Negative / Null Result ReportOpen accessEnvironmental Science
Melinda C. Power, Marc G. Weisskopf, Stacey Alexeeff et al. · 2010 · Environmental Health Perspectives
BACKGROUND: Traffic-related particles induce oxidative stress and may exert adverse effects on central nervous system function, which could manifest as cognitive impairment. OBJECTIVE: We assessed the association between black carbon (BC), a marker of traffic-related air pollution, and cognition in older men. METHODS: A total of 680 men (mean ± SD, 71 ± 7 years of age) from the U.S. Department of Veterans Affairs Normative Aging Study completed a battery of seven cognitive tests at least once between 1996 and 2007. We assessed long-term exposure to traffic-related air pollution using a validat
View details →Negative / Null Result ReportOpen accessMedicine
Claus Z. Simonsen, Albert J. Yoo, Leif H. Sørensen et al. · 2018 · JAMA Neurology
Importance: Endovascular therapy (EVT) is the standard of care for select patients who had a stroke caused by a large vessel occlusion in the anterior circulation, but there is uncertainty regarding the optimal anesthetic approach during…
View details →Negative / Null Result ReportOpen accessMathematics
Alexander Coppock, Thomas J. Leeper, Kevin Mullinix · 2018 · Proceedings of the National Academy of Sciences
The extent to which survey experiments conducted with nonrepresentative convenience samples are generalizable to target populations depends critically on the degree of treatment effect heterogeneity. Recent inquiries have found a strong…
View details →Negative / Null Result ReportOpen accessMedicine
Charles E. Geyer, Judy E. Garber, Richard D. Gelber et al. · 2022 · Annals of Oncology
BACKGROUND: The randomized, double-blind OlympiA trial compared 1 year of the oral poly(adenosine diphosphate-ribose) polymerase inhibitor, olaparib, to matching placebo as adjuvant therapy for patients with pathogenic or likely pathogenic variants in germline BRCA1 or BRCA2 (gBRCA1/2pv) and high-risk, human epidermal growth factor receptor 2-negative, early breast cancer (EBC). The first pre-specified interim analysis (IA) previously demonstrated statistically significant improvement in invasive disease-free survival (IDFS) and distant disease-free survival (DDFS). The olaparib group had fewe
View details →Negative / Null Result ReportEconomics, Econometrics and Finance
Boris Podobnik, Zhi‐Qiang Jiang, Wei‐Xing Zhou et al. · 2011 · Physical Review E
For stationary time series, the cross-covariance and the cross-correlation as functions of time lag $n$ serve to quantify the similarity of two time series. The latter measure is also used to assess whether the cross-correlations are…
View details →Negative / Null Result ReportOpen accessMedicine
André Lamy, P.J. Devereaux, Dorairaj Prabhakaran et al. · 2013 · New England Journal of Medicine
BACKGROUND: Previously, we reported that there was no significant difference at 30 days in the rate of a primary composite outcome of death, myocardial infarction, stroke, or new renal failure requiring dialysis between patients who…
View details →Negative / Null Result ReportOpen accessMaterials Science
Bapi Sarker, Dimitrios G. Papageorgiou, Raquel Silva et al. · 2013 · Journal of Materials Chemistry B
Microencapsulation of cells by using biodegradable hydrogels offers numerous attractive features for a variety of biomedical applications including tissue engineering. This study highlights the fabrication of microcapsules from an…
View details →Negative / Null Result ReportOpen accessMedicine
Ming Yang, Shuo Chen, Bo Huang et al. · 2020 · European Urology Focus
BACKGROUND: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), involves multiple organs. Testicular involvement is largely unknown. OBJECTIVE: To determine the pathological changes…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anna Müller, Michaela Wenzel, Henrik Strahl et al. · 2016 · Proceedings of the National Academy of Sciences
and different assays, including proteomics, ionomics, and fluorescence light microscopy. We found that daptomycin causes a gradual decrease in membrane potential but does not form discrete membrane pores. Although we found no evidence for…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Michela Carlana · 2019 · The Quarterly Journal of Economics
Abstract I study whether exposure to teacher stereotypes, as measured by the Gender-Science Implicit Association Test, affects student achievement. I provide evidence that the gender gap in math performance, defined as the score of boys…
View details →Negative / Null Result ReportEarth and Planetary Sciences
