Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Bilan Yang, Xiaoli Xi, Hongsheng Yu et al. · 2024 · Cancer Reports
Abstract Background The optimal treatment strategy for early‐stage hepatocellular carcinoma (HCC) remains controversial, specifically in regard to surgical resection (SR) and ablation. The aim of this study was to investigate the impact of SR and ablation on recurrence and prognosis in early‐stage HCC patients, to optimize treatment strategies and improve long‐term survival. Methods A retrospective analysis was conducted on 801 patients diagnosed with Barcelona Clinic Liver Cancer (BCLC) stage 0/A HCC and treated with SR or ablation between January 2015 and December 2019. The effectiveness and
View details →DOI: 10.1002/cnr2.2030 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Tomoko Hyakumura, Tomoko Hyakumura, Ulises Aregueta-Robles et al. · 2021 · Frontiers in Neuroscience
Active implantable neurological devices like deep brain stimulators have been used over the past few decades to treat movement disorders such as those in people with Parkinson’s disease and more recently, in psychiatric conditions like obsessive compulsive disorder. Electrode-tissue interfaces that support safe and effective targeting of specific brain regions are critical to success of these devices. Development of directional electrodes that activate smaller volumes of brain tissue requires electrodes to operate safely with higher charge densities. Coatings such as conductive hydrogels (CHs)
View details →DOI: 10.3389/fnins.2021.761525 Negative / Null Result ReportOpen accessSports medicine
JL Ayers, M DeBeliso, TG Sevene et al. · 2016 · Biology of Sport
Olympic weightlifting movements and their variations are believed to be among the most effective ways to improve power, strength, and speed in athletes. This study investigated the effects of two Olympic weightlifting variations (hang cleans and hang snatches), on power (vertical jump height), strength (1RM back squat), and speed (40-yard sprint) in female collegiate athletes. 23 NCAA Division I female athletes were randomly assigned to either a hang clean group or hang snatch group. Athletes participated in two workout sessions a week for six weeks, performing either hang cleans or hang snatc
View details →DOI: 10.5604/20831862.1201814 Negative / Null Result ReportOpen accessPsychology
sara hasani, abolghasem mehrinezhad, Roshanak khodabakhsh pirkalani · 2020 · مجله علوم روانشناختی
Background: Obsessive-compulsive disorder is one of the most common and disabling psychological disorders. Many studies have investigated the effectiveness of mindfulness and exposure on the improvement of obsessive-compulsive disorder, but the key question is which of the two combinations of exposure, mindfulness, and mindfulness of exposure is most effective on obsessive-compulsive disorder in women? Aims: To compare the effects of exposure, mindfulness and mindfulness-exposure consciousness on combined obsessive-compulsive disorder in Arak women. Method: This was a quasi-experimental study
Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology
Shingo Hatakeyama, Hayato Yamamoto, Akiko Okamoto et al. · 2012 · International Journal of Nephrology
The oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis. We evaluated the effect of AST-120 on dialysis initiation and its potential to improve survival in patients with chronic kidney disease. The present retrospective pair-matched study included 560 patients, grouped according to whether or not they received AST-120 before dialysis (AST-120 and non-AST-120 groups). The cumulative dialysis initiation free rate and survival rate were compared by the Kaplan-Meier method. Multivariate analysis was used to determine the impact of AST-
View details →DOI: 10.1155/2012/376128 Negative / Null Result ReportOpen accessMedicine
Pius Pum Tseuguem, Télesphore Benoît Nguelefack, Elvine Pami Nguelefack-Mbuyo et al. · 2026 · Scientific Reports
