Negative / Null Result ReportMedicine
Wu S, Yang L, Cai Y et al. · 2026 · Eye (London, England)
Objective This study aimed to compare the diagnostic performance of Dixon T2-weighted imaging (Dixon-T2WI), T2 mapping, and T1 mapping in evaluating orbital activity in Graves' orbitopathy (GO). Methods Seventy-three GO patients were…
View details →DOI: 10.1038/s41433-026-04560-8 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Nicholas M. Vogt, Jack F. V. Hunt, Yue Ma et al. · 2021 · Annals of Clinical and Translational Neurology
Abstract Background The brain is the most cholesterol‐rich organ and myelin contains 70% of total brain cholesterol. Statins are potent cholesterol‐lowing medications used by millions of adults for prevention of vascular disease, yet the effect of statins on cholesterol‐rich brain white matter (WM) is largely unknown. Methods We used longitudinal neuroimaging data acquired from 73 healthy, cognitively unimpaired, statin‐naïve, middle‐aged adults during an 18‐month randomized controlled trial of simvastatin 40 mg daily (n = 35) or matching placebo (n = 38). ANCOVA models (covariates: age, sex,
View details →DOI: 10.1002/acn3.51421 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Mohammad Hassan Sohouli, Ghazaleh Eslamian, Nasser Malekpour Alamdari et al. · 2023 · Frontiers in Nutrition
BackgroundWe decided to conduct this study with the aim of investigating the effects of N-Acetylcysteine (NAC) on obesity complications and senescence of visceral adipose tissue in obese adults.Methods and analysisThe present study was conducted as a randomized clinical trial (RCT) (Clinical trial registry number: IRCT20220727055563N1) on 40 obese adults candidates for bariatric surgery, who were randomly assigned to receive 600 mg of NAC (n = 20) or placebo as a control (n = 20) for 4 weeks. During bariatric surgery, visceral adipose tissue was used to examine gene expression and senescence c
View details →DOI: 10.3389/fnut.2023.1237869 Negative / Null Result ReportOpen accessPsychiatry
Stanley N. Caroff, Fan Mu, Rajeev Ayyagari et al. · 2018 · BMC Psychiatry
Abstract Background Data are limited on the benefits and risks of dose reduction in managing side effects associated with antipsychotic treatment. As an example, antipsychotic dose reduction has been recommended in the management of tardive dyskinesia (TD), yet the benefits of lowering doses are not well studied. However, stable maintenance treatment is essential to prevent deterioration and relapse in schizophrenia. Methods A retrospective cohort study was conducted to analyze the healthcare burden of antipsychotic dose reduction in patients with schizophrenia. Medical claims from six US stat
View details →DOI: 10.1186/s12888-018-1889-2 Negative / Null Result ReportOpen accessPsychology
Erika C. S. Künstler, Melanie D. Penning, Natan Napiórkowski et al. · 2018 · Frontiers in Psychology
Older adults show higher dual task performance decrements than younger adults. While this is assumed to be related to attentional capacity reductions, the precise affected functions are not specified. Such specification is, however, possible based on the “theory of visual attention” (TVA) which allows for modeling of distinct attentional capacity parameters. Furthermore, it is unclear whether older adults show qualitatively different attentional effects or whether they show the same effects as younger adults experience under more challenging conditions. By varying the complexity of the seconda
View details →DOI: 10.3389/fpsyg.2018.01564 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Olga Maria Nardone, Giulio Calabrese, Alessia La Mantia et al. · 2025 · Therapeutic Advances in Gastroenterology
Background: Managing extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD) patients remains challenging due to considerable heterogeneity in diagnostic criteria and the lack of a standardised definition and validated diagnostic pathways. Delays in recognising and treating EIMs can lead to significant disease progression. Therefore, early detection and treatment are crucial. Objectives: We aimed to assess the effectiveness of a dedicated immune-mediated inflammatory diseases (IMIDs) clinic in reducing EIM diagnostic delays and improving patients’ outcomes. Design: A single-c
View details →DOI: 10.1177/17562848251323529 Negative / Null Result ReportOpen accessPediatrics
Mohaddeseh Badpeyma, Roghayeh Molani-Gol, Fatemeh Sistanian et al. · 2024 · Iranian Journal of Neonatology
Background: This study aims to determine the effect of different GnRH agonist brands on body mass index (BMI), weight, and height in patients referred to the pediatric endocrinology clinic of Akbar Hospital.Methods: In this cohort study, 80 girls aged 5-8 years diagnosed with precocious puberty cases were included according to the Tanner staging and at the second puberty stage. The patients were classified into three groups of GnRH agonists, A, B, and C, receiving Diphereline, Microrelin, and Variopeptyl, respectively. Height, weight, and BMI were calculated every three months.Results: In grou