Chris Derksen, Ross Brown · 2012 · Geophysical Research Letters
Analysis of Northern Hemisphere spring terrestrial snow cover extent (SCE) from the NOAA snow chart Climate Data Record (CDR) for the April to June period (when snow cover is mainly located over the Arctic) has revealed statistically…
View details →Negative / Null Result ReportOpen accessMedicine
Bojing Liu, Fang Fang, Nancy L. Pedersen et al. · 2017 · Neurology
OBJECTIVE: To examine whether vagotomy decreases the risk of Parkinson disease (PD). METHODS: Using data from nationwide Swedish registers, we conducted a matched-cohort study of 9,430 vagotomized patients (3,445 truncal and 5,978…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Jelte M. Wicherts, Marjan Bakker, Dylan Molenaar · 2011 · PLoS ONE
BACKGROUND: The widespread reluctance to share published research data is often hypothesized to be due to the authors' fear that reanalysis may expose errors in their work or may produce conclusions that contradict their own. However, these hypotheses have not previously been studied systematically. METHODS AND FINDINGS: We related the reluctance to share research data for reanalysis to 1148 statistically significant results reported in 49 papers published in two major psychology journals. We found the reluctance to share data to be associated with weaker evidence (against the null hypothesis
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Corinne F. Maurice, Sarah C. L. Knowles, Joshua Ladau et al. · 2015 · The ISME Journal
Recent studies have provided an unprecedented view of the microbial communities colonizing captive mice; yet the host and environmental factors that shape the rodent gut microbiota in their natural habitat remain largely unexplored. Here, we present results from a 2-year 16 S ribosomal RNA gene sequencing-based survey of wild wood mice (Apodemus sylvaticus) in two nearby woodlands. Similar to other mammals, wild mice were colonized by 10 bacterial phyla and dominated by the Firmicutes, Bacteroidetes and Proteobacteria. Within the Firmicutes, the Lactobacillus genus was most abundant. Putative
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Rameshwar Dubey, Angappa Gunasekaran, Stephen J. Childe · 2018 · Management Decision
Purpose The purpose of this paper is to examine when and how organizations build big data analytics capability (BDAC) to improve supply chain agility (SCA) and gain competitive advantage. Design/methodology/approach The authors grounded…
View details →Negative / Null Result ReportBusiness, Management and Accounting
Kathyayini Kathy Rao, Carol Tilt, Laurence Lester · 2012 · Corporate Governance
Purpose The purpose of this paper is to investigate the relationship between environmental reporting and corporate governance attributes of companies in Australia. Design/methodology/approach The paper adopts a quantitative analysis…
View details →Negative / Null Result ReportEnergy
Sungeun Yang, Young Joo Tak, Jiwhan Kim et al. · 2016 · ACS Catalysis
Single-atom catalysts (SACs) provide an ideal platform for reducing noble-metal usage. SACs also exhibit unusual catalytic properties due to the absence of a metal surface. The role of the support may have a significant effect on the…
View details →Negative / Null Result ReportOpen accessMedicine
Melissa L. Johnson, Byoung Chul Cho, Alexander Luft et al. · 2022 · Journal of Clinical Oncology
PURPOSE The open-label, phase III POSEIDON study evaluated tremelimumab plus durvalumab and chemotherapy (T + D + CT) and durvalumab plus chemotherapy (D + CT) versus chemotherapy alone (CT) in first-line metastatic non–small-cell lung…
View details →Negative / Null Result ReportOpen accessMedicine
Steffen Boettcher, Peter G. Miller, Rohan Sharma et al. · 2019 · Science
p53—still hazy after all these years? The gene encoding the p53 tumor suppressor protein is the most frequently mutated gene in human cancer. Yet decades after the gene's discovery, the biology of cancer-associated missense mutations in…
View details →Negative / Null Result ReportMaterials Science
Yue Liu, Xinfeng Zhou, Zirui Jia et al. · 2022 · Advanced Functional Materials
Abstract Polymeric metal‐organic framework (MOF)‐derived composites are promising functional materials because of their exceptional chemical homogeneity, designable components, and adjustable pore size. The modulation of oxygen and Mn…
View details →Negative / Null Result ReportOpen accessNeuroscience
Tobias U. Hauser, Reto Iannaccone, Philipp Stämpfli et al. · 2013 · NeuroImage
