Negative / Null Result ReportOpen accessMedicine
Luciana Mascia, Vito Fanelli, Alice Mistretta et al. · 2024 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale Lung-protective strategies using low Vt and moderate positive end-expiratory pressure (PEEP) are considered best practice in critical care, but interventional trials have never been conducted in patients with acute brain…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Inmaculada Martínez‐Zarzoso, Martina Vidovic, Anca M. Voicu · 2016 · The Journal of Environment & Development
The aim of this article is to investigate the relationship between environmental stringency and intra–European Union (EU) trade flows. Two main hypotheses are tested. First, we test whether the stringency of a country's environmental…
View details →Negative / Null Result ReportOpen accessPsychology
Victoria Whitelock, Suzanne Higgs, Jeffrey M. Brunstrom et al. · 2018 · Appetite
Focusing attention on food during a meal has been shown to reduce later snack consumption. We report the results of two studies that aimed to replicate this effect and to elucidate the underlying mechanisms. We hypothesised that focused attention during a lunchtime meal would improve visual memory and/or memory for the satiating effects of the meal, and that this would reduce later food intake. In Study 1, participants (N = 108, 52.8% female, BMI M = 25.75 kg/m2) were randomly allocated to eat a fixed lunchtime meal while listening to instructions that encouraged them to pay attention to the s
View details →Negative / Null Result ReportOpen accessMedicine
Sriram Ramgopal, Cameron Dezfulian, Robert W. Hickey et al. · 2019 · JAMA Network Open
Importance: A high Pao2, termed hyperoxemia, is postulated to have deleterious health outcomes. To date, the association between hyperoxemia during the ongoing management of critical illness and mortality has been incompletely evaluated in children. Objective: To examine whether severe hyperoxemia events are associated with mortality among patients admitted to a pediatric intensive care unit (PICU). Design, Setting, and Participants: A retrospective cohort study was conducted over a 10-year period (January 1, 2009, to December 31, 2018); all 23 719 PICU encounters at a quaternary children's ho
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Imogen Wadlow, Clare Paton‐Walsh, Hugh Forehead et al. · 2019 · Atmosphere
Motivated by public interest, the Clean Air and Urban Landscapes (CAUL) hub deployed instrumentation to measure air quality at a roadside location in Sydney. The main aim was to compare concentrations of fine particulate matter (PM2.5) measured along a busy road section with ambient regional urban background levels, as measured at nearby regulatory air quality stations. The study also explored spatial and temporal variations in the observed PM2.5 concentrations. The chosen area was Randwick in Sydney, because it was also the subject area for an agent-based traffic model. Over a four-day campai
View details →Negative / Null Result ReportOpen accessMedicine
Michael Scott Doyle, Bethany N. Swope, Jerome A. Hogsette et al. · 2011 · Journal of Medical Entomology
In 2006-2007, stable flies, Stomoxys calcitrans (L.) (Diptera: Muscidae), were suspected of being enzootic vectors of West Nile virus (family Flaviviridae, genus Flavivirus, WNV) during a die-off of American white pelicans (Pelecanus…
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Alexis Rojas, Pedro Patarroyo, Liang Mao et al. · 2017 · Geology
Large-scale biogeographic provinces of Cretaceous ammonoids, as currently defined in the literature, were delimited using qualitative assessments of taxonomic inventories. Using aggregated species occurrences in the Paleobiology Database, we generated a geographic network to quantify connectivity of Albian epicontinental basins and used the flow-based Infomap algorithm to delineate bioprovinces. Despite taxonomic, stratigraphic, and geographic limitations of the data, the Infomap bioprovinces are largely concordant with the traditional, qualitatively derived biogeographic model, including the
View details →Negative / Null Result ReportMedicine
Alicia K. Klanecky, Dennis E. McChargue, Lindsay Bruggeman · 2012 · American Journal on Addictions
Alcohol use to replace inadequate dissociative capabilities, or chemical dissociation, has been linked to college students with childhood or adolescent sexual abuse (CASA). Insofar as CASA-exposed persons experience a restricted range of…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Miroslav Petr, Petr Šťastný, Ondřej Pecha et al. · 2014 · PLoS ONE
To date, polymorphisms in several genes have been associated with a strength/power performance including alpha 3 actinin, ciliary neurotrophic factor, vitamin D receptor, or angiotensin I converting enzyme, underlining the importance of genetic component of the multifactorial strength/power-related phenotypes. The single nucleotide variation in peroxisome proliferator-activated receptor alpha gene (PPARA) intron 7 G/C (rs4253778; g.46630634G>C) has been repeatedly found to play a significant role in response to different types of physical activity. We investigated the effect of PPARA intron 7
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Hector Roux de Bézieux, Koen Van den Berge, Kelly Street et al. · 2024 · Nature Communications
