Negative / Null Result ReportOpen accessMedicine
Oliver Shutkever, David J. Gracie, Caroline Young et al. · 2018 · Inflammatory Bowel Diseases
Background: The microbiome is implicated in the pathogenesis of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Whether a distinct microbiome profile is associated with the reporting of IBS-type symptoms in IBD…
View details →Negative / Null Result ReportOpen accessPsychology
Meiling Liu, Pär Anders Granhag, Sara Landström et al. · 2010 · The Open Criminology Journal
In this paper we focused on children's deception (10-12 years, Experiment 1), and adult's ability detect deception in children (Experiment 2). The self-presentational perspective By asking unanticipated questions we put the liars in the…
View details →Negative / Null Result ReportOpen accessMedicine
Paul Blanc‐Durand, Axel Van Der Gucht, Antoine Verger et al. · 2018 · PLoS ONE
INTRODUCTION: Aim was to develop a full automatic clustering approach of the time-activity curves (TAC) from dynamic 18F-FET PET and evaluate its association with IDH1 mutation status and survival in patients with gliomas. METHODS: Thirty-seven patients (mean age: 45±13 y) with newly diagnosed gliomas and dynamic 18F-FET PET before any histopathologic investigation or treatment were retrospectively included. Each dynamic 18F-FET PET was realigned to the first image and spatially normalized in the Montreal Neurological Institute template. A tumor mask was semi-automatically generated from Z-sco
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Michele Duarte de Menezes, Sérgio Henrique Godinho Silva, Carlos Rogério de Mello et al. · 2016 · Scientia Agricola
This study compared the performance of ordinary kriging (OK) and regression kriging (RK) to predict soil physical-chemical properties in topsoil (0-15 cm). Mean prediction of error and root mean square of prediction error were used to assess the prediction methods. Two watersheds with contrasting soil-landscape features were studied, for which the prediction methods were performed differently. A multiple linear stepwise regression model was performed with RK using digital terrain models (DTMs) and remote sensing images in order to choose the best auxiliary covariates. Different pedogenic facto
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Patrick Moore, R. Justin DeRose, James N. Long et al. · 2012 · Forests
Enhancement of forest growth through silvicultural modification of stand density is one strategy for increasing carbon (C) sequestration. Using the Fire and Fuels Extension of the Forest Vegetation Simulator, the effects of even-aged, uneven-aged and no-action management scenarios on C sequestration in a southern Appalachian red spruce-Fraser fir forest were modeled. We explicitly considered C stored in standing forest stocks and the fate of forest products derived from harvesting. Over a 100-year simulation period the even-aged scenario (250 Mg C ha−1) outperformed the no-action scenario (241
View details →Negative / Null Result ReportPsychology
Shree Krishna Subburaj, Angela Stewart, Arjun Rao et al. · 2020
Modeling team phenomena from multiparty interactions inherently requires combining signals from multiple teammates, often by weighting strategies. Here, we explored the hypothesis that strategic weighting signals from individual teammates…
View details →Negative / Null Result ReportMedicine
Andrew M. Penn, Maximilian B. Bibok, Viera Saly et al. · 2018 · Biomarkers
OBJECTIVE: To validate our previously developed 16 plasma-protein biomarker panel to differentiate between transient ischaemic attack (TIA) and non-cerebrovascular emergency department (ED) patients.METHOD: Two consecutive cohorts of ED…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sean M. Carroll, Katherine S. Xue, Christopher J. Marx · 2014 · BMC Microbiology
BACKGROUND: A common assumption of microorganisms is that laboratory stocks will remain genetically and phenotypically constant over time, and across laboratories. It is becoming increasingly clear, however, that mutations can ruin strain integrity and drive the divergence or "domestication" of stocks. Since its discovery in 1960, a stock of Methylobacterium extorquens AM1 ("AM1") has remained in the lab, propagated across numerous growth and storage conditions, researchers, and facilities. To explore the extent to which this lineage has diverged, we compared our own "Modern" stock of AM1 to a
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Chris H. Carlson, Solomon Z. Dobrowski, Hugh D. Safford · 2012 · Carbon Balance and Management
BACKGROUND: Forest fuel treatments have been proposed as tools to stabilize carbon stocks in fire-prone forests in the Western U.S.A. Although fuel treatments such as thinning and burning are known to immediately reduce forest carbon stocks, there are suggestions that these losses may be paid back over the long-term if treatments sufficiently reduce future wildfire severity, or prevent deforestation. Although fire severity and post-fire tree regeneration have been indicated as important influences on long-term carbon dynamics, it remains unclear how natural variability in these processes might
