Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Maximiliano A. Hawkes, Mauricio F. Farez, Ismael L. Calandri et al. · Arquivos de Neuro-Psiquiatria
ABSTRACT Lack of stroke awareness and slow activation of emergency medical services (EMS) are frequently reported reasons for delayed arrival to the hospital. We evaluated these variables in our population. Methods Review of hospital records and structured telephone interviews of 100 consecutive stroke patients. Forward stepwise logistic regression was used for the statistical analysis. Results Seventy patients (75%) arrived at the hospital 4.5 hours after stroke symptoms onset. The use of EMS did not improve arrival times. Most patients who recognized their symptoms did not use EMS (p < 0.02)
View details →Negative / Null Result ReportMedicine
Suda Y, Ishida K, Shibanuma N et al. · 2026 · BMC musculoskeletal disorders
Background Previously, it was reported that preoperative medial tibial bone marrow lesions (BMLs) were not associated with worse postoperative outcomes after medial unicompartmental knee arthroplasty (UKA). However, the effect of BMLs in…
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Qirui Chen, Yan Liu, Yi Liu et al. · 2023 · Thoracic Cancer
Abstract Background To investigate the effect of continuous oral aspirin in perioperative period on bleeding in pneumonectomy. Methods A total of 170 patients who underwent pneumonectomy in our hospital from March 2021 to March 2022 were selected as the study objects. All patients took oral aspirin before surgery and did not take other antiplatelet agent or anticoagulants at the same time. The continuation group included 85 cases and continued to take aspirin 100 mg/day during the perioperative period, and the interruption group included 85 cases who stopped aspirin for 7 days before surgery a
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
C. Rust, D. Tonge, L. L. van denHeuvel et al. · 2025 · Brain and Behavior
ABSTRACT Introduction Recent studies have challenged the idea of sterile blood, suggesting the presence of a blood microbiome. The detection of microbial nucleic acids in blood is thought to reflect the status of distant microbial niches, including the gut. However, the origins and viability of these microbes remain debated. In this study, blood microbiome signatures in Parkinson's disease (PD), schizophrenia (SCZ), and posttraumatic stress disorder (PTSD) were evaluated by extracting RNA‐sequencing (RNA‐seq) reads that did not map to the human genome. Furthermore, we investigated the correlat
View details →Negative / Null Result ReportOpen accessMining engineering. Metallurgy
Srija Balachandran, Kerstin Forsberg, Tom Lemaître et al. · 2021 · Metals
Selective leaching of Li from spent LIBs thermally pretreated by pyrolysis and incineration between 400 and 700 °C for 30, 60, and 90 min followed by water leaching at high temperature and high L/S ratio was examined. During the thermal pretreatment Li 2 CO 3 and LiF were leached. Along with Li salts, AlF 3 was also found to be leached with an efficiency not higher than 3.5%. The time of thermal pretreatment did not have a significant effect on Li leaching efficiency. The leaching efficiency of Li was higher with a higher L/S ratio. At a higher leaching temperature (80 °C), the leaching of Li
View details →Negative / Null Result ReportMedicine
Fontaine E · 2025 · Current opinion in clinical nutrition and metabolic care
Purpose of review Many clinical trials have failed to demonstrate the superiority of one nutritional protocol over another. This raises questions about the assessment tools used. In particular, intention-to-treat data analysis can mask…
View details →Negative / Null Result ReportOpen accessMedicine
Shi-gui Yang, Bin Cao, Li-rong Liang et al. · 2012 · PLoS ONE
BACKGROUND: There is limited data on the clinical outcome of patients with pandemic H1N1 (pH1N1) pneumonia who received oseltamivir treatment, especially when the treatment was administered more than 48 hours after symptom onset. METHODS: During the pandemic in 2009, a cohort of pH1N1 influenza pneumonia was built in China, and their clinical information was collected systematically, and analyzed with Cox models. RESULTS: 920 adults and 541 children with pneumonia who didn't receive corticosteroids were analyzed. In-hospital mortality was higher in adults who did not receive antiviral therapy
View details →Negative / Null Result ReportOpen accessBotany
Yuliang Liu, Xinye Liu, Xue Wang et al. · 2020 · BMC Plant Biology
Abstract Background As global warming becomes increasingly severe, it is urgent that we enhance the heat tolerance of crops. We previously reported that Arabidopsis thaliana PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C9 (AtPLC9) promotes heat tolerance. Results In this study, we ectopically expressed AtPLC9 in rice to examine its potential to improve heat tolerance in this important crop. Whereas AtPLC9 did not improve rice tolerance to salt, drought or cold, transgenic rice did exhibit greater heat tolerance than the wild type. High-throughput RNA-seq revealed extensive and dynamic transcriptome
