Negative / Null Result ReportMedicine
Sawyer Z, Sorial M, Liauw JC · 2026 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
IntroductionImmune checkpoint inhibitors have improved outcomes for solid tumors but are associated with immune-related adverse events (irAEs). Literature suggests that patients with an absolute lymphocyte count (ALC) ≥ 2000 cells/mm3…
View details →DOI: 10.1177/10781552251415528 Negative / Null Result ReportMedicine
Beaugard CA, Khan S, Oblath R et al. · 2026 · Journal of dual diagnosis
Objective Psychiatric and substance use disorders commonly co-occur, yet treatment is often siloed. To improve treatment utilization for individuals with co-occurring disorders in the psychiatric setting it important to understand current…
View details →DOI: 10.1080/15504263.2025.2606022 Negative / Null Result Report
Buchard A, Seragnoli F, Sabe M et al. · 2025 · Preprint
Abstract Early maladaptive schemas (EMS) are highly prevalent in patients seeking psychedelic-assisted psychotherapy and correlate strongly with baseline depression and anxiety. This study characterized EMS in 192 adults and longitudinally…
View details →DOI: 10.21203/rs.3.rs-8214817/v1 Negative / Null Result Report
Gobet F, Evans N, Chatfield-Jouin F et al. · 2025 · Preprint
Artificial Intelligence (AI) is transforming many aspects of daily life and improving efficiency and outcomes in various sectors, ranging from healthcare to education. However, this rapid integration also introduces significant anxiety…
View details →DOI: 10.31234/osf.io/h7zje_v1 Negative / Null Result ReportMedicine
Carreras JP, Carney BC, Lee D et al. · 2026 · Journal of burn care & research : official publication of the American Burn Association
Skin fibrosis, especially hypertrophic scars (HTS), remains understudied with few effective treatments. Studying HTS is challenging due to its natural tendency to improve over time, making it hard to separate intervention effects. This…
View details →DOI: 10.1093/jbcr/irag012 Negative / Null Result ReportMedicine
Forster SE, Forman SD, Dickey MW et al. · 2026 · Drug and alcohol dependence
Background Veterans are disproportionately affected by cocaine use disorder (CUD), a condition without approved pharmacotherapies, marked by high return to use rates. Prize-Based Contingency Management (PBCM) is an effective behavioral…
View details →DOI: 10.1016/j.drugalcdep.2025.113003 Negative / Null Result ReportMedicine
McQuistan MR, Young LB, Pendleton C · 2025 · Journal of dental education
Objectives Research indicates significant improvement in average attitudes toward those in poverty following poverty simulations, but little research addresses whether students benefit uniformly. This study measured variability in poverty…
View details →DOI: 10.1002/jdd.70090 Negative / Null Result ReportMedicine
Zhou DD, Lord SJ, Lin FP et al. · 2026 · Lung cancer (Amsterdam, Netherlands)
Background In NSCLC, TP53 mutations are heterogeneous with varied effects on protein synthesis, function and clinical outcomes. We hypothesize that a refined classification of TP53 mutations, beyond binary categorization, could improve…
View details →DOI: 10.1016/j.lungcan.2025.108891 Negative / Null Result ReportMedicine
Hernández L, Williamson TM, Campbell T et al. · 2025 · The Canadian journal of cardiology
Background Cardiac rehabilitation (CR) participation improves depressive and anxious symptoms post-coronary catheterization, yet it is unclear to what extent improvements are clinically significant. This study characterized the proportion…
View details →DOI: 10.1016/j.cjca.2025.10.009 Negative / Null Result ReportMedicine
Lanham BS, Morris RL · 2026 · Marine environmental research
The strength of biotic stressors (i.e., predation) can determine the success of shellfish reef restoration projects. In recruitment limited systems where seeding is a common restoration strategy, ensuring the survival of seeded individuals…
View details →DOI: 10.1016/j.marenvres.2026.108221 Negative / Null Result ReportMedicine
Donate APG, Cousijn J, Rømer Thomsen K · 2026 · Psychopharmacology
Rationale People who use cannabis often report using it to improve sleep and/or manage mental health symptoms. Cannabis products differ in their typical cannabinoid composition, particularly in their relative THC and CBD content, which may…
View details →DOI: 10.1007/s00213-026-07103-x Failed Experiment Report
Fortugno P, Foti F, Caparra P et al. · 2026 · Preprint
Bergamot-derived products have gained increasing interest as dietary supplements in small animal nutrition, due to their potential to improve meat quality, and provide functional bioactive compounds. This paper investigated the effects of…
View details →DOI: 10.20944/preprints202604.2084.v1 Negative / Null Result ReportMedicine
Ceccatto Andrade VP, Araujo Júnior E, Callado GY et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology
Objective The transdermal administration of testosterone is a promising alternative to improve sexual health in postmenopausal women with decreased sexual desire, although its use remains off-label in Brazil and several other countries.…
View details →DOI: 10.1016/j.ejogrb.2026.115242 Negative / Null Result ReportMedicine
Miftakhov R, Fortygina P, Zuzina A et al. · 2026 · Scientific reports
Astrocytes communicate bidirectionally with neurons by releasing various signaling molecules. This astrocyte-neuron "dialogue" is essential for long-term processes in the nervous system, and its disruption correlates with various…
View details →DOI: 10.1038/s41598-026-56373-0 Negative / Null Result ReportMedicine
Duque-Estrada P, Markussen B, Schutyser M et al. · 2026 · Food chemistry
Thermal treatment can improve plant protein digestibility by inactivating antinutrients and partially denaturing proteins, but depending on the conditions applied, heating may also promote aggregation and amino acid modifications that…
View details →DOI: 10.1016/j.foodchem.2026.149181 Negative / Null Result ReportMedicine
Su Y, Hu Q, Dou Z et al. · 2026 · Food research international (Ottawa, Ont.)
