Negative / Null Result ReportOpen accessMedicine
Nadine Haase, Julianna Rugor, Łukasz Przybył et al. · 2014 · PLoS ONE
Relaxin is a corpus-luteum produced protein hormone with vasodilatatory, anti-fibrotic, and angiogenic properties that are opposite to angiotensin (Ang) II. We investigated whether or not relaxin ameliorates Ang II-induced target-organ damage. We used double transgenic rats harboring both human renin and angiotensinogen genes (dTGR) that develop severe hypertension, target-organ damage, and die untreated within 7-8 weeks. Recombinant relaxin at a low (26 μg/kg/d) and a high dose (240 μg/kg/d) was given to 4 week-old dTGR and age-matched Sprague-Dawley rats (SD). Systolic blood pressure increas
View details →DOI: 10.1371/journal.pone.0093743Cited by 11 Negative / Null Result ReportMedicine
Mélissa De Regge, Koenraad G. Monsieurs, K. Vandewoude et al. · 2012 · PubMed
Automated external defibrillators (AEDs) have shown to improve survival after cardiopulmonary arrest (CPA) in many, but not all clinical settings. A recent study reported that the use of AEDs in-hospital did not improve survival. The…
View details →DOI: 10.2143/acb.67.4.2062666Cited by 11 Negative / Null Result ReportOpen accessMedicine
Faith Hartley, Martin A. Ebert, Alistair Cook · 2025 · Clinical & Translational Immunology
The most successful immunotherapies for solid malignancies to date, immune checkpoint inhibitors, target the essential role of T cells in antitumor immunity. However, T-cell dysfunction presents a major hindrance to treatment efficacy, warranting research into combined treatment strategies for improving outcomes. The use of radiotherapy for this purpose has garnered much interest. Preclinical study has established that radiotherapy activates various immune mechanisms to improve T-cell activation, localisation and function within tumors, which improves response to immune checkpoint inhibitors.
View details →DOI: 10.1002/cti2.70030Cited by 11 Negative / Null Result ReportOpen accessMedicine
Jing Cheng, Carl Gao, Reeta Ala‐Jaakkola et al. · 2024 · JAMA Network Open
Importance: Probiotic supplementation may improve bowel movements. However, large, properly designed studies are lacking. Objective: To evaluate the potential benefit of Bifidobacterium animalis subsp lactis HN019 on constipation,…
View details →DOI: 10.1001/jamanetworkopen.2024.36888Cited by 11 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Matthew MacLachlan, Michael K. Adjemian, Xiaoli Etienne et al. · 2025 · Nature Communications
The advent of COVID-19 ended an era of stable US retail food prices that followed the world food price crisis of 2010–2012. Pandemic-related disruptions, avian influenza outbreaks, and the Russia-Ukraine war drove 2022 food-at-home…
View details →DOI: 10.1038/s41467-025-61660-xCited by 11 Negative / Null Result ReportOpen accessComputer Science
Haoze Wu · 2017
In this project, we aimed to improve the runtime of Minisat, a Conflict-Driven Clause Learning (CDCL) solver that solves the Propositional Boolean Satisfiability (SAT) problem. We first used a logistic regression model to predict the…
View details →DOI: 10.1145/3017680.3022464Cited by 11 Negative / Null Result Report
Uraiwan Buatoom, Muhammad Usman Jamil · 2023 · Applied Sciences
In image classification, various techniques have been developed to enhance the performance of principal component analysis (PCA) dimension reduction techniques with guiding weighting features to remove redundant and irrelevant features.…
View details →DOI: 10.3390/app13032005Cited by 11 Negative / Null Result ReportOpen accessPsychology
Sarah Shi Hui Wong, Sophia Xuefei Qiu · 2026 · Educational Psychology Review
Abstract Generative artificial intelligence (AI) tools such as ChatGPT can boost creative performance, but do these boosts translate into learning gains? This study examined whether the benefits of ChatGPT for creativity persist even when its assistance is removed, and how people can effectively use ChatGPT to enhance their learning and independent creativity. University students ( N = 196) solved a creative product improvement task either independently (human-only group) or using ChatGPT freely (general-AI group) or using ChatGPT in a guided way (regulated-AI group). Specifically, the regulat
