20,192 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Michael Bang Petersen, Lasse Laustsen · 2018 · Political Psychology
Animal models of conflict behavior predict that an organism's behavior in a conflict situation is influenced by physical characteristics related to abilities to impose costs on adversaries. Stronger and larger organisms should be more…
View details →Suzanne Lockyer, Rob Hodgson, Jo C Dumville et al. · 2013 · Trials
Abstract Background Spin in the reporting of randomized controlled trials, where authors report research in a way that potentially misrepresents results and mislead readers, has been demonstrated in the broader medical literature. We…
View details →Salah Uddin Khan, Henrik Salje, Abu Sayeed Md. Abdul Hannan et al. · 2014 · PLoS neglected tropical diseases
BACKGROUND: Japanese encephalitis (JE) virus infection can cause severe disease in humans, resulting in death or permanent neurologic deficits among survivors. Studies indicate that the incidence of JE is high in northwestern Bangladesh. Pigs are amplifying hosts for JE virus (JEV) and a potentially important source of virus in the environment. The objectives of this study were to describe the transmission dynamics of JEV among pigs in northwestern Bangladesh and estimate the potential impact of vaccination to reduce incidence among pigs. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a comprehe
View details →Michael Notaras, Rachel Hill, Joseph A. Gogos et al. · 2015 · Molecular Psychiatry
The BDNF gene Val66Met single-nucleotide polymorphism is carried by ~0.55% of Sub-Saharan Africans, 19.9% of Europeans and 43.6% of Asians, but may be carried by up to 72% of some Sub-Asian population groups. 1 The switch from a guanine to…
View details →Oleg Badunenko, Diego Romero‐Ávila · 2013 · International Economic Review
We extend the deterministic, nonparametric production frontier framework by incorporating financial development. Our analysis convincingly shows that (1) failure to account for financial development overstates the role of physical capital…
View details →Zhuan Li, Yohei Yamauchi, Maki Kamakura et al. · 2011 · Journal of Virology
Tankyrase 1 is a poly(ADP-ribose) polymerase (PARP) which localizes to multiple subcellular sites, including telomeres and mitotic centrosomes. Poly(ADP-ribosyl)ation of the nuclear mitotic apparatus (NuMA) protein by tankyrase 1 during…
View details →Dipongkor Saha, Samuel D. Rabkin, Robert L. Martuza · 2020 · Journal for ImmunoTherapy of Cancer
Background Temozolomide (TMZ) chemotherapy is a current standard of care for glioblastoma (GBM), however it has only extended overall survival by a few months. Because it also modulates the immune system, both beneficially and negatively,…
View details →Sumit K. Subudhi, Bilal A. Siddiqui, Ana M. Aparicio et al. · 2021 · Journal for ImmunoTherapy of Cancer
BACKGROUND: Immune checkpoint therapy (ICT) has low response rates in patients with metastatic castration-resistant prostate cancer (mCRPC), in part due to few T cells in the tumor microenvironment (TME). Anti-cytotoxic T…
View details →Edwin Hoe, Fiona C. McKay, Stephen D. Schibeci et al. · 2010 · The Journal of Immunology
Common genetic variants of IL-7 receptor alpha (IL-7Ralpha) have recently been shown to affect susceptibility to multiple sclerosis (MS) and type 1 diabetes, and survival following bone marrow transplantation. Transcription of the gene…
View details →Katja Werlenius, Sara Kinhult, Tora S. Solheim et al. · 2023 · JAMA Network Open
Importance: Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective: To evaluate the efficacy and safety of disulfiram and copper as add-on to alkylating chemotherapy in patients with recurrent glioblastoma. Design, Setting, and Participants: This was a multicenter, open-label, randomized phase II/III clinical trial with parallel group design. Patients were recruited at 7 study sites in Sweden and 2 sites in Norway between January 2017 and November 2020. Eligible patients were 18 years
View details →Safina Islam, Olivia Joseph, Atiha Chaudry et al. · 2021 · Research Involvement and Engagement
