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Browse the failure-mode index

20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Efficacy and safety of mycophenolate mofetil in patients with high-grade locally advanced or metastatic osteosarcoma (ESMMO): a multicenter, phase II clinical trial.

Koonrungsesomboon N, Teeyakasem P, Dukaew N et al. · 2025 · International journal of clinical oncology

Background Osteosarcoma is a prevalent and aggressive bone malignancy primarily affecting young adults. Despite advances in standard treatment, the 5-year survival rate remains low, highlighting the need for new chemotherapy options.…

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Negative / Null Result ReportMedicine

Best Overall Response-Associated Signature to Doxorubicin in Soft Tissue Sarcomas: A Transcriptomic Analysis from ANNOUNCE.

Liu J, Moura DS, Jones RL et al. · 2024 · Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose This exploratory analysis evaluated the tumor samples of the patients treated with doxorubicin (with or without olaratumab) in a negative phase III ANNOUNCE trial to better understand the complexity of advanced soft tissue sarcomas…

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Negative / Null Result ReportMedicine

Recent Advances in Clinical Trials in Multiple System Atrophy.

Bendetowicz D, Fabbri M, Sirna F et al. · 2024 · Current neurology and neuroscience reports

Purpose of review This review summarizes previous and ongoing neuroprotection trials in multiple system atrophy (MSA), a rare and fatal neurodegenerative disease characterized by parkinsonism, cerebellar, and autonomic dysfunction. It also…

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Negative / Null Result ReportMedicine

A Phase 2 Trial of RANKL Antibody, Denosumab, in Two Cohorts of Patients with Recurrent/Refractory Osteosarcoma, a Report from the Children's Oncology Group.

Janeway KA, Chou AJ, Buxton A et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose Mouse models demonstrate a role for RANK and its ligand, RANKL, in osteosarcoma. The primary objective of this single-arm, open-label phase 2 trial was to determine whether denosumab, a RANKL mAb, improved disease control in…

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Negative / Null Result ReportMedicine

Performance of the Healthy Aging Brain Care Monitor Self Report in Monitoring Post-Intensive Care Syndrome Among Acute Respiratory Failure Survivors.

Savsani PK, Khan SH, Perkins AJ et al. · 2025 · Critical care medicine

Objectives To describe the performance of the Healthy Aging Brain Care Monitor Self Report (HABC-M SR) in assessment of post-intensive care syndrome (PICS) among Acute Respiratory Failure ICU survivors. Design Secondary data analysis of a…

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Negative / Null Result ReportOpen accessMedicine

Triple Therapy: A Safe, Cost-Effective Regimen of Heparin, Aspirin and Clopidogrel for Managing Intracranial Vessel Occlusions in Patients With Acute Ischemic Stroke Who Are Ineligible for Intravenous Thrombolytics and Endovascular Thrombectomy.

Chaudhari A, Almajali M, Khan N et al. · 2026 · Stroke (Hoboken, N.J.)

Background Endovascular thrombectomy (EVT) has transformed the management of acute ischemic stroke, but remains inaccessible to many patients due to anatomic, clinical, or logistical limitations. Treatment strategies for patients with…

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Negative / Null Result ReportOpen accessMedicine

Intraperitoneal Perfusion with Cisplatin or Mitomycin C Improves Survival in Mice Bearing Peritoneal Metastases from Ovarian Cancer.

Andersson Y, Løvstakken E, Herud TM et al. · 2025 · Annals of surgical oncology

Background Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery is a potentially curative treatment for patients with peritoneal metastases. Currently, there is no standardized protocol for performing HIPEC and…

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Negative / Null Result ReportOpen accessMedicine

Pooling Alzheimer's disease clinical trial data to develop personalized medicine approaches is easier said than done: A proof-of-principle study and call to action.

Dubbelman MA, Vromen EM, Tijms BM et al. · 2024 · Alzheimer's & dementia (New York, N. Y.)

With the advent of the first generation of disease-modifying treatments for Alzheimer's disease, it is clearer now more than ever that the field needs to move toward personalized medicine. Pooling data from past trials may help identify…

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Negative / Null Result ReportMedicine

A Randomized Trial of Direct Instruction Language for Learning in Children With Autism Spectrum Disorder.

Scahill L, Shillingsburg MA, Ousley O et al. · 2022 · Journal of the American Academy of Child and Adolescent Psychiatry

Objective To compare Direct Instruction Language for Learning (DI) plus treatment as usual (TAU) with TAU alone in children with autism spectrum disorder and moderate language delay. Method In this study, 83 children (age range, 4 years to…

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Negative / Null Result ReportOpen accessMedicine

Assessment of Skin in Patients With Systemic Sclerosis Using High-Frequency Ultrasound and Shear Wave Elastography: A Comparative Study With Histology, Molecular, and Clinical Parameters.

Desai R, Tan F, Wu M et al. · 2026 · Arthritis care & research

Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large-scale comparison of US-based assessment with histologic markers of skin fibrosis has not been…

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Negative / Null Result ReportMedicine

RETRACTED: F173. Negative Trial of Scopolamine in Major Depressive Disorder Does Not Demonstrate Neurophysiological Changes Seen With the Antidepressant Response of Ketamine.

