A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
1934 results for "Mpro" · page 14 of 65
M. Müllner, K. Zwintz, E. Corsaro et al. · 2021 · Astronomy & Astrophysics
Context. In recent years, our understanding of solar-like oscillations from main sequence to red giant stars has improved dramatically thanks to pristine data collected from space telescopes. One of the remaining open questions focuses on…
J. Jithish, Nagarajan Mahalingam, Bo Wang et al. · 2025 · Cybersecurity
Abstract The forthcoming 6G technology offers significant potential for the advancement of the smart grid domain. 6G promises ultra-low latency, higher data transfer rates, native Artificial Intelligence (AI) support, enhanced connectivity, and improved security for smart grids. Smart grids are vulnerable to cyberattacks, such as Distributed Denial-of-Service (DDoS) attacks, posing a significant threat to grid functionality. To address security concerns, smart grids implement intrusion detection systems (IDS), but detecting novel attacks such as subtle multi-domain DDoS attacks through traditi
Andrew J. Steward, Daniel J. Kelly, Diane R. Wagner · 2016 · Tissue Engineering Part A
Although hydrostatic pressure (HP) is known to regulate chondrogenic differentiation of mesenchymal stromal/stem cells (MSCs), improved insight into the mechanotransduction of HP may form the basis for novel tissue engineering strategies.…
Hannah R. Spaulding, Tiffany Quindry, Kayleen Hammer et al. · 2019 · Journal of Applied Physiology
Progressive muscle injury and weakness are hallmarks of Duchenne muscular dystrophy. We showed previously that quercetin (Q) partially protected dystrophic limb muscles from disease-related injury. As quercetin activates PGC-1α through…
Wei Tang, Yuwei Qiu, Huijie Lu et al. · 2021 · Frontiers in Surgery
Study Objective: This study aimed to investigate whether stroke volume variation (SVV)-guided goal-directed therapy (GDT) can improve postoperative outcomes in elderly patients undergoing minimally invasive esophagectomy (MIE) compared…
Rebecca D. Dodd, Amanda Scherer, Wesley Huang et al. · 2020 · Clinical Cancer Research
Abstract Purpose: Nanoparticle-encapsulated drug formulations can improve responses to conventional chemotherapy by increasing drug retention within the tumor and by promoting a more effective antitumor immune response than free drug. New…
Niklas Mattsson-Carlgren, Sebastian Palmqvist, Kanta Horie et al. · 2026 · The Lancet Neurology
BACKGROUND: Alzheimer's disease pathology can be accurately identified with blood biomarkers (core 1 biomarkers), including plasma p-tau217 tests. Biomarkers that change longitudinally after diagnosis (core 2 biomarkers) can increase confidence that Alzheimer's disease pathology is contributing to cognitive symptoms. Plasma eMTBR-tau243 reflects tau tangle pathology and is a promising core 2 biomarker. We aimed to examine whether, among patients positive for plasma p-tau217, plasma eMTBR-tau243 improves classification of established Alzheimer's disease and predicts cognitive decline and tau ta
Yanna Zhang, Ming Yan, Jiehua He et al. · 2010 · Journal of obstetrics and gynaecology research
AIM: In the past 10 years, therapeutic advances have led to improved short-term efficacy for cervical carcinoma; however, the 5-year survival rate was not significantly enhanced. To investigate the effects of blood vessel invasion (BVI)…
Domenica Lorusso, Laurence Gladieff, David M O'Malley et al. · 2026 · The Lancet
BACKGROUND: Relacorilant is a selective glucocorticoid receptor antagonist that increases the sensitivity of many cancer cell types to chemotherapy. The efficacy and safety of relacorilant plus nab-paclitaxel were assessed in the phase 3 ROSELLA (GOG-3073, ENGOT-ov72, APGOT-Ov10, and LACOG-0223) trial; the combination showed significant improvement in progression-free survival among patients with platinum-resistant ovarian cancer compared with nab-paclitaxel monotherapy. Results of the final overall survival analysis are reported here. METHODS: intravenously on the aforementioned schedule). Pa
Remonda Raafat Ragheb, Rodayana Atef, Kareem Abdou et al. · 2026 · AAPS PharmSciTech
Abstract Venous thromboembolism (VTE) and pulmonary embolism (PE), remains a major global health burden, necessitating prolonged and reliable anticoagulant therapy. Although Apixaban (APX) is a cornerstone oral anticoagulant for VTE management, its therapeutic performance is limited by poor aqueous solubility and low oral bioavailability. To overcome these challenges, this study introduces a hybrid niosomal delivery system designed to enhance the absorption and systemic persistence of APX. The system was engineered by integrating hybrid of surfactants together with cholesterol to form a stable
Elliott J. Jenkins, Joseph A. Killick, Owain Zerilli et al. · 2025 · The Journal of Physiology
Abstract Long‐term heat acclimation has been shown to elevate haemoglobin mass (Hb mass ) and enhance maximal oxygen consumption (). To date, however, all evidence derives from exercise‐induced heat stress, making it unclear whether passive strategies, which allow athletes to maintain training intensities, can produce similar adaptations. Moreover, while heat‐induced increases in are often attributed to haematological changes, adaptation of other convective components of oxygen transport may underpin these improvements. To investigate whether 5 weeks of hot‐water immersion (HWI) would enhance
