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Browse the failure-mode index

20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Evaluation of a Clinical Practice Algorithm for Pediatric Complicated Pneumonia: A Retrospective, Observational, Single-Center Study.

Ostertag-Hill CA, Cummings OW, Renaud EJ · 2026 · Rhode Island medical journal (2013)

Objective The diagnostic evaluation, antibiotic treatment, and type and timing of surgical intervention for pediatric patients with complicated pneumonia is not standardized and may lead to increased length of stay, more radiation…

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Negative / Null Result ReportMedicine

Comparison of Different Lighting Protocols on Female Cat Reproduction.

Lantermino A, Lapuente C, Blanco PG et al. · 2026 · Reproduction in domestic animals = Zuchthygiene

The aim of this study was to describe and compare the effect of different lighting protocols on sexual cyclicity and serum melatonin in domestic female cats. Additionally, anti-Müllerian hormone (AMH) concentrations and ultrasound or…

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Negative / Null Result ReportMedicine

Long-term increase in Mediterranean diet adherence combined with decrease in ultra-processed food consumption is associated with reduction in depressive symptoms: Results from the Moli-sani study.

Bracone F, Di Castelnuovo A, Costanzo S et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)

Background and aims Mediterranean diet (MD) has been associated with a reduced risk of depressive symptoms, while high intake of ultra-processed foods (UPFs) has been linked to poorer mental health. However, the long-term combined effects…

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Negative / Null Result ReportMedicine

Radiation dose for common pediatric computed tomography examinations and evaluation of clinical image quality in pediatric chest CT scans.

Findikli I, Yalcin A, Kasapgil O et al. · 2026 · Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

The increasing use of computed tomography (CT) in pediatric patients has prompted researchers to investigate the radiation dose associated with pediatric CT scans. Studies optimizing image quality and minimizing radiation dose in pediatric…

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Negative / Null Result ReportMedicine

Psychological Resilience Moderates Autonomous Motivation After Mild Traumatic Brain Injury: A Randomized Controlled Trial of a Remote Walking Program.

Chang YC, Tsai HF, Shi RS et al. · 2026 · The Journal of head trauma rehabilitation

Objective The aim of this study was to evaluate whether a 12-week remotely delivered walking program based on self-determination theory (SDT) improves autonomous exercise motivation in adults with mild traumatic brain injury (mTBI) versus…

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Negative / Null Result ReportMedicine

Marine heatwaves have no impact on fertilization, early development and sensitivity to metal toxicity in the sea urchin Paracentrotus lividus.

Gambardella C, Soro P, Miroglio R et al. · 2026 · Marine environmental research

Marine Heatwaves (MHWs) have become more severe and frequent worldwide under global warming. They are projected to intensify under different climate scenarios, with unknown consequences for the marine biota. In this study we assess the…

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Negative / Null Result ReportMedicine

Incidence of Gastrointestinal Adverse Events Following Left Hepatic Lobe Radiation Segmentectomy for the Treatment of Hepatocellular Carcinoma.

De La Garza-Ramos C, Silver C, Islam F et al. · 2026 · Cardiovascular and interventional radiology

Purpose Describe the incidence and severity of gastrointestinal tract-related adverse events (GIAE) following radiation segmentectomy (RS) for hepatocellular carcinoma (HCC) in the left hepatic lobe. Materials and methods A single-center…

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Negative / Null Result ReportMedicine

Evaluation of squid shiokara products marketed in Japan using sensory tests, amino acid and organic acid profiles, and analysis of bacterial communities

Mizusawa N, Nishimura K, Ouchi D et al. · 2026 · Fish Sci

Shiokara is a traditional Japanese salted and fermented seafood product. The aim of this study was to compare various commercially available squid shiokara products in Japan by examining their NaCl content, free amino acid content (all…

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Negative / Null Result ReportMedicine

Dung beetles do not profit from enhanced spatial heterogeneity in temperate production forests: A forest manipulation experiment

Asch J, Scherer‐Lorenzen M, Pierick K et al. · 2026 · Journal of Applied Ecology.

