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Browse the failure-mode index

20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Increased cytokine production capacity and persistent inflammation after achieving remission of Cushing's syndrome.

van Houten P, van de Ven AC, van Herwaarden AE et al. · 2026 · Journal of clinical & translational endocrinology

Endogenous Cushing's syndrome (CS) is characterized by chronic hypercortisolism. After achieving remission, morbidity remains increased and quality of life remains impaired. Moreover, the incidence of inflammatory disorders increases after…

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Negative / Null Result ReportMedicine

Chronic atorvastatin treatment weakens procontractile influence of NADPH oxidase derived ROS in systemic murine arteries.

Shvetsova AA, Zakirjanova GF, Ostapchuk KP et al. · 2026 · Pflugers Archiv : European journal of physiology

The beneficial effects of statins for cardiovascular system were widely described in various pathologies. However, much less is known about the effects of statins in healthy organism, especially in systemic resistance arteries. We aimed to…

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Negative / Null Result Report

The Utility of MRI for spinal clearance in blunt trauma. A retrospective cohort study of 539 blunt trauma patients in a level one trauma center in Singapore

Cayden L, Chandrasagran RA, Adam C et al. · 2026 · Preprint

Abstract Introduction: The majority of spinal injuries occur secondary to blunt trauma and patients with significant blunt trauma must be assumed to have an unstable spinal injury until complete radiological and clinical assessment. MRI…

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Negative / Null Result ReportMedicine

Passive heat therapy is feasible but does not affect cardiometabolic health outcomes in persons with spinal cord injury - a pilot study.

Hoekstra SP, Leicht CA, Kellogg D Jr et al. · 2026 · Experimental physiology

Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face…

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Negative / Null Result ReportMedicine

The effect of antihypertensive treatment on longitudinal changes in PLGF and sFlt-1 in women with new onset hypertension in pregnancy.

Tyrell E, Lau KGY, Bednorz M et al. · 2026 · Acta obstetricia et gynecologica Scandinavica

Introduction To assess longitudinal changes in serum sFlt-1 and PLGF in women with newly diagnosed hypertension in pregnancy before and after commencing antihypertensive therapy, aiming at tight BP control ( Material and methods This was a…

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Negative / Null Result ReportMedicine

Self-disclosure to Peers and Changes in Personal Recovery in Community-dwelling People with Mental Disorders: A One-year Longitudinal Study.

Yokoyama K, Shimokihara S, Miyajima R et al. · 2026 · Community mental health journal

This study examined whether overall and domain-specific self-disclosure to peers at baseline was prospectively associated with changes in personal recovery over one-year among community-dwelling adults with mental disorders in Japan. A…

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Negative / Null Result ReportMedicine

Dupilumab in the treatment of severe chronic rhinosinusitis with nasal polyps (CRSwNP) in cystic fibrosis patients.

Di Girolamo A, Cristallo M, Daddato MF et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Chronic rhinosinusitis with nasal polyps (CRSwNP) manifests as either a solitary upper airway involvement or as part of a more intricate clinical picture, such as Cystic Fibrosis (CF). The altered viscoelastic properties of mucus…

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Negative / Null Result ReportMedicine

Tight stomatal regulation and high intrinsic capacity of carbon assimilation inferred from isotopic composition negatively correlate with drought-driven decline in sclerophyllous species.

Piper FI, Paula S, Urrutia-Jalabert R · 2026 · Annals of botany

Background and aims Long-term droughts reduce the carbon (C) and water pools of trees, causing mortality. However, the underlying physiological mechanisms explaining tree mortality remain unclear, and evidence from mature forests is…

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Negative / Null Result ReportMedicine

Linezolid-Induced Serotonin Release from QGP-1 Cells.

Tsutsumi T, Kashiwagi H, Imai S et al. · 2026 · Drug research

Background Nausea and vomiting are commonly reported side effects of long-term linezolid therapy, which is indispensable for tuberculosis and osteoarticular infections. Since the mechanism underlying the development of nausea and vomiting…

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Negative / Null Result ReportMedicine

Octa evaluation of macular and optic disc vascular changes after PRP.

Karabacak DD, Doğruya S, Altınışık M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

PURPOSE: This study aimed to evaluate the impact of panretinal photocoagulation (PRP) on macular and optic nerve head microvascular parameters using optical coherence tomography angiography (OCTA) in eyes with proliferative diabetic…

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Negative / Null Result ReportMedicine

Interaction of ambient temperature and conditioning temperatures on moisture addition throughout pelleting, the pelleting process, and enzyme activity

Renner A, Estanich EB, Lynch EA et al. · 2026 · Journal of Applied Poultry Research.

Thermal processes during steam conditioning and pellet die extrusion aid in pelleting but may degrade exogenous feed enzymes. This study determined how ambient temperature interacts with varying steam conditioning temperatures to influence…

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Negative / Null Result ReportMedicine

Effect of Three Types of Specially-Designed Myopia Control Spectacle Lenses on Astigmatism: A Two-Year Result.

Wen K, Yang B, Liu L et al. · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Purpose This study sought to determine whether specially-designed myopia control spectacle lenses had any effect on astigmatism in clinical practice. Methods Medical records of 74 patients (age: 6 to 12 years old) involving the use of…

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Negative / Null Result ReportMedicine

Age and sex differences in longitudinal CPAP adherence patterns.

Vodapally M, Chan-Golston AM, Sandhu J et al. · 2026 · Respiratory medicine

Study objective This study investigated long-term adherence to continuous positive airway pressure (CPAP) therapy among adult patients with obstructive sleep apnea (OSA), with a focus on identifying associations between age, sex, residual…

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Negative / Null Result ReportMedicine

Inflammation may explain part of atherosclerotic cardiovascular disease risk conferred by elevated remnant lipoproteins: a cohort and Mendelian randomization study.

Wadström BN, Wulff AB, Pedersen KM et al. · 2026 · Atherosclerosis

Background and aims Elevated remnant lipoproteins are a causal risk factor for atherosclerotic cardiovascular disease. We tested the hypothesis that low-grade inflammation can explain part of the increased risk of peripheral artery disease…

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Negative / Null Result ReportOpen accessMedicine

Visceral adipose tissue and liver fat on 17-beta estradiol-dominant gender-affirming hormone therapy: A US-based cohort.

Talathi R, Juhasz V, Delgado M et al. · 2026 · The Journal of clinical endocrinology and metabolism

Context Data on the metabolic effects of contemporaneous gender-affirming hormone therapy (GAHT) are limited. Objective To characterize the metabolic effects of GAHT ie, estradiol with anti-androgen therapy. Design Prospective…

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Negative / Null Result ReportMedicine

Active Aging: Learning English and Developing Fine Psychomotor Abilities.

Baranowska K, Dylewski R, Fugiel J et al. · 2026 · Experimental aging research

Background Recent studies highlight that cognitive processes involved in learning share neural pathways with those controlling fine motor skills. Building on this insight, the mini-EDUball method was developed to integrate cognitive and…

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Negative / Null Result ReportMedicine

Profession-Specific Ageism Changes Following a Two-Day Long-Term Care Placement in Dental Students.

Izumi M, Mizutani S, Fujimoto A et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Background Ageism among dental students can impede equitable geriatric care. Developing educational interventions to reduce profession-specific and general ageist attitudes is an urgent priority in aging societies. Objective To determine…

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