In single-cell RNA sequencing (scRNA-Seq), gene expression is assessed individually for each cell, allowing the investigation of developmental processes, such as embryogenesis and cellular differentiation and regeneration, at unprecedented resolution. In such dynamic biological systems, cellular states form a continuum, e.g., for the differentiation of stem cells into mature cell types. This process is often represented via a trajectory in a reduced-dimensional representation of the scRNA-Seq dataset. While many methods have been suggested for trajectory inference, it is often unclear how to h
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Clara Collart, Christo P. Christov, James C. Smith et al. · 2011 · Molecular and Cellular Biology
Noncoding Y RNAs are essential for the initiation of chromosomal DNA replication in mammalian cell extracts, but their role in this process during early vertebrate development is unknown. Here, we use antisense morpholino nucleotides (MOs)…
View details →Negative / Null Result ReportOpen accessMedicine
Kosuke Kitamura, Toshiyuki China, Mayuko Kanayama et al. · 2018 · Prostate International
To determine the clinical predictive factors affecting the recovery from postoperative urinary incontinence after robot-assisted radical prostatectomy (RARP). We consecutively analyzed 320 patients who underwent RARP between January 2012…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Sophie Q. van Rijssel, Guusje J. Koorneef, G. F. Veen et al. · 2025 · Science
Organic farming is often considered to be more sustainable than conventional farming. However, both farming systems comprise highly variable management practices. In this study, we show that in organic and conventional arable fields, the…
View details →Negative / Null Result ReportOpen accessMedicine
Stefan D. Anker, Javed Butler, Muhammad Usman et al. · 2022 · Nature Medicine
Abstract The EMPEROR-Preserved trial showed that the sodium–glucose co-transporter 2 inhibitor empagliflozin significantly reduces the risk of cardiovascular death or hospitalization for heart failure (HHF) in heart failure patients with left ventricular ejection fraction (LVEF) > 40%. Here, we report the results of a pre-specified analysis that separately evaluates these patients stratified by LVEF: preserved (≥ 50%) ( n = 4,005; 66.9%) or mid-range (41–49%). In patients with LVEF ≥ 50%, empagliflozin reduced the risk of cardiovascular death or HHF (the primary endpoint) by 17% versus plac
View details →Negative / Null Result ReportOpen accessMedicine
Guodong Sun, Yang Zhang, Shanshan Mo et al. · 2021 · International Journal of General Medicine
PURPOSE: To analyze the risk factors of multiple organ dysfunction syndromes (MODS) caused by sepsis. PATIENTS AND METHODS: A total of 180 patients with sepsis admitted to The First Affiliated Hospital of Harbin Medical University (No. 23,…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Duc Tin Tran, Sri Nagarjun Batchu, Andrew Advani · 2024 · Frontiers in Cardiovascular Medicine
Interferons (IFNs) and IFN-related pathways play key roles in the defence against microbial infection. However, these processes may also be activated during the pathogenesis of non-infectious diseases, where they may contribute to organ injury, or function in a compensatory manner. In this review, we explore the roles of IFNs and IFN-related pathways in heart disease. We consider the cardiac effects of type I IFNs and IFN-stimulated genes (ISGs); the emerging role of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway; the seemingly paradoxical effects of the type
View details →Negative / Null Result ReportOpen accessNursing
Tatiana Galvão, Bethany H. Brown, Peter Hecker et al. · 2011 · Cardiovascular Research
AIMS: The impact of a high-fat diet on the failing heart is unclear, and the differences between polyunsaturated fatty acids (PUFA) and saturated fat have not been assessed. Here, we compared a standard low-fat diet to high-fat diets…
View details →Negative / Null Result ReportOpen accessMedicine
Stephen J. Nicholls · 2012 · Cleveland Clinic Journal of Medicine
The AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) found, in an interim analysis, no cardiovascular benefit from taking extended-release niacin…
View details →Negative / Null Result ReportOpen accessMedicine
Gil Cunha De Santis, Luciana Correa Oliveira de Oliveira, Pedro Manuel Marques Garibaldi et al. · 2022 · Emerging infectious diseases
To assess whether high-dose coronavirus disease (COVID-19) convalescent plasma (CCP) transfusion may benefit patients with severe COVID-19, we conducted a multicenter randomized trial in Brazil. Patients with severe COVID-19 who were within 10 days of initial symptom onset were eligible. Patients in the CCP group received 3 daily doses of CCP (600 mL/d) in addition to standard treatment; control patients received standard treatment only. Primary outcomes were death rates at days 30 and 60 of study randomization. Secondary outcomes were ventilator-free days and hospital-free days. We enrolled 1
View details →Negative / Null Result Report
Karin Isler · 2011 · BioEssays
Abstract Recently, Weisbecker and Goswami presented the first comprehensive comparative analysis of brain size, metabolic rate, and development periods in marsupial mammals. In this paper, a strictly energetic perspective is applied to…
View details →Negative / Null Result Report
Manju Dhandapani, Sivashanmugam Dhandapani, Meena Agarwal et al. · 2013 · Journal of Clinical Nursing