View details →DOI: 10.1007/s10648-026-10118-7Cited by 11 Negative / Null Result ReportOpen accessMedicine
Bilal A. Siddiqui, Sumit K. Subudhi, Padmanee Sharma · 2022 · Cell Reports Medicine
The addition of atezolizumab (anti-PD-L1) to enzalutamide (androgen receptor antagonist) did not prolong survival in metastatic prostate cancer.1Powles T. Yuen K.C. Gillessen S. Kadel 3rd, E.E. Rathkopf D. Matsubara N. Drake C.G. Fizazi K.…
View details →DOI: 10.1016/j.xcrm.2022.100613Cited by 10 Negative / Null Result ReportOpen accessMedicine
Fangzheng Wang, Jiang Chuner, Quanquan Sun et al. · 2018 · Journal of Cancer
In this study, we examined whether combining neoadjuvant chemotherapy (NAC) and/or concurrent chemotherapy (CC) with intensity-modulated radiotherapy (IMRT) improved survival in patients with stage II nasopharyngeal carcinoma (NPC). Two hundred forty-two stage II NPC patients were enrolled between May 2008 and April 2014 and received radical IMRT with simultaneous integrated boost technique using 6 MV photons; some patient groups also received chemotherapy every 3 weeks for 2-3 cycles. The median follow-up duration was 69 months for all patients. At the last follow-up, 18 patients had experien
View details →DOI: 10.7150/jca.25042Cited by 10 Negative / Null Result ReportNeuroscience
Brent A Bushey, Victor H Auld, John E Volk et al. · 2011 · PubMed
This study examined whether combining lipid emulsion and advanced cardiac life support (ACLS) improves survival in an unanesthetized swine model of bupivacaine- and hypoxia-induced cardiovascular collapse. Arterial and venous catheters and…
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Alicia Huerta‐Chagoya, Joohyun Kim, Ravi Mandla et al. · 2026 · The Lancet Diabetes & Endocrinology
BACKGROUND: Polygenic risk scores (PRSs) improve prediction of the development of type 2 diabetes over the use of clinical risk factors alone; however, they perform poorly in populations of non-European ancestry, limiting their global…
View details →DOI: 10.1016/s2213-8587(25)00405-xCited by 10 Negative / Null Result ReportOpen accessHealth Professions
Shanti Prasad Khanal, Chitra Bahadur Budhathoki, Orkan Okan · 2025 · BMC Public Health
BACKGROUND: There is a gap in theory-based interventions targeting adolescent health literacy. This study evaluated the impact of a school-based health literacy intervention on self-efficacy, health literacy awareness, situation, and…
View details →DOI: 10.1186/s12889-025-24827-1Cited by 10 Negative / Null Result ReportOpen accessComputer Science
Ali Raza, Fareeha Hanif, Heba Abdelgader Mohammed · 2026 · Scientific Reports
Lung cancer remains one of the leading causes of cancer-related mortality worldwide, and accurate early diagnosis plays a critical role in improving patient survival. In this study, a comparative analysis of multiple lightweight Convolutional Neural Network (CNN) variants is presented for multi-class lung cancer classification using histopathological images. Four CNN architectures were designed to systematically explore the trade-off between model complexity and classification performance. Each variant was trained and evaluated within a unified experimental framework incorporating data augment
View details →DOI: 10.1038/s41598-026-36652-6Cited by 10 Negative / Null Result ReportOpen accessPhysics and Astronomy
Matthias Klein, J. J. Mohr, C. T. Davies · 2024 · Astronomy and Astrophysics
Galaxy clusters are useful cosmological probes and interesting astrophysical laboratories. As the cluster samples continue to grow in size, a deeper understanding of the sample characteristics and improved control of systematics becomes more crucial. For this analysis we created a new and larger ACT-DR5-based thermal Sunyaev–Zel’dovich Effect- (tSZE-) selected galaxy cluster catalog with improved control over sample purity and completeness. We employed the red sequence based cluster redshift and confirmation tool MCMF together with optical imaging data from the Legacy Survey DR-10 and infrared
