Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Ulrike Fasbender, Anne Burmeister, Mo Wang · 2023 · Journal of Vocational Behavior
In this paper, we investigate the risks and side effects of workplace friendships for coworkers. Combining the dialectical perspective on workplace friendships with a self-regulatory perspective, we argue that workplace friendships can…
View details →Negative / Null Result ReportOpen accessHealth Professions
Hamzah Abdul Rahman, Mu’taman Jarrar, Mohammad Sobri Don · 2015 · Global Journal of Health Science
BACKGROUND AND OBJECTIVE: Nursing knowledge and skills are required to sustain quality of care and patient safety. The numbers of nurses with Bachelor degrees in Malaysia are very limited. This study aims to predict the impact of nurse level of education on quality of care and patient safety in the medical and surgical wards in Malaysian private hospitals. METHODOLOGY: A cross-sectional survey by questionnaire was conducted. A total 652 nurses working in the medical and surgical wards in 12 private hospitals were participated in the study. Multistage stratified simple random sampling performed
View details →Negative / Null Result ReportOpen accessNeuroscience
Jessica E. Salvatore, Alexis C. Edwards, Jeanette N. McClintick et al. · 2015 · Translational Psychiatry
Adult antisocial behavior (AAB) is moderately heritable, relatively common and has adverse consequences for individuals and society. We examined the molecular genetic basis of AAB in 1379 participants from a case-control study in which the cases met criteria for alcohol dependence. We also examined whether genes of interest were expressed in human brain. AAB was measured using a count of the number of Antisocial Personality Disorder criteria endorsed under criterion A from the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV). Participants were genotyped on the Illumi
View details →Negative / Null Result ReportSocial Sciences
Jolanda Jetten, S. Alexander Haslam, Fiona Kate Barlow · 2012 · Social Psychological and Personality Science
Why are conservatives happier than liberals? Napier and Jost (2008) argue that this is because conservative ideology has a palliative (system-justifying) function that protects conservatives’ (but not liberals’) happiness. We develop…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Fei Tian, Yanting Shen, Zhenzhu Chen et al. · 2017 · BioMed Research International
BACKGROUND: MicroRNAs (miRNAs) are small noncoding RNAs that are involved in many biological regulation processes. Studies have reported that miRNAs are enriched in human plasma and plasma-derived exosome as novel diagnostic biomarkers. The aim of this study was to determine whether the miRNA expression levels are different between plasma and plasma-derived exosome. METHODS: We sequenced and quantified the miRNAs in plasma and exosome from healthy blood samples and validated three miRNAs in the two groups of lung cancer samples by qRT-PCR. RESULTS: The sequencing results showed that only sever
View details →Negative / Null Result ReportOpen accessMedicine
Reina Yamaji, Shinya Yamada, Mai Quynh Le et al. · 2015 · Journal of Virology
UNLABELLED: Highly pathogenic H5N1 avian influenza viruses have caused outbreaks among poultry worldwide, resulting in sporadic infections in humans with approximately 60% mortality. However, efficient transmission of H5N1 viruses among…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Amparo Ferrero, Ana Esplugues, Marisa Estarlich et al. · 2017 · Environmental Pollution
derived from a lifetime risk of leukemia above 1/100 000. Monitoring season, maternal country of birth and parental tobacco consumption were associated with residential benzene exposure (indoor and outdoors). Additionally, indoor levels…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Chunyan Wang, Bernardo A. Huberman · 2012 · Scientific Reports
The massive amounts of data that social media generates has facilitated the study of online human behavior on a scale unimaginable a few years ago. At the same time, the much discussed apparent randomness with which people interact online…
View details →Negative / Null Result ReportOpen accessPsychology
Glenn I. Roisman, Cathryn Booth‐LaForce, Jay Belsky et al. · 2013 · Attachment & Human Development
This paper advises caution in relation to the increasing interest in molecular-genetic association studies in developmental psychology based on a set of empirical examples from the NICHD Study of Early Child Care and Youth Development…
View details →Negative / Null Result ReportOpen accessNeuroscience
Janet H. Hsiao, Jeehye An, Yueyuan Zheng et al. · 2021 · Cognition
Recent research has suggested the importance of part-based information in face recognition in addition to global, whole-face information. Nevertheless, face drawing experience was reported to enhance selective attention to the eyes but did…
View details →Negative / Null Result ReportOpen accessMedicine
Susanne R. Youngren-Ortiz, David B. Hill, Peter Hoffmann et al. · 2017 · Journal of Aerosol Medicine and Pulmonary Drug Delivery
BACKGROUND: Aerosol delivery of chemotherapeutic nanocarriers represents a promising alternative for lung cancer therapy. This study optimized gemcitabine (Gem)-loaded gelatin nanocarriers (GNCs) cross-linked with genipin (Gem-GNCs) to…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Matthew A. Thomas, Benjamin B. Mirus, Joel B. Smith · 2020 · Hydrological Processes
