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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1894 results for "Mpro" · page 14 of 64

Negative / Null Result Report

Clinical Decision Support System with Renal Dose Adjustment Did Not Improve Subsequent Renal and Hepatic Function among Inpatients: The Japan Adverse Drug Event Study

Ryuhei Wada, Jiro Takeuchi, Tsukasa Nakamura et al. · 2020 · Applied Clinical Informatics

Abstract Background Medication dose adjustment is crucial for patients with renal dysfunction (RD). The assessment of renal function is generally mandatory; however, the renal function may change during the hospital stay and the manual…

View details →DOI: 10.1055/s-0040-1721056Cited by 8
Negative / Null Result Report

Association of oral contraceptive and metformin did not improve insulin resistance in women with polycystic ovary syndrome

Margareth Chiharu Iwata, Livia Porquere, Isabel C. Espósito Sorpreso et al. · 2015 · Revista da Associação Médica Brasileira

Summary Objective: Objective: to compare clinical and laboratory parameters in women with polycystic ovary syndrome (PCOS) using metformin or combined oral contraceptive (COC) after 6 months. Methods: retrospective study analyzing records…

View details →DOI: 10.1590/1806-9282.61.03.215Cited by 8
Negative / Null Result Report

CURING HEPATITIS C WITH THE NEW DIRECT ACTING ANTIVIRALS DID NOT IMPROVE INSULIN RESISTANCE AFTER ONE YEAR

Lohanna STRAUHS-NITSCH, Marcela Ferro CAMPIOLO, Daphne Benatti Gonçalves MORSOLETTO et al. · 2020 · Arquivos de Gastroenterologia

ABSTRACT BACKGROUND: Chronic hepatitis C still figures as an important cause of morbidity among the Brazilian population, and is closely associated with metabolic disturbances, including insulin resistance (IR), which can be evaluated by…

View details →DOI: 10.1590/s0004-2803.202000000-50Cited by 8
Negative / Null Result Report

Para‐aortic lymphadenectomy did not improve overall survival among women with type I endometrial cancer

Lin Li, Mingming Tang, Dan Nie et al. · 2020 · International Journal of Gynecology & Obstetrics

Abstract Objective To compare outcomes and prognosis among women with type I endometrial cancer undergoing hysterectomy and bilateral salpingo‐oophorectomy (H‐BSO) with or without systematic pelvic lymphadenectomy (PLD) or para‐aortic…

View details →DOI: 10.1002/ijgo.13228Cited by 8
Negative / Null Result Report

Evening Caffeine Did Not Improve 100-m Swimming Time Trials Performed 60 Min Post-Ingestion or the Next Morning After Sleep

Josh W. Newbury, Bryan Saunders, Lewis A. Gough · 2022 · International Journal of Sport Nutrition and Exercise Metabolism

The potential ergogenic benefits of caffeine (CAF) are well known within the athletic community, often leading to its use in adolescent swimming cohorts to enhance their performance. However, it has previously been reported that CAF has…

View details →DOI: 10.1123/ijsnem.2022-0042Cited by 8
Negative / Null Result Report

Does the Establishment of National New Areas Improve Urban Ecological Efficiency? Empirical Evidence Based on Staggered DID Model

Jingbin Wang, Huiling Qiao, Jing Liu et al. · 2022 · International Journal of Environmental Research and Public Health

The environmental effects of national new areas have been an important topic but received little attention in academia. This study conducts a quasi-natural experiment using panel data of China’s 282 prefecture-level cities from 2006 to…

View details →DOI: 10.3390/ijerph192013623Cited by 8
Negative / Null Result Report

Combining a transosseous cerclage wire after patellar tendon reattachment to treat patella distal pole fracture did not improve functional outcome

Li-Yang Kuo, Chun-Yu Chen, Kai-Cheng Lin · 2022 · Scientific Reports

Abstract This study aims to investigate whether an augmented wire in the treatment of patella distal pole fracture could improve knee range of motion (ROM) and radiographic features. Thirty-five consecutive patients with patellar distal…

View details →DOI: 10.1038/s41598-022-13641-zCited by 8
Negative / Null Result Report

DID FOREIGN OWNERSHIP OF KOREAN CREDIT RATING AGENCIES IMPROVE THEIR RATINGS?