Fereshteh Bakhshalipoor, Marzieh Bolandi, Fariborz Nahidi et al. · 2026 · Scientific Reports
This study evaluated the effects of double nanoemulsions of saffron petal extract (DN-SPE), stabilized with soybean (SPI) and pea protein isolates (PPI), alone or combined with Lepidium sativum L. seed gum (LSG) (SL or PL), on the quality…
Roxana-Maria Amărandi, Luminița Marin, Brînduşa Drăgoi et al. · 2024 · Molecular Pharmaceutics
High Resolution Image Download MS PowerPoint Slide Liposomes, small bilayer phospholipid-containing vesicles, are frequently used to ensure slow drug release for a prolonged and improved therapeutic effect. Nevertheless, current findings…
P. Sumithran, K. Purcell, S. Kuyruk et al. · 2017 · Clinical Obesity
Summary Consistent, strong predictors of obesity treatment outcomes have not been identified. It has been suggested that broadening the range of predictor variables examined may be valuable. We explored methods to predict outcomes of a…
Kamel Mouloudj, Tiziana Amoriello, Eeman Almokdad et al. · 2026 · Sustainability
Product waste in grocery supply chains remains a major concern for multiple stakeholders, particularly retailers, due to the direct financial losses it generates and the potential risks it poses to customer health and safety. In this context, digital technologies—especially artificial intelligence (AI)—offer promising opportunities to improve retail performance and reduce waste. Accordingly, this study aims to investigate the factors influencing retailers’ intentions to adopt AI-based solutions for product waste reduction. To achieve this objective, the Technology Acceptance Model (TAM) was ex
Lama Alfehaid, Nada Alsuhebany, Yahya M K Tawfik et al. · 2026 · Frontiers in Cardiovascular Medicine
Venous thromboembolism (VTE) is a leading cause of preventable hospital-acquired morbidity and mortality. Despite the availability of effective prophylaxis, its application in clinical practice remains inconsistent, often due to uncertainty in risk stratification. This review evaluates the validity and implementation of VTE risk assessment models (RAMs) in medical inpatients. Seven widely used RAMs, Caprini, Padua, IMPROVE, IMPROVEDD, Wells, Geneva, and Kucher e-alert, are critically examined alongside emerging digital and biomarker-enhanced tools. The Padua and IMPROVE scores show consistent
Rolando A. Rebolledo, Bo Liu, Mohammed Z. Akhtar et al. · 2015 · BioMed Research International
Effect of glucocorticoid administration on improving the outcomes of kidney and liver allografts has not been clearly elucidated. This study investigated the effect of prednisolone administration after onset of brain death (BD) on kidney…
Émilie Le Rhun, Lakshmi Nayak, Mary Jane Lim-Fat et al. · 2024 · Neuro-Oncology
BACKGROUND: There are no validated tools for the clinical neurological assessment of patients with leptomeningeal metastases (LM). However, clinical examination during the course of the disease guides medical management and is part of response assessment in clinical trials. Because neuroimaging may not always be obtained owing to rapid clinical deterioration, clinical neurological assessment of LM is essential, and standardization is important to minimize rater disagreement. METHODS: The Response Assessment in Neuro-oncology-LM group launched a 2-step process, aiming at improving and standardi
E. G. J. M. Arts, Bram Orobio de Castro, Ellen Luteijn et al. · 2024 · Social Development
Abstract This study investigated whether interactive virtual reality (VR) training of social and emotional abilities (InterAction) improves socio‐emotional functioning of youth with developmental language disorders (DLD). To this end we conducted a multiple baseline intervention study, comparing participants’ social abilities during a baseline phase with their changes in abilities during the intervention and posttest phase. The training group consisted of 29 adolescents ( 20 boys, 9 girls ) with DLD from the Netherlands. The training consisted of nine, weekly (45–50 min) individual sessions wi
Sibi Chakravathy Parivendan, Kashfia Sailunaz, Suresh Neethirajan · 2025 · Animals
This review critically analyzes recent advancements in dairy cow behavior recognition, highlighting novel methodological contributions through the integration of advanced artificial intelligence (AI) techniques such as transformer models and multi-view tracking with social network analysis (SNA). Such integration offers transformative opportunities for improving dairy cattle welfare, but current applications remain limited. We describe the transition from manual, observer-based assessments to automated, scalable methods using convolutional neural networks (CNNs), spatio-temporal models, and at
Natsu Sasaki, Reiko Kuroda, Kanami Tsuno et al. · 2022 · Neuropsychopharmacology Reports