Abstract The devastating impacts of the widespread flooding and landsliding in Puerto Rico following the September 2017 landfall of Hurricane Maria highlight the increasingly extreme atmospheric disturbances and enhanced hazard potential…
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Marcos S. Lopes, H. Bovenhuis, Maren van Son et al. · 2017 · Journal of Animal Science
The first attempts of applying marker-assisted selection (MAS) in animal breeding were not very successful because the identification of markers closely linked to QTL using low-density microsatellite panels was difficult. More recently,…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Daisuke Hamada, Masataka Nakayama, Jun Saiki · 2020 · Cognitive Research Principles and Implications
BACKGROUND: The wisdom of crowds and collective decision-making are important tools for integrating information between individuals, which can exceed the capacity of individual judgments. They are based on different forms of information integration. The wisdom of crowds refers to the aggregation of many independent judgments without deliberation and consensus, while collective decision-making is aggregation with deliberation and consensus. Recent research has shown that collective decision-making outperforms the wisdom of crowds. Additionally, many studies have shown that metacognitive knowled
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Yue Du, Ying‐Ping Wang, Dafeng Hui et al. · 2022 · Global Change Biology
Abstract Global warming intensifies the hydrological cycle, which results in changes in precipitation regime (frequency and amount), and will likely have significant impacts on soil respiration ( R s ). Although the responses of R s to…
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Peter C. Banacos, Michael L. Ekster · 2010 · Weather and Forecasting
Abstract The occurrence of rare but significant severe weather events associated with elevated mixed-layer (EML) air in the northeastern United States is investigated herein. A total of 447 convective event days with one or more…
View details →Negative / Null Result ReportOpen accessMedicine
Ji‐Feng Feng, Liang Wang, Xun Yang et al. · 2019 · Cancer Management and Research
Background: We firstly identified a combination of lactate dehydrogenase (LDH) along with albumin (ALB), which was defined as LAR (LDH/ALB ratio). The purpose of our study here was initially to explore the prognostic role of LAR in…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Kalijn F. Bol, Gerty Schreibelt, Martine Bloemendal et al. · 2024 · Nature Communications
Autologous natural dendritic cells (nDCs) treatment can induce tumor-specific immune responses and clinical responses in cancer patients. In this phase III clinical trial (NCT02993315), 148 patients with resected stage IIIB/C melanoma were randomized to adjuvant treatment with nDCs (n = 99) or placebo (n = 49). Active treatment consisted of intranodally injected autologous CD1c+ conventional and plasmacytoid DCs loaded with tumor antigens. The primary endpoint was the 2-year recurrence-free survival (RFS) rate, whereas the secondary endpoints included median RFS, 2-year and median overall surv
View details →Negative / Null Result ReportOpen accessMedicine
Bertrand Sauneuf, Benoît Champigneulle, Alexis Soummer et al. · 2013 · Critical Care
INTRODUCTION: The overall outcome of septic shock has been recently improved. We sought to determine whether this survival gain extends to the high-risk subgroup of patients with cirrhosis. METHODS: Cirrhotic patients with septic shock admitted to a medical intensive care unit (ICU) during two consecutive periods (1997-2004 and 2005-2010) were retrospectively studied. RESULTS: Forty-seven and 42 cirrhotic patients presented with septic shock in 1997-2004 and 2005-2010, respectively. The recent period differed from the previous one by implementation of adjuvant treatments of septic shock includ
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Fengling Zhang, Xingjia Xiang, Yuanqiu Dong et al. · 2020 · Animals
Intestinal bacterial communities form an integral component of the organism. Many factors influence gut bacterial community composition and diversity, including diet, environment and seasonality. During seasonal migration, birds use many habitats and food resources, which may influence their intestinal bacterial community structure. Hooded crane (Grus monacha) is a migrant waterbird that traverses long distances and occupies varied habitats. In this study, we investigated the diversity and differences in intestinal bacterial communities of hooded cranes over the migratory seasons. Fecal sample
View details →Negative / Null Result ReportOpen accessMedicine
Mats Enlund, Anders Berglund, Anna Enlund et al. · 2023 · EClinicalMedicine
Background: Anaesthesia may impact long-term cancer survival. In the Cancer and Anaesthesia study, we hypothesised that the hypnotic drug propofol will have an advantage of at least five percentage points in five-year survival over the inhalational anaesthetic sevoflurane for breast cancer surgery. Methods: From 2118 eligible breast cancer patients scheduled for primary curable, invasive breast cancer surgery, 1764 were recruited after ethical approval and individual informed consent to this open label, single-blind, randomised trial at four county- and three university hospitals in Sweden and
