Negative / Null Result ReportOpen accessNursing
Mohamad Wessam Alnouri, Kenneth Anthony Roquid, Rémy Bonnavion et al. · 2024 · Proceedings of the National Academy of Sciences
Inflammation is a protective response to pathogens and injury. To be effective it needs to be resolved by endogenous mechanisms in order to avoid prolonged and excessive inflammation, which can become chronic. Specialized pro-resolving mediators (SPMs) are a group of lipids derived from omega-3 fatty acids, which can induce the resolution of inflammation. How SPMs exert their anti-inflammatory and pro-resolving effects is, however, not clear. Here, we show that SPMs such as protectins, maresins, and D-series resolvins function as biased positive allosteric modulators (PAM) of the prostaglandin
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Mariassunta Giannetti, Martina Jašová, Maria Loumioti et al. · 2026 · Management Science
<span>Using confidential information on banks’ portfolios, we show that banks that emphasize the sustainability of their lending policies in their disclosures do not exhibit a reduced environmental impact and if anything, they extend…
View details →Negative / Null Result ReportOpen accessMedicine
Meisam Yousefi, Wai Suet Lee, Biaoguo Yan et al. · 2022 · PLoS Pathogens
Transmembrane Protein 41B (TMEM41B) and Vacuole Membrane Protein 1 (VMP1) are two ER-associated lipid scramblases that play a role in autophagosome formation and cellular lipid metabolism. TMEM41B is also a recently validated host factor required by flaviviruses and coronaviruses. However, the exact underlying mechanism of TMEM41B in promoting viral infections remains an open question. Here, we validated that both TMEM41B and VMP1 are essential host dependency factors for all four serotypes of dengue virus (DENV) and human coronavirus OC43 (HCoV-OC43), but not chikungunya virus (CHIKV). While
View details →Negative / Null Result ReportOpen accessNeuroscience
Shaomin Peng, Geliang Gan, Caihong Qiu et al. · 2013 · Stem Cells Translational Medicine
Retinal degenerations are a major cause of impaired vision in the elderly. Degenerations originate in either photoreceptors or the retinal pigment epithelium (RPE). RPE forms the outer blood-retinal barrier and functions intimately with…
View details →Negative / Null Result Report
Malin Hildebrandt, Sabine Koch, Thomas Fuchs · 2016 · Behavioral Sciences
The treatment of deficits in social interaction, a shared symptom cluster in persons with schizophrenia (negative symptoms) and autism spectrum disorder (DSM-5 A-criterion), has so far remained widely unsuccessful in common approaches of…
View details →Negative / Null Result ReportMedicine
Andrée-Anne Houde, Stéphanie-May Ruchat, Catherine Allard et al. · 2015 · Epigenomics
AIM: To assess the associations between gestational diabetes mellitus (GDM) and DNA methylation levels at genes related to energy metabolism. PATIENTS & METHODS: Ten loci were selected from our recent epigenome-wide association study on…
View details →Negative / Null Result ReportOpen accessMedicine
Tracy L. Diamond, Winnie Ngo, Min Xu et al. · 2022 · Antimicrobial Agents and Chemotherapy
Islatravir (ISL) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) that inhibits human immunodeficiency virus (HIV) reverse transcription by blocking reverse transcriptase (RT) translocation on the primer:template. ISL…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Aisling A. Geraghty, Alexandra Sexton‐Oates, Eileen C. O’Brien et al. · 2018 · Nutrients
The epigenetic profile of the developing fetus is sensitive to environmental influence. Maternal diet has been shown to influence DNA methylation patterns in offspring, but research in humans is limited. We investigated the impact of a low glycaemic index dietary intervention during pregnancy on offspring DNA methylation patterns using a genome-wide methylation approach. Sixty neonates were selected from the ROLO (Randomised cOntrol trial of LOw glycaemic index diet to prevent macrosomia) study: 30 neonates from the low glycaemic index intervention arm and 30 from the control, whose mothers re
View details →Negative / Null Result ReportPsychology
Lauren A. Stutts, Kerstin K. Blomquist · 2018 · International Journal of Eating Disorders
OBJECTIVE: The present study employed a longitudinal design to examine the moderating role of self-compassion in the relationship between weight/shape concerns and the outcomes of eating pathology and stress in a diverse college student…
View details →Negative / Null Result ReportEngineering
John Keane, Wei Zhang, Chris H. Kim · 2011 · IEEE Journal of Solid-State Circuits
Variations in the number and characteristics of charges or traps contributing to transistor degradation lead to a distribution of device “ages” at any given time. This issue is well understood in the study of time dependent dielectric…
View details →Negative / Null Result ReportOpen accessMedicine
Chung-Young Lee, Se-Hee An, Il Hwan Kim et al. · 2017 · Scientific Reports
