Negative / Null Result ReportOpen accessMedicine
James D. Doecke, Giovanni Bellomo, Lisa Vermunt et al. · 2025 · Alzheimer s & Dementia
INTRODUCTION: Plasma phosphorylated tau (p-tau)181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and amyloid beta ratio (Aβ42/40) may have diagnostic and prognostic value in Alzheimer's disease (AD). Here we assess which markers can best identify AD from controls and other non-AD dementias in a large international multi-center study. METHODS: Plasma samples (n = 1298) were collected from six international centers. Aβ40, Aβ42, GFAP, NfL, and p-tau181 were measured using single molecule array. In each group, AD diagnosis/co-pathology was defined according to cerebrosp
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Hezixian Guo, L.-T. Pan, Qiuyi Wu et al. · 2025 · Nutrients
Type 2 diabetes (T2D) is a complex metabolic disease characterized by chronic hyperglycemia due to insulin resistance and inadequate insulin secretion. Beyond the classically implicated organs, emerging evidence highlights the gut as a central player in T2D pathophysiology through its interactions with metabolic organs. The gut hosts trillions of microbes and enteroendocrine cells that influence inflammation, energy homeostasis, and hormone regulation. Disruptions in gut homeostasis (dysbiosis and increased permeability) have been linked to obesity, insulin resistance, and β-cell dysfunction,
View details →Negative / Null Result ReportOpen accessMedicine
Saeede Saadati, Rasoul Godini, Anjana Reddy et al. · 2025 · Frontiers in Immunology
Insulin resistance is a central pathological feature of several chronic metabolic disorders, including obesity, type 2 diabetes, polycystic ovary syndrome, and cardiovascular disease. While its pathogenesis is multifactorial, lipid dysregulation and chronic low-grade inflammation are recognised as two major, interconnected processes that impair insulin action across multiple tissues. This review summarises core mechanistic themes linking these processes, with a focus on three key signalling pathways that are particularly relevant to metabolic regulation and to the interplay between lipid metab
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Maurizio Agelli, Nicola Corona, Fabio Maggio et al. · 2024 · Machines
Continuous crop monitoring enables the early detection of field emergencies such as pests, diseases, and nutritional deficits, allowing for less invasive interventions and yielding economic, environmental, and health benefits. The work organization of modern agriculture, however, is not compatible with continuous human monitoring. ICT can facilitate this process using autonomous Unmanned Ground Vehicles (UGVs) to navigate crops, detect issues, georeference them, and report to human experts in real time. This review evaluates the current state of ICT technology to determine if it supports auton
View details →Negative / Null Result ReportOpen accessSocial Sciences
Sue Lim, Ralf Schmälzle, Gary Bente · 2025 · Computers in Human Behavior Artificial Humans
Interactions with artificial intelligence (AI) based agents can positively influence human behavior and judgment. However, studies to date focus on text-based conversational agents (CA) with limited embodiment, restricting our understanding of how social influence principles, such as physical similarity, apply to AI agents (i.e., artificial social influence). We address this gap by leveraging latest advances in AI (large language models) and combining them with immersive virtual reality (VR). Specifically, we built VR-ECAs, or embodied conversational agents that can engage in turn-taking conve
View details →Negative / Null Result ReportOpen accessMedicine
Laura Krygere, Povilas Jukna, Kristina Jarienė et al. · 2024 · Biomedicines
Endometriosis is a common gynecological condition affecting approximately 10% of women of reproductive age, characterized by the abnormal presence of endometrial-like tissue outside the uterus. Although endometriosis was first described over 300 years ago, its underlying mechanisms remain poorly understood, and accurate, prompt diagnosis continues to be challenging. Currently, there is a lack of effective, non-invasive diagnostic methods, and available treatments often come with significant side effects and high recurrence rates. This has spurred interest in investigating the role of pro- and
View details →Negative / Null Result ReportOpen accessMedicine
Josef S. Smolen, Christopher J. Edwards, Victoria Konzett et al. · 2026 · Annals of the Rheumatic Diseases
OBJECTIVES: This study aims to provide an update of the European Alliance of Associations for Rheumatology (EULAR) rheumatoid arthritis (RA) management recommendations addressing the most recent insights. METHODS: An International Task…
View details →Negative / Null Result ReportOpen accessMedicine
Meryem A. Yücel, Robert Luke, Rickson C. Mesquita et al. · 2025 · Communications Biology
As data analysis pipelines grow more complex in brain imaging research, understanding how methodological choices affect results is essential for ensuring reproducibility and transparency. This is especially relevant for functional Near-Infrared Spectroscopy (fNIRS), a rapidly growing technique for assessing brain function in naturalistic settings and across the lifespan, yet one that still lacks standardized analysis approaches. In the fNIRS Reproducibility Study Hub (FRESH) initiative, we asked 38 research teams worldwide to independently analyze the same two fNIRS datasets. Despite using dif
View details →Negative / Null Result ReportOpen accessNeuroscience
Yves‐Alain Barde · 2025 · Physiological Reviews