View details →DOI: 10.22038/ijn.2024.74125.2433 Negative / Null Result ReportOpen accessVeterinary medicine
Andra DEGAN, Ruxandra TUDOR, Ruxandra COSTEA et al. · 2019 · Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Veterinary Medicine
General anesthesia produces different degrees of central nervous depression and changes in the peripheral circulation, therefore affecting the patient’s thermoregulatory mechanism. Moreover, the lack of proper, specially designed equipment for magnetic resonance imaging (MRI) environment monitoring can represent a challenge for the anesthetist. We examined the temperature variations correlated with different anesthetic protocols in dogs that underwent general anesthesia in order to evaluate changes in rectal and distal extremities temperature, before and after anesthesia. This study was conduc
View details →DOI: 10.15835/buasvmcn-vm:2019.0024 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Gan Gao, Fang‐bin Hao, Qian‐Nan Wang et al. · 2023 · Brain and Behavior
Abstract Introduction This study investigated the effect of indirect revascularization surgery in adult patients with moyamoya disease (MMD) complicated with hyperhomocysteinemia (HHcy), and the effect of HHcy on the progression of adult MMD. Methods A retrospective case‐control study was conducted in patients with MMD, with or without HHcy (n = 123). Postoperative collateral angiogenesis was evaluated using the Matsushima grading system and disease progression using the Suzuki staging system. Cerebral blood flow was evaluated before and after surgery using dynamic susceptibility contrast magn
View details →DOI: 10.1002/brb3.3093 Negative / Null Result ReportOpen accessMedicine
Barjor Gimi, Lara Leoni, Jose Oberholzer et al. · 2006 · Cell Transplantation
The increasing incidence of diabetes and the need to further understand its cellular basis has resulted in the development of new diagnostic and therapeutic techniques. Nonetheless, the quest to noninvasively ascertain β-cell mass and function has not been achieved. Manganese (Mn)-enhanced MRI is presented here as a tool to image β-cell functionality in cell culture and isolated islets. Similar to calcium, extracellular Mn was taken up by glucose-activated β-cells resulting in 200% increase in MRI contrast enhancement, versus nonactivated cells. Similarly, glucose-activated islets showed an in
View details →DOI: 10.3727/000000006783982151 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Anqi Wang, Anqi Wang, Xuan Meng et al. · 2024 · Frontiers in Neurology
ObjectiveTo determine the efficacy of mechanical thrombectomy combined with prolonged mild hypothermia compared with conventional treatment in managing acute middle cerebral artery occlusion, and to explore whether extending the duration of hypothermia can improve neurological function.MethodFrom 2018 to June 2023, a retrospective analysis was conducted on 45 patients with acute middle cerebral artery occlusion treated at the NICU of Suzhou Kowloon Hospital, affiliated with Shanghai Jiao Tong University School of Medicine. After thrombectomy, patients were admitted to the neurological intensiv
View details →DOI: 10.3389/fneur.2024.1406293 Negative / Null Result ReportOpen accessDentistry
Avita Rath, Chong Junning, Priyadarshini HR et al. · 2021 · Dentistry 3000
AIM:To compare the effects of a plaque disclosing toothpaste with a regular fluoridated toothpaste for supragingival biofilm reduction in patients with chronic gingivitis. MATERIALS AND METHODS:This study was a randomized controlled trial with a parallel design. Forty patients, both males and females aged 18-25 years with chronic generalized gingivitis (N=40) were randomly allocated to two groups of twenty each (n=20), using lottery method. Participants in the experimental group brushed with a plaque disclosing toothpaste, while participants in the control group brushed with regular fluoridate
View details →DOI: 10.5195/d3000.2021.117 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Nikola Jajcay, David Tomeček, Iveta Fajnerová et al. · 2026 · Frontiers in Computational Neuroscience
An increasing number of studies are currently focusing on “personality neuroscience,” a term denoting the research aimed at neuroimaging correlates of inter-individual temperament and character variability. Among other methods, a graph theoretical analysis of the functional connectivity in resting-state functional magnetic resonance imaging data was applied in a study by, reporting novel functional connectivity correlates of personality traits. The current paper presents a conceptual replication of the results of this study and discusses the related challenges, including an extension of the or
View details →DOI: 10.3389/fncom.2026.1796308 Negative / Null Result ReportOpen accessDentistry
Damla Erkal, Turgut Felek, Oana-Paula Butean et al. · 2025 · BMC Oral Health