Denis Yongmin Joe, Frederick Dongchuhl Oh · 2016 · Contemporary Economic Policy

In this study, we investigate whether foreign equity participation fostered the growth of Korea's credit rating industry during the 2002–2013 period. We find that the rating quality deteriorated steadily even though the foreign ownership…

View details →DOI: 10.1111/coep.12176Cited by 8
Negative / Null Result Report

Significant Improvement of Somatic Symptom Disorder With Brief Psychoeducational Intervention by PMHNP in Primary Care

Kim K. Johnson, Carole Bennett, Haresh Rochani · 2020 · Journal of the American Psychiatric Nurses Association

Objective: Patients with somatic symptom disorders (SSD) are prevalent in primary care, urgent care, and emergency rooms and present with reduced quality of life, increased disability, and suicidality . Criteria for SSD include (1) somatic…

View details →DOI: 10.1177/1078390320960524Cited by 7
Negative / Null Result Report

Ethanol Extract of Fructus ligustri lucidi Increased Circulating 1,25(OH) 2 D 3 Levels, but Did Not Improve Calcium Balance in Mature Ovariectomized Rats

Xiao-Li Dong, Si-Si Cao, Li-Ping Zhou et al. · 2016 · The American Journal of Chinese Medicine

Our previous studies found that different extracts or fractions of Fructus ligustri lucidi (FLL) played different roles in altering the regulation of bone and mineral metabolism in different animal models. The present study was designed to…

View details →DOI: 10.1142/s0192415x16500695Cited by 7
Negative / Null Result Report

Long‐chain alcohols did not improve predictions of the composition of tall fescue and red clover mixtures over n ‐alkanes alone

N. Vargas Jurado, A. E. Tanner, S. R. Blevins et al. · 2014 · Grass and Forage Science

Abstract Feed intake and diet choice affect production efficiency in livestock. Plant waxes, in particular n ‐alkanes, have been used as markers to predict intake and diet preferences. Still, when n ‐alkane profiles of plants within mixed…

View details →DOI: 10.1111/gfs.12134Cited by 7
Negative / Null Result Report

Randomized trial within a trial of yellow ‘post‐it notes’ did not improve questionnaire response rates among participants in a trial of treatments for neck pain

Helen E Tilbrook, Taeko Becque, Hannah Buckley et al. · 2014 · Journal of Evaluation in Clinical Practice

Abstract Rationale Attrition is a threat to the validity of randomized trials. Few randomized studies have been conducted within randomized trials to test methods of reducing attrition. Aim To test whether using yellow post‐it notes on…

View details →DOI: 10.1111/jep.12284Cited by 7
Negative / Null Result Report

Beta‐alanine did not improve high‐intensity performance throughout simulated road cycling

Pedro Perim, Nathan Gobbi, Breno Duarte et al. · 2021 · European Journal of Sport Science

ABSTRACT This study investigated the effect of beta‐alanine supplementation on short‐duration sprints and final 4‐km simulated uphill cycling time‐trial performance during a comprehensive and novel exercise protocol representative of the…

View details →DOI: 10.1080/17461391.2021.1940304Cited by 7
Negative / Null Result Report

Shoot thinning of Semillon in a hot climate did not improve yield and berry and wine quality

Roberta De Bei, Lukas Papagiannis, Sigfredo Fuentes et al. · 2020 · OENO One

Aim: Shoot thinning is a common canopy management practice used to obtain a desired shoot density and to improve canopy microclimate. Since thinning is often carried out manually, the cost can be high. In this study the effect of severe…

View details →DOI: 10.20870/oeno-one.2020.54.3.2984Cited by 7
Negative / Null Result Report

Lack of significant effect of gut microbiota on weight gain in newly emerged worker honeybee

