Negative / Null Result ReportOpen accessMedicine
Stefan Buettner, Bas Groot Koerkamp, Aslam Ejaz et al. · 2017 · Journal of Surgical Oncology
INTRODUCTION: While preoperative chemotherapy (pCT) is utilized in many intra-abdominal cancers, the use of pCT among patients with intrahepatic cholangiocarcinoma (ICC) remains ill defined. As such, the objective of the current study was…
View details →Negative / Null Result ReportOpen accessMedicine
Carolina Barroso, Pedro Carvalho, M.C. Nunes et al. · 2021 · Frontiers in Immunology
The current treatments applied in aquaculture to limit disease dissemination are mostly based on the use of antibiotics, either as prophylactic or therapeutic agents, with vaccines being available for a limited number of fish species and pathogens. Antimicrobial peptides are considered as promising novel substances to be used in aquaculture, due to their antimicrobial and immunomodulatory activities. Hepcidin, the major iron metabolism regulator, is found as a single gene in most mammals, but in certain fish species, including the European sea bass ( Dicentrarchus labrax ), two different hepci
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Magali Petit, François Vézina · 2013 · Journal of Experimental Biology
Summary In small resident bird species living at northern latitudes, winter cold acclimatization is associated with an increase in pectoral muscle size and haematocrit level and this is thought to drive the seasonal increase in summit…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Hlalefang Khobai, Nwabisa Kolisi, Clement Moyo et al. · 2020 · International Journal of Energy Economics and Policy
The importance of renewable energy consumption has grown to a large extent over the recent years. The benefits of renewable energy consumption ranging from improved environmental quality to higher economic growth are well documented. However, the impact of renewable energy consumption on unemployment has received relatively less attention. This study examines the relationship between renewable energy consumption and unemployment in South Africa over the period 1990-2014. The Autoregressive Distributed Lag (ARDL) model was employed to test the long-run and short-run impacts of renewable energy
View details →Negative / Null Result ReportOpen accessNeuroscience
Natalia Sánchez, Sungwoo Park, James M. Finley · 2017 · Scientific Reports
The theory that the sensorimotor system minimizes energetic cost during locomotion has long been supported by both computational models and empirical studies. However, it has yet to be determined if the behavior to which people converge when exposed to a novel perturbation during locomotion is also energetically optimal. We address this issue in the context of adaptation to walking on a split-belt treadmill, which can impose a left-right asymmetry in step lengths. In response to this asymmetry, participants gradually adjust their foot placement to adopt steps of equal length. Here, we characte
View details →Negative / Null Result ReportMedicine
Benoît Tyl, Meriam Kabbaj, Sara M. Azzam et al. · 2011 · The Journal of Clinical Pharmacology
The effect of bilastine on cardiac repolarization was studied in 30 healthy participants during a multiple-dose, triple-dummy, crossover, thorough QT study that included 5 arms: placebo, active control (400 mg moxifloxacin), bilastine at…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Mohammad R. Jahan‐Parvar, Hassan Mohammadi · 2011 · The Journal of developing areas
We test the validity of the Dutch disease hypothesis by examining the relationship between real oil prices and real exchange rates in a sample of fourteen oil exporting countries. Autoregressive distributed lag (ARDL) bounds tests of…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Andrés Baselga, Miguel B. Araújo · 2010 · Journal of Biogeography
Abstract Aim The aim of community‐level modelling is to improve the performance of species distributional models by taking patterns of co‐occurrence among species into account. Here, we test this expectation by examining how well three…
View details →Negative / Null Result ReportOpen accessMedicine
Harri Merisaari, Parisa Movahedi, Ileana Montoya Perez et al. · 2016 · Magnetic Resonance in Medicine
Purpose To evaluate different fitting methods for intravoxel incoherent motion (IVIM) imaging of prostate cancer in the terms of repeatability and Gleason score prediction. Methods Eighty‐one patients with histologically confirmed prostate…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Alina Franzen, Timo Vogt, Tim Müller et al. · 2017 · Oncotarget
// Alina Franzen 1 , Timo J. Vogt 1 , Tim Müller 2 , Jörn Dietrich 1 , Andreas Schröck 1 , Carsten Golletz 2 , Peter Brossart 3 , Friedrich Bootz 1 , Jennifer Landsberg 4 , Glen Kristiansen 2 and Dimo Dietrich 1 1 Department of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany 2 Institute of Pathology, University Hospital Bonn, Bonn, Germany 3 Department of Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany 4 Department of Dermatology, Bonn, University Hospital Bonn, Germany Correspondence to: Dimo Dietrich, email: dimo.di