Abstract Extracts of Paullinia pinnata have demonstrated therapeutic effects in monosodium urate (MSU)-induced gout in rats, notably by reducing inflammation and hyperalgesia, as well as enhancing antioxidant activity in vivo. However, their in vitro antioxidant potential and their effects on MSU-stimulated macrophages remain insufficiently explored. This study aims to investigate the in vitro antioxidant properties of P. pinnata, with a particular focus on MSU uptake in stimulated macrophages. The in vitro antioxidant activities of aqueous (AEPP) and methanolic (MEPP) extracts of P. pinnata l
View details →DOI: 10.1038/s41598-026-48124-y Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Fabian Timm, Esther Kuehn, Esther Kuehn et al. · 2020 · Frontiers in Human Neuroscience
Repetitive sensory stimulation of the fingertip induces Hebbian plasticity in the sensorimotor cortex that benefits the tactile and motor behavior of the hand in healthy younger adults, older adults, and patients. To use this method outside the laboratory, robust and portable stimulation systems are needed that allow prolonged stimulation phases over several hours without compromising on signal intensity or personal mobility. Here, we introduce two stimulation gloves that apply finger- and frequency-specific mechanical stimulation to individual fingertips over prolonged periods. The stimulator
View details →DOI: 10.3389/fnhum.2020.00177 Negative / Null Result ReportOpen accessPsychology
Weiping Yang, Weiping Yang, Ao Guo et al. · 2018 · Frontiers in Psychology
In older adults, cognitive abilities, such as those associated with vision and hearing, generally decrease with age. According to several studies, audio-visual perceptual training can improve perceived competence regarding visual and auditory stimuli, suggesting that perceptual training is effective and beneficial. However, whether audio-visual perceptual training can induce far-transfer effects in other forms of untrained cognitive processing that are not directly trained in older adults remains unclear. In this study, the classic P300 component, a neurophysiological indicator of cognitive pr
View details →DOI: 10.3389/fpsyg.2018.02537 Negative / Null Result Report
S. Saini, Sarita Pandey, Kanika · 2026 · Journal of Clinical and Diagnostic Research
Introduction: Rehabilitation plays a vital role in managing Parkinson’s Disease (PD), particularly in addressing both motor and cognitive impairments. Dual Task Training (DTT) improves motor symptoms and cognitive performance, while…
View details →DOI: 10.7860/jcdr/2026/89283.23743 Failed Experiment ReportOpen accessHistory of scholarship and learning. The humanities
Md. Karimul Islam, Nishad Nasrin, Jannatul Naim et al. · 2023 · Humanities & Social Sciences Communications
Abstract Beggars have largely been leading miserable lives in the lower stratum of society since time immemorial. Government or private-led policies are rarely undertaken to improve the lives of this unfortunate societal segment. The local governments in divisional cities of Bangladesh have adopted a series of interventions aimed at improving the socioeconomic wellbeing of beggars and equipping them with alternative livelihood management options. We evaluated the effectiveness of this intervention (the rehabilitation of beggars) in the Khulna City Corporation (KCC) area, Bangladesh; we gathere
View details →DOI: 10.1057/s41599-023-02196-7 Negative / Null Result ReportOpen accessOrthopedic surgery
Neal Singleton, Vaughan Poutawera · 2017 · Journal of Orthopaedic Surgery
Aim: It has been reported in the literature that patients with poor preoperative mental health are more likely to have worse functional outcomes following primary total hip and knee arthroplasty. We could find no studies investigating whether preoperative mental health also affects length of hospital stay following surgery. The aim of this study was to determine whether preoperative mental health affects length of hospital stay and long-term functional outcomes following primary total hip and knee arthroplasty. We also aimed to determine whether mental health scores improve after arthroplasty
View details →DOI: 10.1177/2309499017718902 Negative / Null Result ReportOpen accessMedicine
A. Elgebaly · 2018 · Anesthesiology Research and Practice