Abstract Introduction This study hypothesized that large language models (LLMs) would underperform compared to expert clinicians in diagnosing and managing complex endodontic anomalies, such as dens invaginatus, when provided with periapical radiographs. Although LLMs have shown promise in dental education and basic diagnostics, their effectiveness in nuanced clinical reasoning has remained unclear. Methods Nineteen anonymized periapical radiographs depicting challenging endodontic conditions were paired with clinical vignettes. Six advanced LLMs and one expert endodontist independently answer
View details →DOI: 10.1186/s12903-025-06987-z Failed Experiment ReportOpen accessPsychology
Masataka Takebe, Kenta Tsumura, Ken'ichiro Nakashima · 2023 · Current Research in Ecological and Social Psychology
Rodeheffer et al. (2012) showed that when people perceive resource scarcity, they are more likely to judge racially ambiguous people as out-group members. In their first experiment, 71 White participants viewed a slideshow depicting either resource scarcity or abundance; subsequently, they judged 20 biracial faces created by averaging a White and a Black face. We conducted this experiment's preregistered conceptual replication study in Japan. Specifically, after observing a slideshow depicting either resource scarcity or abundance, East Asian participants judged 20 biracial faces produced by a
View details →DOI: 10.1016/j.cresp.2023.100169 Negative / Null Result ReportOpen accessPublic aspects of medicine
Simiao Chen, Pascal Geldsetzer, Till Bärnighausen · 2020 · SSM: Population Health
Population aging in middle-income countries, including China, has resulted in strong economic incentives to increase the retirement age. These economic incentives should be weighed up against the effects of later retirement on physical and mental health and wellbeing. We aimed to determine the causal effect of retirement on perceived stress, an important measure of mental well-being. We used data from the China Health and Nutrition Survey in 2015 and adopted a non-parametric regression discontinuity design (RDD) to measure the causal effect of retirement on stress. Stress was assessed using th
View details →DOI: 10.1016/j.ssmph.2019.100462 Negative / Null Result ReportOpen accessMedicine
Rogier A. Kievit, Delia Fuhrmann, Gesa Sophia Borgeest et al. · 2018 · Wellcome Open Research
Background: Fluid intelligence declines with advancing age, starting in early adulthood. Within-subject declines in fluid intelligence are highly correlated with contemporaneous declines in the ability to live and function independently. To support healthy aging, the mechanisms underlying these declines need to be better understood. Methods: In this pre-registered analysis, we applied latent growth curve modelling to investigate the neural determinants of longitudinal changes in fluid intelligence across three time points in 185,317 individuals (N=9,719 two waves, N=870 three waves) from the U
View details →DOI: 10.12688/wellcomeopenres.14241.2 Negative / Null Result ReportOpen accessMedicine
Rogier A. Kievit, Delia Fuhrmann, Gesa Sophia Borgeest et al. · 2018 · Wellcome Open Research
Background: Fluid intelligence declines with advancing age, starting in early adulthood. Within-subject declines in fluid intelligence are highly correlated with contemporaneous declines in the ability to live and function independently. To support healthy aging, the mechanisms underlying these declines need to be better understood. Methods: In this pre-registered analysis, we applied latent growth curve modelling to investigate the neural determinants of longitudinal changes in fluid intelligence across three time points in 185,317 individuals (N=9,719 two waves, N=870 three waves) from the U
View details →DOI: 10.12688/wellcomeopenres.14241.1 Negative / Null Result ReportOpen accessDermatology
Gi-Wook Lee, Keunyoung Kim, Seong-Jang Kim et al. · 2023 · Acta Dermato-Venereologica
Atopic dermatitis (AD) is an inflammatory skin disease associated with increased systemic and vascular inflammation. Although dupilumab has been proven to be effective against severe AD, imaging studies analysing its inflammation-reducing effect have rarely been reported. The aim of this study was to evaluate the effect of dupilumab on systemic and vascular inflammation in adult patients with severe AD, using 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT). A total of 33 adult patients with severe AD and 25 healthy controls underwent 18F-FDG PET/CT at b
View details →DOI: 10.2340/actadv.v103.5320 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Zhaoying Li, Shanyu Liu, Yuling Shen et al. · 2025 · Frontiers in Neuroscience
BackgroundAbnormalities in brain activity patterns during episodic memory tasks have been inconsistently reported in amnestic mild cognitive impairment (aMCI) patients using functional magnetic resonance imaging (fMRI). This study applied traditional Chinese medicine (TCM) syndrome differentiation to categorize aMCI patients into distinct subgroups, aiming to clarify the neural mechanisms underlying their cognitive profiles.MethodsParticipants included aMCI patients categorized into the turbid phlegm clouding the orifices (PCO) or spleen-kidney deficiency (SKD) syndrome subgroups, alongside co
View details →DOI: 10.3389/fnins.2025.1555365 Negative / Null Result ReportMedicine