J. Elijah Powell, Erick V.S. Motta, Joanito Liberti et al. · 2025 · Royal Society Open Science

The western honeybee, Apis mellifera, harbours a simple and distinct microbiota that has been linked to various positive outcomes for the host. Among these cited benefits is improved weight gain for bees that have been inoculated with…

View details →DOI: 10.1098/rsos.242151Cited by 7
Negative / Null Result Report

Supplementing 2 g per day bovine lactoferrin from late gestation until weaning did not improve lactation performance of mixed parity sows

Fan Liu, Jordon Hogg, Susie Kracht et al. · 2019 · Animal Production Science

Context Lactoferrin is a non-haem binding protein that possesses antimicrobial, antioxidant and anti-inflammatory properties. A previous study showed lactoferrin supplementation from early gestation to weaning improved lactation…

View details →DOI: 10.1071/an18286Cited by 6
Negative / Null Result Report

Calcium and magnesium supplementation of ewes grazing pasture did not improve lamb survival

Susan M. Robertson, Shawn R. McGrath, Samuel Scarlett et al. · 2022 · Animal Production Science

Context Clinical deficiencies of calcium and magnesium may result in the metabolic disorders hypocalcaemia and hypomagnesaemia, resulting in ewe and lamb mortality. However, the contribution of subclinical deficiencies to perinatal lamb…

View details →DOI: 10.1071/an22113Cited by 6
Negative / Null Result Report

Gum Guar fiber associated with fructose reduces serum triacylglycerol but did not improve the glucose tolerance in rats

Caio SM Motoyama, Mônica JS Pinto, Fabio S Lira et al. · 2010 · Diabetology & Metabolic Syndrome

Abstract Introduction The increased intake of dietary fructose can be associated with alterations on energy homeostasis and lipid/carbohydrate metabolism, such as insulin resistance and dislipidemia. On the other hand, the ingestion of…

View details →DOI: 10.1186/1758-5996-2-61Cited by 6
Negative / Null Result Report

Education Finance Reform and the Great Recession: Did State Policy and Fiscal Federalism Improve Education Spending, School Resources, and Student Achievement in Pennsylvania?

Matthew P. Steinberg, Rand Quinn, J. Cameron Anglum · 2020 · Journal of Education Finance

abstract: We estimate the impact of school finance reform on adequate and equitable district spending, school resources and student achievement in Pennsylvania. From the 2008-09 to the 2010-11 school years, amid the Great Recession,…

View details →DOI: 10.1353/jef.2020.a760723Cited by 6
Negative / Null Result Report

Did School Meal Programs and SNAP Participation Improve Diet Quality of US Children from Low-Income Households: Evidence from NHANES 2013–2014?

Tzuan A. Chen, Lorraine R. Reitzel, Ezemenari M. Obasi et al. · 2021 · Nutrients

Nutrition assistance programs such as school meals and the Supplemental Nutrition Assistance Program (SNAP) are designed to provide a safety net for the dietary intake of children from low-income families. However, compared with eligible…

View details →DOI: 10.3390/nu13103574Cited by 6
Negative / Null Result Report

Cover crops did not improve soil health but hydroclimatology may guide decisions preventing cash crop yield loss

Debankur Sanyal, Avik Mukherjee, Amin Rahhal et al. · 2023 · Frontiers in Soil Science

Introduction Cover crop (CC) is an essential tool to improve or maintain soil health, potentially improving cash crop productivity. Several recent reports of cash crop yield reduction following cover cropping necessitated this research to…

View details →DOI: 10.3389/fsoil.2023.1111821Cited by 6
Negative / Null Result Report

Did expanded access to denture services improve chewing ability in the Korean older population? Results of a regression discontinuity analysis

Nam-Hee Kim, Ichiro Kawachi · 2020 · Scientific Reports

Abstract The Korean National Health Insurance expanded the dental insurance in 2012 to cover denture services for older adults. We analyzed whether the new policy improved of chewing ability in the eligible population. We used regression…

View details →DOI: 10.1038/s41598-020-68189-7Cited by 6
Negative / Null Result Report

Challenging the understanding of significant improvement and outcome in schizophrenia – the concept of reliable and clinically significant change methods

