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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1898 results for "Mpro" · page 37 of 64

Negative / Null Result ReportOpen accessMedicine

Seven-day supplementation with piceatannol does not improve endothelial function at rest or after exercise: a pilot study.

Kasai N, Hayashi K, Kito M et al. · 2025 · Physical activity and nutrition

Purpose Piceatannol, a polyphenolic compound found in high concentrations in passion fruit, has been reported to exert multiple physiological effects in preclinical studies, including vascular relaxation and increased expression of…

View details →DOI: 10.20463/pan.2025.0034
Negative / Null Result ReportMedicine

Sexual Function in a Randomized Trial of Pelvic Yoga for Urinary Incontinence.

Yang N, Subak LL, Shatkin-Margolis A et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Importance Urinary incontinence (UI) can negatively affect sexual function in women. Although many women with UI seek complementary strategies such as pelvic floor yoga techniques to improve sexual functioning, evidence of their efficacy…

View details →DOI: 10.1097/spv.0000000000001705
Negative / Null Result ReportMedicine

[SMS-based health checkup encouragement evaluation: Focusing on effectiveness in younger age groups].

Naemura N, Fukuda Y · 2026 · [Nihon koshu eisei zasshi] Japanese journal of public health

Objectives Improving the screening rates in specific health checkups and guidance represents a challenge for health insurance providers and local governments nationwide. In this study, we evaluated SMS-based health checkup encouragement…

View details →DOI: 10.11236/jph.25-133
Negative / Null Result ReportMedicine

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double-blind randomized clinical trial in patients with mild to moderate atopic dermatitis.

van der Meulen LWJ, Bergmans ME, Assil S et al. · 2026 · British journal of clinical pharmacology

Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this…

View details →DOI: 10.1002/bcp.70630
Negative / Null Result ReportMedicine

Identifying Candidate Mediators Linking ADHD Symptoms and Internalising Problems in Adolescence: An Exploratory Longitudinal Mediation Analysis.

Murray AL, Dryburgh K, Sonuga-Barke EJS · 2026 · Journal of attention disorders

Objective ADHD and internalising symptoms such as anxiety and depression are known to be associated in adolescence and understanding the mechanisms linking them is important for improving mental health outcomes for adolescents with ADHD…

View details →DOI: 10.1177/10870547261419589
Negative / Null Result ReportMedicine

How changes to frequency of treatment and mode of treatment improved paediatric speech-language pathology services: A pragmatic clinical trial.

Van Epps VM, Daur-Schierholz M, Dortenzio M et al. · 2026 · International journal of speech-language pathology

Purpose This pragmatic clinical trial examined the functional impact of a modified speech-language pathology intervention delivery model (including telepractice, reduced therapy frequency, and emphasised home programmes with parent…

View details →DOI: 10.1080/17549507.2026.2630835
Negative / Null Result ReportMedicine

Pilot Testing a Narrative Psychoeducational Video to Reduce Stigma and Improve Mental Health Literacy and Help-Seeking Among Latinx Adults: Examining Gender Differences and Contextual Insights.

Saravia DH, Silvan YA, Martinez JI · 2026 · Community mental health journal

Despite similar rates of mental illness, non-Latinx Whites (NLW) received care at higher rates compared to Latinxs (National Institute of Mental Health, 2024). Latinx adults report lower mental health literacy (MHL) and higher stigma…

View details →DOI: 10.1007/s10597-025-01584-4
Negative / Null Result ReportMedicine

Impact of Running Shoe Midsole Properties on Energy Cost of Running: Insights Into Midsole Stiffness and Resilience Properties.

Rodrigo-Carranza V, Alda-Blanco A, Kuzmeski J et al. · 2026 · International journal of sports physiology and performance

Purpose The mechanisms behind improvements in running economy (RE) from shoes with supercritical foams (SCF) compared with a traditional midsole material (ethylene vinyl acetate [EVA]) remain only partially understood. This study aimed to…

View details →DOI: 10.1123/ijspp.2025-0475
Negative / Null Result ReportOpen accessMedicine

Impact of adding a medical intern to the emergency department night shift.

Glass-Biran AH, Eyre A, Stein G et al. · 2026 · BMJ open quality

Objective To evaluate whether adding a fourth physician to the emergency department night shift would improve metrics. Methods This retrospective cohort study used data from the Meir Medical Centre emergency department, 1 January 2021 to…

View details →DOI: 10.1136/bmjoq-2025-003648
Negative / Null Result ReportMedicine

Intraoperative Parathyroid Hormone in Minimally Invasive Parathyroidectomy (MIP) for Primary Hyperparathyroidism With Concordant Localisation.