Aims and objectives To assess the factors associated with development of pressure ulcer in patients with severe traumatic brain injury ( TBI ) and study its prognostic significance with respect to neurological outcome at three months.…
View details →Negative / Null Result Report
Aaron Yerke, Daisy Fry Brumit, Anthony A. Fodor · 2024 · Microbiome
Abstract Background Normalization, as a pre-processing step, can significantly affect the resolution of machine learning analysis for microbiome studies. There are countless options for normalization scheme selection. In this study, we…
View details →Negative / Null Result Report
Zhonghao Xin, Lingling Pu, Weina Gao et al. · 2017 · Scientific Reports
Abstract Riboflavin deficiency is widespread in many regions over the world, especially in underdeveloped countries. In this study, we investigated the effects of riboflavin deficiency on protein expression profiles in HepG2 cells in order…
View details →Negative / Null Result ReportOpen accessMedicine
Erik W. Ingwersen, Wessel T. Stam, Bono J.V. Meijs et al. · 2023 · Surgery
BACKGROUND: Machine learning is increasingly advocated to develop prediction models for postoperative complications. It is, however, unclear if machine learning is superior to logistic regression when using structured clinical data. Postoperative pancreatic fistula and delayed gastric emptying are the two most common complications with the biggest impact on patient condition and length of hospital stay after pancreatoduodenectomy. This study aimed to compare the performance of machine learning and logistic regression in predicting pancreatic fistula and delayed gastric emptying after pancreato
View details →Negative / Null Result ReportOpen accessPsychology
Jia Hoong Ong, Denis Burnham, Paola Escudero · 2015 · PLoS ONE
This study examines whether non-tone language listeners can acquire lexical tone categories distributionally and whether attention in the training phase modulates the effect of distributional learning. Native Australian English listeners were trained on a Thai lexical tone minimal pair and their performance was assessed using a discrimination task before and after training. During Training, participants either heard a Unimodal distribution that would induce a single central category, which should hinder their discrimination of that minimal pair, or a Bimodal distribution that would induce two
View details →Negative / Null Result ReportMedicine
Verônica Contini, Marcelo M. Victor, Guilherme Pinto Bertuzzi et al. · 2012 · Journal of Clinical Psychopharmacology
Results from pharmacogenetic investigations of methylphenidate (MPH) response in patients with ADHD are still inconsistent, especially among adults. This study investigates the role of genetic variants (SLC6A4, HTR1B, TPH2, DBH, DRD4,…
View details →Negative / Null Result ReportOpen accessPsychology
Daniel M. Bagner, Michelle D. Berkovits, Stefany Coxe et al. · 2023 · JAMA Pediatrics
Importance: Early behavior problems in children with developmental delay (DD) are prevalent and impairing, but service barriers persist. Controlled studies examining telehealth approaches are limited, particularly for children with DD.…
View details →Negative / Null Result ReportOpen accessNeuroscience
Sook-Lei Liew, Tziporah Thompson, Joel Ramirez et al. · 2018 · Frontiers in Neuroscience
We routinely make fine motor adjustments to maintain optimal motor performance. These adaptations have been attributed to both implicit, error-based mechanisms, and explicit, strategy-based mechanisms. However, little is known about the neural basis of implicit vs. explicit learning. Here, we aimed to use anodal transcranial direct current stimulation (tDCS) to probe the relationship between different brain regions and learning mechanisms during a visuomotor adaptation task in humans. We hypothesized that anodal tDCS over the cerebellum (CB) should increase implicit learning while anodal tDCS
View details →Negative / Null Result ReportOpen accessNeuroscience
Tao Yu, Hui Gao, Benjamin Ackerman et al. · 2016 · BMC Genomics
BACKGROUND: Restricted and Repetitive Behaviors (RRB), one of the core symptom categories for Autism Spectrum Disorders (ASD), comprises heterogeneous groups of behaviors. Previous research indicates that there are two or more factors (subcategories) within the RRB domain. In an effort to identify common variants associated with RRB, we have carried out a genome-wide association study (GWAS) using the Autism Genetic Resource Exchange (AGRE) dataset (n = 1,335, all ASD probands of European ancestry) for each identified RRB subcategory, while allowing for comparisons of associated single nucleot
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Yitong Li, Erika S. Wittchen, Elizabeth Monaghan-Benson et al. · 2019 · PLoS ONE
As a key homeostasis regulator in mammals, the MERTK receptor tyrosine kinase is crucial for efferocytosis, a process that requires remodeling of the cell membrane and adjacent actin cytoskeleton. Membrane and cytoskeletal reorganization also occur in endothelial cells during inflammation, particularly during neutrophil transendothelial migration (TEM) and during changes in permeability. However, MERTK's function in endothelial cells remains unclear. This study evaluated the contribution of endothelial MERTK to neutrophil TEM and endothelial barrier function. In vitro experiments using primary
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