View details →Negative / Null Result ReportOpen accessMedicine
J Kjaergaard, Carsten Bogh Juhl, Peter Lange et al. · 2020 · ERJ Open Research
OBJECTIVES: The aim of this study was to establish whether early pulmonary rehabilitation after severe exacerbation of chronic obstructive pulmonary disease (COPD) reduces mortality and hospital admissions, and increases physical…
View details →Negative / Null Result ReportOpen accessMedicine
Michael H. Roh, Vickie Y. Jo, Edward B. Stelow et al. · 2010 · American Journal of Clinical Pathology
A fine-needle aspiration sample composed exclusively of Hürthle cells is interpreted as "suspicious for a follicular neoplasm, Hürthle cell type" (SFNHCT). Because some nonneoplastic Hürthle cell proliferations in Hashimoto thyroiditis…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Neil A. Hagen, Bernard Lapointe, May Ong-Lam et al. · 2011 · Current Oncology
BACKGROUND: Cancer pain is highly prevalent, and existing treatments are often insufficient to provide adequate relief. OBJECTIVES: We assessed the long-term safety and efficacy of subcutaneous tetrodotoxin treatment in reducing the intensity of chronic cancer-related pain. METHODS: In this multicentre open-label longitudinal trial, 30 μg tetrodotoxin was administered subcutaneously twice daily for 4 days in a heterogeneous cohort of patients with persistent pain despite opioids and other analgesics. "Responder" was defined as a mean reduction of 30% or more in pain intensity from baseline; an
View details →Negative / Null Result ReportMedicine
Fabrício Pereira, Alexandra Martini de Oliveira, Breno S. Diniz et al. · 2010 · Archives of Clinical Neuropsychology
The Direct Assessment of Functional Status-Revised (DAFS-R) is an instrument developed to objectively measure functional capacities required for independent living. The objective of this study was to translate and culturally adapt the…
View details →Negative / Null Result ReportOpen accessMedicine
Mona Ståhle‐Bäckdahl · 2026 · Acta Dermato Venereologica
The aim of the study was to investigate clinical aspects of pruritus in maintenance hemodialysis patients and to evaluate factors of putative pathogenic importance. 60-65% of the patients in a maintenance hemodialysis program during a…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Matthew R. Masters, Amr H. Mahmoud, Markus A. Lill · 2025 · Nature Communications
Co-folding models represent a major innovation in deep-learning-based protein-ligand structure prediction. The recent publications of RoseTTAFold All-Atom, AlphaFold3, and others have shown high-quality results on predicting the structures of proteins interacting with small-molecules, nucleic-acids, and other proteins. Despite these advanced capabilities and broad potential, the current study presents critical findings that question the adherence of these models to fundamental physical principles. Through adversarial examples based on established physical, chemical, and biological principles,
View details →Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
T. Acciavatti, Matteo Lupi, Rita Santacroce et al. · 2017 · Human Psychopharmacology Clinical and Experimental
OBJECTIVE: Comorbidities between psychiatric diseases and use of traditional substances of abuse are common. Nevertheless, there are few data regarding the use of novel psychoactive substances (NPS) among psychiatric patients. Aim of this…
View details →Negative / Null Result ReportOpen accessMedicine
Vladimir Lazarević, A-S Hörstedt, Bertil Johansson et al. · 2014 · Blood Cancer Journal
The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively…
View details →Negative / Null Result ReportOpen accessMedicine
Cheng‐Yu Long, Kun‐Ling Lin, Chin-Ru Shen et al. · 2021 · Scientific Reports
The study aims to evaluate the effectiveness of local injection of autologous platelet rich plasma (A-PRP) as a treatment for women suffering from stress urinary incontinence (SUI). In a prospective intervention study, twenty consecutive women suffering from SUI were treated with A-PRP injection at anterior vaginal wall where mid-urethra locates. Self-reported questionnaires were used to measure pre-treatment, 1 month and 6 months post-treatment symptom severity. Secondary outcomes of sexual function and treatment effect sorted by age were analyzed with valid statistical methods. A-PRP is effe
View details →Negative / Null Result ReportOpen accessSocial Sciences
Andrea L. Roberts, Kristen Lyall, Janet W. Rich‐Edwards et al. · 2015 · Autism
We sought to determine whether maternal (a) physical harm from intimate partner abuse during pregnancy or (b) sexual, emotional, or physical abuse before birth increased risk of autism spectrum disorder. We calculated risk ratios for…
View details →Negative / Null Result ReportOpen accessNeuroscience
Mahmoud G. El Baassiri, Zachariah Raouf, Sarah Badin et al. · 2024 · Journal of Neuroinflammation
