Negative / Null Result ReportMedicine
Lagravinese G, Castellana G, Genco M et al. · 2026 · Applied psychophysiology and biofeedback
Chronic obstructive pulmonary disease (COPD) is associated with persistent dyspnea, reduced functional capacity, and significant cognitive and affective impairments. Pulmonary rehabilitation improves the physical and psychological…
View details →DOI: 10.1007/s10484-025-09763-5 Negative / Null Result Report
Nilsson M, Berrebi J, Nikkhou-Aski S et al. · 2025 · Preprint
BackgroundThe hippocampus is crucial for learning, memory, and stress regulation but is vulnerable to biological and environmental influences that compromise its structural and metabolic integrity. Proton magnetic resonance spectroscopy…
View details →DOI: 10.31234/osf.io/gcmsq_v1 Negative / Null Result Report
Karademir G, Durbas A, Diril SK et al. · 2025 · Preprint
Abstract Background Superior capsular reconstruction (SCR) is a treatment option for irreparable rotator cuff tears (IRCTs), but graft failure remains a significant limitation. While fascia (FA) grafts are commonly utilized, their…
View details →DOI: 10.21203/rs.3.rs-8001106/v1 Negative / Null Result ReportMedicine
Broll A, Goldhacker M, Hahnel S et al. · 2025 · Journal of dentistry
Objectives This retrospective in vitro study evaluated the impact of input data quantity on the morphology of dental crowns generated by AI-based software. The hypothesis suggests that increased input data quantity improves the quality of…
View details →DOI: 10.1016/j.jdent.2025.105767 Negative / Null Result Report
Toshida K, Sugitani Y, Itoh S et al. · 2025 · Preprint
Abstract Background: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide. While systemic therapies have improved outcomes, predicting tumor histopathology remains difficult. Machine learning (ML) offers a…
View details →DOI: 10.21203/rs.3.rs-7704748/v1 Negative / Null Result Report
Chen W, Zhang C, Guo W et al. · 2025 · Preprint
Apple is an important economic species, and it always suffered by biotic stress during its growth and development. Fungi and pests are two types of biotic stress that have significant destructive effects on apples. Besides, the LRR-RLKs…
View details →DOI: 10.22541/au.175022852.28343178/v1 Negative / Null Result Report
Zhang X, Li F, Li J et al. · 2025 · Preprint
Introduction Supervised physical activity (PA) interventions have demonstrated efficacy and safety in improving health outcomes among frail populations. However, the growing disparity between limited healthcare resources and the rapidly…
View details →DOI: 10.1101/2025.06.26.25330386 Negative / Null Result Report
Lagravinese G, Castellana G, Genco M et al. · 2025 · Preprint
Abstract Background: Chronic obstructive pulmonary disease (COPD) is associated with persistent dyspnea, reduced functional capacity, and significant cognitive and affective impairments. Pulmonary rehabilitation improves the physical and…
View details →DOI: 10.21203/rs.3.rs-6974767/v1 Negative / Null Result Report
Pulliainen H, Kataja E, Löyttyniemi E et al. · 2025 · Preprint
Abstract Background We examined whether an interactive four-dimensional (4D) ultrasound intervention decreases prenatal and early postnatal depressive symptoms and improves maternal-fetal attachment. Methods This randomized controlled…
View details →DOI: 10.21203/rs.3.rs-6672112/v1 Negative / Null Result ReportMedicine
Gill P, Tao X, Zhan Y et al. · 2026 · American journal of obstetrics and gynecology
Background Preimplantation genetic testing for aneuploidy is used to improve in vitro fertilization outcomes by identifying embryos with lethal chromosomal abnormalities that impair development or lead to pregnancy loss. The adoption of…
View details →DOI: 10.1016/j.ajog.2025.12.033 Negative / Null Result ReportMedicine
Barwood M, Barwood H, Davis D et al. · 2025 · International journal of sports physiology and performance