Abstract Objectives This study aimed to examine the effectiveness of vaccination to improve mental health among employees in Japan based on a prospective study. Methods The data were retrieved from the Employee Cohort Study conducted…
Yuko Shimizu‐Motohashi · 2025 · Brain and Development
Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disorder caused by variants of the DMD that leads to progressive muscle degeneration. Recent advances in gene therapy have opened new therapeutic avenues, particularly through the use of adeno-associated virus (AAV)-mediated micro-dystrophin delivery. Delandistrogene moxeparvovec, the first FDA-approved gene therapy for DMD, has demonstrated transgene expression and potential functional improvement in early phase trials, although its long-term efficacy, durability, and safety remain unconfirmed. Immune-mediated toxicities including
Padma Kaul, Dat T. Tran, Roopinder K. Sandhu et al. · 2020 · Journal of the American College of Emergency Physicians Open
STUDY OBJECTIVE: Patients with syncope are frequently admitted to the hospital, but whether this improves outcome is unknown. We tested whether hospitalization reduced mortality in patients who presented to emergency departments (EDs) with…
Fulai Zhou, Guangmao Mu, Honglei Bi et al. · 2025 · Cancers
Background. The dense hyaluronan (HA)-rich stroma in solid tumors can prevent effective tumor growth inhibition by hindering drug delivery and immune cell infiltration. However, the degradation of HA alone by systemic delivery of hyaluronidase has not shown significant improvement of tumor growth inhibition. Objectives/Methods. In this study, we targeted hyaluronan degradation by using antibody–enzyme (AbEn) molecules by fusing antibodies to a recombinant human hyaluronidase (HYAL). Results. The AbEn molecules were stable, retained both antigen-binding and enzymatic activities, and demonstrate
Tom Solomon, Cory Hooper, Ava Easton et al. · 2026 · The Lancet Neurology
BACKGROUND: Herpes simplex virus (HSV) encephalitis is characterised by inflammation and swelling of the brain, resulting in death or severe neurocognitive sequelae. HSV encephalitis is treated with the antiviral aciclovir but still has substantial mortality and morbidity. Adjunct corticosteroids are sometimes used, but whether they improve the outcome is unclear. We aimed to establish the safety and efficacy of adjunct corticosteroids in HSV encephalitis. METHODS: In this multicentre, observer-blind, randomised, phase 3 trial, adults with HSV encephalitis admitted to 53 hospitals in the UK we
Yang Fu, Jie Liu, Zeming Mo et al. · 2026 · MedComm
ABSTRACT Melanoma is the most aggressive skin malignant tumor, typically exhibiting a high mutation burden and potentially harboring mutations in NRAS, BRAF, or NF1. To enhance survival rates, these driver alterations can achieve significant antitumor activity through targeted therapy. In the past decade, BRAF inhibitors combined with MEK inhibitors significantly improved the prognosis of BRAF mutation melanoma. Nevertheless, researchers have attempted various strategies to block the NRAS signaling pathway, NRAS mutation in melanoma is still considered to be untargetable. In recent years, MEK
Fiyinfoluwa Demilade Ojeniyi, Adeola Oluwakemi Ayoola, Olajumoke Ibitoye et al. · 2025 · Scientific Reports
Rapid diagnostic tests (RDTs) have revolutionized malaria diagnosis, playing a crucial role in improving timely treatment and supporting surveillance efforts, especially in resource-limited settings. However, the performance of RDTs can…
Rong Yuan, Tajul Ariffin Masron, Yujie Chen et al. · 2025 · International Journal of Environmental Science and Technology
Abstract The alarming rate of environmental degradation worldwide has prompted a renewed focus on government effectiveness as an essential factor affecting environmental quality. Few studies have demonstrated the role of government effectiveness in environmental degradation under the influence of economic development. Consequently, this study aims to investigate the effect of government effectiveness and how it impacts environmental degradation using panel data from 61 regions from 2007 to 2021 and the generalized method of moments (GMM) estimator. The results show that improving government ef
Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer et al. · 2025 · Pharmaceutics
Selenium nanoparticles (SeNPs) have emerged as promising metal-based nanoparticles for drug delivery due to their unique physicochemical properties, intrinsic bioactivity, and biocompatibility. SeNPs offer a lower toxicity, higher bioavailability, and flexibility to be customized for surface chemistry compared to traditional selenium compounds. Advances in synthetic strategies, including chemical reduction, green biosynthesis, and surface functionalization with polymers, peptides, or ligands, have improved their stability, targeting capability, and circulation time. SeNP-based systems have dem
Sandra Heskamp, Otto C. Boerman, Janneke D.M. Molkenboer‐Kuenen et al. · 2014 · Molecular Pharmaceutics
Bevacizumab and cetuximab are approved for the treatment of cancer. However, in advanced colorectal cancer, addition of cetuximab to chemotherapy with bevacizumab did not improve survival. The reason for the lack of activity remains…