Abstract Background Public involvement in clinical translational research is increasingly recognised as essential for relevant and reliable research. Public involvement must be diverse and inclusive to enable research that has the…
View details →Karolina Strzebońska, Marcin Waligóra · 2019 · BMC Medical Ethics
BACKGROUND: Novel precision oncology trial designs, such as basket and umbrella trials, are designed to test new anticancer agents in more effective and affordable ways. However, they present some ethical concerns referred to scientific validity, risk-benefit balance and informed consent. Our aim is to discuss these issues in basket and umbrella trials, giving examples of two ongoing cancer trials: NCI-MATCH (National Cancer Institute - Molecular Analysis for Therapy Choice) and Lung-MAP (Lung Cancer Master Protocol) study. MAIN BODY: We discuss three ethical requirements for clinical trials w
View details →Mayukh Chakrabarti, Hyunbum Jang, Ruth Nussinov · 2016 · The Journal of Physical Chemistry B
Human HRAS, KRAS, and NRAS genes encode four isoforms of Ras, a p21 GTPase. Mutations in KRAS account for the majority of RAS-driven cancers. The KRAS has two splice variants, K-Ras4A and K-Ras4B. Due to their reversible palmitoylation,…
View details →Gil Awada, Laïla Ben Salama, Jennifer Cremer et al. · 2020 · Journal for ImmunoTherapy of Cancer
BACKGROUND: No treatment demonstrated to improve survival in patients with recurrent glioblastoma (rGB) in a randomized trial. Combining axitinib with the programmed cell death ligand 1 blocking monoclonal antibody avelumab may result in…
View details →Britta Jänicke, Fred Meier, Daniel Fenner et al. · 2016 · International Journal of Climatology
ABSTRACT Model‐based studies on urban heat islands can be seriously affected by errors in near‐surface air temperature ( T 2), especially if errors differ between cities and their rural surroundings. Furthermore, errors in T 2 strongly…
View details →Toru Ishikawa · 2012 · The Professional Geographer
Abstract This study examined the relationships between geospatial thinking and spatial ability, focusing on knowledge and reasoning about fundamental concepts in geospatial science. Scores on a geospatial thinking test had low correlations…
View details →Yong‐Hao Pua, Hakmook Kang, Julian Thumboo et al. · 2019 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: Machine-learning methods are flexible prediction algorithms with potential advantages over conventional regression. This study aimed to use machine learning methods to predict post-total knee arthroplasty (TKA) walking limitation,…
View details →Yinxue Liu, Paul Bates, Jeffrey Neal et al. · 2021 · Water Resources Research
Abstract Accurate terrain representation is critical to estimating flood risk in urban areas. However, all current global elevation data sets can be regarded as digital surface models in urban areas as they contain building artifacts that…
View details →Chun‐Yen Tsai · 2014 · International Journal of Science Education
The scientific competencies advocated by the Programme for International Student Assessment (PISA) focus on the abilities needed in students' adult lives. This study investigated how such scientific competencies could be improved by using…
View details →Yoshimasa Miyagawa, Kazuhiro Araki, Ayako Bun et al. · 2018 · Clinical Breast Cancer
INTRODUCTION: Although eribulin and nab-paclitaxel are chemotherapy agents widely used for locally advanced or metastatic breast cancer (MBC), their predictive factors remain unknown. Because the absolute neutrophil-to-lymphocyte ratio…
View details →Simone Baldi, Marta Menicatti, Giulia Nannini et al. · 2021 · Nutrients
Altered circulating levels of free fatty acids (FFAs), namely short chain fatty acids (SCFAs), medium chain fatty acids (MCFAs), and long chain fatty acids (LCFAs), are associated with metabolic, gastrointestinal, and malignant diseases. Hence, we compared the serum FFA profile of patients with celiac disease (CD), adenomatous polyposis (AP), and colorectal cancer (CRC) to healthy controls (HC). We enrolled 44 patients (19 CRC, 9 AP, 16 CD) and 16 HC. We performed a quantitative FFA evaluation with the gas chromatography-mass spectrometry method (GC-MS), and we performed Dirichlet-multinomial
