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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1934 results for "Mpro" · page 15 of 65

Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Improving ricotta cheese shelf life using saffron petal extract double nanoemulsions stabilized by plant proteins and Lepidium sativum L. gum

Fereshteh Bakhshalipoor, Marzieh Bolandi, Fariborz Nahidi et al. · 2026 · Scientific Reports

This study evaluated the effects of double nanoemulsions of saffron petal extract (DN-SPE), stabilized with soybean (SPI) and pea protein isolates (PPI), alone or combined with Lepidium sativum L. seed gum (LSG) (SL or PL), on the quality…

View details →DOI: 10.1038/s41598-026-52693-3Cited by 9
Negative / Null Result ReportOpen accessPsychology

Virtual reality training to improve socio‐emotional functioning in adolescents with developmental language disorders: A multiple baseline effectiveness study

E. G. J. M. Arts, Bram Orobio de Castro, Ellen Luteijn et al. · 2024 · Social Development

Abstract This study investigated whether interactive virtual reality (VR) training of social and emotional abilities (InterAction) improves socio‐emotional functioning of youth with developmental language disorders (DLD). To this end we conducted a multiple baseline intervention study, comparing participants’ social abilities during a baseline phase with their changes in abilities during the intervention and posttest phase. The training group consisted of 29 adolescents ( 20 boys, 9 girls ) with DLD from the Netherlands. The training consisted of nine, weekly (45–50 min) individual sessions wi

View details →DOI: 10.1111/sode.12784Cited by 9
Negative / Null Result ReportOpen accessEngineering

Statistical Analysis of Machinery Variance by Python

Joao Gabriel Ostrowski, József Menyhárt · 2020 · Acta Polytechnica Hungarica

Based particularly on data technologies, information is rapidly evolving in engineering. In mechanical engineering, maintenance is benefiting the most from data innovations, the reduction of maintenance costs, and the improvement of system…

View details →DOI: 10.12700/aph.17.5.2020.5.8Cited by 9
Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics

Harnessing Hybrid Niosomes for Improved Oral Bioavailability of an Anticoagulant: Design, Optimization and In-Vivo Pharmacokinetics and Pharmacodynamics Evaluations

Remonda Raafat Ragheb, Rodayana Atef, Kareem Abdou et al. · 2026 · AAPS PharmSciTech

Abstract Venous thromboembolism (VTE) and pulmonary embolism (PE), remains a major global health burden, necessitating prolonged and reliable anticoagulant therapy. Although Apixaban (APX) is a cornerstone oral anticoagulant for VTE management, its therapeutic performance is limited by poor aqueous solubility and low oral bioavailability. To overcome these challenges, this study introduces a hybrid niosomal delivery system designed to enhance the absorption and systemic persistence of APX. The system was engineered by integrating hybrid of surfactants together with cholesterol to form a stable

View details →DOI: 10.1208/s12249-026-03374-xCited by 9
Negative / Null Result ReportOpen accessHealth Professions

Effects of a Digital Intervention to Improve DASH and Blood Pressure Among US Adults

Hailey Miller, Sandy Askew, Miriam B. Berger et al. · 2024 · Hypertension

BACKGROUND: Dietary Approaches to Stop Hypertension (DASH) is a recommended first-line treatment for adults with hypertension, yet adherence to DASH is low. To evaluate the efficacy of a digital health intervention (DHI), compared with…

View details →DOI: 10.1161/hypertensionaha.124.23887Cited by 9
Negative / Null Result ReportOpen accessSocial Sciences

Scaling Up the Success for All Model of School Reform: Final Report from the Investing in Innovation (i3) Evaluation

Janet Quint, Pei Zhu, Rekha Balu et al. · 2015 · SSRN Electronic Journal

Success for All (SFA) combines a challenging elementary reading program, whole-school reform elements, and an emphasis on continuous improvement. In 2010, the Success for All Foundation (SFAF) received a scale-up grant under the U.S.…

Negative / Null Result ReportMedicine

Comparing Mortality Prediction by Quick Sequential Organ Failure Assessment with Emergency Physician Judgment

William R. Cleek, Nicholas J. Johnson, Bjorn Watsjold et al. · 2019 · Shock

STUDY OBJECTIVE: The quick sequential organ failure assessment (qSOFA) was proposed to identify infected patients at risk for mortality, an indication of sepsis, in nonintensive care unit settings. This study tests whether qSOFA improves…