Rebecca Schennach, Hans‐Jürgen Möller, Michael Obermeier et al. · 2015 · International Journal of Methods in Psychiatric Research

Abstract Significant changes of schizophrenia patients during inpatient treatment were evalutaed and compared to established outcome criteria. The concept of reliable and clinically significant change methods was applied to three hundred…

View details →DOI: 10.1002/mpr.1476Cited by 5
Negative / Null Result Report

Supplementation of graded levels of rumen-protected choline to a pelleted total mixed ration did not improve the growth and slaughter performance of fattening lambs

Qin Huo, Xuezhao Sun, Tingting Wu et al. · 2022 · Frontiers in Veterinary Science

Choline is an essential nutrient in ruminant diets, which contributes to the fundamental biological functions of the animal. However, choline is easily degraded in the rumen before it can be absorbed. Rumen-protected choline (RPC)…

View details →DOI: 10.3389/fvets.2022.1034895Cited by 5
Negative / Null Result Report

Supplementing rumen‐protected methionine to lactating multiparous dairy cows did not improve reproductive performance

David Süss, Michael Iwersen, Vanessa Schweinzer et al. · 2019 · Reproduction in Domestic Animals

Abstract There is evidence that supplementing methionine has positive effects on uterine environment, oocyte quality and embryo development in cattle. Thus, the objective of this study was to evaluate reproductive traits of cows…

View details →DOI: 10.1111/rda.13509Cited by 5
Negative / Null Result Report

Partial replacement of soybean meal with full-fat black soldier fly larvae meal in plant-based nursery diets did not influence fecal Escherichia coli colony forming units or improve fecal consistency when pigs were weaned into non-disinfected pens

B Christensen, C Zhu, M Niazy et al. · 2023 · Translational Animal Science

Abstract At weaning, one hundred pigs (21 d of age; 6.96 ± 0.23 kg BW) were used to determine the effect of partially replacing soybean meal (SBM) in corn- and SBM-based nursery diets on growth performance, fecal scores, Escherichia coli…

View details →DOI: 10.1093/tas/txad121Cited by 5
Negative / Null Result Report

Plyometrics Did Not Improve Jump-Landing Biomechanics in Individuals With a History of Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial

Hyunjae Jeon, Sean Krysak, Steven J. Pfeiffer et al. · 2022 · International Journal of Athletic Therapy and Training

Second anterior cruciate ligament (ACL) injury has similar biomechanical risk factors as primary injury. Standard of care rehabilitation does not adequately mitigate these biomechanical risks. This study examined the effectiveness of a…

View details →DOI: 10.1123/ijatt.2020-0072Cited by 5
Negative / Null Result Report

Multimodal analgesia did not improve post‐operative pain scores, reduce opioid consumption or reduce length of stay following hip arthroscopy

Ryan M. Degen, Andrew Firth, Herman Sehmbi et al. · 2023 · Knee Surgery, Sports Traumatology, Arthroscopy

Abstract Purpose To determine whether different regimens of multimodal analgesia will reduce postoperative pain scores, opioid consumption, costs and hospital length‐of‐stay following hip arthroscopy. Methods From 2018 to 2021, 132…

View details →DOI: 10.1007/s00167-023-07445-5Cited by 5
Negative / Null Result Report

STABILIZER

Charlie Curtsinger, Emery D. Berger · 2013 · ACM SIGPLAN Notices

Researchers and software developers require effective performance evaluation. Researchers must evaluate optimizations or measure overhead. Software developers use automatic performance regression tests to discover when changes improve or…

View details →DOI: 10.1145/2499368.2451141Cited by 5
Negative / Null Result Report

Union-Find Decoders For Homological Product Codes

Nicolas Delfosse, Matthew B. Hastings · 2021 · Quantum

Homological product codes are a class of codes that can have improved distance while retaining relatively low stabilizer weight. We show how to build union-find decoders for these codes, using a union-find decoder for one of the codes in…

View details →DOI: 10.22331/q-2021-03-10-406Cited by 4