Liang H, Gui Y, Lv K et al. · 2026 · Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
Objective To compare the imaging efficacy and patient tolerability of a novel cellulose-based oral contrast agent with a conventional starch-based agent in gastric contrast-enhanced ultrasound,thus providing evidence-based support for…
View details →DOI: 10.3881/j.issn.1000-503x.17161 Negative / Null Result ReportOpen accessMedicine
Bellew S, Tjiattas-Saleski L, Butz D et al. · 2026 · The western journal of emergency medicine
Introduction Computed tomography (CT) is an essential diagnostic tool for evaluating emergency department (ED) patients. Between 15-20% of patients who present to the ED in the United States (US) undergo CT imaging. CT imaging with the use…
View details →DOI: 10.5811/westjem.62947 Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Yu Gao, Stephanie Yoon, Ting Martin Ma et al. · 2024 · Physics and Imaging in Radiation Oncology
Background and purpose: Magnetic Resonance Imaging (MRI)-guided Stereotactic body radiotherapy (SBRT) treatment to prostate bed after radical prostatectomy has garnered growing interests. The aim of this study is to evaluate intra-fractional anatomic and dose/volume metric variations for patients receiving this treatment. Materials and methods: Nineteen patients who received 30–34 Gy in 5 fractions on a 0.35T MR-Linac were included. Pre- and post-treatment MRIs were acquired for each fraction (total of 75 fractions). The Clinical Target Volume (CTV), bladder, rectum, and rectal wall were conto
View details →DOI: 10.1016/j.phro.2024.100573 Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Y. S. Kudryavtsev, M. M. Beregov, A. B. Berdalin et al. · 2021 · Вестник рентгенологии и радиологии
Objective: to compare the results of staging the severity of viral pneumonia in patients with COVID-19 based on the results of chest computed tomography (CT) using the empirical visual scale CT 0–4 and chest CT severity score (CT-SS) point scale, as well as to assess their prognostic value.Material and methods. Chest CT scans and anamnestic data in patients hospitalized to a non-specialized center repurposed for the treatment of new coronavirus infection, were analyzed. Chest CT analysis was performed by two radiologists using CT 0–4 and CT-SS scales.Results. The time course of changes in the
View details →DOI: 10.20862/0042-4676-2021-102-5-296-303 Negative / Null Result ReportMedicine
Kaba M, Eyüboğlu GB, Karadas M · 2026 · Polymers
This study aimed to assess the effect of etching protocols on the bonding performance of three universal adhesives to dentin under different aging conditions. Specimens were obtained from human molars and randomly allocated to 6 groups ( n…
View details →DOI: 10.3390/polym18121516 Negative / Null Result ReportMedicine
Alwadani B · 2026 · Healthcare (Basel, Switzerland)
Purpose Variation in knee MRI diagnostic yield is often interpreted as reflecting imaging effectiveness. However, in real-world healthcare systems, diagnostic yield may instead be driven by referral behavior and patient selection.…
View details →DOI: 10.3390/healthcare14121628 Negative / Null Result ReportOpen accessGeriatrics
Lars Donath, Sebastian Ludyga, Daniel Hammes et al. · 2017 · BMC Geriatrics
Abstract Background Aging is accompanied by a decline of executive function. Aerobic exercise training induces moderate improvements of cognitive domains (i.e., attention, processing, executive function, memory) in seniors. Most conclusive data are obtained from studies with dementia or cognitive impairment. Confident detection of exercise training effects requires adequate between-day reliability and low day-to-day variability obtained from acute studies, respectively. These absolute and relative reliability measures have not yet been examined for a single aerobic training session in seniors.
View details →DOI: 10.1186/s12877-017-0634-x Negative / Null Result ReportOpen accessMedicine
Zeren G, Bakır EO, Tufaro V et al. · 2026 · Journal of cardiovascular development and disease
Intravascular imaging (IVI) was introduced 35 years ago to assess coronary artery pathology and plaque vulnerability. However, from its first applications it became apparent that it can also be useful in percutaneous coronary intervention…
View details →DOI: 10.3390/jcdd13010038 Negative / Null Result ReportMedicine
Guo Y, Wei D, Xu S et al. · 2026 · Risk analysis : an official publication of the Society for Risk Analysis
This study examines the potential of comics as an infotainment strategy for engaging the public in climate change mitigation from the perspective of the situational theory of public. A 2 × 2 × 2 factorial experiment (N = 320) was conducted…
View details →DOI: 10.1111/risa.70234 Negative / Null Result Report
Zhao Y, Zhao Q, Yu X et al. · 2026 · Preprint
Abstract Learning behavior is an important acquired behavior in fish, and the capacity for learning and memory plays a crucial role in foraging or anti-predator behavior. In this study, we selected the juveniles of S. schlegelii as the…
View details →DOI: 10.21203/rs.3.rs-9638734/v1 