Purpose Topical menthol application improves thermal perception and enhances performance but reduces sweat production in hot environments. In the aquatic environment, where sweat evaporation is of limited thermoregulatory benefit (ie,…
View details →DOI: 10.1123/ijspp.2025-0038 Negative / Null Result ReportMedicine
Birene B, Ferreira A, Raimond E et al. · 2025 · Journal of perinatal medicine
Objectives Large-for-gestational-age (LGA) fetuses present significant maternal and neonatal risks. However, prenatal screening is prone to inaccuracies, leading to potentially unnecessary interventions. This study aims to evaluate the…
View details →DOI: 10.1515/jpm-2025-0015 Negative / Null Result ReportMedicine
Tsai PS, Wu KC, Wu CH · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Osteoarthritis (OA) is a degenerative and deteriorating disease. The accompanying pain, stiffness, inflammation of the synovial joint, and the loss of articular function compromise the mobility, stability, and routine of patients' lives.…
View details →DOI: 10.1016/j.biopha.2025.118519 Negative / Null Result ReportMedicine
Alstrup T, Pedersen JO, Kjær EM et al. · 2025 · Plastic and reconstructive surgery
Background Fat grafting is a gentle technique used to correct soft-tissue defects, but it is challenged by low graft survival rates. To enhance retention, mesenchymal stromal cells (MSCs) have been explored. Autologous MSC therapy has…
View details →DOI: 10.1097/prs.0000000000012121 Negative / Null Result ReportMedicine
Schmitt O, Knecht C, Sobczak B et al. · 2025 · Neuroimmunomodulation
Introduction Little is known about the effects of a positive human-animal relationship on animal health and resilience. This study investigated the effects of regular positive human-animal interactions on pigs' response to an immune…
View details →DOI: 10.1159/000544748 Negative / Null Result ReportOpen accessMedicine
López-Samanes Á, Moreno-Pérez D, Aguilar-Navarro M et al. · 2026 · Journal of the International Society of Sports Nutrition
Introduction The aim of this study was to evaluate the acute effect of beetroot juice ingestion on sprint performance and neuromuscular properties of male trained sprinters. Methods Twelve male sprinters (24.3 ± 4.8 years) participated in…
View details →DOI: 10.1080/15502783.2026.2674220 Negative / Null Result ReportMedicine
Mahieux M, Braga Nan L, Zbair M et al. · 2025 · Waste management (New York, N.Y.)
Carbon-based materials gained attention for their potential to improve anaerobic digestion (AD) performance. Meanwhile, in situ biomethanation, where external H 2 is injected into the AD process to enhance the CH 4 content in biogas, is…
View details →DOI: 10.1016/j.wasman.2025.114869 Negative / Null Result ReportMedicine
Doğan MB, Gündüz N, Kazan HÖ et al. · 2025 · European journal of radiology
Objective Muscle invasion in bladder cancer is a crucial factor influencing treatment decisions and prognosis. We hypothesize that the integration of tumor shape characteristics with the VI-RADS scoring system improves the predictive…
View details →DOI: 10.1016/j.ejrad.2025.112104 Negative / Null Result Report
Wilkening J, Jungeblut HM, Adamovic I et al. · 2025 · Preprint
Intermittent theta burst stimulation (iTBS) is a promising non-invasive treatment for major depressive disorder (MDD), though significant variability exists in patient responses. This quadruple-blind, sham-controlled crossover randomized…
View details →DOI: 10.1101/2025.04.06.25325324 Negative / Null Result Report
Litman M, Azarpeykan S, Hood RJ et al. · 2025 · Preprint
In patients with ischaemic stroke, retrograde perfusion of the penumbra by the leptomeningeal collateral vessels (LMCs) is a strong predictor of clinical outcome, thus raising the possibility that enhancing LMC flow could offer a novel…
View details →DOI: 10.1101/2025.03.25.644833 Negative / Null Result ReportOpen accessMedicine
Santoro E, Broockman DE, Kalla JL et al. · 2025 · Proceedings of the National Academy of Sciences of the United States of America