BDNF is synthesized and secreted by excitatory neurons. Decades of work with animal models prepared the ground for interpreting the results of human genome analyses associating polymorphisms with memory deficits, mood disorders and…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Bonnie M. Meguid, Hilde Coffé, Ana Catalano Weeks et al. · 2025 · Comparative Political Studies
Despite their Männerparteien reputation, populist radical right (PRR) parties have recently expanded their agendas to include women’s interests. When do they embrace these interests, and what shapes their stance? We propose a theory of…
View details →Negative / Null Result ReportOpen accessMedicine
Ashwin Ramaswamy, Alvira Tyagi, Hannah Hugo et al. · 2026 · Nature Medicine
ChatGPT Health was launched in January 2026 as OpenAI's consumer health tool and has reached millions of users. Here we conducted a structured stress test of triage recommendations using 60 clinician-authored vignettes across 21 clinical domains under 16 factorial conditions, yielding 960 total responses. Performance followed an inverted U-shaped pattern, with the most dangerous failures concentrated at clinical extremes-nonurgent presentations (35%) and emergency conditions (48%). Among gold-standard emergencies, the system undertriaged 52% of cases, directing patients with diabetic ketoacido
View details →Negative / Null Result ReportOpen accessHealth Professions
Seunghyeon Wang · 2026 · Scientific Reports
Ensuring consistent compliance with Personal Protective Equipment (PPE) requirements on construction sites is crucial for worker safety. Although deep learning-based methods already perform well in detecting non-PPE cases, there is still…
View details →Negative / Null Result ReportOpen accessSocial Sciences
David Weisburd · 2026
Hot spots policing has emerged as one of the most important and widely diffused of what are sometimes termed the “new policing” strategies. Such strategies were developed in response to a critique of police effectiveness in preventing…
View details →Negative / Null Result ReportOpen accessMedicine
Mats Enlund, Anders Berglund, Anna Enlund et al. · 2022 · Anesthesiology
BACKGROUND: Several retrospective studies using administrative or single-center data have failed to show any difference between general anesthesia using propofol versus inhaled volatiles on long-term survival after breast cancer surgery.…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Amanda Rotella, Adam Maxwell Sparks, Sandeep Mishra et al. · 2021 · PLoS ONE
Some evidence suggests that people behave more cooperatively and generously when observed or in the presence of images of eyes (termed the 'watching eyes' effect). Eye images are thought to trigger feelings of observation, which in turn motivate people to behave more cooperatively to earn a good reputation. However, several recent studies have failed to find evidence of the eyes effect. One possibility is that inconsistent evidence in support of the eyes effect is a product of individual differences in sensitivity or susceptibility to the cue. In fact, some evidence suggests that people who ar
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
In-Woo Park, Yan Fan, Xiaoyu Luo et al. · 2014 · PLoS ONE
HIV-1 infection enhances HCV replication and as a consequence accelerates HCV-mediated hepatocellular carcinoma (HCC). However, the precise molecular mechanism by which this takes place is currently unknown. Our data showed that infectious HIV-1 failed to replicate in human hepatocytic cell lines. No discernible virus replication was observed, even when the cell lines transfected with HIV-1 proviral DNA were co-cultured with Jurkat T cells, indicating that the problem of liver deterioration in the co-infected patient is not due to the replication of HIV-1 in the hepatocytes of the HCV infected
View details →Negative / Null Result ReportOpen accessMedicine
Richard A. Brown, Susan E. Ramsey, Christopher W. Kahler et al. · 2011 · Journal of Studies on Alcohol and Drugs
OBJECTIVE: A previous pilot study found positive outcomes among alcohol-dependent individuals with elevated depressive symptoms who received cognitive-behavioral treatment for depression (CBT-D; n = 19) compared with a relaxation training…
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Claus Neurohr, Nikolaus Kneidinger, Alessandro Ghiani et al. · 2021 · American Journal of Transplantation
Long-term survival after lung transplantation is limited by chronic allograft dysfunction. The aim of this study was to investigate the effect of locally augmented immunosuppression with liposomal cyclosporine A for inhalation (L-CsA-i)…
View details →Negative / Null Result ReportOpen accessEngineering
Shane Esola, Brian Wisner, Prashanth A. Vanniamparambil et al. · 2018 · Applied Sciences
The research presented in this article aims to demonstrate how acoustic emission (AE) monitoring can be implemented in an industrial setting to assist with part qualification, as mandated by related industry standards. The combined structural and nondestructive evaluation method presented departs from the traditional pass/fail criteria used for part qualification, and contributes toward a multi-dimensional assessment by taking advantage of AE data recorded during structural testing. To demonstrate the application of this method, 16 composite fixed-wing-aircraft spars were tested using a struct
View details →Negative / Null Result ReportOpen accessPsychology
Marlou Poppelaars, Anna Lichtwarck‐Aschoff, Roy Otten et al. · 2021 · Frontiers in Psychology
Depressive symptoms and disorders are major public health concerns, affecting many adolescents and young adults. Despite extensive research, depression prevention programs for youth show limited effectiveness. Moreover, the maximal potential of youth psychotherapy — on which depression prevention programs are based — may have been reached. Commercial video games may offer an engaging alternative vehicle for youth to practice emotional and social skills vital to mental health. The current study investigated the potential for the commercial video game Journey to prevent the exacerbation of depre