View details →Negative / Null Result ReportMedicine
Yang G, Milne GL, Nogueira MS et al. · 2026 · International journal of cancer
Despite widespread interest, large randomized controlled trials have failed to demonstrate chemopreventive benefits of antioxidant supplementation, raising concerns about its efficacy and safety. Building on our prior observation of a…
View details →Negative / Null Result ReportMedicine
Samaniego-González E, Podlipnik S, Ribero S et al. · 2026 · Actas dermo-sifiliograficas
Background Management of patients with cutaneous melanoma and positive sentinel lymph node biopsy (SLNB) has shifted toward surveillance rather than complete lymph node dissection (CLND), because CLND has failed to demonstrate a survival…
View details →Negative / Null Result ReportOpen accessMedicine (General)
MM. Tahmasbi, F. Farahmand , AA. Amis · 1999 · Acta Medica Iranica
The resistant* of pateSa against lateral displacement (Le. the stability), was studied tinder a range of conditions in vitro, at a range of knee flexion angles. Muscle forces were applied in physiological directions along the separate quadriceps muscles. Normal muscle actions with constant tension showed constant patellar stability up to sixty degrees knee flexion, and then a significant increase at ninety degrees. A pathological knee was simulated by relaxing vastus medians, and ■ lateral stability then dropped by 47%. Isolated rttlnaeular release in the pathological knee did not improv
View details →Negative / Null Result ReportOpen accessPsychology
Stephanie M Sherman, Timothy P Buckley, Elsa Baena et al. · 2016 · Frontiers in Psychology
Many college students struggle to perform well on exams in the early morning. Although students drink caffeinated beverages to feel more awake, it is unclear whether these actually improve performance. After consuming coffee (caffeinated or decaffeinated), college-age adults completed implicit and explicit memory tasks in the early morning and late afternoon (Experiment 1). During the morning, participants ingesting caffeine demonstrated a striking improvement in explicit memory, but not implicit memory. Caffeine did not alter memory performance in the afternoon. In Experiment 2, participants
View details →Negative / Null Result ReportOpen accessMicrobiology
Amanda Louise White, Gregory Jaye Bix · 2023 · Biomolecules
Therapeutic angiogenesis has long been considered a viable treatment for vasculature disruptions, including cerebral vasculature diseases. One widely-discussed treatment method to increase angiogenesis is vascular endothelial growth factor (VEGF) A. In animal models, treatment with VEGFA proved beneficial, resulting in increased angiogenesis, increased neuronal density, and improved outcome. However, VEGFA administration in clinical trials has thus far failed to replicate the promising results seen in animal models. The lack of beneficial effects in humans and the difficulty in medicinal trans
View details →Negative / Null Result ReportOpen accessMedicine
Emma T L Cheng, Mohammad Cheik-Hussein, Noelle Lin et al. · 2023 · PLoS ONE
Background Pregabalin is a drug used to treat neuropathic pain, and its use has increased substantially since 2007. Early trials found a strong treatment effect on pain for post-herpetic neuralgia and diabetic neuropathy. However more recent studies have failed to replicate these results. Methods This meta-epidemiological study aimed to assess change in the reported effectiveness of pregabalin in neuropathic pain trials over time, and if a change is present, determine any associated factors. Data sources We performed electronic searches for published trials in Medline, Embase and Cochrane Cent
View details →Negative / Null Result ReportOpen accessAstrophysics
Yuta Hamada, Masatoshi Yamada · 2017 · European Physical Journal C: Particles and Fields
Abstract The null result in the LHC may indicate that the standard model is not drastically modified up to very high scales, such as the GUT/string scale. Having this in the mind, we suggest a novel leptogenesis scenario realized in the false vacuum of the Higgs field. If the Higgs field develops a large vacuum expectation value in the early universe, a lepton number violating process is enhanced, which we use for baryogenesis. To demonstrate the scenario, several models are discussed. For example, we show that the observed baryon asymmetry is successfully generated in the standard model with
View details →Negative / Null Result ReportOpen accessOptics. Light
Alex Midasala · 2024 · Results in Optics
A viable solution to detect the one-way speed of light anisotropy in linear motion is by using an Isosceles triangle-shaped design for the experimental setup, from which two light pulses from both ends of one of the triangle’s sides are sent to the same clock upon the detection of the incident and the reflected pulse, thereby evading the need for synchronization. The relativistic effects are taken into account in the timing measurements by incorporating the Lorentz transformation equations of length contraction and time dilation, which produces a non-null result for the time difference of the
