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20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The impact of hormonal contraceptives containing estradiol, estradiol valerate, and estetrol on liver proteins, lipids, glucose, blood pressure, and bone. A literature review.

Cagnacci A, Xholli A, Gabbi L et al. · 2026 · The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

Objective We investigated the metabolic profile induced by contraceptives containing body-identical oestrogens. Methods A literature search was made for articles on contraceptives with oestradiol/nomegestrol acetate (E2/NOMAc), oestradiol…

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Negative / Null Result ReportMedicine

Quantification of Changes in Bifidobacteria and Lactobacilli Colony-forming Units During Rifaximin Treatment and Synbiotic Gel in Healthy Volunteers.

Cassís-Nosthas ML, Vorácková FV, Dzib FT et al. · 2026 · Journal of visualized experiments : JoVE

Although the gut microbiota is generally stable, it can be influenced by antibiotic treatment. Rifaximin, which is used to treat gastrointestinal disorders, is frequently administered with probiotics to reduce the risk of dysbiosis.…

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Negative / Null Result ReportMedicine

Cerebral physiology following general anaesthesia with sevoflurane or propofol in healthy volunteers - a randomised, single-blind cross-over trial.

Madsen SS, Asghar MS, Lindberg U et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

Although general anaesthesia is a very common medical procedure, knowledge of how the brain physiologically recovers remains limited. In this randomized cross-over trial, we investigated brain physiology during recovery from general…

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Negative / Null Result ReportMedicine

Long-term risk of major adverse cardiovascular events after carotid endarterectomy-a 9-year prospective cohort study of the Athero-Express biobank.

Mol BM, de Bresser CJM, de Kleijn PV et al. · 2026 · European stroke journal

Carotid endarterectomy (CEA) is performed to lower the long-term risk of stroke in patients with carotid stenosis. Data evaluating long-term outcomes after CEA are scarce, but crucial for accurately determining long-term benefits. We aimed…

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Negative / Null Result ReportMedicine

Efficacy of Aerobic Exercise on Brain MRI Measures in Parkinson's Disease.

Langeskov-Christensen M, Nygaard MKE, Eskildsen SF et al. · 2026 · Neurorehabilitation and neural repair

Objectives Medical disease-modifying treatments are lacking in Parkinson's disease (PD). Physical exercise is potentially an inexpensive and easily accessible disease-modifying therapy, but this remains to be studied using recent promising…

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Negative / Null Result ReportMedicine

Auditory mismatch-negativity predicts response to dorsomedial prefrontal intermittent theta-burst stimulation in major depressive disorder.

Anderson M, Bodén R, Wass CE et al. · 2026 · Journal of affective disorders

Background Impaired plasticity has been implicated in major depressive disorder (MDD), which is reflected in impaired automatic sensory detection as measured using mismatch negativity (MMN). Intermittent theta-burst stimulation (iTBS) is…

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Negative / Null Result ReportOpen accessMedicine

Increased cytokine production capacity and persistent inflammation after achieving remission of Cushing's syndrome.

van Houten P, van de Ven AC, van Herwaarden AE et al. · 2026 · Journal of clinical & translational endocrinology

Endogenous Cushing's syndrome (CS) is characterized by chronic hypercortisolism. After achieving remission, morbidity remains increased and quality of life remains impaired. Moreover, the incidence of inflammatory disorders increases after…

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Negative / Null Result ReportMedicine

Chronic atorvastatin treatment weakens procontractile influence of NADPH oxidase derived ROS in systemic murine arteries.

Shvetsova AA, Zakirjanova GF, Ostapchuk KP et al. · 2026 · Pflugers Archiv : European journal of physiology

The beneficial effects of statins for cardiovascular system were widely described in various pathologies. However, much less is known about the effects of statins in healthy organism, especially in systemic resistance arteries. We aimed to…

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Negative / Null Result Report

The Utility of MRI for spinal clearance in blunt trauma. A retrospective cohort study of 539 blunt trauma patients in a level one trauma center in Singapore

Cayden L, Chandrasagran RA, Adam C et al. · 2026 · Preprint

Abstract Introduction: The majority of spinal injuries occur secondary to blunt trauma and patients with significant blunt trauma must be assumed to have an unstable spinal injury until complete radiological and clinical assessment. MRI…

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Negative / Null Result ReportMedicine

Passive heat therapy is feasible but does not affect cardiometabolic health outcomes in persons with spinal cord injury - a pilot study.

Hoekstra SP, Leicht CA, Kellogg D Jr et al. · 2026 · Experimental physiology

Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face…

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Negative / Null Result ReportMedicine

The effect of antihypertensive treatment on longitudinal changes in PLGF and sFlt-1 in women with new onset hypertension in pregnancy.

Tyrell E, Lau KGY, Bednorz M et al. · 2026 · Acta obstetricia et gynecologica Scandinavica

Introduction To assess longitudinal changes in serum sFlt-1 and PLGF in women with newly diagnosed hypertension in pregnancy before and after commencing antihypertensive therapy, aiming at tight BP control ( Material and methods This was a…

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Negative / Null Result ReportMedicine

Self-disclosure to Peers and Changes in Personal Recovery in Community-dwelling People with Mental Disorders: A One-year Longitudinal Study.

Yokoyama K, Shimokihara S, Miyajima R et al. · 2026 · Community mental health journal

This study examined whether overall and domain-specific self-disclosure to peers at baseline was prospectively associated with changes in personal recovery over one-year among community-dwelling adults with mental disorders in Japan. A…

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Negative / Null Result ReportMedicine

Dupilumab in the treatment of severe chronic rhinosinusitis with nasal polyps (CRSwNP) in cystic fibrosis patients.

Di Girolamo A, Cristallo M, Daddato MF et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Chronic rhinosinusitis with nasal polyps (CRSwNP) manifests as either a solitary upper airway involvement or as part of a more intricate clinical picture, such as Cystic Fibrosis (CF). The altered viscoelastic properties of mucus…

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Negative / Null Result ReportMedicine

Tight stomatal regulation and high intrinsic capacity of carbon assimilation inferred from isotopic composition negatively correlate with drought-driven decline in sclerophyllous species.

Piper FI, Paula S, Urrutia-Jalabert R · 2026 · Annals of botany

Background and aims Long-term droughts reduce the carbon (C) and water pools of trees, causing mortality. However, the underlying physiological mechanisms explaining tree mortality remain unclear, and evidence from mature forests is…

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Negative / Null Result ReportMedicine

Linezolid-Induced Serotonin Release from QGP-1 Cells.

Tsutsumi T, Kashiwagi H, Imai S et al. · 2026 · Drug research

Background Nausea and vomiting are commonly reported side effects of long-term linezolid therapy, which is indispensable for tuberculosis and osteoarticular infections. Since the mechanism underlying the development of nausea and vomiting…

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Negative / Null Result ReportMedicine

Octa evaluation of macular and optic disc vascular changes after PRP.

Karabacak DD, Doğruya S, Altınışık M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

PURPOSE: This study aimed to evaluate the impact of panretinal photocoagulation (PRP) on macular and optic nerve head microvascular parameters using optical coherence tomography angiography (OCTA) in eyes with proliferative diabetic…

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Negative / Null Result ReportMedicine

Interaction of ambient temperature and conditioning temperatures on moisture addition throughout pelleting, the pelleting process, and enzyme activity

Renner A, Estanich EB, Lynch EA et al. · 2026 · Journal of Applied Poultry Research.

Thermal processes during steam conditioning and pellet die extrusion aid in pelleting but may degrade exogenous feed enzymes. This study determined how ambient temperature interacts with varying steam conditioning temperatures to influence…

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