View details →Negative / Null Result ReportMedicine
Joji Suzuki, Jeffrey DeVido, Inder Kalra et al. · 2015 · American Journal on Addictions
BACKGROUND AND OBJECTIVES: Opioid dependent patients are hospitalized frequently. We aimed to determine if initiation of buprenorphine treatment during hospitalization facilitates entry into treatment following discharge. METHODS:…
View details →Negative / Null Result ReportMedicine
Hasan Akın, Aysun Ölçmen, Özgür İşgörücü et al. · 2011 · The Thoracic and Cardiovascular Surgeon
Mediastinal lymph node dissection, an important part of surgery for non-small cell lung cancer, is associated with a risk of chylothorax. Although mortality has significantly decreased in recent years, it still worries thoracic surgeons.…
View details →Negative / Null Result ReportOpen accessMedicine
Koji Matsuo, Muneaki Shimada, Harushige Yokota et al. · 2017 · Oncotarget
// Koji Matsuo 1, 2, * , Muneaki Shimada 3, 4, * , Harushige Yokota 5 , Toyomi Satoh 6 , Hidetaka Katabuchi 7 , Shoji Kodama 8, 9 , Hiroshi Sasaki 10, 11 , Noriomi Matsumura 12, 13 , Mikio Mikami 14 and Toru Sugiyama 15 1 Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA 2 Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA 3 Department of Obstetrics and Gynecology, Tottori University, Tottori, Japan 4 Current affiliation: Department of Obstetrics and Gynecology, Tohoku Univ
View details →Negative / Null Result ReportOpen accessMedicine
Anwaar Saeed, Robin Park, Harsh B. Pathak et al. · 2024 · Nature Communications
CAMILLA is a basket trial (NCT03539822) evaluating cabozantinib plus the ICI durvalumab in chemorefractory gastrointestinal cancer. Herein, are the phase II colorectal cohort results. 29 patients were evaluable. 100% had confirmed pMMR/MSS tumors. Primary endpoint was met with ORR of 27.6% (95% CI 12.7-47.2%). Secondary endpoints of 4-month PFS rate was 44.83% (95% CI 26.5-64.3%); and median OS was 9.1 months (95% CI 5.8-20.2). Grade≥3 TRAE occurred in 39%. In post-hoc analysis of patients with RAS wild type tumors, ORR was 50% and median PFS and OS were 6.3 and 21.5 months respectively. Explo
View details →Negative / Null Result ReportOpen accessMedicine
Jing Wang, Ting Xu, Lirong Wu et al. · 2022 · JTO Clinical and Research Reports
IntroductionDurvalumab after concurrent chemoradiation (CCRT) for NSCLC improves survival, but only in a subset of patients. We investigated the effect of severe radiation-induced lymphopenia (sRIL) on survival in these…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kyle J. Bednar, Elena Shanina, Romain Ballet et al. · 2017 · The Journal of Immunology
Abstract CD22, a sialic acid–binding Ig-type lectin (Siglec) family member, is an inhibitory coreceptor of the BCR with established roles in health and disease. The restricted expression pattern of CD22 on B cells and most B cell lymphomas…
View details →Negative / Null Result ReportOpen accessMedicine
Subin Park, Ki Kyoung Yi, Riji Na et al. · 2013 · Behavioral and Brain Functions
BACKGROUND: Previous research on serum total cholesterol and suicidality has yielded conflicting results. Several studies have reported a link between low serum total cholesterol and suicidality, whereas others have failed to replicate these findings, particularly in patients with major affective disorders. These discordant findings may reflect the fact that studies often do not distinguish between patients with bipolar and unipolar depression; moreover, definitions and classification schemes for suicide attempts in the literature vary widely. METHODS: Subjects were patients with one of the th
View details →Negative / Null Result ReportOpen accessMedicine
Maximilian J. Mair, Barbara Kiesel, Katharina Feldmann et al. · 2021 · Journal of Neuro-Oncology
PURPOSE: Immune modulatory therapies including immune checkpoint inhibitors have so far failed to result in clinically meaningful efficacy in glioma. We aimed to investigate lymphocyte activation gene 3 (LAG-3), an inhibitory receptor on immune cells and target of second-generation immune checkpoint inhibitors, in glioma. METHODS: 97 patients with diffuse glioma (68 with glioblastoma, 29 with WHO grade II-III glioma) were identified from the Neuro-Biobank of the Medical University of Vienna. LAG-3 expression in the inflammatory microenvironment was assessed by immunohistochemistry (monoclonal
View details →Negative / Null Result ReportOpen accessMedicine
Vanessa Pitz, Mary B. Makarious, Sara Bandrés‐Ciga et al. · 2024 · npj Parkinson s Disease
Although many rare variants have been reportedly associated with Parkinson's disease (PD), many have not been replicated or have failed to replicate. Here, we conduct a large-scale replication of rare PD variants. We assessed a total of 27,590 PD cases, 6701 PD proxies, and 3,106,080 controls from three data sets: 23andMe, Inc., UK Biobank, and AMP-PD. Based on well-known PD genes, 834 variants of interest were selected from the ClinVar annotated 23andMe dataset. We performed a meta-analysis using summary statistics of all three studies. The meta-analysis resulted in five significant variants
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