A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
741 results for "aging" · page 2 of 25
Homa Hosseinmardi, Amir Ghasemian, Aaron Clauset et al. · 2021 · Proceedings of the National Academy of Sciences
Although it is under-studied relative to other social media platforms, YouTube is arguably the largest and most engaging online media consumption platform in the world. Recently, YouTube's scale has fueled concerns that YouTube users are…
Dave R.M. Langers, Emile de Kleine, Pim van Dijk · 2012 · Frontiers in Systems Neuroscience
The pathophysiology underlying tinnitus, a hearing disorder characterized by the chronic perception of phantom sound, has been related to aberrant plastic reorganization of the central auditory system. More specifically, tinnitus is thought to involve changes in the tonotopic representation of sound. In the present study we used high-resolution functional magnetic resonance imaging to determine tonotopic maps in the auditory cortex of 20 patients with tinnitus but otherwise near-normal hearing, and compared these to equivalent outcomes from 20 healthy controls with matched hearing thresholds.
Gerrit Fischer, Axel Stadie, Róbert Reisch et al. · 2011 · Operative Neurosurgery
BACKGROUND: Improvements in preoperative imaging and intraoperative visualization have led to a refinement in surgical techniques. OBJECTIVE: Report of a 20-year experience with application of the keyhole technique as a contribution to the…
Christopher Summerfield, Valentin Wyart, Vanessa M. Johnen et al. · 2011 · Frontiers in Human Neuroscience
Repetitions of a sensory event elicit lower levels of brain activity than its initial presentation ("repetition suppression," RS). According to one view, RS depends on the biophysics of neuronal discharge, and is thus an automatic consequence of stimulus processing ("fatigue" model). Another account suggests that RS depends on the statistical structure of the environment, and occurs when repeated stimuli are less surprising than novel stimuli ("surprise reduction" model). In support of the latter view, functional magnetic resonance imaging studies have shown that RS is modulated by the local p
Ladan Arissian, Christopher Smeenk, F. Turner et al. · 2010 · Physical Review Letters
Tunneling is often used to describe multiphoton ionization of rare gas atoms in infrared fields. We test the tunneling approximation and its nonadiabatic extension by measuring the unperturbed momentum distribution along the κ direction of…
Frida Magda Sumual, David Paul Elia Saerang, Herman Karamoy et al. · 2021 · Accounting
This present study intends to analyze the factors affecting the performance of the local government of North Sulawesi. The population of this study includes the members of the Regional People’s Representative Assembly and the leaders of Regional Apparatus Organizations managing the Regional Revenue and Expenditure Budget (APBD). Those Regional Apparatus Organizations include Education and Culture Office, Health Office, Regional Revenue Service, Tourism Office, Public Works Office, and Auditor Inspectorate of North Sulawesi Province. The sampling technique used is the saturated sampling techniq
Xiaoyan Ma, Kevin S. Bartlett, K. Harmon et al. · 2013 · Atmospheric measurement techniques
Abstract. Cloud–Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) provide global vertical profiles of aerosol optical properties for the first time. In this study, we employed about 6 yr (2006–2011) of CALIPSO level 3 monthly mean gridded aerosol optical depth (AOD) products (daytime and nighttime) for cloud-free conditions, to compare with the Moderate Resolution Imaging Spectroradiometer (MODIS) Terra/Aqua level 3 monthly mean AOD dataset for the same time period. While the spatial distribution and seasonal variability of CALIPSO AOD is generally consistent with that of
An Wu, Gennady Dvoryanchikov, Elizabeth Pereira et al. · 2015 · Nature Communications
Gustatory stimuli are detected by taste buds and transmitted to the hindbrain via sensory afferent neurons. Whether each taste quality (sweet, bitter and so on) is encoded by separate neurons ('labelled lines') remains controversial. We used mice expressing GCaMP3 in geniculate ganglion sensory neurons to investigate taste-evoked activity. Using confocal calcium imaging, we recorded responses to oral stimulation with prototypic taste stimuli. Up to 69% of neurons respond to multiple tastants. Moreover, neurons tuned to a single taste quality at low concentration become more broadly tuned when
Marian E. Berryhill · 2014 · Frontiers in Psychology
The popularity of non-invasive brain stimulation techniques in basic, commercial, and applied settings grew tremendously over the last decade. Here, we focus on one popular neurostimulation method: transcranial direct current stimulation (tDCS). Many assumptions regarding the outcomes of tDCS are based on the results of stimulating motor cortex. For instance, the primary motor cortex is predictably suppressed by cathodal tDCS or made more excitable by anodal tDCS. However, wide-ranging studies testing cognition provide more complex and sometimes paradoxical results that challenge this heuristi
N. J. Schweitzer, Michael J. Saks, Emily R. Murphy et al. · 2011 · Psychology Public Policy and Law
