Negative / Null Result ReportOpen accessMedicine
Hanzaleh Jour Ebrahimiyan, Nafise Ansarinejad, Farshid Fardad · 2023 · Disease and Diagnosis
Background: Chemotherapy-induced peripheral neuropathy is one of the most common side effects of chemotherapy. This study aimed to determine the effectiveness of venlafaxine and duloxetine in improving chronic neurotoxicity induced by chemotherapy in cancer patients. Materials and Methods: The study was performed on cancer patients undergoing outpatient chemotherapy or hospitalization in Rasoul Akram hospital. The admitted patients were blindly divided into two groups. The first group was treated with venlafaxine, and the second group was treated with duloxetine. The treatment lasted up until
View details →DOI: 10.34172/ddj.2023.389 Negative / Null Result ReportOpen accessMedicine
Abu Sadat Mohammad Sayeem Bin Shahid, Shahnawaz Ahmed, Tanzina Tazul Renesa et al. · 2022 · PLoS ONE
Background Fibersol-2 has some beneficial effects on human health. We aimed to evaluate the digestive tolerability and acceptability of Fibersol-2 in healthy and diarrheal children, as well as improvement in stool consistencies in young diarrheal children. Methods Sixty children of either sex, aged 1-3 years having four groups (healthy children/low dose, healthy children/high dose, children with diarrhea/low dose and children with diarrhea/high dose) were enrolled into this exploratory study between 1st August to 23rd October 2017. Two presumptive doses, low (2.5g) and high (5g), twice daily w
View details →DOI: 10.1371/journal.pone.0274302 Negative / Null Result ReportOpen accessVeterinary medicine
ali kargarirezapour, somayye ghobadi, afshin zakeri · 2013 · Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī
Glucans derived from yeast cell wall are promising alternatives to antibiotics, as they have been shown to improve growth performance and stimulate the immune system of immature broilers. In this study we evaluated the effect of different levels of yeast beta-glucan (YBG) on some blood parametrs of broiler chickens. In a factorial experiment based on completely randomized design (the first factor: YBG levels: 0, 0.04 and 0.08% of basal diet and sex as a second factor) 144 day old chicks (72 male and 72 female) were selected and allocated to different treatments (three replicates of each treatm
Negative / Null Result ReportOpen accessAnimal culture
C Von Mühlen, NL Conrad, AP Roll et al. · 2025 · Brazilian Journal of Poultry Science
ABSTRACT This study evaluated the impact of dietary Saccharomyces boulardii and Saccharomyces cerevisiae on the immunity of birds vaccinated against Pasteurella multocida and Salmonella gallinarum. A total of 105 male Cobb 500 broilers were divided into four groups: T1 (vaccinated, no supplement, n = 30), T2 (vaccinated, S. boulardii supplement, n = 30), T3 (vaccinated, S. cerevisiae supplement, n = 30), and T4 (non-vaccinated, no supplement, n = 15). Chickens received a corn-soy diet with 1x107 CFU/g of S. boulardii or S. cerevisiae for 42 days. Immune response was assessed by indirect ELISA
View details →DOI: 10.1590/1806-9061-2024-1993 Negative / Null Result ReportOpen accessSports medicine
Alison Bulow, Judith E Anderson, Jeff R S Leiter et al. · 2021 · International Journal of Sports Physical Therapy
# Background Adolescent females are at much greater risk for ACL injury than their male counterparts when participating in the same sports. Preventative and pre-operative rehabilitation neuromuscular (NM) exercise programs are often recommended to improve knee function and reduce injury rates. The effectiveness of perturbation-based NM training program has been established in an adult population but has yet to be investigated in the at-risk adolescent female population. # Purpose To determine the effectiveness of a perturbation-based NM exercise program in a group of physically active adolesce
View details →DOI: 10.26603/001c.25685 Negative / Null Result ReportOpen accessSurgery
Rajeev Kumar, Anita Malik, Monika Kohli et al. · 2013 · Archives of Clinical and Experimental Surgery
Background: Intracranial endoscopy is a minimum invasive procedure, which reduces trauma to the brain, is cost-effective, and carries a shortened hospital stay with an improved postoperative outcome. Objective: To monitor intracranial pressure changes during intracranial endoscopy among children and adults under general anesthesia/sedation, and to compare the intracranial pressure changes between children and adults receiving general anesthesia and among adults receiving general anesthesia and sedation. Methods: The present cross-sectional study was conducted in one of the tertiary care hospit
