Negative / Null Result ReportOpen accessMedicine
Elisa Alonso‐Perez, Marian Suarez-Gestal, Manuel Calaza et al. · 2014 · Arthritis Research & Therapy
INTRODUCTION: We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was interpreted as indicating that men require more genetic susceptibility than women to develop SLE. METHODS: Nineteen SLE-associated loci (thirteen of which are shared with the previous study) were analyzed in 1,457 SLE patients and 1,728 healthy controls of European ancestry. Genetic risk load was calculated as sex-specific sum genetic risk scores (GRS(s)). RESULTS: Our results did not r
View details →DOI: 10.1186/ar4585Cited by 15 Negative / Null Result ReportMedicine
Cezar H. Lorenzi, Douglas Teixeira Leffa, Rodrigo A. Bressan et al. · 2022 · Journal of Child Psychology and Psychiatry
BACKGROUND: Very few predictive models in Psychiatry had their performance validated in independent external samples. A previously developed multivariable demographic model for attention-deficit/hyperactivity disorder (ADHD) accurately…
View details →DOI: 10.1111/jcpp.13682Cited by 15 Negative / Null Result ReportAgricultural and Biological Sciences
Patrick R.J. Fortuna, Helle Bielefeldt‐Ohmann, Dmitry A. Ovchinnikov et al. · 2018 · Stem Cells and Development
Horses are susceptible to a number of neurotropic viruses, including West Nile virus (WNV), which is a pathogen of global significance in both horses and humans. However, there are no in vitro models with which to study infectious…
View details →DOI: 10.1089/scd.2017.0106Cited by 15 Negative / Null Result ReportOpen accessMedicine
Colleen Lacey, Lisa Ohlhauser, Jodie R. Gawryluk · 2019 · Frontiers in Neurology
Background Clarifying the neuropathology of depression as a symptom of Parkinson's disease (PD) has been the goal of recent neuroimaging studies; however, results have been conflicting and lack replication. The purpose of the current study was to replicate recent methods that have used diffusion tensor imaging (DTI) to compare individuals with PD with and without depression and to extend previous findings to allow for a better understanding of the results. Methods Thirty-seven participants with de novo PD were retrieved from the Parkinson's Progression Marker's Initiative (PPMI) and were separ
View details →DOI: 10.3389/fneur.2019.00884Cited by 15 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Canan Kop Bozbay, Ahmet Akdag, Helin Atan et al. · 2020 · Animal Bioscience
OBJECTIVE: The objectives of this study were to compare the effects of normal and low protein content (PC) of starter diet supplemented or not with blends of branched-chain amino acids (BCAAs) on growth performance of broilers under summer conditions and to investigate whether these effects altered some quality traits and the characteristics of gastrointestinal tract. METHODS: A total of 768 mixed-sex broiler chicks (Ross 308, one-d-old) with an average initial body weight (BW) of 47.6±1.03 g were allocated into six treatments with four replications in 2×3 factorial arrangement. Factors were:
View details →DOI: 10.5713/ajas.19.0828Cited by 15 Negative / Null Result ReportOpen accessImmunology and Microbiology
Cécile Hérate, Clarisse Vigne, Carolin A. Guenzel et al. · 2016 · Retrovirology
BACKGROUND: Through incorporation into virus particles, the HIV-1 Vpr protein participates in the early steps of the virus life cycle by influencing the reverse transcription process. We previously showed that this positive impact on reverse transcription was related to Vpr binding to the uracil DNA glycosylase 2 enzyme (UNG2), leading to enhancement of virus infectivity in established CD4-positive cell lines via a nonenzymatic mechanism. RESULTS: We report here that Vpr can form a trimolecular complex with UNG2 and the p32 subunit (RPA32) of the replication protein A (RPA) complex and we expl
View details →DOI: 10.1186/s12977-016-0257-xCited by 14 Negative / Null Result ReportOpen accessMedicine
Renee W. Y. Chan, Louisa Chan, Chris Ka Pun Mok et al. · 2017 · Scientific Reports
H9N2 viruses are the most widespread influenza viruses in poultry in Asia. We evaluated the infection and tropism of human and avian H9 influenza virus in the human respiratory tract using ex vivo respiratory organ culture. H9 viruses infected the upper and lower respiratory tract and the majority of H9 viruses had a decreased ability to release virus from the bronchus rather than the lung. This may be attributed to a weak neuraminidase (NA) cleavage of carbon-6-linked sialic acid (Sia) rather than carbon-3-linked Sia. The modified cleavage of N-acetlylneuraminic acid (Neu5Ac) and N-glycolylne
View details →DOI: 10.1038/s41598-017-05853-5Cited by 14 Negative / Null Result ReportOpen accessMathematics
Christian Bokhove · 2022 · Educational Research and Evaluation