The polymerase of avian influenza A virus (AIV) is a heterotrimer composed of PB2, PB1, and PA. PB2 plays a role in overcoming the host barrier; however, the genetic prerequisites for avian PB2 to acquire mammalian pathogenic mutations have not been well elucidated. Previously, we identified a prototypic avian PB2 that conferred non-replicative and non-pathogenic traits to a PR8-derived recombinant virus when it was used to infect mice. Here, we demonstrated that key amino acid mutations (I66M, I109V, and I133V, collectively referred to as MVV) of this prototypic avian PB2 increase the replica
View details →Negative / Null Result ReportOpen accessNeuroscience
Priya Landa, Ann‐Marie Differ, Kaukab Rajput et al. · 2013 · BMC Medical Genetics
BACKGROUND: Pendred syndrome is a common autosomal recessive disorder causing deafness. Features include sensorineural hearing impairment, goitre, enlarged vestibular aqueducts (EVA) and occasionally Mondini dysplasia. Hearing impairment and EVA may occur in the absence of goitre or thyroid dyshormonogensis in a condition known as non-syndromic EVA. A significant number of patients with Pendred syndrome and non-syndromic EVA show only one mutation in SLC26A4. Two genes, KCNJ10, encoding an inwardly rectifying potassium channel and FOXI1, a transcriptional factor gene, are thought to play a rol
View details →Negative / Null Result ReportMedicine
Douglas K. Rex, Indira Bhavsar-Burke, Daniel Buckles et al. · 2024 · Annals of Internal Medicine
BACKGROUND: Real-time prediction of histologic features of small colorectal polyps may prevent resection and/or pathologic evaluation and therefore decrease colonoscopy costs. Previous studies showed that computer-aided diagnosis (CADx)…
View details →Negative / Null Result ReportOpen accessMedicine
Arthur Caye, Jessica Agnew‐Blais, Louise Arseneault et al. · 2019 · Epidemiology and Psychiatric Sciences
AIM: Few personalised medicine investigations have been conducted for mental health. We aimed to generate and validate a risk tool that predicts adult attention-deficit/hyperactivity disorder (ADHD). METHODS: Using logistic regression models, we generated a risk tool in a representative population cohort (ALSPAC - UK, 5113 participants, followed from birth to age 17) using childhood clinical and sociodemographic data with internal validation. Predictors included sex, socioeconomic status, single-parent family, ADHD symptoms, comorbid disruptive disorders, childhood maltreatment, ADHD symptoms,
View details →Negative / Null Result ReportOpen accessNeuroscience
James B. Adams, Daniel P. Howsmon, Uwe Krüger et al. · 2017 · PLoS ONE
INTRODUCTION: A number of previous studies examined a possible association of toxic metals and autism, and over half of those studies suggest that toxic metal levels are different in individuals with Autism Spectrum Disorders (ASD). Additionally, several studies found that those levels correlate with the severity of ASD. METHODS: In order to further investigate these points, this paper performs the most detailed statistical analysis to date of a data set in this field. First morning urine samples were collected from 67 children and adults with ASD and 50 neurotypical controls of similar age an
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R Kelly Garrett, Shannon Poulsen · 2019 · Journal of Computer-Mediated Communication
Abstract We present two studies evaluating the effectiveness of flagging inaccurate political posts on social media. In Study 1, we tested fact-checker flags, peer-generated flags, and a flag indicating that the publisher self-identified…
View details →Negative / Null Result ReportOpen accessMedicine
Raffaele Di Fenza, Naman S. Shetty, Stefano Gianni et al. · 2023 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale The effects of high-dose inhaled nitric oxide on hypoxemia in coronavirus disease (COVID-19) acute respiratory failure are unknown. Objectives The primary outcome was the change in arterial oxygenation (PaO2/Fi O2) at 48…
View details →Negative / Null Result ReportOpen accessMedicine
Yan Sun, Ying Cheng, Xuezhi Hao et al. · 2016 · BMC Cancer
BACKGROUND: Extensive-disease small-cell lung cancer (ED-SCLC) is characterized by rapid progression and relapse, despite high initial response rates to chemotherapy. The primary objective of this trial was to demonstrate the non-inferiority of amrubicin and cisplatin (AP) combination therapy compared with the standard first-line regimen of etoposide and cisplatin (EP) for previously untreated ED-SCLC in a Chinese population. When non-inferiority was verified, the objective was switched from non-inferiority to superiority. METHODS: From June 2008 to July 2010, 300 patients were enrolled and ra
View details →Negative / Null Result ReportOpen accessMedicine
Mauro Giovanni Carta, Maria Efisia Lecca, Luca Saba et al. · 2015 · BMC Psychiatry
BACKGROUND: To compare the six-month outcome on mood, cognition and quality of life (QoL) in patients with severe carotid atherosclerosis (CA) who underwent carotid endarterectomy (CEA) with subjects who refused treatment. METHODS: Cohort study on consecutive inpatients with CA (stenosis ≥ 50 %) (N = 46; age 72.56 ± 7.26; male 65.2 %). Intervention cohort: subjects who decided to undergo CEA (N = 35); Control cohort patients who refused CEA (N = 11). DSM-IV-Psychiatric diagnosis made by clinicians using interviews, QoL measured by Short Form Health Survey (SF-12); cognitive performance by WAIS