Recent developments in the neuropsychology of criminal behavior have given rise to concerns that neuroimaging evidence (such as MRI and functional MRI [fMRI] images) could unduly influence jurors. Across four experiments, a nationally…
François Waldner, Diego de Abelleyra, Santiago R. Verón et al. · 2016 · International Journal of Remote Sensing
Accurate cropland information is of paramount importance for crop monitoring. This study compares five existing cropland mapping methodologies over five contrasting Joint Experiment for Crop Assessment and Monitoring (JECAM) sites of medium to large average field size using the time series of 7-day 250 m Moderate Resolution Imaging Spectroradiometer (MODIS) mean composites (red and near-infrared channels). Different strategies were devised to assess the accuracy of the classification methods: confusion matrices and derived accuracy indicators with and without equalizing class proportions, asse
Nathan A. Lewis, Nicholas A. Turiano, Brennan R. Payne et al. · 2016 · Aging Neuropsychology and Cognition
With an increasingly aging population, more work is needed to identify factors which may promote the maintenance of normal cognitive functioning. The current study tested the concurrent association between sense of purpose in life and the…
Dori Steinberg, Erica Levine, Sandy Askew et al. · 2013 · Journal of Medical Internet Research
BACKGROUND: Daily self-monitoring of diet and physical activity behaviors is a strong predictor of weight loss success. Text messaging holds promise as a viable self-monitoring modality, particularly among racial/ethnic minority populations. OBJECTIVE: This pilot study evaluated the feasibility of a text messaging intervention for weight loss among predominantly black women. METHODS: Fifty obese women were randomized to either a 6-month intervention using a fully automated system that included daily text messages for self-monitoring tailored behavioral goals (eg, 10,000 steps per day, no sugar
Jared W. Magnani, Carlee Moser, Joanne M. Murabito et al. · 2014 · Circulation Arrhythmia and Electrophysiology
BACKGROUND: Endogenous sex hormones have been related to cardiovascular outcomes and mortality. We hypothesized that sex hormones are related to atrial fibrillation (AF) in a community-based cohort of middle-aged to older men. METHODS AND…
Christian von Bodman, Kazuhito Matsushita, Caroline Savage et al. · 2012 · The Journal of Urology
PURPOSE: We determined whether pelvic soft tissue and bony dimensions on endorectal magnetic resonance imaging influence the recovery of continence after radical prostatectomy, and whether adding significant magnetic resonance imaging…
Alice Tseng, Leah Szadkowski, Sharon Walmsley et al. · 2013 · Annals of Pharmacotherapy
BACKGROUND: Interactions between antiretroviral (ARV) therapy and medications to treat age-related comorbidities are a growing concern in the aging HIV population. OBJECTIVE: To investigate the association of age with potential drug-drug…
Ioannis Pavlidis, Panagiotis Tsiamyrtzis, Dvijesh Shastri et al. · 2012 · Scientific Reports
In the present study we quantify stress by measuring transient perspiratory responses on the perinasal area through thermal imaging. These responses prove to be sympathetically driven and hence, a likely indicator of stress processes in…
Hung-Yu Liu, Kun‐Hsien Chou, Pei‐Lin Lee et al. · 2016 · Cephalalgia
Objectives To investigate the structural changes of hippocampus and amygdala and their relationships with migraine frequency and prognosis. Methods Hippocampus and amygdala volumes were measured by 3-T brain magnetic resonance imaging…
Patrick L. Kelly, Ori D. Fox, Alexei V. Filippenko et al. · 2014 · The Astrophysical Journal
We constrain the properties of the progenitor system of the highly reddened Type Ia supernova (SN Ia) 2014J in Messier 82 (M82; d ≈ 3.5 Mpc). We determine the supernova (SN) location using Keck-II K-band adaptive optics images, and we find…
Ian Y. Wong, Raymond Wong, Paul Zhao et al. · 2012 · Retina
PURPOSE: To investigate the relationship of hypercholesterolemia and choroidal thickness in normal healthy volunteers. METHOD: This was a cross-sectional observational study. Volunteers with no ocular abnormalities were examined using…
Robert Steinmetz, David L. Garshelis, Wanlop Chutipong et al. · 2013 · Journal of Mammalogy
Asiatic black bears (Ursus thibetanus) and sun bears (Helarctos malayanus) are ecologically similar and coexist extensively across Southeast Asia. We used foraging signs identified to bear species to examine their food selection and…
Ariella Kristal, Ashley V. Whillans, Max H. Bazerman et al. · 2020 · Proceedings of the National Academy of Sciences
Honest reporting is essential for society to function well. However, people frequently lie when asked to provide information, such as misrepresenting their income to save money on taxes. A landmark finding published in PNAS [L. L. Shu, N. Mazar, F. Gino, D. Ariely, M. H. Bazerman, Proc. Natl. Acad. Sci. U.S.A. 109, 15197–15200 (2012)] provided evidence for a simple way of encouraging honest reporting: asking people to sign a veracity statement at the beginning instead of at the end of a self-report form. Since this finding was published, various government agencies have adopted this practice.
