A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
1934 results for "Mpro" · page 37 of 65
Chen W, Zhang C, Guo W et al. · 2026 · Journal of experimental botany
Apple is an important economic species, but it suffers from biotic stress during its growth and development. Fungi and pests are two types of biotic stress that have significant destructive effects on apple. Members of the leucine-rich…
Selimović-Pašić A, Haglund L, Bensberg M et al. · 2026 · Preprint
The BCL-2 inhibitor venetoclax (VEN) in combination with hypomethylating agents (HMAs) has improved treatment responses in acute myeloid leukaemia (AML), but the mechanisms underlying their synergy remain unclear. We investigated the role…
Gama de Matos D, de Santana JL, Aidar FJ et al. · 2025 · Preprint
Background: Frailty is a multifactorial condition that significantly impacts older adults health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…
Lima LC, Caetano D, Pinto L et al. · 2026 · Preprint
Abstract The global burden of bone fractures is projected to double by 2050, and this trend is driven by an aging population, higher incidence of car accidents, cancer-related bone damage, and osteoporosis, which compromises bone…
Oncul S, Lee H, Singh S et al. · 2026 · Journal of immunology (Baltimore, Md. : 1950)
B cells constitute ∼15% to 20% of tumor-infiltrating lymphocytes in melanoma. Their presence in the tumor microenvironment correlates with improved survival and enhanced response to immune checkpoint blockade therapy. Yet, the functional…
Riesenbach IC, Tsomik G, Chiasson M et al. · 2026 · Aquaculture.
Insects, such as black soldier flies (BSF), have garnered attention in the aquaculture industry as a sustainable protein and lipid alternative to fishmeal and fish oil. However, research is lacking on which components of BSF improve fish…
Lagravinese G, Castellana G, Genco M et al. · 2026 · Applied psychophysiology and biofeedback
Chronic obstructive pulmonary disease (COPD) is associated with persistent dyspnea, reduced functional capacity, and significant cognitive and affective impairments. Pulmonary rehabilitation improves the physical and psychological…
Nilsson M, Berrebi J, Nikkhou-Aski S et al. · 2025 · Preprint
BackgroundThe hippocampus is crucial for learning, memory, and stress regulation but is vulnerable to biological and environmental influences that compromise its structural and metabolic integrity. Proton magnetic resonance spectroscopy…
Karademir G, Durbas A, Diril SK et al. · 2025 · Preprint
Abstract Background Superior capsular reconstruction (SCR) is a treatment option for irreparable rotator cuff tears (IRCTs), but graft failure remains a significant limitation. While fascia (FA) grafts are commonly utilized, their…
Broll A, Goldhacker M, Hahnel S et al. · 2025 · Journal of dentistry
Objectives This retrospective in vitro study evaluated the impact of input data quantity on the morphology of dental crowns generated by AI-based software. The hypothesis suggests that increased input data quantity improves the quality of…
Toshida K, Sugitani Y, Itoh S et al. · 2025 · Preprint
Abstract Background: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide. While systemic therapies have improved outcomes, predicting tumor histopathology remains difficult. Machine learning (ML) offers a…
Chen W, Zhang C, Guo W et al. · 2025 · Preprint
Apple is an important economic species, and it always suffered by biotic stress during its growth and development. Fungi and pests are two types of biotic stress that have significant destructive effects on apples. Besides, the LRR-RLKs…
Zhang X, Li F, Li J et al. · 2025 · Preprint
Introduction Supervised physical activity (PA) interventions have demonstrated efficacy and safety in improving health outcomes among frail populations. However, the growing disparity between limited healthcare resources and the rapidly…
Lagravinese G, Castellana G, Genco M et al. · 2025 · Preprint
Abstract Background: Chronic obstructive pulmonary disease (COPD) is associated with persistent dyspnea, reduced functional capacity, and significant cognitive and affective impairments. Pulmonary rehabilitation improves the physical and…
Pulliainen H, Kataja E, Löyttyniemi E et al. · 2025 · Preprint
Abstract Background We examined whether an interactive four-dimensional (4D) ultrasound intervention decreases prenatal and early postnatal depressive symptoms and improves maternal-fetal attachment. Methods This randomized controlled…
Gill P, Tao X, Zhan Y et al. · 2026 · American journal of obstetrics and gynecology