View details →DOI: 10.1097/shk.0000000000001496Cited by 9
Negative / Null Result ReportOpen accessMedicine

A comprehensive review of venous thromboembolism risk assessment models for hospitalized medical patients: comparative evidence, implementation challenges, and future directions

Lama Alfehaid, Nada Alsuhebany, Yahya M K Tawfik et al. · 2026 · Frontiers in Cardiovascular Medicine

Venous thromboembolism (VTE) is a leading cause of preventable hospital-acquired morbidity and mortality. Despite the availability of effective prophylaxis, its application in clinical practice remains inconsistent, often due to uncertainty in risk stratification. This review evaluates the validity and implementation of VTE risk assessment models (RAMs) in medical inpatients. Seven widely used RAMs, Caprini, Padua, IMPROVE, IMPROVEDD, Wells, Geneva, and Kucher e-alert, are critically examined alongside emerging digital and biomarker-enhanced tools. The Padua and IMPROVE scores show consistent

View details →DOI: 10.3389/fcvm.2025.1738139Cited by 9
Negative / Null Result ReportOpen accessEngineering

A vascularized 3D bioengineered lung tumor model for anticancer drug screening

Mingqi Wang, Yulin Ye, Ruqiang Yuan et al. · 2025 · Cancer Cell International

The limited clinical translation of preclinical anticancer drug efficacy underscores the urgent need for advanced models that faithfully replicate tumor pathophysiology. While three-dimensional (3D) tumor cultures improve the fidelity of…

View details →DOI: 10.1186/s12935-025-04064-7Cited by 9
Negative / Null Result Report

Clinical Decision Support System with Renal Dose Adjustment Did Not Improve Subsequent Renal and Hepatic Function among Inpatients: The Japan Adverse Drug Event Study

Ryuhei Wada, Jiro Takeuchi, Tsukasa Nakamura et al. · 2020 · Applied Clinical Informatics

Abstract Background Medication dose adjustment is crucial for patients with renal dysfunction (RD). The assessment of renal function is generally mandatory; however, the renal function may change during the hospital stay and the manual…

View details →DOI: 10.1055/s-0040-1721056Cited by 8
Negative / Null Result Report

Association of oral contraceptive and metformin did not improve insulin resistance in women with polycystic ovary syndrome

Margareth Chiharu Iwata, Livia Porquere, Isabel C. Espósito Sorpreso et al. · 2015 · Revista da Associação Médica Brasileira

Summary Objective: Objective: to compare clinical and laboratory parameters in women with polycystic ovary syndrome (PCOS) using metformin or combined oral contraceptive (COC) after 6 months. Methods: retrospective study analyzing records…

View details →DOI: 10.1590/1806-9282.61.03.215Cited by 8
Negative / Null Result Report

CURING HEPATITIS C WITH THE NEW DIRECT ACTING ANTIVIRALS DID NOT IMPROVE INSULIN RESISTANCE AFTER ONE YEAR

Lohanna STRAUHS-NITSCH, Marcela Ferro CAMPIOLO, Daphne Benatti Gonçalves MORSOLETTO et al. · 2020 · Arquivos de Gastroenterologia

ABSTRACT BACKGROUND: Chronic hepatitis C still figures as an important cause of morbidity among the Brazilian population, and is closely associated with metabolic disturbances, including insulin resistance (IR), which can be evaluated by…

View details →DOI: 10.1590/s0004-2803.202000000-50Cited by 8
Negative / Null Result Report

Evening Caffeine Did Not Improve 100-m Swimming Time Trials Performed 60 Min Post-Ingestion or the Next Morning After Sleep

Josh W. Newbury, Bryan Saunders, Lewis A. Gough · 2022 · International Journal of Sport Nutrition and Exercise Metabolism

The potential ergogenic benefits of caffeine (CAF) are well known within the athletic community, often leading to its use in adolescent swimming cohorts to enhance their performance. However, it has previously been reported that CAF has…

View details →DOI: 10.1123/ijsnem.2022-0042Cited by 8
Negative / Null Result Report