Changes in response contingencies require adjusting ones assumptions about outcomes of behaviors. Such adaptation processes are driven by reward prediction error (RPE) signals which reflect the inadequacy of expectations. Signals resembling RPEs are known to be encoded by mesencephalic dopamine neurons projecting to the striatum and frontal regions. Although regions that process RPEs, such as the dorsal anterior cingulate cortex (dACC), have been identified, only indirect evidence links timing and network organization of RPE processing in humans. In electroencephalography (EEG), which is well
View details →Negative / Null Result ReportMedicine
Yann Malato, Syed Naqvi, Nina Schürmann et al. · 2011 · Journal of Clinical Investigation
Recent evidence has contradicted the prevailing view that homeostasis and regeneration of the adult liver are mediated by self duplication of lineage-restricted hepatocytes and biliary epithelial cells. These new data suggest that liver…
View details →Negative / Null Result ReportOpen accessMedicine
Matthew M. Grabowski, Pablo F. Recinos, Amy S. Nowacki et al. · 2014 · Journal of neurosurgery
OBJECT: The impact of extent of resection (EOR) on survival for patients with glioblastoma (GBM) continues to be a point of debate despite multiple studies demonstrating that increasing EOR likely extends survival for these patients. In…
View details →Negative / Null Result ReportEconomics, Econometrics and Finance
Kangyin Dong, Xiucheng Dong, Qingzhe Jiang · 2019 · World Economy
Abstract Significant difference in the emission–renewables nexus across countries with different income levels is frequently ignored in previous studies. To empirically investigate whether the effect of renewable energy consumption on…
View details →Negative / Null Result ReportEconomics, Econometrics and Finance
Antonio Trujillo‐Ponce · 2012 · Accounting and Finance
Abstract This paper empirically analyses the factors that determine the profitability of Spanish banks for the period of 1999–2009. We conclude that the high bank profitability during these years is associated with a large percentage of…
View details →Negative / Null Result ReportOpen accessMedicine
Jean‐Pierre Gérard, D. Azria, S. Gourgou-Bourgade et al. · 2012 · Journal of Clinical Oncology
PURPOSE: The ACCORD 12 trial investigated the value of two different preoperative chemoradiotherapy (CT-RT) regimens in T3-4 Nx M0 resectable rectal cancer. Clinical results are reported after follow-up of 3 years. PATIENTS AND METHODS:…
View details →Negative / Null Result ReportNeuroscience
Anna Weinberg, Greg Hajcak · 2010 · Emotion
The present study examined electrocortical evidence for a negativity bias, focusing on the impact of specific picture content on a range of event-related potentials (ERPs). To this end, ERPs were recorded while 67 participants viewed a…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
BI Ageing Clock Team, Thomas M. Stubbs, Marc Jan Bonder et al. · 2017 · Genome biology
BACKGROUND: DNA methylation changes at a discrete set of sites in the human genome are predictive of chronological and biological age. However, it is not known whether these changes are causative or a consequence of an underlying ageing process. It has also not been shown whether this epigenetic clock is unique to humans or conserved in the more experimentally tractable mouse. RESULTS: We have generated a comprehensive set of genome-scale base-resolution methylation maps from multiple mouse tissues spanning a wide range of ages. Many CpG sites show significant tissue-independent correlations w
View details →Negative / Null Result ReportOpen accessMedicine
Deirdre K. Tobias, An Pan, Chandra L. Jackson et al. · 2014 · New England Journal of Medicine
BACKGROUND: The relation between body weight and mortality among persons with type 2 diabetes remains unresolved, with some studies suggesting decreased mortality among overweight or obese persons as compared with normal-weight persons (an…
View details →Negative / Null Result ReportOpen accessComputer Science
Jafar Tanha, Yousef Abdi, Negin Samadi et al. · 2020 · Journal Of Big Data
Abstract Since canonical machine learning algorithms assume that the dataset has equal number of samples in each class, binary classification became a very challenging task to discriminate the minority class samples efficiently in imbalanced datasets. For this reason, researchers have been paid attention and have proposed many methods to deal with this problem, which can be broadly categorized into data level and algorithm level. Besides, multi-class imbalanced learning is much harder than binary one and is still an open problem. Boosting algorithms are a class of ensemble learning methods in
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