View details →Negative / Null Result ReportOpen accessMedicine
Garth Funston, Gary Abel, Emma J. Crosbie et al. · 2021 · Cancers
CA125 is widely used as an initial investigation in women presenting with symptoms of possible ovarian cancer. We sought to develop CA125-based diagnostic prediction models and to explore potential implications of implementing model-based thresholds for further investigation in primary care. This retrospective cohort study used routinely collected primary care and cancer registry data from symptomatic, CA125-tested women in England (2011-2014). A total of 29,962 women were included, of whom 279 were diagnosed with ovarian cancer. Logistic regression was used to develop two models to estimate o
View details →Negative / Null Result ReportOpen accessMedicine
William R. Freeman, Francesco Bandello, Eric H. Souied et al. · 2023 · Ophthalmology Retina
To evaluate the safety and efficacy of repeat injections of Brimonidine Drug Delivery System (Brimo DDS) Generation 2 (Gen 2) containing 400-μg brimonidine in patients with geographic atrophy (GA) secondary to age-related macular…
View details →Negative / Null Result ReportOpen accessMedicine
Mikael Fink Vallentin, Asger Granfeldt, Carsten Meilandt et al. · 2022 · Resuscitation
OBJECTIVE: The Calcium for Out-of-hospital Cardiac Arrest (COCA) trial was a randomized, placebo-controlled, double-blind trial of calcium for out-of-hospital cardiac arrest. The primary and secondary outcomes have been reported previously. This article describes the long-term outcomes of the trial. METHODS: Patients aged ≥18 years were included if they had a non-traumatic out-of-hospital cardiac arrest during which they received adrenaline. The trial drug consisted of calcium chloride (5 mmol) or saline placebo given after the first dose of adrenaline and again after the second dose of adrena
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Arley Calle-Tobón, Juliana Pérez-Pérez, Nicolás Forero-Pineda et al. · 2022 · PLoS ONE
Aedes spp. comprise the primary group of mosquitoes that transmit arboviruses such as dengue, Zika, and chikungunya viruses to humans, and thus these insects pose a significant burden on public health worldwide. Advancements in next-generation sequencing and metagenomics have expanded our knowledge on the richness of RNA viruses harbored by arthropods such as Ae. aegypti and Ae. albopictus. Increasing evidence suggests that vector competence can be modified by the microbiome (comprising both bacteriome and virome) of mosquitoes present in endemic zones. Using an RNA-seq-based metataxonomic app
View details →Negative / Null Result ReportOpen accessMedicine
S. Takahashi, Atsushi Kudoh, Yoshio Okawa et al. · 2012 · FEBS Journal
Candida glabrata is often the second or third most common cause of candidiasis after Candida albicans. C. glabrata infections are difficult to treat, often resistant to many azole antifungal agents and are associated with a high mortality…
View details →Negative / Null Result ReportMedicine
Jessica Cox, Andrew C. Bernard, Anthony J. Bottiggi et al. · 2014 · Journal of the American College of Surgeons
BACKGROUND: The influence of in-house (IH) attendings on trauma patient survival and efficiency measures, such as emergency department length of stay (LOS), ICU LOS, and hospital LOS, has been debated for more than 20 years. No study has…
View details →Negative / Null Result Report
John Macleod, Matthew Hickman · 2010 · Addiction
ABSTRACT In the United Kingdom, as in many places, cannabis use is considered substantially within a criminal justice rather than a public health paradigm with prevention policy embodied in the Misuse of Drugs Act. In 2002 the maximum…
View details →Negative / Null Result ReportEarth and Planetary Sciences
Sandip Pal, Temple R. Lee · 2019 · Geophysical Research Letters
Abstract The complexities in the atmospheric boundary layer depth (BLD) features over coastal regions pose challenges for meteorological forecasts, air quality, greenhouse gas mixing and transport, and wind energy production. Here, for the…
View details →Negative / Null Result ReportOpen accessMedicine
Jinhua Chen, Yu‐Chun Yen, Shing‐Hwa Liu et al. · 2016 · Medicine
The use of induction chemotherapy (CT) is controversial. We compared the survival of head and neck cancer patients receiving docetaxel- or platinum-based induction CT before concomitant chemoradiotherapy (CCRT) with the survival of those receiving upfront CCRT alone. Data from the National Health Insurance and cancer registry databases in Taiwan were linked and analyzed. We enrolled patients who had head and neck cancer between January 1, 2002 and December 31, 2011. Follow-up was from the index date to December 31, 2013. We included head and neck patients diagnosed according to the Internation
View details →Negative / Null Result Report
Travis M. Seale-Carlisle, Laura Mickes · 2016 · Royal Society Open Science
In the USA and the UK, many thousands of police suspects are identified by eyewitnesses every year. Unfortunately, many of those suspects are innocent, which becomes evident when they are exonerated by DNA testing, often after having been…
View details →Negative / Null Result Report