An article by Kim et al. from 2014 examined individual- and school-level variables affecting the information and communication technology (ICT) literacy level of Korean elementary school students, finding differential gender effects. In…
View details →DOI: 10.1080/13803611.2021.2022319Cited by 13 Negative / Null Result ReportOpen accessMedicine
Zhe Wang, Xiaoli Xie, Jinglu Zhao et al. · 2018 · Bioscience Reports
Biliary atresia (BA) is a multifactorial pathogenic disease with possible genetic components. As a member of membrane skeletal proteins in the liver and bile ducts, a haplotype composed by five single nucleotide polymorphisms (SNPs) on adducin 3 (ADD3) has been identified as associated with BA. However, limited study was designed to further elaborate the mutual relationship amongst those replicated SNPs to disease. We selected three susceptibility SNPs in ADD3 and conducted a replication study using 510 BA cases and 1473 controls to evaluate the individual function of the SNPs and further stra
View details →DOI: 10.1042/bsr20171688Cited by 13 Negative / Null Result ReportOpen accessMedicine
Fabiana Dalla Vecchia Genvigir, Álvaro Cerda, Thiago Dominguez Crespo Hirata et al. · 2020 · Journal of Translational Genetics and Genomics
Mycophenolic acid (MPA) is a potent antiproliferative drug prescribed to prevent acute rejection in kidney transplantation. MPA reversibly inhibits the enzymes involved in the synthesis of guanosine nucleotides, thus preventing DNA replication of immune cells. Consequently, the repression of both cell and humoral immunity induces renal allograft tolerance. MPA is an effective and safe immunosuppressive drug, but some patients show variability in drug concentration, acute rejection, graft dysfunction, or MPA-related adverse events. Although the pharmacogenomics of immunosuppressive drugs has be
View details →DOI: 10.20517/jtgg.2020.37Cited by 13 Negative / Null Result ReportOpen accessImmunology and Microbiology
Alex B. Kleinpeter, Donna L. Mallery, Nadine Renner et al. · 2024 · Nature Communications
The HIV-1 capsid is composed of capsid (CA) protein hexamers and pentamers (capsomers) that contain a central pore hypothesised to regulate capsid assembly and facilitate nucleotide import early during post-infection. These pore functions are mediated by two positively charged rings created by CA Arg-18 (R18) and Lys-25 (K25). Here we describe the forced evolution of viruses containing mutations in R18 and K25. Whilst R18 mutants fail to replicate, K25A viruses acquire compensating mutations that restore nearly wild-type replication fitness. These compensating mutations, which rescue reverse t
View details →DOI: 10.1038/s41467-024-51971-wCited by 13 Negative / Null Result ReportSocial Sciences
Branden B. Johnson, Marcus Mayorga · 2020 · Human and Ecological Risk Assessment An International Journal
Cross-sectional surveys, despite their value, are unable to probe dynamics of risk perceptions over time. An earlier longitudinal panel study of Americans’ views on Ebola risk inspired this partial replication on Americans’ views of Zika…
View details →DOI: 10.1080/10807039.2020.1820852Cited by 13 Negative / Null Result ReportOpen accessNeuroscience
Alice Mason, Casimir J. H. Ludwig, Simon Farrell · 2016 · Quarterly Journal of Experimental Psychology
Reward is thought to enhance episodic memory formation via dopaminergic consolidation. Bunzeck, Dayan, Dolan, and Duzel [(2010). A common mechanism for adaptive scaling of reward and novelty. Human Brain Mapping, 31, 1380-1394] provided functional magnetic resonance imaging (fMRI) and behavioural evidence that reward and episodic memory systems are sensitive to the contextual value of a reward-whether it is relatively higher or lower-as opposed to absolute value or prediction error. We carried out a direct replication of their behavioural study and did not replicate their finding that memory p
View details →DOI: 10.1080/17470218.2016.1233439Cited by 12 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Rajrani Ruhel, Mohit Mazumder, Prabu Gnanasekaran et al. · 2021 · FEBS Journal
Geminivirus replication initiator protein (Rep) is a multifunctional viral protein required for replication. During the process of viral replication, Rep acts as a site- and strand-specific endonuclease, ligase, ATPase, and helicase. B'…
View details →DOI: 10.1111/febs.16053Cited by 12 Negative / Null Result ReportOpen accessMedicine
Maija K. Pietilä, Irina C. Albulescu, Martijn J. van Hemert et al. · 2017 · Viruses
Semliki Forest virus (SFV) is an arthropod-borne alphavirus that induces membrane invaginations (spherules) in host cells. These harbor the viral replication complexes (RC) that synthesize viral RNA. Alphaviruses have four replicase or nonstructural proteins (nsPs), nsP1-4, expressed as polyprotein P1234. An early RC, which synthesizes minus-strand RNA, is formed by the polyprotein P123 and the polymerase nsP4. Further proteolytic cleavage results in a late RC consisting of nsP1-4 and synthesizing plus strands. Here, we show that only the late RCs are highly active in RNA synthesis in vitro. F