View details →Negative / Null Result ReportOpen accessScience
Milton Gering, Tayla Johnson, Colin Tredoux · 2023 · South African Journal of Science
The effect of stress on face identification is not yet clear, with recent experiments finding positive, negative and null results. Here we report the results of two experiments examining the effect of stress on eyewitness performance in line-up face recognition tasks. Both experiments use a stress manipulation and live mock crime paradigm to examine the relationship between stress at encoding and subsequent line-up performance. Experiment 1 replicated an experiment by Sauerland et al. (Behav Sci Law. 2016;34(4):580–594) which induced stress using the Maastricht Acute Stress Test. The replicati
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Tom A. de Graaf, Tom A. de Graaf, Alexander T. Sack et al. · 2018 · Frontiers in Neuroscience
Experiments often challenge the null hypothesis that an intervention, for instance application of non-invasive brain stimulation (NIBS), has no effect on an outcome measure. In conventional statistics, a positive result rejects that hypothesis, but a null result is meaningless. Informally, however, researchers often do find null results meaningful to a greater or lesser extent. We present a model to guide interpretation of null results in NIBS research. Along a “gradient of surprise,” from Replication nulls through Exploration nulls to Hypothesized nulls, null results can be less or more surpr
View details →Negative / Null Result ReportOpen accessTechnology (General)
Szostek Karol, Szostek Roman · 2023 · Technical Transactions
The work presents the concept of a device for the measurement of the one-way speed of light. The minimum parameters of this device have also been determined based on the Special Theory of Ether without transverse contraction. The Special Theory of Ether is a relativistic theory of kinemat-ics with a universal frame of reference in which light propagates and is an alternative explanation for the null result of the Michelson-Morley experiment. An experiment based on the proposed device can be one of the ways to falsify the Special Theory of Relativity and Special Theory of Ether.
View details →Negative / Null Result ReportOpen accessDentistry
Dragos Epistatu, Octavian-Marius Dinca, Cristian Vladan et al. · 2023 · Dentistry Journal
The aim of this study is to evaluate the long-term changes of sinus lift material. Materials and methods: We included a total number of 35 patients (20 men and 15 women), between 32 and 80 years old, evaluated on a timeframe of up to 11.6 years. Diverse biomaterials were used (allograft, xenograft, alloplastic, combinations of them), with autologous bone in some cases. Results: The appearance of the top plane of the bone over time took a large dome shape (36% of cases), a linear shape (32% of cases), an irregular shape (23% of cases), or had micro domes above the implants (7%). No significant
View details →Negative / Null Result ReportOpen accessInternal medicine
Dae-Yeon Kim, Hee-Soon Park, Dong-Jae Han et al. · 2013 · Kidney Research and Clinical Practice
Renal failure caused by scrub typhus is known to be reversible. In most cases, renal function is almost fully restored after appropriate antibiotic treatment. A 71-year-old man was diagnosed with scrub typhus complicated by renal failure. A renal biopsy revealed histopathologic findings consistent with acute tubulointerstitial nephritis. Renal function did not improve 18 months after discharge and the patient required continuous hemodialysis. Although severe renal failure requiring dialysis is a rare complication of scrub typhus, we describe a case of scrub typhus requiring maintenance hemodia
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Michele Bottosso, Gaia Griguolo, Severine Guiu et al. · 2025 · npj Breast Cancer
Abstract Brain metastases (BMs) are a common complication of advanced breast cancer (BC), and their management has significantly evolved. We evaluated the clinical impact of these changes dividing patients diagnosed with BCBMs at three Institutions according to year of BMs diagnosis: 2000-2007 (group A), 2008-2014 (group B) and 2015-2022 (group C). Stereotactic radiotherapy increased (p < 0.001), and WBRT decreased (p = 0.010) over time. Among HER2+ BC patients, more received anti-HER2 therapy after BM diagnosis in recent years (p < 0.011). Overall survival (OS) did not improve in the entire c
View details →Negative / Null Result ReportOpen accessOphthalmology
Jemal Zeberga Shifa, Alemayehu Mekonnen Gezmu, Gezahen Negusse Ayane et al. · 2019 · The Pan-American Journal of Ophthalmology
A 22-year-old female patient was diagnosed to have HIV and treated by highly active antiretroviral therapy (HAART) since 2012 had developed a reduction of vision in both eyes secondary to cataract. The cataract was extracted from both eyes with no immediate postoperative complication. During follow-up, it was recognized that she had had bilateral Stage 3 macular hole in both eyes. The visual acuity in both eyes was 6/60 which did not improve with application of pinhole. Pars plana vitrectomy was done and sealed the macular hole in the left eye. The visual acuity remained the same in both eyes