View details →DOI: 10.1051/0004-6361/202451203Cited by 10 Negative / Null Result ReportOpen accessMedicine
Y. Kanemitsu, Yasuhiro Shimizu, Junki Mizusawa et al. · 2026 · Journal of Clinical Oncology
JCOG0603 demonstrated improved disease-free survival (DFS) with adjuvant mFOLFOX6 after hepatectomy compared with hepatectomy alone in colorectal liver-only metastasis (CRLM), but the overall survival (OS) data were immature. Here, we…
View details →DOI: 10.1200/jco-25-01231Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lei Li, Hongchao Huang, Yin He et al. · 2025 · Military Medical Research
Sepsis is a dysregulated host response to infection that frequently results in fatal multiple organ dysfunction. Despite advances in clinical identification and management, both its incidence and mortality have remained persistently high. Emerging evidence indicates that cell-free DNA (cfDNA), as a novel biomarker and molecular therapeutic target, holds promise for improving the clinical management of sepsis. cfDNA refers to DNA fragments present in body fluids, including naked DNA, membrane-coated DNA, nucleosomes, and neutrophil extracellular traps (NETs). cfDNA is released from host cells o
View details →DOI: 10.1186/s40779-025-00668-2Cited by 10 Replication FailureOpen accessMedicine
Hideaki Bando, Jun Watanabe, Yusuke Takahashi et al. · 2026 · Nature Medicine
Tumor-informed circulating tumor DNA (ctDNA) enables detection of molecular residual disease (MRD) after curative resection of colorectal cancer (CRC), but whether early intervention improves outcomes remains uncertain. ALTAIR was a…
View details →DOI: 10.1038/s41591-026-04428-0Cited by 10 Negative / Null Result ReportOpen accessMedicine
Pinar Sargin, Mark F. Roethle, Shuang Jia et al. · 2022 · Gut Microbes
The increasing incidence of Type 1 diabetes has coincided with the emergence of the low-fiber, high-gluten Western diet and other environmental factors linked to dysbiosis. Since Lactiplantibacillus plantarum 299 v (Lp299v) supplementation improves gut barrier function and reduces systemic inflammation, we studied its effects in spontaneously diabetic DRlyp/lyp rats provided a normal cereal diet (ND) or a gluten-free hydrolyzed casein diet (HCD). All rats provided ND developed diabetes (62.5±7.7 days); combining ND with Lp299v did not improve survival. Diabetes was delayed by HCD (72.2±9.4 day
View details →DOI: 10.1080/19490976.2022.2136467Cited by 10 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Chitra Priyadarshani, Ranjan Laik, Sumit Sow et al. · 2025 · Archives of Agronomy and Soil Science
Integrated crop residue management with micronutrient application can effectively addresses dual challenges of maintaining productivity while enhancing grain nutritional quality of rice in calcareous soils. This study evaluated the role of different soil properties for enhancing yield and grain quality of rice under 29 years of long-term effects of crop residue incorporation and zinc (Zn) fertilization in calcareous Typic Haplaquepts soils. Results showed 100% crop residue incorporation significantly enhanced soil organic carbon (SOC), available nitrogen, available Zn, soil respiration, and we
View details →DOI: 10.1080/03650340.2025.2603669Cited by 10 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Anna Carolina Bruno Ferreira, Ygor Velloso Tavares, Nina Rezende Fontana et al. · 2026 · Molecules
The widespread utilization of synthetic dyes within the textile industry, driven by their chemical recalcitrance and diverse chromatic spectra, constitutes a significant global environmental challenge. Improper discharge of these highly stable effluents into natural water bodies leads to severe ecological imbalances, affecting aquatic life and soil integrity while posing indirect risks to human health due to their mutagenic potential. Conventional physicochemical treatment methods are often hindered by prohibitive operational costs and the frequent generation of hazardous secondary pollutants.