Background Preimplantation genetic testing for aneuploidy is used to improve in vitro fertilization outcomes by identifying embryos with lethal chromosomal abnormalities that impair development or lead to pregnancy loss. The adoption of…
Barwood M, Barwood H, Davis D et al. · 2025 · International journal of sports physiology and performance
Purpose Topical menthol application improves thermal perception and enhances performance but reduces sweat production in hot environments. In the aquatic environment, where sweat evaporation is of limited thermoregulatory benefit (ie,…
Birene B, Ferreira A, Raimond E et al. · 2025 · Journal of perinatal medicine
Objectives Large-for-gestational-age (LGA) fetuses present significant maternal and neonatal risks. However, prenatal screening is prone to inaccuracies, leading to potentially unnecessary interventions. This study aims to evaluate the…
Tsai PS, Wu KC, Wu CH · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Osteoarthritis (OA) is a degenerative and deteriorating disease. The accompanying pain, stiffness, inflammation of the synovial joint, and the loss of articular function compromise the mobility, stability, and routine of patients' lives.…
Alstrup T, Pedersen JO, Kjær EM et al. · 2025 · Plastic and reconstructive surgery
Background Fat grafting is a gentle technique used to correct soft-tissue defects, but it is challenged by low graft survival rates. To enhance retention, mesenchymal stromal cells (MSCs) have been explored. Autologous MSC therapy has…
Schmitt O, Knecht C, Sobczak B et al. · 2025 · Neuroimmunomodulation
Introduction Little is known about the effects of a positive human-animal relationship on animal health and resilience. This study investigated the effects of regular positive human-animal interactions on pigs' response to an immune…
López-Samanes Á, Moreno-Pérez D, Aguilar-Navarro M et al. · 2026 · Journal of the International Society of Sports Nutrition
Introduction The aim of this study was to evaluate the acute effect of beetroot juice ingestion on sprint performance and neuromuscular properties of male trained sprinters. Methods Twelve male sprinters (24.3 ± 4.8 years) participated in…
Mahieux M, Braga Nan L, Zbair M et al. · 2025 · Waste management (New York, N.Y.)
Carbon-based materials gained attention for their potential to improve anaerobic digestion (AD) performance. Meanwhile, in situ biomethanation, where external H 2 is injected into the AD process to enhance the CH 4 content in biogas, is…
Doğan MB, Gündüz N, Kazan HÖ et al. · 2025 · European journal of radiology
Objective Muscle invasion in bladder cancer is a crucial factor influencing treatment decisions and prognosis. We hypothesize that the integration of tumor shape characteristics with the VI-RADS scoring system improves the predictive…
Wilkening J, Jungeblut HM, Adamovic I et al. · 2025 · Preprint
Intermittent theta burst stimulation (iTBS) is a promising non-invasive treatment for major depressive disorder (MDD), though significant variability exists in patient responses. This quadruple-blind, sham-controlled crossover randomized…
Litman M, Azarpeykan S, Hood RJ et al. · 2025 · Preprint
In patients with ischaemic stroke, retrograde perfusion of the penumbra by the leptomeningeal collateral vessels (LMCs) is a strong predictor of clinical outcome, thus raising the possibility that enhancing LMC flow could offer a novel…
Santoro E, Broockman DE, Kalla JL et al. · 2025 · Proceedings of the National Academy of Sciences of the United States of America
Scholars and practitioners widely posit that listening to other people enhances efforts to persuade them. Listening may enhance persuasion by promoting cognitive processing, reducing defensiveness, and improving perceptions of the…
Viriyarattanasak C, Takemura Y, Hashimoto T et al. · 2025 · Journal of the science of food and agriculture
Background Softening of winter-harvested frozen broccoli is a challenge. Application of boron (B) can improve fruit texture, but its effects on processed vegetables remain unexplored. This study is the first to investigate the impact of…
Borgognoni AB, Freund SS, Baas J et al. · 2026 · Frontiers in surgery
Introduction Early osseointegration is essential for the long-term success of uncemented custom-made prostheses, particularly in oncologic bone reconstruction where bone stock is compromised. Strontium (Sr) has demonstrated osteogenic…
Hsu PS, Barnes EH, Barnes M et al. · 2025 · Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Background Sustained unresponsiveness (SU) remains a major challenge for peanut OIT. The short chain fatty acid (SCFA) butyrate has the potential to upregulate regulatory T cells (Tregs) to improve long term tolerance. We conducted a…