Park L, Furey M, Nugent A et al. · 2018 · Biological psychiatry

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This conference abstract has been retracted at the request of author Maura Furey,…

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Negative / Null Result ReportOpen accessMedicine

Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial.

Molto A, López-Medina C, Van den Bosch FE et al. · 2021 · Annals of the rheumatic diseases

Objectives To compare the benefits of a tight-control/treat-to-target strategy (TC/T2T) in axial spondyloarthritis (axSpA) with those of usual care (UC). Methods Pragmatic, prospective, cluster-randomised, controlled, open, 1-year trial…

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Negative / Null Result ReportOpen accessMedicine

Biological and clinical insights from a randomized phase 2 study of an anti-oncostatin M monoclonal antibody in systemic sclerosis.

Denton CP, Del Galdo F, Khanna D et al. · 2022 · Rheumatology (Oxford, England)

Objectives The cytokine oncostatin M (OSM) is implicated in the pathology of SSc. Inhibiting OSM signalling using GSK2330811 (an anti-OSM monoclonal antibody) in patients with SSc has the potential to slow or stop the disease process.…

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Negative / Null Result ReportOpen accessMedicine

Addition of HIV self-test kits to partner notification services to increase HIV testing of male partners of pregnant women in Zambia: two parallel randomised trials.

Mutale W, Freeborn K, Graybill LA et al. · 2021 · The Lancet. Global health

Background Testing men for HIV during their partner's pregnancy can guide couples-based HIV prevention and treatment, but testing rates remain low. We investigated a combination approach, using evidence-based strategies, to increase HIV…

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Negative / Null Result ReportOpen accessMedicine

An internet-based cognitive-behavioral self-management intervention for patients with hand osteoarthritis or fibromyalgia - Two randomized controlled trials.

Terpstra JA, van Beugen S, van der Vaart R et al. · 2026 · Internet interventions

Background Rheumatic and musculoskeletal diseases have a high burden. We aimed to evaluate the effectiveness of a therapist-guided internet-based cognitive-behavioral therapy (iCBT) on pain coping and secondary physical, psychological, and…

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Negative / Null Result ReportMedicine

A Stepped-Wedge Randomized Controlled Trial: Effects of eHealth Interventions for Pain Control Among Adults With Cancer in Hospice.

Wilkie DJ, Yao Y, Ezenwa MO et al. · 2020 · Journal of pain and symptom management

Context Unrelieved cancer pain at the end of life interferes with achieving patient-centered goals. Objective To compare effects of usual hospice care and PAINRelieveIt® on pain outcomes in patients and their lay caregivers. Methods In a…

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Negative / Null Result ReportOpen accessMedicine

Randomized, double-blind, placebo-controlled, crossover trial of oral doxycycline for epistaxis in hereditary hemorrhagic telangiectasia.

Thompson KP, Sykes J, Chandakkar P et al. · 2022 · Orphanet journal of rare diseases

Background Vascular malformations in hereditary hemorrhagic telangiectasia (HHT) lead to chronic recurrent bleeding, hemorrhage, stroke, heart failure, and liver disease. There is great interest in identifying novel therapies for epistaxis…

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Negative / Null Result ReportMedicine

Accommodation, pattern glare, and coloured overlays.

Allen PM, Dedi S, Kumar D et al. · 2012 · Perception

We manipulated the accommodative response using positive and negative lenses to study any association between symptoms of pattern glare and accommodation. Two groups of eighteen young adults were selected from seventy-eight on the basis…

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Negative / Null Result ReportOpen accessMedicine

Effect of acute kidney injury and overall survival in patients with postoperative head and neck cancer who received chemoradiotherapy with cisplatin: A supplementary analysis of the phase II/III trial of JCOG1008.

Imamura Y, Kiyota N, Tahara M et al. · 2024 · Cancer medicine

Background In a randomized phase II/III trial (JCOG1008), weekly cisplatin (40 mg/m 2 ) was non-inferior to 3-weekly cisplatin (100 mg/m 2 ) for postoperative high-risk head and neck cancer. We investigated how acute kidney injury (AKI), a…

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Negative / Null Result ReportOpen accessMedicine

No association between chronotype and cardiovascular response to a cognitive challenge in the morning using a Bayesian approach.

Wüst LN, Cajochen C, Lasauskaite R · 2025 · Neurobiology of sleep and circadian rhythms

A chronotype is defined as a preference for certain behaviours (e.g., sleep and wake) to occur at specific times of day. It is therefore also temporally linked with cognitive performance across the day. In an exploratory analysis, we…

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Negative / Null Result ReportOpen accessMedicine

Effect of different doses of gadolinium contrast agent on clinical outcomes in MS.

Ackermans N, Taylor C, Tam R et al. · 2019 · Multiple sclerosis journal - experimental, translational and clinical

Objective The objective of this paper is to evaluate potential dose-dependent adverse effects of gadolinium-based contrast agents (GBCAs) on MS progression. Methods Outcomes from a cohort of 612 secondary progressive MS (SPMS) patients,…

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