19,915 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Shahid N, Kim CH, Jabilona KB et al. · 2026 · PloS one
Tyrosine kinase inhibitors (TKI) are often used in combination with other chemotherapeutic nucleoside/nucleobase analogues, such as gemcitabine and 6-mercaptopurine, in the treatment of various cancers. Past studies have shown that several…
View details →Lubineau M, Watkins CP, Glasel H et al. · 2023 · Proceedings. Biological sciences
Does word flickering facilitate reading? Despite a lack of scientific evidence, flickering glasses and lamps for dyslexia are being marketed in various countries. We conducted four experiments to assess their efficacy. Two experiments…
View details →Salerno JW, Xu S, Rainforth M et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : Cardiovascular disease (CVD) is the leading cause of death globally. The World Health Organization has called for investigations into traditional systems of medicine for CVD prevention. Ayurveda includes a…
View details →Stark R, Zigman JM, Andrews ZB · 2025 · Journal of neuroendocrinology
The olfactory bulb (OB) is an emerging neuroendocrine centre regulating appetite, metabolism, and behaviours such as those linked to anxiety, motivation and spatial navigation. These processes are likely mediated by one or more of the many…
View details →Liu S, Hu S, Chen J et al. · 2025 · Psychological research
Previous research has shown that the addition of happy or angry expressions to other-race faces can assist infants in overcoming the perceptual narrowing of face race and reinstating their recognition of other-race faces. In the present…
View details →Draper B, Wand APF · 2025 · Current opinion in psychiatry
Purpose of review Depression and physical illnesses have long been recognized as risk factors for suicidal behaviour in late life. Qualitative studies have previously identified frailty as being an issue in late life suicidal behaviour,…
View details →Beirowski B, Huang H, Babetto E · 2026 · eLife
Axon degeneration (AxD), accompanied by glial remodeling, is a pathological hallmark of many neurodegenerative diseases, leading to the disruption of neuronal connectivity. Understanding the mechanisms in neurons and glia that regulate AxD…
View details →Levin ME, Mukasa MN, Bowers EM et al. · 2025 · Behavioral sciences (Basel, Switzerland)
Adherence challenges are common among digital mental health interventions (DMHIs). Single-session DMHIs may help by providing a low-intensity intervention that takes less time to complete. This pilot randomized controlled trial sought to…
View details →Lunde P, Finbråten HS, Pripp AH et al. · 2025 · International journal of cardiology. Cardiovascular risk and prevention
Background and aims Adherence to treatment is a significant challenge for patients with cardiac disease. Optimizing health literacy (HL) is essential in this context. Mobile health (mHealth) interventions have been suggested to improve…
View details →Ferro M, Cilla S, Macchia G et al. · 2026 · Cancer reports (Hoboken, N.J.)
Background This study investigates the impact of radiotherapy (RT) on fatigue levels in prostate cancer (PC) patients, considering the significant physical and psychological impact of fatigue associated with cancer and its treatments.…
View details →stocker t · 2026 · Preprint
Hyperlactatemia, and/or lactic acidosis, is a common complication in wildlife due to the sensitivity of these species to capture induce complications. The treatment of lactic acidosis in humans is equally as controversial as in veterinary…
View details →Sieborg J, Maul JT, Wu JJ et al. · 2025 · Acta dermato-venereologica
Biosimilars are designed to be analogous to the biologic originators. However, comprehensive comparisons between biosimilars are limited and lacking for patients with psoriasis. This study's objective was to compare 1-year drug survival of…
View details →Hossain SJ, Tofail F, Mehrin SF et al. · 2023 · Pediatrics
Background and objectives Previously, in 30 Bangladeshi villages, 2 groups of children with iron-deficiency anemia (IDA) and nonanemic (NA) iron sufficiency aged 6 to 24 months participated in 2 parallel cluster randomized controlled…
View details →Bingöl G, Jesurasa S, Stroethoff M et al. · 2025 · Frontiers in cardiovascular medicine
Remote ischemic preconditioning (RIPC) has been shown in several experimental studies as an organ protective procedure against ischemic injury, but the implementation of RIPC into routine clinical practice has so far failed due to…
View details →Mayer L, Lichtblau M, Furian M et al. · 2025 · Journal of the American Heart Association
Background Exposure to high altitude triggers hypoxic pulmonary vasoconstriction with a rise in pulmonary artery pressure (PAP). This may lead to symptomatic pulmonary hypertension with impaired right heart function and exercise capacity.…