κ-Carrageenase with alkaline resistance can promote the resource utilization of κ-carrageenan industrial residues. In this study, a rational design strategy integrating surface charge optimization and consensus sequence analysis was…
View details →DOI: 10.1016/j.foodres.2026.119085 Negative / Null Result ReportMedicine
Peng Z, Xu C, Zhang Y et al. · 2026 · Innovative Food Science and Emerging Technologies.
Radio frequency (RF) heating, as a promising alternative roasting method, could effectively improve peanut oil quality and degrade aflatoxins. However, during the peanut oil processing, the modification effect and mechanism on protein by…
Negative / Null Result ReportMedicine
Littmann J, Steiner N, Cabrejo-Jones K et al. · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
Background A Moberg osteotomy is a dorsal closing wedge osteotomy of the base of the first proximal phalanx that is thought to augment the effect of cheilectomy by increasing dorsiflexion and ultimately improve patient outcomes in Hallux…
View details →DOI: 10.1053/j.jfas.2025.11.019 Failed Experiment Report
Matiya DJ, Tutt K, Wakefield JG et al. · 2026 · Preprint
The greater wax moth, Galleria mellonella , is an increasingly important invertebrate model for infection biology, yet silk extrusion during handling complicates larval injections and hampers survival assessment. Here, we develop and…
View details →DOI: 10.64898/2026.01.20.700541 Negative / Null Result ReportMedicine
Sun Q, Miao Z, Bian L et al. · 2026 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Methionine oxidation in monoclonal antibodies (mAbs) could critically compromise drug stability and efficacy. This investigation comprehensively evaluated the structural and functional impacts of oxidation on a mAb An under long-term…
View details →DOI: 10.1016/j.jchromb.2026.124920 Failed Experiment Report
Bradley A, Gmiro Y, Stoakes A et al. · 2026 · Preprint
Concerns about the impact of social media on young adult mental health persists despite weak and inconclusive empirical evidence. This study aimed to replicate a highly-cited study showing improved well-being after limiting time on social…
View details →DOI: 10.31234/osf.io/pehxw_v2 Replication FailureMedicine
Nguyen TT, Kanemoto Y, Sawada T et al. · 2026 · Bioscience, biotechnology, and biochemistry
Vitamin D (VD) and Wnt signaling both play important roles in bone metabolism and are targeted in osteoporosis therapy. Combination treatment with VD derivatives and anti-sclerostin antibodies that activate Wnt signaling improves clinical…
View details →DOI: 10.1093/bbb/zbag084 Replication Failure
Gama de Matos D, de Santana JL, Aidar FJ et al. · 2026 · Preprint
Background: Frailty is a multifactorial condition that significantly impacts older adults' health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…
View details →DOI: 10.20944/preprints202602.0236.v1 Replication FailureMedicine
Gama de Matos D, de Santana JL, Aidar FJ et al. · 2026 · Journal of clinical medicine
Background : Frailty is a multifactorial condition that significantly impacts older adults' health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…
View details →DOI: 10.3390/jcm15051679 Negative / Null Result ReportMedicine
Chen W, Zhang C, Guo W et al. · 2026 · Journal of experimental botany
Apple is an important economic species, but it suffers from biotic stress during its growth and development. Fungi and pests are two types of biotic stress that have significant destructive effects on apple. Members of the leucine-rich…
View details →DOI: 10.1093/jxb/erag089 Negative / Null Result Report
Selimović-Pašić A, Haglund L, Bensberg M et al. · 2026 · Preprint
The BCL-2 inhibitor venetoclax (VEN) in combination with hypomethylating agents (HMAs) has improved treatment responses in acute myeloid leukaemia (AML), but the mechanisms underlying their synergy remain unclear. We investigated the role…
View details →DOI: 10.64898/2026.04.13.718134 Negative / Null Result Report
Gama de Matos D, de Santana JL, Aidar FJ et al. · 2025 · Preprint
Background: Frailty is a multifactorial condition that significantly impacts older adults health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…
View details →DOI: 10.20944/preprints202511.1155.v1 Negative / Null Result Report
Lima LC, Caetano D, Pinto L et al. · 2026 · Preprint
Abstract The global burden of bone fractures is projected to double by 2050, and this trend is driven by an aging population, higher incidence of car accidents, cancer-related bone damage, and osteoporosis, which compromises bone…
View details →DOI: 10.21203/rs.3.rs-8722217/v1 Negative / Null Result ReportMedicine
Oncul S, Lee H, Singh S et al. · 2026 · Journal of immunology (Baltimore, Md. : 1950)
B cells constitute ∼15% to 20% of tumor-infiltrating lymphocytes in melanoma. Their presence in the tumor microenvironment correlates with improved survival and enhanced response to immune checkpoint blockade therapy. Yet, the functional…
View details →DOI: 10.1093/jimmun/vkag004 Negative / Null Result ReportMedicine
Riesenbach IC, Tsomik G, Chiasson M et al. · 2026 · Aquaculture.
Insects, such as black soldier flies (BSF), have garnered attention in the aquaculture industry as a sustainable protein and lipid alternative to fishmeal and fish oil. However, research is lacking on which components of BSF improve fish…