Chew BMH, Lim SSA, Gan TRX et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Objective There is increasing use of intraoperative parathyroid hormone (ioPTH) in minimally invasive parathyroidectomy (MIP). While ioPTH has improved cure rate, there is little evidence to suggest effectiveness in primary…

View details →DOI: 10.1002/ohn.70218
Negative / Null Result ReportMedicine

Natural versus GnRHa-HRT cycle for FET in tubal infertility with prior failed natural cycles: a propensity score-matched retrospective cohort study.

Li L, Gao S, Zhu H et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Introduction Frozen embryo transfer offers improved cumulative pregnancy rates and reduces complications compared to fresh cycles. Successful outcomes depend on both embryonic potential and endometrial receptivity, necessitating…

View details →DOI: 10.1016/j.ejogrb.2026.115194
Negative / Null Result ReportMedicine

A network-based team situation awareness enhanced training strategy and experimental validation in simulated maritime collaboration.

Min Y, Wanyan X, Liu S et al. · 2025 · Ergonomics

This study proposes a network-based training strategy to improve the team situation awareness (TSA) of crews in complex socio-technical systems. Eighty-four participants were recruited and divided into twenty-one teams to receive different…

View details →DOI: 10.1080/00140139.2025.2538703
Negative / Null Result ReportOpen accessMedicine

Unplanned hospital presentations in oncology patients receiving chemotherapy: a secondary analysis of a randomized controlled trial to explore opportunities for improving supportive care.

Kim B, Boustany C, Fethney J et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Purpose This study aimed to report the incidence, common reasons, and associated risk factors for unplanned hospital presentations during chemotherapy treatment. Methods A secondary analysis using data from a randomized controlled trial…

View details →DOI: 10.1007/s00520-026-10510-7
Negative / Null Result ReportMedicine

4-year overall survival after the introduction of adjuvant therapy for patients with stage III melanoma: A population-based study.

Janssen JC, Schurink AW, Verhoef C et al. · 2026 · European journal of cancer (Oxford, England : 1990)

Background Adjuvant systemic therapy for resected stage III melanoma was introduced in clinical practice following the improved recurrence free survival in randomized controlled trials. However, after ten years of follow-up, adjuvant…

View details →DOI: 10.1016/j.ejca.2025.116202
Negative / Null Result ReportMedicine

Improvements in pharmacokinetics, bleeding control, and cost analysis after PK-guided transition to extended-half-life factor IX in hemophilia B: A multicentric study.

Chovi-Trull M, Megías-Vericat JE, Palanques-Pastor T et al. · 2026 · Thrombosis research

Introduction Extended half-life factor IX concentrates (FIX-EHL) have been shown to improve clinical outcomes and reduce treatment burden in patients with hemophilia B (HB). Objectives To analyze the differences in pharmacokinetic (PK) and…

View details →DOI: 10.1016/j.thromres.2025.109580
Negative / Null Result Report

Pilot Testing a Narrative Psychoeducational Video to Reduce Stigma and Improve Mental Health Literacy and Help-Seeking Among Latinx Adults: Examining Gender Differences and Contextual Insights

Saravia DH, Silvan YA, Martinez JI · 2025 · Preprint

Abstract Despite similar rates of mental illness, non-Latinx Whites received care at higher rates compared to Latinxs (NIMH, 2024). Latinx adults report lower mental health literacy (MHL) and higher stigma compared to NLW, which can…

View details →DOI: 10.21203/rs.3.rs-7444634/v1
Negative / Null Result ReportMedicine

Preoperative Short-Term Nutrition and Exercise Trial Program for Patients with Esophageal Cancer: A Randomized Clinical Trial: Thoracic Oncology.

Kawata S, Hiramatsu Y, Honke J et al. · 2026 · Annals of surgical oncology

Background Esophagectomy confers high postoperative morbidity and mortality. To improve postoperative outcomes, this study investigated the effectiveness of a 2-week prehabilitation program on the preoperative cardiopulmonary function of…

View details →DOI: 10.1245/s10434-025-18804-6
Negative / Null Result ReportMedicine

Alcohol-impregnated port protectors to reduce central line-associated bloodstream infection in the neonatal intensive care unit: a quality improvement study.