View details →DOI: 10.3390/v9100292Cited by 12 Negative / Null Result ReportOpen accessSocial Sciences
Amy Nivette, Christof Nägel, Emily Gilbert · 2023 · Police Practice and Research
High-profile incidents of police misconduct can have serious consequences for public trust in the police. A recent study in the British Journal of Political Science found that Eric Garner’s death in NYC lead to more negative attitudes towards the police in London among Black residents compared to White and Asian residents. The current study aimed to replicate this transnational effect by assessing the impact of George Floyd’s death on Londoners’ perceptions of police. Using the same data and methodological approach, we did not replicate the immediate effect on Black Londoners’ attitudes. We di
View details →DOI: 10.1080/15614263.2023.2185241Cited by 11 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Abiriga Francis, O. Ongom Patrick, Rubaihayo Patrick et al. · 2020 · Journal of Plant Breeding and Crop Science
This study was conducted to determine the yield stability of advanced cowpea lines in diverse agro-ecological zones of Uganda in order to facilitate documentation requirements for national performance trials (NPT). Thirty cowpea genotypes were evaluated against six checks in three localities, over three growing seasons, making a total of 9 unique environments. The trials were laid in a 6x6 alpha lattice design with three replications and grain yield was the principal trait measured. Single-site and multi-location data were summarized using analysis of variance. Further analysis of stability wa
View details →DOI: 10.5897/jpbcs2020.0891Cited by 11 Negative / Null Result ReportOpen accessImmunology and Microbiology
Natalia Ristic, Mario P. S. Chin · 2010 · Retrovirology
BACKGROUND: The viral genome of HIV-1 contains several secondary structures that are important for regulating viral replication. The stem-loop 1 (SL1) sequence in the 5' untranslated region directs HIV-1 genomic RNA dimerization and packaging into the virion. Without SL1, HIV-1 cannot replicate in human T cell lines. The replication restriction phenotype in the SL1 deletion mutant appears to be multifactorial, with defects in viral RNA dimerization and packaging in producer cells as well as in reverse transcription of the viral RNA in infected cells. In this study, we sought to characterize SL
View details →DOI: 10.1186/1742-4690-7-73Cited by 11 Negative / Null Result ReportOpen accessNeuroscience
Sera Wiechert, Leonie Hannah Shoshana Loewy, Ineke Wessel et al. · 2023 · Memory
Post-traumatic stress disorder is characterised by recurring memories of a traumatic experience despite deliberate attempts to forget (i.e., suppression). The Think/No-Think (TNT) task has been used widely in the laboratory to study…
View details →DOI: 10.1080/09658211.2023.2208791Cited by 11 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Shaoyuan Tan, Weixin Wu, Xinna Ge et al. · 2023 · One Health Advances
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen for the global pork industry. Although modified live virus (MLV) vaccines are commonly used for PRRSV prevention and control, they still carry a risk of infecting the host and replicating in target cells, thereby increasing the likehood of virus recombination and reversion to virulence. In this study, we inserted the target sequence of miR-142 into the nsp2 hypervariable region of PRRSV to inhibit viral replication in its host cells of pigs, with the aim of achieving virus attenuation. The chimeri
View details →DOI: 10.1186/s44280-023-00002-2Cited by 10 Negative / Null Result ReportOpen accessMedicine
Marwah Karim, Manjari Mishra, Chieh‐Wen Lo et al. · 2025 · Nature Communications
In search for broad-spectrum antivirals, we discover a small molecule inhibitor, RMC-113, that potently suppresses the replication of multiple RNA viruses including SARS-CoV-2 in human lung organoids. We demonstrate selective inhibition of…
View details →DOI: 10.1038/s41467-025-61759-1Cited by 10 Negative / Null Result ReportOpen accessNeuroscience
Christopher J. Wertz, Faith M Hanlon, Nicholas A. Shaff et al. · 2018 · Schizophrenia Bulletin
Inhibitory failure represents a core dysfunction in patients with schizophrenia (SP), which has predominantly been tested in the literature using reactive (ie, altering behavior after a stimulus) rather than proactive (ie, purposefully…
View details →DOI: 10.1093/schbul/sby086Cited by 10 Negative / Null Result ReportOpen accessPsychology
Kaylin Ratner, Anthony L. Burrow, Felix Thoemmes · 2016 · Royal Society Open Science