J. Duguay, P. M. Biron, J. Lacey · 2022 · Water Resources Research
Abstract When rivers collide, complex three‐dimensional coherent flow structures are generated along the confluence's mixing interface. These structures mix streamborne pollutants and suspended sediment and have considerable bearing on the…
View details →Negative / Null Result ReportOpen accessMedicine
Saeede Saadati, Rasoul Godini, Anjana Reddy et al. · 2025 · Frontiers in Immunology
Insulin resistance is a central pathological feature of several chronic metabolic disorders, including obesity, type 2 diabetes, polycystic ovary syndrome, and cardiovascular disease. While its pathogenesis is multifactorial, lipid dysregulation and chronic low-grade inflammation are recognised as two major, interconnected processes that impair insulin action across multiple tissues. This review summarises core mechanistic themes linking these processes, with a focus on three key signalling pathways that are particularly relevant to metabolic regulation and to the interplay between lipid metab
View details →Negative / Null Result ReportOpen accessHealth Professions
Seunghyeon Wang · 2026 · Scientific Reports
Ensuring consistent compliance with Personal Protective Equipment (PPE) requirements on construction sites is crucial for worker safety. Although deep learning-based methods already perform well in detecting non-PPE cases, there is still…
View details →Negative / Null Result Report
Kye L. McCarthy, Peter Caputi, Brin F.S. Grenyer · 2017 · Psychology and Psychotherapy: Theory, Research and Practice
Objective Significant change events are helpful moments within a psychotherapy session that have been shown in previous research to relate strongly to outcome. They are special moments and therefore provide rich data for research into…
View details →Negative / Null Result Report
Tsai‐Ling Liao, Ching‐Heng Lin, Hsin‐Hua Chen et al. · 2017 · Journal of the American Heart Association
Background Accumulating evidence suggests an increased risk of stroke after herpes zoster ( HZ ). This risk is elevated in immunocompromised patients. The incidence of HZ in Asia is higher than in Western countries. However, the…
View details →Negative / Null Result Report
Asia Mendelevich, Svetlana Vinogradova, Saumya Gupta et al. · 2021 · Nature Communications
Abstract A sensitive approach to quantitative analysis of transcriptional regulation in diploid organisms is analysis of allelic imbalance (AI) in RNA sequencing (RNA-seq) data. A near-universal practice in such studies is to prepare and…
View details →Negative / Null Result ReportOpen accessEnergy
Casey M. Godwin, David C. Hietala, Aubrey R. Lashaway et al. · 2017 · Environmental Science & Technology
For algal biofuels to be economically sustainable and avoid exacerbating nutrient pollution, algal cultivation and processing must maximize rates of biofuel production while simultaneously minimizing the consumption of nitrogen (N) and…
View details →Negative / Null Result Report
Ruella Rouf, Sara M. Karaba, Jenny Dao et al. · 2011 · Microbiology
The environmental bacterium Stenotrophomonas maltophilia is increasingly described as a multidrug-resistant pathogen of humans, being associated with pneumonia, among other diseases. But the degree to which S. maltophilia is capable of…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Heini Sánez Tähtisalo, Sanni Ruotsalainen, Nina Mars et al. · 2020 · Scientific Reports
Polygenic risk scores (PRSs) for essential hypertension, calculated from > 900 genomic loci, were recently found to explain a significant fraction of hypertension heritability and complications. To investigate whether variation of hypertension PRS also captures variation of antihypertensive drug responsiveness, we calculated two different PRSs for both systolic and diastolic blood pressure: one based on the top 793 independent hypertension-associated single nucleotide polymorphisms and another based on over 1 million genome-wide variants. Using our pharmacogenomic GENRES study comprising four
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Boshu Ru, Dingcheng Li, Yueqi Hu et al. · 2019 · IEEE Transactions on NanoBioscience
Serendipitous drug usage refers to the unexpected relief of comorbid diseases or symptoms when taking medication for a different known indication. Historically, serendipity has contributed significantly to identifying many new drug…
View details →Negative / Null Result ReportOpen accessMedicine
Yen‐Jen Chen, Hsien‐Te Chen, Horng‐Chaung Hsu · 2015 · Journal of Orthopaedic Surgery and Research
BACKGROUND: Survival is a key factor physicians consider when selecting a treatment modality for the treatment of spinal metastases. Various assessment systems can predict length of survival and facilitate selection of the most appropriate treatment. Spinal palsy is a prognostic parameter in the Tokuhashi scoring system but not in the Tomita scoring system. A limitation of these scoring systems is that studies of them have included different tumor types. The aim of this study was to evaluate the usefulness of preoperative neurological status as a prognostic factor in non-small-cell lung cancer
View details →