Central European forest management strategies promoting structurally homogeneous closed‐canopy forests have led to landscape‐level declines in biodiversity and ecosystem multifunctionality. Conservation‐targeted management programs aim at…

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Negative / Null Result ReportMedicine

Exopolysaccharide biosynthesis and regulation in Leuconostoc mesenteroides influences water holding capacity of fermented plant-based milks.

Sukarno AS, Dong A, Gumulya Y et al. · 2026 · International journal of food microbiology

Physical instability remains a major challenge in fermented plant-based yoghurts in the absence of added texturizing agents. Cultures can improve water holding capacity (WHC) through production of exopolysaccharide (EPS). This study…

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Negative / Null Result ReportMedicine

The influence of adolescent idiopathic scoliosis on hip joint development: a two-year longitudinal evaluation of the hip center-edge angle.

Matsumoto T, Yokoe T, Takahashi T et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

PURPOSE: Several studies have reported an association between adolescent idiopathic scoliosis (AIS) and hip decentration (HD). However, these previous studies evaluated the hip center-edge (CE) angle at only a single time point. This study…

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Negative / Null Result ReportMedicine

Non-modifiable cardiovascular risk factors and coronary plaque characteristics in patients with acute coronary syndromes.

Scalamera R, Covani M, Andreaggi S et al. · 2026 · European heart journal. Cardiovascular Imaging

Aims Cardiovascular risk factors predict adverse clinical outcomes, including acute coronary syndromes (ACS). A recent study showed a close correlation between the number of modifiable risk factors and plaque vulnerability. However, the…

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Negative / Null Result ReportMedicine

Bark beetles as ecosystem engineers: triggered tree mortality rearranges the assemblage of Tree-related Microhabitats in old-growth coniferous forest

Przepióra F, Ciach M · 2025 · Forest Ecology and Management.

Although species with ecosystem engineering capabilities like woodpeckers, ungulates or saproxylic insects may initiate the formation of Tree-related Microhabitats (TreMs), their overall impact on TreM assemblages remains unexplored. Bark…

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Negative / Null Result ReportMedicine

Heat-Killed <i>Enterococcus faecalis</i> EF-2001 Promotes Systemic Th1-Skewed Immune Activation Without Detectable Reduction of Influenza Viral Load in Mice.

Ohashi T, Hagihara M, Asai N et al. · 2026 · Microorganisms

Heat-killed Enterococcus faecalis EF-2001 (EF-2001) is a postbiotic preparation reported to modulate host immunity. However, its specific impact on host immune responses and virological outcomes during the early phase of influenza…

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Negative / Null Result ReportMedicine

Impact of neoadjuvant immunotherapy on postoperative cardiac adverse events in NSCLC: insights from a bidirectional cohort.

Yan C, Zhang X, Hu S et al. · 2026 · International journal of surgery (London, England)

The impact of neoadjuvant chemo-immunotherapy (nCIT) on perioperative cardiac safety in patients undergoing lung cancer resection remains unclear. This study aimed to evaluate the incidence and risk factors of postoperative cardiac adverse…

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Negative / Null Result ReportMedicine

Effect of acute intraperitoneal injection of methylglyoxal on organ injury and oxidative stress in chicks (Gallus gallus domestics).

Okino M, Makino R, Aoki M et al. · 2026 · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

Methylglyoxal (MGO) is an α-dicarbonyl compound and produced from several metabolic pathways, including glucose metabolism. This compound induces oxidative stress and organ damage in mammals and is associated with various diseases,…

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Negative / Null Result ReportMedicine

Shortening the perioperative prophylactic antimicrobial duration in pediatric ventriculoperitoneal (VP) shunt insertion.

Tada A, Ihara S, Suwa J et al. · 2026 · Pediatrics international : official journal of the Japan Pediatric Society

Background Perioperative antimicrobial therapy is important to prevent central nervous system (CNS) infections following cerebrospinal fluid (CSF) shunt insertion, but the optimal duration remains unclear. This study aimed to evaluate the…

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