Traumatic brain injury (TBI) is a chronic and debilitating disease, associated with a high risk of psychiatric and neurodegenerative diseases. Despite significant advancements in improving outcomes, the lack of effective treatments underscore the urgent need for innovative therapeutic strategies. The brain-gut axis has emerged as a crucial bidirectional pathway connecting the brain and the gastrointestinal (GI) system through an intricate network of neuronal, hormonal, and immunological pathways. Four main pathways are primarily implicated in this crosstalk, including the systemic immune syste
View details →Negative / Null Result ReportMedicine
Lionel A. Marzette, Leon W. Herndon · 2011 · Ophthalmic surgery, lasers & imaging retina
BACKGROUND AND OBJECTIVE: To compare the success and complication rates of patients with glaucoma who had an Ex-PRESS mini glaucoma shunt device implantation (Optonol, Ltd., Neve Ilan, Israel) to those who had conventional trabeculectomy.…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jill M. Haenfler, Geena Skariah, Caitlin M. Rodriguez et al. · 2018 · Frontiers in Molecular Neuroscience
Fragile X Syndrome (FXS) is the most common inherited cause of intellectual disability and autism. It results from expansion of a CGG nucleotide repeat in the 5’ untranslated region of FMR1. Large expansions elicit repeat and promoter hyper-methylation, heterochromatin formation, FMR1 transcriptional silencing, and loss of the Fragile X protein, FMRP. Efforts aimed at correcting the sequelae resultant from FMRP loss have thus far proven insufficient, perhaps because of FMRP’s pleiotropic functions. As the repeats do not disrupt the FMRP coding sequence, reactivation of endogenous FMR1 gene exp
View details →Negative / Null Result ReportOpen accessPsychology
Thomas Mangin, Nathalie André, Abdelrhani Benraïss et al. · 2021 · Psychology of sport and exercise
The ego-depletion effect refers to a temporary failure of self-control exertion after first performing an effortful task. This phenomenon has experienced a replication crisis in the past few years. In the present series of experiments, we…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ying Shen, Mumtahena Rahman, Stephen Piccolo et al. · 2015 · Bioinformatics
MOTIVATION: Although gene-expression signature-based biomarkers are often developed for clinical diagnosis, many promising signatures fail to replicate during validation. One major challenge is that biological samples used to generate and…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Junpeng Wang, Xue Yubo, Minghao Liu · 2016
As the world's first completely decentralized digital payment system, the emergence of bitcoin represents a revolutionary phenomenon in financial markets. This paper mainly studies the fluctuations of bitcoin price and discusses weather…
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Megan Best, Phyllis Butow, Ian Olver · 2016 · Journal of Clinical Medicine
Background: Despite known health benefits of spiritual care and high patient interest in discussing spirituality with their physicians, the frequency of spiritual discussions in the medical consultation is low. We investigated spiritual…
View details →Negative / Null Result ReportOpen accessMedicine
Florian Thibord, Melissa V. Chan, Ming‐Huei Chen et al. · 2022 · Human Genetics and Genomics Advances
Host genetic variants influence the susceptibility and severity of several infectious diseases, and the discovery of genetic associations with coronavirus disease 2019 (COVID-19) phenotypes could help to develop new therapeutic strategies…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zahra Yazdanpour, Omid Tadjrobehkar, Motahareh Shahkhah · 2020 · BMC Microbiology
BACKGROUND: Antibiotic resistance is an increasing phenomenon in many bacterial pathogens including uropathogenic Escherichia coli. Hypothetical anti-virulent agents could be a solution, but first clear virulence associated gene-pool of antibiotic resistant isolates have to be determined. The aim of this study is to investigate the significant associations between genes encoding VFs with antibiotic resistance and phylogenetic groups in UPEC isolates. RESULTS: The majority of 248 UPEC isolates belonged to phylogenetic group B2 (67.3%). The maximum and minimum resistance was attributed to amoxic
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Juan Pablo Nani, Fernanda Marcondes de Rezende, Francisco Peñagaricano · 2019 · BMC Genomics
BACKGROUND: Fertility is among the most important economic traits in dairy cattle. Genomic prediction for cow fertility has received much attention in the last decade, while bull fertility has been largely overlooked. The goal of this study was to assess genomic prediction of dairy bull fertility using markers with large effect and functional annotation data. Sire conception rate (SCR) was used as a measure of service sire fertility. Dataset consisted of 11.5 k U.S. Holstein bulls with SCR records and about 300 k single nucleotide polymorphism (SNP) markers. The analyses included the use of bo
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