View details →Negative / Null Result ReportOpen accessMedicine
Abigail T. Berman, Leslie A. Litzky, Virginia A. LiVolsi et al. · 2011 · Cancer
BACKGROUND: The clinical benefit of postoperative mediastinal radiation for completely resected Masaoka stage 2 thymoma remains controversial. Due to its indolent nature and infrequent recurrences, no study has definitively determined the…
View details →Negative / Null Result ReportOpen accessHealth Professions
Junko Ueshima, Akio Shimizu, Keisuke Maeda et al. · 2022 · Journal of the American Medical Directors Association
This position paper prepared by the Japanese Working Group on Integrated Nutrition for Dysphagic People (JWIND) aims to summarize the need for nutritional management in adult patients with dysphagia, the issues that nutrition professionals should address, and the promising approaches as well as to propose a vision for the future of nutritional care for adult patients with dysphagia. JWIND is a joint certification system recognized by the Japan Dietetic Association and the Japanese Society of Dysphagia Rehabilitation; its members are mostly experts known as "Certified Specialist of Registered D
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Youlu Chen, Yong Zeng, Xiaowei Zhu et al. · 2020 · Bioactive Materials
Compared with paclitaxel, sirolimus has been more used in the treatment of vascular restenosis gradually as an anti-proliferative drug, but few basic studies have elucidated its mechanism. The anti-proliferative effects of sirolimus or…
View details →Negative / Null Result ReportOpen accessMedicine
Hao Chen, Donghang Zheng, Jeff Abbott et al. · 2013 · Antimicrobial Agents and Chemotherapy
Lethal viral infections produce widespread inflammation with vascular leak, clotting, and bleeding (disseminated intravascular coagulation [DIC]), organ failure, and high mortality. Serine proteases in clot-forming (thrombotic) and…
View details →Negative / Null Result ReportOpen accessMedicine
Shuang-Jie Cao, Yue Zhang, Yuxiu Zhang et al. · 2023 · British Journal of Anaesthesia
BACKGROUND: Experimental evidence indicates that i.v. anaesthesia might reduce cancer recurrence compared with volatile anaesthesia, but clinical information is observational only. We therefore tested the primary hypothesis that…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Koichi Araki, Shivaprakash Gangappa, Dirck L. Dillehay et al. · 2010 · The Journal of Experimental Medicine
Recently, several cases of fatal lymphocytic choriomeningitis virus (LCMV) infection occurred in transplant recipients being treated with the immunosuppressive calcineurin inhibitor FK506. These findings were surprising because LCMV is a…
View details →Negative / Null Result ReportOpen accessMedicine
Ilaria Salvato, Antonio Marchini · 2024 · Cancers
Despite decades of research and the best up-to-date treatments, grade 4 Glioblastoma (GBM) remains uniformly fatal with a patient median overall survival of less than 2 years. Recent advances in immunotherapy have reignited interest in utilizing immunological approaches to fight cancer. However, current immunotherapies have so far not met the anticipated expectations, achieving modest results in their journey from bench to bedside for the treatment of GBM. Understanding the intrinsic features of GBM is of crucial importance for the development of effective antitumoral strategies to improve pat
View details →Negative / Null Result Report
Kai Zhu, Manya Tu, Yingcheng Li · 2022 · Land
Curbing carbon emissions by restricting economic growth could decrease human well-being across the world and especially in developing countries, suggesting that we need to find alternative approaches to reducing carbon emissions. Against…
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Eyad Atalah, C.M Hernández-Cruz, T. Benítez-Santana et al. · 2010 · Aquaculture Research
The effect of different arachidonic acid (ARA) dietary contents at several dietary eicosapentaenoic acid (EPA) levels on the growth, survival and biochemical composition of gilthead seabream larvae was studied to better define the…
View details →Negative / Null Result ReportOpen accessChemistry
Marco R. Oggioni, Joana Rosado Coelho, Leonardo Furi et al. · 2015 · Current Pharmaceutical Design
There is a growing concern by regulatory authorities for the selection of antibiotic resistance caused by the use of biocidal products. We aimed to complete the detailed information on large surveys by investigating the relationship…
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Frederick F. Lang, Nam Tran, Vinay K. Puduvalli et al. · 2017 · Journal of Clinical Oncology
2002 Background: DNX-2401 is a replication-competent, tumor-selective, oncolytic adenovirus with enhanced infectivity that causes durable tumor control by killing tumor cells and eliciting antitumor immunity. To increase immune activation,…
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