Scholars and practitioners widely posit that listening to other people enhances efforts to persuade them. Listening may enhance persuasion by promoting cognitive processing, reducing defensiveness, and improving perceptions of the…
View details →DOI: 10.1073/pnas.2421982122 Negative / Null Result ReportMedicine
Viriyarattanasak C, Takemura Y, Hashimoto T et al. · 2025 · Journal of the science of food and agriculture
Background Softening of winter-harvested frozen broccoli is a challenge. Application of boron (B) can improve fruit texture, but its effects on processed vegetables remain unexplored. This study is the first to investigate the impact of…
View details →DOI: 10.1002/jsfa.14249 Negative / Null Result ReportOpen accessMedicine
Borgognoni AB, Freund SS, Baas J et al. · 2026 · Frontiers in surgery
Introduction Early osseointegration is essential for the long-term success of uncemented custom-made prostheses, particularly in oncologic bone reconstruction where bone stock is compromised. Strontium (Sr) has demonstrated osteogenic…
View details →DOI: 10.3389/fsurg.2026.1818358 Negative / Null Result ReportMedicine
Hsu PS, Barnes EH, Barnes M et al. · 2025 · Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Background Sustained unresponsiveness (SU) remains a major challenge for peanut OIT. The short chain fatty acid (SCFA) butyrate has the potential to upregulate regulatory T cells (Tregs) to improve long term tolerance. We conducted a…
View details →DOI: 10.1111/cea.70127 Negative / Null Result ReportOpen accessMedicine
Lyu A, Mungalsingh MA, Silva AE et al. · 2026 · Investigative ophthalmology & visual science
Purpose Macular degeneration impairs central vision, compelling patients to use their peripheral vision for reading, which is difficult due to reduced spatial resolution and crowding. Although perceptual learning improves reading,…
View details →DOI: 10.1167/iovs.67.1.16 Negative / Null Result ReportMedicine
Ghazzagh A, Naderi A, Agha-Alinejad H et al. · 2025 · International journal of sport nutrition and exercise metabolism
Taurine (TAU) has been shown to improve time to exhaustion (TTE) and fat oxidation during exercise; however, no studies have examined the effect of acute TAU supplementation on maximal fat oxidation (MFO) and related intensity to MFO…
View details →DOI: 10.1123/ijsnem.2024-0076 Negative / Null Result ReportMedicine
Fawzy M, Elsuity MA, Magdi Y et al. · 2025 · BJOG : an international journal of obstetrics and gynaecology
Background Artificial oocyte activation (AOA) is used to improve fertilisation rates in intracytoplasmic sperm injection (ICSI) cycles. Objectives To assess the effectiveness of AOA on fertilisation, embryo development, and clinical…
View details →DOI: 10.1111/1471-0528.18085 Negative / Null Result ReportOpen accessMedicine
Lu Y, Sun P, Jin H et al. · 2025 · Neurology and therapy
Introduction Ischemic stroke is the second leading cause of mortality and a major contributor to disability worldwide. Hospital length of stay (LOS) is a marker of medical efficiency for stroke care. There is limited information on this…
View details →DOI: 10.1007/s40120-025-00712-2 Negative / Null Result ReportMedicine
Jung SH, Jung M, Chung K et al. · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Purpose To compare the patient-reported outcome (PRO) improvements and cartilage status of trochlear cartilage defects (TCDs) after additional arthroscopic microdrilling versus no treatment for TCDs during medial open-wedge high tibial…
View details →DOI: 10.1016/j.arthro.2025.01.009 Negative / Null Result ReportMedicine
Martín-Olmedo JJ, Miras-Moreno S, Cuadra-Montes K et al. · 2025 · International journal of sport nutrition and exercise metabolism
L-citrulline (CIT) supplementation seems to improve resistance training performance; yet, whether malate has additive ergogenic effects when combined with CIT is unknown. This randomized, double-blind, placebo-controlled crossover trial…
View details →DOI: 10.1123/ijsnem.2024-0006 