View details →Tom Koeman, Pauline Slottje, Leo J. Schouten et al. · 2017 · Occupational and Environmental Medicine
OBJECTIVE: To prospectively study suspected occupational risk factors for amyotrophic lateral sclerosis (ALS). METHODS: For this case-cohort analysis within the prospective Netherlands Cohort Study, 58 279 men and 62 573 women aged 55-69…
View details →Hassan Mohammadi, Yuting Tan · 2015 · Econometrics
Examinations of the dynamics of daily returns and volatility in stock markets of the U.S., Hong Kong and mainland China (Shanghai and Shenzhen) over 2 January 2001 to 8 February 2013 suggest: (1) evidence of unidirectional return spillovers from the U.S. to the other three markets; but no spillover between Hong Kong and either of the two mainland China markets; (2) evidence of unidirectional ARCH and GARCH effects from the U.S. to the other three markets; (3) correlations of returns vary across markets, with the highest correlation of 93.5% between the two Chinese markets, medium correlation o
View details →Susan C. Kleiman, Emily Bulik-Sullivan, Elaine M. Glenny et al. · 2017 · PLoS ONE
OBJECTIVE: This study examined associations between the composition and diversity of the intestinal microbiota and measures of depression, anxiety, eating disorder psychopathology, stress, and personality in a group of healthy adult females. METHODS: Female participants (n = 91) ages 19-50 years with BMI 18.5-25 kg/m2 were recruited from central North Carolina between July 2014 and March 2015. Participants provided a single fecal sample and completed an online psychiatric questionnaire that included five measures: (i) Beck Anxiety Inventory; (ii) Beck Depression Inventory-II; (iii) Eating Diso
View details →Konrad Neumann, Ulrike Grittner, Sophie K. Piper et al. · 2017 · PLoS Biology
Despite the potential benefits of sequential designs, studies evaluating treatments or experimental manipulations in preclinical experimental biomedicine almost exclusively use classical block designs. Our aim with this article is to bring the existing methodology of group sequential designs to the attention of researchers in the preclinical field and to clearly illustrate its potential utility. Group sequential designs can offer higher efficiency than traditional methods and are increasingly used in clinical trials. Using simulation of data, we demonstrate that group sequential designs have t
View details →I. A. G. Snellen, L. Guzman-Ramirez, M. R. Hogerheijde et al. · 2020 · Astronomy & Astrophysics
Context. ALMA observations of Venus at 267 GHz that show the apparent presence of phosphine (PH 3 ) in its atmosphere have been presented in the literature. Phosphine currently has no evident production routes on the planet’s surface or in…
View details →Patrick Kline, Christopher Walters · 2021 · Econometrica
This paper develops methods for detecting discrimination by individual employers using correspondence experiments that send fictitious resumes to real job openings. We establish identification of higher moments of the distribution of…
View details →Shoji Kawakami, Yoshio Tahara, Teruo Noguchi et al. · 2016 · Circulation Journal
BACKGROUND: Prehospital ECG improves survival following ST-segment elevation myocardial infarction (STEMI). Although a new International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment…
View details →Sae‐Won Han, Hyun‐Jung Lee, Jeong Mo Bae et al. · 2012 · International Journal of Cancer
The prognostic impact of CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) on the treatment outcome of colon cancer patients receiving adjuvant 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX) is unclear. We…
View details →Hyehyun Jeong, Kyu‐pyo Kim, Jae Ho Jeong et al. · 2023 · Hepatology
BACKGROUND AND AIMS: The effectiveness of gemcitabine-based adjuvant chemotherapy is unclear in cholangiocarcinoma. We investigated the role of adjuvant gemcitabine plus cisplatin (GemCis) in a homogeneous group of high-risk patients with…
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