Payne V, Hall M, Johnson MJ · 2025 · Archives of disease in childhood. Fetal and neonatal edition

Objective To investigate the effect of alcohol-impregnated port protectors (AIPPs) on neonatal central line-associated bloodstream infection (CLABSI) rates. Design A quality improvement study. Setting A tertiary neonatal unit in the UK.…

View details →DOI: 10.1136/archdischild-2024-327651
Negative / Null Result Report

“Inhaled Nitric Oxide in Neonates with Pulmonary Hypertension in Amazonas, Brazil: Physiological Improvement Versus Impact on Relevant Clinical Outcomes”

Ferreira RD, Faleiros Ferreira CH, Gonçalves-Ferri WA · 2025 · Preprint

Background Inhaled nitric oxide (iNO) is a standard treatment for neonatal pulmonary hypertension in high-resource settings. Yet, its efficacy and cost-effectiveness in low- and middle-income countries (LMICs) remain underexplored. This…

View details →DOI: 10.1101/2025.08.19.25333602
Negative / Null Result ReportMedicine

The telomerase vaccine UV1 combined with ipilimumab and nivolumab versus ipilimumab and nivolumab in advanced melanoma (INITIUM): A randomized open-label phase 2 study.

Lorigan P, Medina TM, Nyakas M et al. · 2026 · European journal of cancer (Oxford, England : 1990)

Purpose Immune checkpoint inhibitor (ICI) combinations have improved outcomes in patients with advanced melanoma; however, long term survival remains poor. The addition of therapeutic cancer vaccines to ICI combinations represents a…

View details →DOI: 10.1016/j.ejca.2025.116162
Negative / Null Result ReportOpen accessMedicine

Improving Diagnostic Quality of Anogenital Photodocumentation in Emergency Department Evaluations for Acute Child Sexual Assault.

Miller ZE, Digirolamo SJ, Molnar J et al. · 2026 · Pediatric quality & safety

Introduction Emergency department evaluations for acute child sexual assault include anogenital photodocumentation as a standard of care, which has implications for accurate clinical care and forensic significance. If photodocumentation…

View details →DOI: 10.1097/pq9.0000000000000876
Negative / Null Result ReportMedicine

Common Divalent Cations Elicit Sublethal Effects of Negatively Charged Nanoplastics on <i>Shewanella oneidensis</i> by Compromising Membrane Protein Functionality.

Zhang S, Jia B, Huang W et al. · 2025 · ACS nano

The toxicity of negatively charged nanoplastics (NNP) to bacteria is generally subtler than that of positively charged counterparts, owing to limited NNP-cell interaction. This study hypothesized that common environmental cations (Na + ,…

View details →DOI: 10.1021/acsnano.5c04610
Negative / Null Result ReportMedicine

Retrospective analysis of early functional and radiological outcomes between robotic, navigated and conventional total knee arthroplasty: A single Surgeon's series.

Leong JWK, Lee BH, Haniball J et al. · 2025 · Journal of clinical orthopaedics and trauma

Background Achieving a neutral mechanical axis alignment (MAA) in Total Knee Arthroplasty (TKA) is associated with increased implant longevity and patient satisfaction, and robot-assisted (robotic) TKA is touted to improve implant…

View details →DOI: 10.1016/j.jcot.2025.103145
Negative / Null Result ReportMedicine

Vilobelimab to improve clinical outcomes in moderate-to-severe hidradenitis suppurativa through an adjunctive effect on draining tunnels: results of the SHINE double-blind placebo-controlled randomized trial.

Giamarellos-Bourboulis EJ, Jemec GBE, Prens EP et al. · 2026 · The British journal of dermatology

Background The results of a previous phase IIa trial suggested efficacy of the anti-C5a compound vilobelimab in a small number of patients with severe hidradenitis suppurativa (HS) refractory to adalimumab treatment. Objectives To study…

View details →DOI: 10.1093/bjd/ljaf398
Negative / Null Result ReportOpen accessMedicine

Does Provider Identity at Triage Improve Machine Learning Prediction of Hospital Admission? A Comparative Analysis of Ten Supervised Classifiers with SHAP Explainability.

Brown AE, Marostica CW, Martini WA · 2026 · Journal of personalized medicine

Background/Objectives: Machine learning (ML) models can predict hospital admission from emergency department (ED) triage data with areas under the receiver operating characteristic curve (AUC) exceeding 0.85. Whether incorporating the…

View details →DOI: 10.3390/jpm16040204