accuracy effectively, but it was superior to γs. Optical rotation of five or sixmembered of cyclic compound has been calculated and 17 pyrrolidine or piperidine derivatives which were calculated by HF and DFT methods gave a
View details →DOI: 10.2298/jsc110905207y Negative / Null Result ReportMedicine
Zhang H, Yang Y, Sun S · 2024 · Acta psychologica
In response to the public's puzzle about why maternity leave has unexpectedly failed to improve fertility problem in the Chinese context of a widespread extension of maternity leave, our study concentrates on a prevailing stigmatization…
View details →DOI: 10.1016/j.actpsy.2024.104413 Negative / Null Result ReportMedicine
Mohammed SA, Gorica E, Albiero M et al. · 2025 · Diabetes
Revascularization strategies failed to improve outcome in patients with diabetes with peripheral artery disease (PAD). Histone modifications are key modulators of gene expression and could play a role in angiogenic response. This study…
View details →DOI: 10.2337/db24-0997 Negative / Null Result ReportOpen accessMedicine
El Jalkh J, Obeid PM, Guermazi D et al. · 2025 · Dermatopathology (Basel, Switzerland)
A 64-year-old patient presented for management of symptomatic skin-colored papules symmetrically distributed over the lateral neck over the past two years, which failed to improve on multiple topical corticosteroids, antifungal creams, and…
View details →DOI: 10.3390/dermatopathology12020015 Negative / Null Result ReportMedicine
Lähteenmäki EI, Lehti S, Jauhiainen M et al. · 2025 · American journal of physiology. Endocrinology and metabolism
Although high-density lipoprotein (HDL) has cardiometabolic protecting properties, interventions to raise HDL cholesterol concentration have failed to improve cardiometabolic health. Hence, HDL composition and functionality might be key…
View details →DOI: 10.1152/ajpendo.00130.2025 