View details →DOI: 10.5455/aces.20130118041840 Negative / Null Result ReportOpen accessSurgery
Eric R. Bain, Bistees George, Syed H. Jafri et al. · 2024 · Journal of Cardiothoracic Surgery
Abstract Background Patients with severe aortic stenosis (AS) and left ventricular (LV) dysfunction demonstrate improvement in left ventricular injection fraction (LVEF) after aortic valve replacement (AVR). The timing and magnitude of recovery in patients with very low LVEF (≤ 25%) in surgical or transcatheter AVR is not well studied. Objective Determine clinical outcomes following transcatheter aortic valve replacement (TAVR) and surgical aortic valve repair (SAVR) in the subset of patients with severely reduced EF ≤ 25%. Methods Single-center, retrospective study with primary endpoint of LV
View details →DOI: 10.1186/s13019-024-02724-9 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Anqi Wang, Anqi Wang, Xuan Meng et al. · 2024 · Frontiers in Neurology
ObjectiveTo determine the efficacy of mechanical thrombectomy combined with prolonged mild hypothermia compared with conventional treatment in managing acute middle cerebral artery occlusion, and to explore whether extending the duration of hypothermia can improve neurological function.MethodFrom 2018 to June 2023, a retrospective analysis was conducted on 45 patients with acute middle cerebral artery occlusion treated at the NICU of Suzhou Kowloon Hospital, affiliated with Shanghai Jiao Tong University School of Medicine. After thrombectomy, patients were admitted to the neurological intensiv
View details →DOI: 10.3389/fneur.2024.1406293 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Yea Eun Kang, Sorim Choung, Ju Hee Lee et al. · 2017 · Endocrinology and Metabolism
BackgroundSlit2 is a new secreted protein from adipose tissue that improves glucose hemostasis in mice; however, there is no study about the serum levels and precise role of Slit2 in human. The aim of this study is to explore the serum level of Slit2 in human, and to identify the role of Slit2 in diabetes mellitus (DM).MethodsThe participants of this study consist of 38 subjects with newly diagnosed DM, and 75 healthy subjects as a control group. Serum Slit2 levels were measured using an enzyme-linked immunosorbent assay. Relationship between circulating Slit2 and diabetic related factors was
View details →DOI: 10.3803/enm.2017.32.3.383 Negative / Null Result ReportOpen accessGeriatrics
Kendra Cooling, Danielle R. Bouchard, Molly Gallibois et al. · 2025 · JAR Life
Objective: To examine the effects of a standing intervention on gait speed for older adults living in long term care (LTC) residences. Design: A parallel superiority cluster randomized controlled trial. Setting and participants: LTC residences. A total of 95 LTC residents (n = 47 control; n = 48 intervention) participated in the study. Methods: LTC residences and therefore the residents from the homes were randomized to either the intervention group (standing up to 100 minutes/week) for 22 weeks or the control group (socializing with staff with no encouragement to stand for up to 100 minutes/w
View details →DOI: 10.1016/j.jarlif.2025.100015 Negative / Null Result ReportOpen accessMedicine
Sung Hee Lim, Jong-Mu Sun, Joohyun Hong et al. · 2021 · The Korean Journal of Internal Medicine
Background/Aims Clinical trials have not consistently supported the use of induction chemotherapy (IC) for locally advanced head and neck squamous cell cancer. Hypopharynx and base of tongue (BOT) cancer has shown relatively poor survival. We investigated the role of IC in improving outcome over current chemoradiotherapy (CRT) in patients with hypopharynx and BOT cancer. Methods Treatment-naïve patients with stage III/IV (M0) hypopharynx or BOT cancer were randomly assigned to receive CRT alone (CRT arm: cisplatin 100 mg/m2 on D1 3-weekly, two times plus radiotherapy 68.4 Gy/30 fractions on we
View details →DOI: 10.3904/kjim.2019.161 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Eva B. Aamodt, Martin Røvang, Mona K. Beyer et al. · 2026 · Frontiers in Neurology