View details →López-de la Rosa A, Díez-Montero C, Martínez-Plaza E et al. · 2024 · Ophthalmology and therapy
Introduction Characterizing lens thickness (LT) in patients with cataracts is important for better understanding the lens aging process and for designing new intraocular lens power formulas. This study aimed to analyze the influence of…
View details →Fitzgerald LS, Reynoso Spurrier CS, Lau NJ et al. · 2025 · American journal of physiology. Endocrinology and metabolism
Mitochondria are key regulators of metabolism and ATP supply in skeletal muscle, while circadian rhythms influence many physiological processes. However, whether mitochondrial function is intrinsically regulated in a circadian manner in…
View details →Fernández-Ruiz M, Sánchez Moreno B, Santiago Almeda J et al. · 2023 · Transplant infectious disease : an official journal of the Transplantation Society
Previous studies have suggested that exposure to statins confers a protective effect in bloodstream infection (BSI) due to the anti-inflammatory and immunomodulatory properties attributed to these lipid-lowering drugs. Scarce evidence is…
View details →Vilk Ayalon N, Omer Vilk N, Sompolinsky Y et al. · 2026 · Reproductive health
BACKGROUND: Frozen embryo transfer (FET) is widely used due to its safety and effectiveness. However, it has been associated with an increased risk of large for gestational age (LGA) infants. Proposed mechanisms include effects of embryo…
View details →Agudelo LR, Yarmush G, Kumar S et al. · 2025 · Biology
Accelerating healing is a clinical goal in both acute and chronic non-healing skin wounds. We leveraged the public Recon database, which seeks to aggregate all of the metabolic pathways in the human body, to uncover whether increasing the…
View details →Sandoval-Alarcón S, Bäumle R, Castellucci HI · 2025 · Applied ergonomics
Dentists face various occupational demands that heighten their risk of developing work-related musculoskeletal disorders (WMSDs), including prolonged static postures, repetitive movements, unsuitable dental instruments, extended work…
View details →Warren WG, Papagianni EP, Hale E et al. · 2022 · Frontiers in pharmacology
Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can…
View details →Khalid E, Vijayan MM · 2025 · Frontiers in endocrinology
Introduction Although the Crh-Crhr1 system is the proximal trigger for the stressor-induced corticosteroid release, its role in initiating the fight-or-flight response to an acute stressor is unclear. We hypothesized that the Crh-Crhr1…
View details →Ouerghi N, Abassi W, Jebabli N et al. · 2026 · Sports (Basel, Switzerland)
The study investigated the effects of high-intensity interval training (HIIT) on cardiorespiratory fitness, hormonal, and psychological markers in adolescents. Twenty-eight healthy male adolescents were randomized to a HIIT group or a…
View details →Toledo FV, Meletti JFA, Silva LMC et al. · 2026 · Brazilian journal of anesthesiology (Elsevier)
Introduction Surgery remains one of the most important treatments for breast cancer. In this context, the quality of postoperative recovery has become a key concern. Adequate control of acute pain is essential to optimize patient comfort…
View details →Salihu AT, Usman JS, Hill KD et al. · 2023 · Experimental brain research
The ability to control balance and prevent falls while carrying out daily life activities may require a predominantly controlled (cognitive) or automatic processing depending on the balance challenge, age, or other factors. Consequently,…
View details →Tatsuoka Y, Zembrzuski KJ, Natalini JG et al. · 2025 · Journal of clinical medicine
Background: Primary graft dysfunction (PGD) is the leading cause of early mortality after lung transplantation. Albumin is commonly used during lung transplantation to maintain intravascular volume while minimizing total intravenous fluid…
View details →Berge M, Hultgren O, Hugosson S et al. · 2026 · Scientific reports
There are large variations in how individual patients respond to allergen immunotherapy (AIT) against grass and/or birch allergy. There are currently no reliable biomarkers to predict which patients are likely to benefit from the…
View details →Mariani C, Al Dababsekh A, Carta F et al. · 2025 · Medicina (Kaunas, Lithuania)
Background and Objectives : Hemostasis during thyroid surgery is crucial to avoid postoperative complications, particularly hematoma, which can cause life-threatening airway compromise. Arista™ AH, a plant-based absorbable hemostatic…
View details →Jobson I, Vo NTN, Kujawinski E et al. · 2025 · Bioelectronic medicine
Background In glioblastoma (GBM) therapy research, tumour treating fields by the company Novocure™, have shown promise for increasing patient overall survival. When used with the chemotherapeutic agent temozolomide, they extend median…
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