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Alexander C. Lehn, Cullen O'Gorman, Sarah Olson et al. · 2017 · Tremor and Other Hyperkinetic Movements
Background: Orthostatic tremor (OT) was first described in 1977. It is characterized by rapid tremor of 13–18 Hz and can be recorded in the lower limbs and trunk muscles. OT remains difficult to treat, although some success has been reported with deep brain stimulation (DBS). Case Report: We report a 68-year-old male with OT who did not improve significantly after bilateral thalamic stimulation. Discussion: Although some patients were described who improved after DBS surgery, more information is needed about the effect of these treatment modalities on OT, ideally i
View details →Negative / Null Result Report
Eggeling-Böcker M, Karabetsos E, Christopoulou M et al. · 2025 · Preprint
Background: Technological advancements, such as the introduction of 5G, offer opportunities but also raise concerns. Although no evidence suggests negative effects of radiofrequency electromagnetic fields (RF-EMF) within defined exposure…
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
H. Tanji, H. Nagasawa, T. Hayashi et al. · 1996 · Behavioural Neurology
We studied the chronic effect of thyrotropin releasing hormone (TRH) in a patient with spinocerebellar degeneration by measuring cerebral metabolic rate for glucose (CMRG1c) using 2-[18F]fluoro-2-deoxy-D-glucose (18FDG) and positron emission tomography (PET). A 56-year-old female, who had suffered from progressive ataxia for 2 years, was treated by intravenous administration of 2 mg TRH for 3 weeks, and CMRG1c of the brain was measured before and after treatment. CMRG1c was markedly decreased in the cerebellum and there was no significant difference before and after the treatment, i.e. mean CM
View details →Negative / Null Result ReportOpen accessScience
NATALIA C. SILVA, KAREN M. LEÃO, JOÃO T. PÁDUA et al. · 2021 · Anais da Academia Brasileira de Ciências
Abstract To evaluate the addition of antioxidants in extenders on post-thaw bovine semen quality and in vitro embryo production efficiency. Six semen samples were collected from five Holstein bulls. In the experiment I, the samples were diluted with AndroMed® and Bovimix® and added antioxidants glutathione (1.5 and 2.5 mM) and melatonin (0.5 and 1.0 mM). In the experiment II, the best treatments obtained in experiment I were used for in vitro fecundation. Glutathione did not improve sperm viability. Melatonin had a negative effect on semen characteristics. Andromed® showed better results in sp
View details →Negative / Null Result ReportOpen accessMedicine
M.Ghasemi, Z. Hajheidari, M. Golpour · 2007 · Journal of Mazandaran University of Medical Sciences
AbstractPemphigus Erythematosus specially its localized form is a rare autoimmune blistering disease combining features of Pemphigus Foliaceus and Lupus Erythematosus. We reported a 60 years old woman with skin lesion which presented Erythemato squamo plaque with oozing in the right cheek. The chief compliant was burning and pruritus. Skin biopsy was obtained and discoid Lupus Erythemato was reported. She was prescribed with topical steroid but did not improve. All of the lab tests such as Anti DNA, ESR, RF, CRP, CH50, C3, C4, ANA were normal. The biopsy repeated and Pemphigus Erythematosus wa
View details →Negative / Null Result ReportOpen accessAgriculture
Marjatta Uosukainen, Mauritz Vestberg · 1994 · Agricultural and Food Science
The importance of different rooting methods and the effects of arbuscular mycorrhizal (AMF) inoculation on the rooting rate, weaning survival and subsequent growth of microcuttings of Malus rootstock YP and the Finnish crab apple cultivars Hanna and Marjatta were studied in four experiments conducted at the Laukaa Research and Elite Plant Unit, Finland. Sucrose in the in vitro rooting medium gave the best support to weaning survival in comparision with glucose and fructose. Directly rooted microcuttings had a higher survival rate than in vitro rooted microcuttings. AMF inoculation did not impr
View details →Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
Daniel A. Ermann, Victoria A. Vardell, Lindsey Fitzgerald et al. · 2026 · eJHaem
ABSTRACT Introduction B‐cell prolymphocytic leukemia (B‐PLL) is a rare, aggressive leukemic B‐cell malignancy historically associated with poor outcomes and recently reclassified in the WHO Fifth Edition but retained as a distinct entity in the ICC. Methods We analyzed 950 patients labeled as B‐PLL in the National Cancer Database (2004–2019), identified using ICD‐O‐3 morphology code 9833/3. Results Median age was 72 years, and 72% received systemic therapy at diagnosis. Median overall survival (OS) was poor (2.8 years) and did not improve over time. Patients initially managed with active surve
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