BackgroundMeasures of white matter hyperintensities (WMHs) represent a crucial part of post-stroke outcome prediction. Automatic WMH segmentation has proven particularly challenging in stroke cases. Using an improved method for WMH segmentation that incorporates stroke lesions, we set out to explore factors associated with higher WMH burden, as well as the association between WMH burden and post-stroke dependency across two different countries that may demonstrate significant variation in radiological presentation.MethodsA total of 384 acute ischemic stroke (AIS) survivors from the Norwegian C
View details →DOI: 10.3389/fneur.2026.1712109 Negative / Null Result ReportOpen accessMedicine
Cherubino Paolo, Sala Andrea, Casalone Rosario et al. · 2005 · Journal of Translational Medicine
Abstract Background Local myogenesis, neoangiogenesis and homing of progenitor cells from the bone marrow appear to contribute to repair of the infarcted myocardium. Implantation into heart tissues of autologous skeletal myoblasts has been associated with improved contractile function in animal models and in humans with acute myocardial ischemia. Since heart infarction is most prevalent in individuals of over 40 years of age, we tested whether culture methods available in our laboratory were adequate to obtain sufficient numbers of differentiated skeletal myoblasts from muscle biopsy specimens
View details →DOI: 10.1186/1479-5876-3-21 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Louise Simeonov, Ravi Das · 2025 · Frontiers in Behavioral Neuroscience
A fundamental question in cognitive neuroscience is how multi-sensory elements are bound into a unified memory trace. The formation of memories is thought to be reliant on precisely timed neural activity. Theta frequency neural oscillations have been proposed to orchestrate the timing of different sensory cortices. Here, we attempt to replicate findings that flickering stimuli presented in synchronous theta frequency will lead to enhanced recall. Additionally, we investigate whether theta frequency sensory flicker can improve encoding of emotional associative memories. The current study failed
View details →DOI: 10.3389/fnbeh.2025.1555081 Negative / Null Result ReportOpen accessAgriculture
Leila Sahampoor, Fatemeh Zaker Tavallaie, Seyed Reza Fani et al. · 2020 · Journal of Crop Protection
Trichoderma is very important as a bio control agent and probably a good alternative for chemical fungicides. Fusarium oxysporum is a plant pathogen that causes wilt in a wide range of plants. The use of gamma irradiation can be employed to increase Trichoderma efficiency against F. oxysporum. The induced mutation provides genetic changes in Trichoderma and in some of the mutated isolates the efficiency of bio control may be improved. In this study the efficiency of mutated T. harzianum CS5 against the F. oxysporum f.sp. radicis-cucumerinum was evaluated. Among 16 wild isolates of Trichoderma,
Negative / Null Result ReportOpen accessAstrophysics
John T. Whelan, Rodrigo Tenorio, Jared K. Wofford et al. · 2023 · The Astrophysical Journal
Improved observational constraints on the orbital parameters of the low-mass X-ray binary Scorpius X-1 were recently published in Killestein et al. In the process, errors were corrected in previous orbital ephemerides, which have been used in searches for continuous gravitational waves from Sco X-1 using data from the Advanced LIGO detectors. We present the results of a reanalysis of LIGO detector data from the third observing run of Advanced LIGO and Advanced Virgo using a model-based cross-correlation search. The corrected region of parameter space, which was not covered by previous searches
View details →DOI: 10.3847/1538-4357/acc8d7 Negative / Null Result ReportOpen accessSpecial aspects of education
Alistair McInerny, Andrew Boudreaux, Mila Kryjevskaia · 2025 · Physical Review Physics Education Research
This article reports on a controlled study to investigate the efficacy of incorporating explicit discussions about the duality of human reasoning and its implications for learning in physics instruction. The central goal is to probe to what extent, if at all, such discussions improve student performance on tasks that tend to elicit intuitively appealing but incorrect responses. We hypothesized that explicitly discussing the reasoning pathways and hazards associated with the interactions between automatic process 1 and deliberate process 2 could boost students’ performance on a variety of topic
View details →DOI: 10.1103/physrevphyseducres.21.010135 Negative / Null Result ReportOpen accessPolitical science (General)
Jason M. Pudlo · Politics and Religion