Harold Bae, Paola Sebastiani, Jenny X. Sun et al. · 2013 · Frontiers in Genetics
Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed by NEO-five-factor inventory in individuals enrolled in the Long Life Family Study (LLFS), a study of 583 families (N up to 4595) with clustering for longevity in the United States and Denmark. Three SNPs, in almost perfect LD, associated with agreeableness reached genome-wide significance (p < 10(-8)) and replicated in a
Xuling Lin, M. Lee, Olivia Buck et al. · 2016 · American Journal of Neuroradiology
BACKGROUND AND PURPOSE: Glioblastoma and primary CNS lymphoma dictate different neurosurgical strategies; it is critical to distinguish them preoperatively. However, current imaging modalities do not effectively differentiate them. We aimed to examine the use of DWI and T1-weighted dynamic contrast-enhanced–MR imaging as potential discriminative tools. MATERIALS AND METHODS: We retrospectively reviewed 18 patients with primary CNS lymphoma and 36 matched patients with glioblastoma with pretreatment DWI and dynamic contrast-enhanced–MR imaging. VOIs were drawn around the tumor on contrast-enhan
Karolina Partheen, Björg Kristjánsdóttir, Karin Sundfeldt · 2011 · Journal of Gynecologic Oncology
OBJECTIVE: Women presenting with a large or complex ovarian cyst are referred to extensive surgical staging to ensure the correct diagnosis and treatment of a possible epithelial ovarian cancer. We hypothesized that measurement of the…
Jens Theysohn, Oliver Kraff, Stefan Maderwald et al. · 2011 · Journal of Magnetic Resonance Imaging
PURPOSE: To evaluate 7T MRI in the assessment of cerebrovascular alterations as seen in vascular dementia by means of detection of cerebral microbleeds (CMB) and depiction of white matter lesions (WML). 7T imaging was evaluated with…
Christopher W. Lewis, Jamiluddin Qazi, Daniel S. Hippe et al. · 2019 · Cancer Medicine
Approximately one-third of Merkel cell carcinoma (MCC) patients eventually develop distant metastatic disease. Little is known about whether the location of the primary lesion is predictive of initial distant metastatic site, or if survival likelihood differs depending on the metastatic site. Such data could inform imaging/surveillance practices and improve prognostic accuracy. Multivariate and competing-risk analyses were performed on a cohort of 215 MCC patients with distant metastases, 31% of whom had two or more initial sites of distant metastasis. At time of initial distant metastasis in
Alecia C. Vogel, Steven E. Petersen, Bradley L. Schlaggar · 2012 · Cerebral Cortex
Regions in left occipitotemporal (OT) cortex, including the putative visual word form area, are among the most commonly activated in imaging studies of single-word reading. It remains unclear whether this part of the brain is more…
C. Schaefer, Mario Geiger, T. Kuntzer et al. · 2017 · Astronomy and Astrophysics
Context. Future large-scale surveys with high-resolution imaging will provide us with approximately 10 5 new strong galaxy-scale lenses. These strong-lensing systems will be contained in large data amounts, however, which are beyond the…
Tamlin S. Conner, Katie Reid · 2011 · Social Psychological and Personality Science
Does intensive focus on happiness change the naturalistic experience of happiness over time? In a 2-week text-messaging experiment, young adult participants ( n = 162) reported their current happiness 1, 3, or 6 times daily. Examination of…