Aim The aim of the study was to assess the nitroglycerin patch as a new additive to Bier's block and its impact on the effects and dose of lidocaine. Methods Forty patients of each sex belonging to ASA I or II underwent elective tendon…
View details →DOI: 10.1155/2018/9674731 Negative / Null Result ReportMedicine
Danyuan Xu, K. Lai, Jia-xing Xie et al. · 2011 · European Respiratory Journal
Background: Eosinophilic bronchitis (EB) is a common cause of chronic cough. Inhaled corticosteroids can improve sputum eosinophilia and cough severity. However, the treatment course with inhaled corticosteroids for EB is unkown.…
View details →DOI: 10.1183/13993003/erj.38.suppl_55.p483 Negative / Null Result ReportOpen accessMedicine
D. Bonilla, R. Kreider, J. Petro et al. · 2021 · Nutrients
Creatine monohydrate (CrM) supplementation has been shown to improve body composition and muscle strength when combined with resistance training (RT); however, no study has evaluated the combination of this nutritional strategy with…
View details →DOI: 10.3390/nu13072303 Negative / Null Result Report
Carolyn M Moffa, William Weintraub, Rocco A DeMaio et al. · 2011 · Circulation: Cardiovascular Quality and Outcomes
Background: The burden of acute heart failure (HF) remains formidable. Length of stay (LOS) must be minimized to control costs, while still maintaining positive outcomes. Inappropriate diagnoses and the lack of coordinated care remain…
View details →DOI: 10.1161/circoutcomes.4.suppl_1.ap142 Negative / Null Result Report
V. Yu. Petrov, I. N. Lavrentyeva, V. V. Vdovin et al. · 2024 · Pediatric Hematology/Oncology and Immunopathology
Hemophilia A presents a serious problem, especially in its severe and inhibitor forms, leading to severe bleeding and complications. The importance of studying the effectiveness and safety of new treatment approaches, particularly…
View details →DOI: 10.24287/1726-1708-2024-23-1-99-107 Negative / Null Result Report
Henry Lam · 2025 · Management Science
When the underlying probability distribution in a stochastic optimization is observed only through data, various data-driven formulations have been studied to obtain approximate optimal solutions. We show that no such formulations can, in…
View details →DOI: 10.1287/mnsc.2024.04482 Negative / Null Result Report
Katie Smithers · 2020 · Veterinary Evidence
PICO question In cats with traumatic coxofemoral injury, does total hip replacement (THR) offer improved outcome when compared with femoral head and neck excision (FHNE) arthroplasty? Clinical bottom line Category of research question…
View details →DOI: 10.18849/ve.v5i4.347 Negative / Null Result Report
David Mills · 2017 · Veterinary Evidence
Therapy and prognosis are entailed by the diagnosis: the holistic success of the EBVM approach therefore firmly and critically rests on diagnostic accuracy.Unfortunately, medical professionals do not appear to be very accurate with…
View details →DOI: 10.18849/ve.v2i3.147 Negative / Null Result Report
Pachara Pearodwong, Nithitad Jiebna, Padet Tummaruk · 2024 · The Thai Journal of Veterinary Medicine
This study examined the impact of intramuscular administration of tolfenamic acid 10 min before artificial insemination (AI) on serum PGF2α levels and reproductive performance in gilts and sows. In Experiment I, 20 gilts were divided into…
View details →DOI: 10.56808/2985-1130.3755 Negative / Null Result Report
Claire M. Douglas, Marnie Newell, Susan Goruk et al. · 2025 · PLOS One
Supplementation of omega-3 (n-3) polyunsaturated fatty acids has been associated with reduced side effects and improved quality of life (QoL) in breast cancer patients receiving chemotherapy. The current study reports secondary outcomes…
View details →DOI: 10.1371/journal.pone.0322178 Negative / Null Result ReportOpen accessPhysics
Ulrich H. E. Hansmann · 1997 · arXiv
We discuss the use of Tsallis generalized mechanics in simulated annealing algorithms. For a small peptide it is shown that older implementations are not more effective than regular simulated annealing in finding ground state configurations. We propose a new implementation which leads to an improvement over regular simulated annealing.