Houses of worship are often shelters after the storm. Yet, as climate change fuels natural disasters and communities increasingly rely on congregations during disaster recovery, are houses of worship ready to be houses of refuge? Examining clergy influence, does a higher concern about climate change by clergy result in improved congregational disaster readiness? Data for the study come from a 2019 nationwide survey of clergy. The survey includes measures of congregational disaster preparedness along with one of the first applications of the SASSY climate concern measure to clergy. Results show
View details →DOI: 10.1017/s1755048325000082 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Phyllis Waruguru, Dasel Mulwa, Michael Okoth et al. · 2025 · Journal of Food Innovation, Nutrition, and Environmental Sciences
Background: Antiretroviral therapy (ART) effectively suppresses HIV viral load. However, people living with HIV (PLWH) fail to achieve optimal viral suppression and especially in resource limited settings. Nutritional supplements such as Moringa oleifera have been traditionally used to improve health outcomes in PLWH, yet their effects on viral load remain under researched. Objective: To evaluate the effect of dietary supplementation with Moringa oleifera seed flour on HIV viral load among adult women receiving ART in a resource-limited setting. Methods: This was a crossover clinical trial inv
View details →DOI: 10.70851/ynxgrq90 Negative / Null Result ReportOpen accessDentistry
Omid Savabi, Farahnaz Nejatidanesh, Mohamad Hossein Fathi et al. · 2013 · Dental Research Journal
Background: The interim restorative materials should have certain mechanical properties to withstand in oral cavity. The aim of this study was to evaluate the hardness and wear resistance of interim restorative materials. Materials and Methods: Fifteen identical rectangular shape specimens with dimensions of 2 mm × 10 mm × 30 mm were made from 7 interim materials (TempSpan, Protemp 3 Garant, Revotek, Unifast LC, Tempron, Duralay, and Acropars). The Vickers hardness and abrasive wear of specimens were tested in dry conditions and after 1 week storage in artificial saliva. The depth of wear was
View details →DOI: 10.4103/1735-3327.113338 Negative / Null Result ReportOpen accessPublic aspects of medicine
Maria Henström, Christine Delisle Nyström, Susanne Andermo et al. · 2025 · BMC Public Health
Abstract Background Early-life interventions are essential for improving public health since lifestyle behaviours are established already in childhood. Child healthcare (CHC) plays a crucial role in this context. The ‘Saga Stories in health talk’ (SSiHT) material includes a flipchart with colourful illustrations to facilitate CHC nurses’ routine health talks with parents and their children, and a hand-out material kit to support healthy lifestyle behaviours in the families. Our aim was to evaluate the effectiveness of the SSiHT intervention at the 5-year routine visit at CHC on parental self-e
View details →DOI: 10.1186/s12889-025-22786-1 Negative / Null Result ReportOpen accessMedicine (General)
Joseph Choi, Rajesh Bhayana, Chenhan D Wang et al. · 2020 · BMJ Open Quality
Ordering and protocolling CT scans after-hours from the emergency department (ED) at our institution previously required discussion between the ED physician and radiology resident, which led to workflow inefficiency. Our intervention consisted of creating an electronic list of CT requests that radiology residents would monitor. Radiology protocolled straightforward requests and contacted the ordering physician for more details when required. We aimed to improve workflow efficiency, increase provider satisfaction and reduce CT turnaround time without significantly affecting CT utilisation. Plan
View details →DOI: 10.1136/bmjoq-2020-000969 Negative / Null Result ReportOpen accessEducation (General)
Sasmita Tarihoran, Jufrizal Jufrizal · 2024 · English Review: Journal of English Education
This study examines the impact of a language program on the speaking skills of students at UIN SYAHADA Padangsidimpuan. With English proficiency being crucial for global communication, the research aimed to assess the program's effectiveness in improving students' speaking abilities. Using an ex post facto research design, 43 English department students were assessed. Speaking tests were administered at the start and end of the semester, and the data were analyzed using the Wilcoxon test. Findings showed a modest increase in mean scores, indicating some positive effect of the program. However,