Para‐aortic lymphadenectomy did not improve overall survival among women with type I endometrial cancer

Lin Li, Mingming Tang, Dan Nie et al. · 2020 · International Journal of Gynecology & Obstetrics

Abstract Objective To compare outcomes and prognosis among women with type I endometrial cancer undergoing hysterectomy and bilateral salpingo‐oophorectomy (H‐BSO) with or without systematic pelvic lymphadenectomy (PLD) or para‐aortic…

View details →DOI: 10.1002/ijgo.13228Cited by 8
Negative / Null Result Report

Does the Establishment of National New Areas Improve Urban Ecological Efficiency? Empirical Evidence Based on Staggered DID Model

Jingbin Wang, Huiling Qiao, Jing Liu et al. · 2022 · International Journal of Environmental Research and Public Health

The environmental effects of national new areas have been an important topic but received little attention in academia. This study conducts a quasi-natural experiment using panel data of China’s 282 prefecture-level cities from 2006 to…

View details →DOI: 10.3390/ijerph192013623Cited by 8
Negative / Null Result Report

Combining a transosseous cerclage wire after patellar tendon reattachment to treat patella distal pole fracture did not improve functional outcome

Li-Yang Kuo, Chun-Yu Chen, Kai-Cheng Lin · 2022 · Scientific Reports

Abstract This study aims to investigate whether an augmented wire in the treatment of patella distal pole fracture could improve knee range of motion (ROM) and radiographic features. Thirty-five consecutive patients with patellar distal…

View details →DOI: 10.1038/s41598-022-13641-zCited by 8
Negative / Null Result Report

DID FOREIGN OWNERSHIP OF KOREAN CREDIT RATING AGENCIES IMPROVE THEIR RATINGS?

Denis Yongmin Joe, Frederick Dongchuhl Oh · 2016 · Contemporary Economic Policy

In this study, we investigate whether foreign equity participation fostered the growth of Korea's credit rating industry during the 2002–2013 period. We find that the rating quality deteriorated steadily even though the foreign ownership…

View details →DOI: 10.1111/coep.12176Cited by 8
Negative / Null Result Report

Significant Improvement of Somatic Symptom Disorder With Brief Psychoeducational Intervention by PMHNP in Primary Care

Kim K. Johnson, Carole Bennett, Haresh Rochani · 2020 · Journal of the American Psychiatric Nurses Association

Objective: Patients with somatic symptom disorders (SSD) are prevalent in primary care, urgent care, and emergency rooms and present with reduced quality of life, increased disability, and suicidality . Criteria for SSD include (1) somatic…

View details →DOI: 10.1177/1078390320960524Cited by 7
Negative / Null Result Report

Ethanol Extract of Fructus ligustri lucidi Increased Circulating 1,25(OH) 2 D 3 Levels, but Did Not Improve Calcium Balance in Mature Ovariectomized Rats

Xiao-Li Dong, Si-Si Cao, Li-Ping Zhou et al. · 2016 · The American Journal of Chinese Medicine

Our previous studies found that different extracts or fractions of Fructus ligustri lucidi (FLL) played different roles in altering the regulation of bone and mineral metabolism in different animal models. The present study was designed to…

View details →DOI: 10.1142/s0192415x16500695Cited by 7
Negative / Null Result Report

Long‐chain alcohols did not improve predictions of the composition of tall fescue and red clover mixtures over n ‐alkanes alone

N. Vargas Jurado, A. E. Tanner, S. R. Blevins et al. · 2014 · Grass and Forage Science

Abstract Feed intake and diet choice affect production efficiency in livestock. Plant waxes, in particular n ‐alkanes, have been used as markers to predict intake and diet preferences. Still, when n ‐alkane profiles of plants within mixed…

View details →DOI: 10.1111/gfs.12134Cited by 7
Negative / Null Result Report

Randomized trial within a trial of yellow ‘post‐it notes’ did not improve questionnaire response rates among participants in a trial of treatments for neck pain

Helen E Tilbrook, Taeko Becque, Hannah Buckley et al. · 2014 · Journal of Evaluation in Clinical Practice

Abstract Rationale Attrition is a threat to the validity of randomized trials. Few randomized studies have been conducted within randomized trials to test methods of reducing attrition. Aim To test whether using yellow post‐it notes on…