Negative / Null Result Report
Anika Jantzen, Miriam Opoku-Pare, Katharina Ruf et al. · 2014 · European Respiratory Journal
Introduction: Exercise and habitual physical activity are important components in the care of patients with cystic fibrosis (CF). Regular exercise and physical activity improve physical fitness, exercise tolerance, quality of life and…
View details →DOI: 10.1183/13993003/erj.44.suppl_58.p1971 Negative / Null Result ReportOpen accessMathematics
Yoav Zeevi, Sofi Astashenko, Liad Mudrik et al. · 2020 · arXiv
The field of psychological sciences has been grappling with the replicability crisis. Various issues have been identified as potential sources of this problem. We bring to light a potential source that has largely been overlooked and demonstrate its significant contribution to the problem: the practice of multiple comparisons. We analyzed 88 papers from the Reproducibility Project in Psychology and found that multiple results are commonly reported in a single paper, ranging from 4 to 730 (M=77.7), without multiple comparison adjustments. We retroactively applied such an adjustment using a hier
Negative / Null Result Report
Duaa S. Alwan · 2023 · E3S Web of Conferences
Early fatigue and rutting are among the most common types of road damage due to their main relationship with pavement performance. These damages occur due to excessive loads on the axles of the vehicles or improper design of the mixture in…
View details →DOI: 10.1051/e3sconf/202342703041 Negative / Null Result ReportOpen accessComputer Science
Shintaro Sakai, Jisun An, Migyeong Kang et al. · 2025 · arXiv
Prior clinical psychology research shows that Western individuals with depression tend to report psychological symptoms, while Eastern individuals report somatic ones. We test whether Large Language Models (LLMs), which are increasingly used in mental health, reproduce these cultural patterns by prompting them with Western or Eastern personas. Results show that LLMs largely fail to replicate the patterns when prompted in English, though prompting in major Eastern languages (i.e., Chinese, Japanese, and Hindi) improves alignment in several configurations. Our analysis pinpoints two key reasons
Failed Experiment ReportOpen accessComputer Science
Tilman Plehn, Michael Spannowsky, Michihisa Takeuchi · 2011 · arXiv
In time for the first tests on LHC data we introduce a set of improvements and tests of purely kinematic top tagging algorithms. First, we show how different jet algorithms can be used for different transverse momentum regimes. Combining pruning and filtering in the reconstruction can enhance the signal over background ratio significantly, while larger jet radii only give minor improvements. Finally, bottom tagging can be added to the top tagger, but at least for the HEPTopTagger does not improve the kinematic selection algorithm.
Negative / Null Result ReportOpen accessComputer Science
Jiarui Xie, Mutahar Safdar, Andrei Mircea et al. · 2024 · arXiv
Machine learning (ML)-based cyber-physical systems (CPSs) have been extensively developed to improve the print quality of additive manufacturing (AM). However, the reproducibility of these systems, as presented in published research, has not been thoroughly investigated due to a lack of formal evaluation methods. Reproducibility, a critical component of trustworthy artificial intelligence, is achieved when an independent team can replicate the findings or artifacts of a study using a different experimental setup and achieve comparable performance. In many publications, critical information nec
Negative / Null Result ReportOpen accessComputer Science
Emily L. Aiken, Andre T. Nguyen, Mauricio Santillana · 2019 · arXiv
We introduce the use of a Gated Recurrent Unit (GRU) for influenza prediction at the state- and city-level in the US, and experiment with the inclusion of real-time flu-related Internet search data. We find that a GRU has lower prediction error than current state-of-the-art methods for data-driven influenza prediction at time horizons of over two weeks. In contrast with other machine learning approaches, the inclusion of real-time Internet search data does not improve GRU predictions.
Negative / Null Result ReportOpen accessPhysics
Dominic Anstey, Eloy de Lera Acedo, Will Handley · 2022 · arXiv
Global 21cm cosmology aims to investigate the cosmic dawn and epoch of reionisation by measuring the sky averaged HI absorption signal, which requires, accurate modelling of, or correction for, the bright radio foregrounds and distortions arising from chromaticity of the antenna beam. We investigate the effect of improving foreground modelling by fitting data sets from many observation times simultaneously in a single Bayesian analysis, fitting for the same parameter set by performing these fits on simulated data. We find that for a hexagonal dipole antenna, this simultaneous fitting produces