View details →DOI: 10.25134/erjee.v12i3.10091 Negative / Null Result ReportOpen accessMedicine
Vatan A, Karabay O, Moralı H et al. · 2026 · BMC infectious diseases
Background Tenofovir alafenamide (TAF) is widely used in antiretroviral therapy due to its improved renal and bone safety compared to tenofovir disoproxil fumarate (TDF). However, concerns remain regarding its potential metabolic effects…
View details →DOI: 10.1186/s12879-026-13377-5 Negative / Null Result ReportOpen accessMedicine
Mirzaei R, Soleimanzadeh A, Asri-Rezaei S · 2026 · Scientific reports
Dog semen conservation at cold temperatures (5 °C) is a valuable reproductive management tool, but it is bedeviled by issues of oxidative stress and mitochondrial damage that reduce sperm quality and viability. Urolithin A (UA), a natural…
View details →DOI: 10.1038/s41598-026-49089-8 Negative / Null Result ReportOpen accessMedicine
Fujishima Y, Anderson D, Kamakura S et al. · 2026 · PNAS nexus
The lymphocyte culture method for chromosomal aberration analysis was established in the 1960s, and culture media supplemented with fetal bovine serum (FBS) have been routinely used. However, issues such as lot-to-lot variability,…
View details →DOI: 10.1093/pnasnexus/pgag120 Negative / Null Result ReportOpen accessMedicine (General)
Oded Hershkovich, Inga Tetroashvili, Adam Lee Goldstein et al. · 2024 · Medicina
Background and Objectives: The incidence of proximal femoral fractures (PFFs) is rising, causing significant morbidity and mortality. Regional anesthesia (RA)’s benefits include the avoidance of intubation and mechanical ventilation, decreased blood loss, and improved analgesia. General anesthesia (GA) offers improved hemodynamic stability. This study examines the in-hospital post-surgical morbidity and mortality seen in PFFs in a cohort of the elderly undergoing GA or RA. Materials and Methods: This is a retrospective cohort study of 319 PFF patients older than 65 years over a single year. Re
View details →DOI: 10.3390/medicina60091446 Negative / Null Result ReportOpen accessGynecology and obstetrics
Fariba Mousavi, Sakineh Mohammad-Alizadeh-Charandabi, Mojgan Mirgafourvand et al. · 2023 · Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān
Introduction: Early symptoms of menopause are very common and often very bothersome. Considering the increasing number of women experiencing these symptoms in the world and Iran, there is a growing need to use methods to reduce these symptoms. Therefore, this study was performed with aim to determine the effect of the combined herbal capsules (Menohelp) on reducing the early symptoms of menopause, number and intensity of hot flashes (primary outcomes), and improving sleep quality and quality of life (secondary outcomes) in menopausal women. Methods: In this double-blind trial in Tabriz, 100 wo
View details →DOI: 10.22038/ijogi.2023.22601 Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Irfan Zubair Shahul Hameed, Darpanarayan Hazra, Priya Ganesan et al. · 2024 · Turkish Journal of Emergency Medicine
OBJECTIVES: In the context of acute hypoxemic respiratory failure (AHRF), ensuring effective preoxygenation and apneic oxygenation emerges as the pivotal approach ensuring for averting hypoxemic adverse events during endotracheal intubation. To investigate this, we conducted an open-label randomized controlled trial, aiming to assess the comparative effectiveness of nasopharyngeal high-flow oxygenation in conjunction with Bag-Valve-Mask (BVM) versus standard BVM preoxygenation in patients experiencing AHRF within the emergency department (ED). METHODS: This prospective single-center, open-labe
View details →DOI: 10.4103/tjem.tjem_176_23 Negative / Null Result ReportOpen accessNursing
Nora Kasparaitytė, Juozas Raistenskis, Lina Budrienė et al. · 2025 · Reabilitacijos Mokslai: Slauga, Kineziterapija, Ergoterapija
Background. Idiopathic scoliosis is among the most common spinal disorders diagnosed in 1–3% of children and adolescents. Treatment choice is related to disease severity, with a Cobb angle of 20–40°, a corrective brace or physiotherapy can stop its progression. However, insufficient research has shown whether combined treatment is better than monotherapy. Aim. To evaluate the effect of combining bracing and physiotherapy to reduce spinal deformity, improve quality of life and lung function, and compare the results with those of monotherapy. Determine the optimal duration of combined rehabilit
View details →DOI: 10.33607/rmske.v1i32.1603 