View details →DOI: 10.3390/molecules31071085Cited by 10 Negative / Null Result ReportOpen accessMedicine
Muhammad Junaid Tahir, Komal Tehzeeb, Farah Javaid et al. · 2023
Background: Parkinson's disease, is a degenerative neurological disorder, may have an adverse effect on movement, balance, and coordination. Physical therapy, a frequent Parkinson's disease treatment, tries to improve the patient's…
View details →DOI: 10.53555/jptcp.v30i19.3685Cited by 10 Negative / Null Result ReportOpen accessMedicine
Jason E. Pope, Ajay Antony, Erika Petersen et al. · 2024 · Pain and Therapy
INTRODUCTION: Drawbacks of fixed-output spinal cord stimulation (SCS) screening trials may lead to compromised trial outcomes and poor predictability of long-term success. Evoked compound action potential (ECAP) dose-controlled closed-loop…
View details →DOI: 10.1007/s40122-024-00631-4Cited by 10 Negative / Null Result ReportOpen accessMedicine
Robin Murray, Alice Egerton, Yueming Gao et al. · 2025 · Biological Psychiatry
Much is known about the use, benefits, and side-effects, of clozapine in treatment resistant schizophrenia (TRS). However, why clozapine is more effective than other antipsychotics in TRS remains unclear. This paper addresses this question. TRS patients show glutamate abnormalities, and clozapine has widespread effects on glutamate. However, these actions have not been proven different to those of other antipsychotics. Immune dysfunction is also reported in TRS, and clozapine has anti-inflammatory actions, but these have not been correlated with clinical improvement. Currently, there is much i
View details →DOI: 10.1016/j.biopsych.2025.06.011Cited by 10 Negative / Null Result Report
Seo-Ha Jeong, Yeon Gyo Nam · 2024 · Healthcare
Background/Objectives: Globally, life expectancy has been increasing with South Korea focusing on improving health to enhance quality of life. The COVID-19 pandemic further emphasized the need for digital transformation in healthcare,…
View details →DOI: 10.3390/healthcare12222261Cited by 10 Negative / Null Result ReportOpen accessMedicine
Chandran Ramakrishna, Mari S. Golub, Abby J. Chiang et al. · 2017 · Behavioural Neurology
Herpes simplex virus 1 (HSV) encephalitis (HSE) has serious neurological complications, involving behavioral and cognitive impairments that cause significant morbidity and a reduced quality of life. We showed that HSE results from dysregulated central nervous system (CNS) inflammatory responses. We hypothesized that CNS inflammation is casually involved in behavioral abnormalities after HSE and that treatment with ACV and pooled human immunoglobulin (IVIG), an immunomodulatory drug, would improve outcomes compared to mice treated with phosphate buffered saline (PBS) or ACV alone. Anxiety level
View details →DOI: 10.1155/2017/5238402Cited by 10 Negative / Null Result ReportOpen accessMedicine
Joseph R. Winer, Hillary Vossler, Christina B. Young et al. · 2024 · Brain Communications
Abstract Co-pathology is frequent in Lewy body disease, which includes clinical diagnoses of both Parkinson’s disease and dementia with Lewy bodies. Measuring concomitant pathology in vivo can improve clinical and research diagnoses and prediction of cognitive trajectories. Tau PET imaging may serve a dual role in Lewy body disease by measuring cortical tau aggregation as well as assessing dopaminergic loss attributed to binding to neuromelanin within substantia nigra. We sought to characterize 18F-PI-2620, a next generation PET tracer, in individuals with Lewy body disease. We recruited 141 p
View details →DOI: 10.1093/braincomms/fcae458Cited by 10 Negative / Null Result ReportOpen accessHealth Professions
Allison Kufta, Ali R. Djalilian · 2025 · Journal of Clinical Medicine
Background/Objectives: Patient education materials (PEMs) in ophthalmology often exceed recommended readability levels, limiting accessibility for many patients. While organizations like the AAO provide relatively easy-to-read resources, topics remain limited, and other associations’ PEMs are too complex. AI chatbots could help clinicians create more comprehensive, accessible PEMs to improve patient understanding. This study aims to compare the readability of patient education materials (PEMs) written by the American Academy of Ophthalmology (AAO) with those generated by large language models
View details →DOI: 10.3390/jcm14196968Cited by 10 Negative / Null Result Report
Gamze Durhan, Ahmet Gürkan Erdemir, Sezin Yuce Sari et al. · 2020 · Breast Care
Objective: Lymphatic irradiation in breast cancer improves locoregional control and has been shown to decrease distant metastasis. However, irradiation also accelerates the formation of atherosclerosis and can cause stenosis,…
View details →DOI: 10.1159/000508244Cited by 10 Negative / Null Result ReportOpen accessEnvironmental Science
Yumei Luo, Quan Chen, Fan Liu et al. · 2023 · Frontiers in Ecology and Evolution
Introduction Plant richness is thought to improve the function of constructed wetlands (CWs), but most CWs are planted with monocultures, with only a few employed polycultures, which have drawn contradictory conclusions. We suppose functional diversity is the key to better performance of plant communities and hypothesize that CWs planted with diverse growth forms are superior in plant growth and nutrient removal. Methods In this study, six emergent plant species categorized into slender type ( Schoenoplectus tabernaemontani, Typha orientalis ), fan type ( Iris sibirica, Acorus calamus ) and la
View details →DOI: 10.3389/fevo.2023.1139053Cited by 10 