Having a sense of meaning in life (MIL) has been acknowledged as a catalyst to psychological flourishing. As such, understanding ways to promote MIL represents a worthy goal for those interested in bolstering positive outcomes. This study sought to replicate the findings of Heintzelman, Trent & King (2013 Psychol. Sci. 24 , 991–998 ( doi:10.1177/0956797612465878 )), who found that MIL could be influenced by external stimulation. Their findings suggest that exposure to coherent stimuli produces significantly higher MIL scores than exposure to incoherent stimuli. Using materials and methodol
View details →DOI: 10.1098/rsos.160431Cited by 10 Negative / Null Result ReportOpen accessDecision Sciences
John Protzko, Jonathan W. Schooler · 2020 · PeerJ
What explanation is there when teams of researchers are unable to successfully replicate already established ‘canonical’ findings? One suggestion that has been put forward, but left largely untested, is that those researchers who fail to replicate prior studies are of low ‘expertise and diligence’ and lack the skill necessary to successfully replicate the conditions of the original experiment. Here we examine the replication success of 100 scientists of differing ‘expertise and diligence’ who attempted to replicate five different studies. Using a bibliometric tool ( h -index) as our indicator
View details →DOI: 10.7717/peerj.8014Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jennifer Zou, Jinjing Zhou, Sarah Faller et al. · 2022 · G3 Genes Genomes Genetics
Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex human traits, but only a fraction of variants identified in discovery studies achieve significance in replication studies. Replication in genome-wide association studies has been well-studied in the context of Winner's Curse, which is the inflation of effect size estimates for significant variants due to statistical chance. However, Winner's Curse is often not sufficient to explain lack of replication. Another reason why studies fail to replicate is that there are fundamental difference
View details →DOI: 10.1093/g3journal/jkac261Cited by 10 Negative / Null Result ReportOpen accessSocial Sciences
Lewend Mayiwar, Linda Lai · 2019 · Social Psychology
Abstract. We performed an independent, direct, and better powered ( N = 295) replication of Study 1, an experiment ( N = 113) by Lammers, Stoker, and Stapel (2009) . Lammers and colleagues distinguished between social power (influence over…
View details →DOI: 10.1027/1864-9335/a000388Cited by 9 Negative / Null Result ReportOpen accessMedicine
Shailesh D. Pawar, Sadhana S. Kode, Sachin S. Keng et al. · 2022 · The Indian Journal of Medical Research
Background & objectives Polio, measles, rubella, influenza and rotavirus surveillance programmes are of great public health importance globally. Virus isolation using cell culture is an integral part of such programmes. Possibility of…
View details →DOI: 10.4103/ijmr.ijmr_1448_21Cited by 9 Negative / Null Result ReportOpen accessMedicine
Pooja Advani, Kathryn J. Ruddy, Joerg Herrmann et al. · 2023 · Frontiers in Oncology
Background The cardiotoxic effects of doxorubicin, trastuzumab, and other anticancer agents are well known, but molecular genetic testing is lacking for the early identification of patients at risk for therapy-related cardiac toxicity. Methods Using the Agena Bioscience MassARRAY system, we genotyped TRPC6 rs77679196, BRINP1 rs62568637, LDB2 rs55756123, RAB22A rs707557, intergenic rs4305714, LINC01060 rs7698718, and CBR3 rs1056892 (V244M) (previously associated with either doxorubicin or trastuzumab-related cardiotoxicity in the NCCTG N9831 trial of anthracycline-based chemotherapy ± trastuzum
View details →DOI: 10.3389/fonc.2023.1139347Cited by 9 Negative / Null Result ReportOpen accessPsychology
Andreea Geambașu, Sybren Spit, Daan van Renswoude et al. · 2022 · Developmental Science
We conducted a close replication of the seminal work by Marcus and colleagues from 1999, which showed that after a brief auditory exposure phase, 7-month-old infants were able to learn and generalize a rule to novel syllables not previously present in the exposure phase. This work became the foundation for the theoretical framework by which we assume that infants are able to learn abstract representations and generalize linguistic rules. While some extensions on the original work have shown evidence of rule learning, the outcomes are mixed, and an exact replication of Marcus et al.'s study has
View details →DOI: 10.1111/desc.13244Cited by 9 Negative / Null Result ReportPsychology
Kory Floyd, Nathan T. Woo · 2020 · Personal Relationships
Abstract Contrary to the claim that loneliness routinely impairs the decoding of social cues such as emotion displays, Knowles, Lucas, Baumeister, and Gardner (2015) proposed that lonely adults “choke under pressure,” experiencing…
View details →DOI: 10.1111/pere.12304Cited by 9 