View details →DOI: 10.1111/jep.12284Cited by 7
Negative / Null Result Report

Beta‐alanine did not improve high‐intensity performance throughout simulated road cycling

Pedro Perim, Nathan Gobbi, Breno Duarte et al. · 2021 · European Journal of Sport Science

ABSTRACT This study investigated the effect of beta‐alanine supplementation on short‐duration sprints and final 4‐km simulated uphill cycling time‐trial performance during a comprehensive and novel exercise protocol representative of the…

View details →DOI: 10.1080/17461391.2021.1940304Cited by 7
Negative / Null Result Report

Shoot thinning of Semillon in a hot climate did not improve yield and berry and wine quality

Roberta De Bei, Lukas Papagiannis, Sigfredo Fuentes et al. · 2020 · OENO One

Aim: Shoot thinning is a common canopy management practice used to obtain a desired shoot density and to improve canopy microclimate. Since thinning is often carried out manually, the cost can be high. In this study the effect of severe…

View details →DOI: 10.20870/oeno-one.2020.54.3.2984Cited by 7
Negative / Null Result Report

Lack of significant effect of gut microbiota on weight gain in newly emerged worker honeybee

J. Elijah Powell, Erick V.S. Motta, Joanito Liberti et al. · 2025 · Royal Society Open Science

The western honeybee, Apis mellifera, harbours a simple and distinct microbiota that has been linked to various positive outcomes for the host. Among these cited benefits is improved weight gain for bees that have been inoculated with…

View details →DOI: 10.1098/rsos.242151Cited by 7
Negative / Null Result Report

Supplementing 2 g per day bovine lactoferrin from late gestation until weaning did not improve lactation performance of mixed parity sows

Fan Liu, Jordon Hogg, Susie Kracht et al. · 2019 · Animal Production Science

Context Lactoferrin is a non-haem binding protein that possesses antimicrobial, antioxidant and anti-inflammatory properties. A previous study showed lactoferrin supplementation from early gestation to weaning improved lactation…

View details →DOI: 10.1071/an18286Cited by 6
Negative / Null Result Report

Calcium and magnesium supplementation of ewes grazing pasture did not improve lamb survival

Susan M. Robertson, Shawn R. McGrath, Samuel Scarlett et al. · 2022 · Animal Production Science

Context Clinical deficiencies of calcium and magnesium may result in the metabolic disorders hypocalcaemia and hypomagnesaemia, resulting in ewe and lamb mortality. However, the contribution of subclinical deficiencies to perinatal lamb…

View details →DOI: 10.1071/an22113Cited by 6
Negative / Null Result Report

Gum Guar fiber associated with fructose reduces serum triacylglycerol but did not improve the glucose tolerance in rats

Caio SM Motoyama, Mônica JS Pinto, Fabio S Lira et al. · 2010 · Diabetology & Metabolic Syndrome

Abstract Introduction The increased intake of dietary fructose can be associated with alterations on energy homeostasis and lipid/carbohydrate metabolism, such as insulin resistance and dislipidemia. On the other hand, the ingestion of…

View details →DOI: 10.1186/1758-5996-2-61Cited by 6
Negative / Null Result Report

Education Finance Reform and the Great Recession: Did State Policy and Fiscal Federalism Improve Education Spending, School Resources, and Student Achievement in Pennsylvania?

Matthew P. Steinberg, Rand Quinn, J. Cameron Anglum · 2020 · Journal of Education Finance

abstract: We estimate the impact of school finance reform on adequate and equitable district spending, school resources and student achievement in Pennsylvania. From the 2008-09 to the 2010-11 school years, amid the Great Recession,…

View details →DOI: 10.1353/jef.2020.a760723Cited by 6
Negative / Null Result Report

Did School Meal Programs and SNAP Participation Improve Diet Quality of US Children from Low-Income Households: Evidence from NHANES 2013–2014?

Tzuan A. Chen, Lorraine R. Reitzel, Ezemenari M. Obasi et al. · 2021 · Nutrients

Nutrition assistance programs such as school meals and the Supplemental Nutrition Assistance Program (SNAP) are designed to provide a safety net for the dietary intake of children from low-income families. However, compared with eligible…

View details →DOI: 10.3390/nu13103574Cited by 6