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Ying Shen, Yuanlong Yan, Yunqiang Liu et al. · 2013 · Human Molecular Genetics
AZFc deletions cause a significant phenotypic heterogeneity with respect to spermatogenesis; however, the reason for this is poorly understood. Recently, testis-specific protein Y-encoded 1 (TSPY1) copy number variation (CNV) was…
View details →Negative / Null Result ReportMedicine
Giorgio Aicardi · 2013 · Rejuvenation Research
Despite decades of research, there is no cure for Alzheimer disease (AD), and current pharmacological treatments only partially mask the symptoms while the disease progresses within the brain. AD is associated with impaired clearance of…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Juliana Abagsonema Abane, Ronald Adamtey, Virceta Owusu Ayim · 2022 · Future Business Journal
Abstract There is mixed evidence that low levels of productivity at the local government level are not common with organizations with strong cultures as these are less prone to any externalities. The paper investigated the link between organizational culture and employee productivity from the perspectives of employees of the Sekondi-Takoradi Metropolitan Assembly (STMA) in Ghana. The study used the quantitative approach with descriptive and cross-sectional designs. The simple random and stratified sampling techniques were used to select 132 respondents from the STMA using a self-administered s
View details →Negative / Null Result ReportOpen accessNeuroscience
Karam Khateeb, Zhaojie Yao, Viktor Kharazia et al. · 2019
Ischemic stroke is a major cause of disability among adults worldwide. Despite its prevalence, few effective treatment options exist to alleviate sensory and motor dysfunctions that result from stroke. In the past, rodent models of stroke…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Masaru Sekijima, Hiroshi Takeda, Katsuaki Yasunaga et al. · 2010 · Journal of Radiation Research
We investigated the mechanisms by which radiofrequency (RF) fields exert their activity, and the changes in both cell proliferation and the gene expression profile in the human cell lines, A172 (glioblastoma), H4 (neuroglioma), and IMR-90…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Eamonn P. Culligan, Julian R. Marchesi, Colin Hill et al. · 2014 · Frontiers in Microbiology
In the current study, a number of salt-tolerant clones previously isolated from a human gut metagenomic library were screened using Phenotype MicroArray (PM) technology to assess their functional capacity. PM's can be used to study gene function, pathogenicity, metabolic capacity and identify drug targets using a series of specialized microtitre plate assays, where each well of the microtitre plate contains a different set of conditions and tests a different phenotype. Cellular respiration is monitored colorimetrically by the reduction of a tetrazolium dye. One clone, SMG 9, was found to be po
View details →Negative / Null Result ReportOpen accessMedicine
Tiffany A. Greenwood, John R. Kelsoe · 2013 · PLoS ONE
The use of clinical features to define subtypes of a disorder may aid in gene identification for complex diseases. In particular, clinical subtypes of mania may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. To assess this possibility, we performed a genome-wide association study using genotype data from the Bipolar Genome Study (BiGS) and subjects that were categorized as having either irritable or elated mania during their most severe episode. A bipolar case-only analysis in the GAIN bipolar sample identified several genomic regions that differed betwe
View details →Negative / Null Result ReportOpen accessSocial Sciences
Trisha Harjani, Melisa-Sinem Basol, Jon Roozenbeek et al. · 2023 · Journal of Trial and Error
Although the spread of misinformation is a pervasive and disruptive global problem, extant research is skewed towards “WEIRD” countries leaving questions about how to tackle misinformation in the developing world with different media and consumption patterns unanswered. We report the results of a game-based intervention against misinformation in India. The game is based on the mechanism of psychological inoculation; borrowed from the medical context, inoculation interventions aim to pre-emptively neutralize falsehoods and help audiences spot and resist misinformation strategies. Though the eff
View details →Negative / Null Result ReportOpen accessMedicine
Arthur Wickenhagen, Meaghan Flagg, Julia R. Port et al. · 2025 · Nature Communications
The emergence of the Omicron lineage represented a major genetic drift in SARS-CoV-2 evolution. This was associated with phenotypic changes including evasion of pre-existing immunity and decreased disease severity. Continuous evolution within the Omicron lineage raised concerns of potential increased transmissibility and/or disease severity. To address this, we evaluate the fitness and pathogenesis of contemporary Omicron variants XBB.1.5, XBB.1.16, EG.5.1, and JN.1 in the upper (URT) and lower respiratory tract (LRT). We compare in vivo infection in Syrian hamsters with infection in primary h
View details →Negative / Null Result ReportMedicine
Nathalie Charlier, Andrew D. Davidson, Kai Dallmeier et al. · 2010 · Journal of General Virology
Chimeric yellow fever virus 17D (YFV-17D) and dengue virus type 2 (DENV2) carrying the surface proteins of Modoc virus (MODV), a not-known-vector (NKV) flavivirus, replicated efficiently in mammalian (Vero-B) and mosquito (C6/36) cells,…
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