Negative / Null Result ReportOpen accessMedicine
Mujda Nooristani, Maxime Maheu, Marie-Soleil Houde et al. · 2019 · PLoS ONE
Noisy galvanic vestibular stimulation (nGVS) has been shown to enhance postural stability during stimulation, and the enhancing effect has been observed to persist for several hours post-stimulation. However, these effects were observed without proper control (sham condition) and the possibility of experimental bias has not been ruled out. The lasting effect of nGVS on postural stability therefore remains in doubt. We investigated the lasting effect of nGVS on postural stability using a control (sham) condition to confirm or infirm the possibility of experimental bias. 28 participants received
View details →Negative / Null Result ReportOpen accessSports medicine
Ayaka Yasuda, Shuhei Sasajima, Takehiro Kosaka et al. · 2023 · Journal of Physical Fitness and Sports Medicine
The purpose of this study was to investigate the effects of stimulation conditions (pressing force and frequency) and subcutaneous tissue properties (thickness and hardness) on the changes in tendon blood circulation caused by acupressure. Before and after acupressure, blood circulation of the Achilles tendon was measured using red laser lights. Acupressure was applied to the Achilles tendon for 3-min under three conditions. The following four conditions (including no stimulation condition) with different combinations of pressing forces and frequencies were established: 1) 50N and 1.5Hz, 2) 25
View details →Negative / Null Result ReportOpen accessFood processing and manufacture
YAN Rui, TANG Min, CHEN Dongfang, HUANG Shirong, MEI Xin · 2023 · Shipin Kexue
The feasibility of using white radish powder as a nitrite substitute in dry fermented pork sausages was evaluated. Four groups of sausage were prepared by using a multi-strain starter culture (VBM-60, Sacco): negative control (NC, without nitrate or nitrite), positive control (PC, with 150 mg/kg sodium nitrite), 0.5% white radish powder (R0.5), and 1% white radish powder (R1). The effects of nitrite substitution by white radish powder on the physicochemical, microbiological and sensory characteristics of dry fermented sausage during production and storage were investigated. The results showed
View details →Negative / Null Result ReportOpen accessOrthopedic surgery
Jinli Guo, Chaona Gao, Haifeng Xin et al. · 2019 · Journal of Orthopaedic Surgery and Research
Abstract Purposes Hip fracture leads to decreased activity and an increased risk of pulmonary complications. The main purpose of this study was to observe the lung capacity, cough capacity of the elderly patient with acute hip fracture, and assess the effects and the feasibility of using a special-designed “upper-body yoga” training to treat elderly patients with hip fracture. Methods This was a prospective, randomized, and single-blind study. Eighty-four subjects aged over 65 years were randomly divided into either a control group or a yoga group to undergo an abdominal breathing program or a
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Jing Zhang, Chengcheng Shao, Jiajia Zhu et al. · 2025 · Frontiers in Cardiovascular Medicine
BackgroundThis study investigated the clinical characteristics of in-hospital cardiac arrest (IHCA) in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock and assessed the related in-hospital and post-discharge mortality.MethodsThis study included 148 patients with AMI complicated by cardiogenic shock who were admitted to the Cardiac Critical Care Center, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University between September 1, 2021 and July 31, 2024. Study participants were divided into two groups according to the occurrence of IHCA (IHCA
View details →Negative / Null Result ReportOpen accessPsychology
Shenghong Ye, Haoyun Yan, Zhengyu Lin et al. · 2022 · Frontiers in Psychology
Consumers often feel embarrassed when buying products like condoms, hemorrhoid cream, and beriberi cream in crowded pharmacies. There is an interesting phenomenon in life: Some beriberi creams use the images of a “real foot”, while others use the images of a “cartoon foot.” Imagine if a young woman needed to go to a retail store for beriberi cream that would embarrass her, she would choose a “real foot image” or a “cartoon foot image” beriberi cream? It has been shown that the embarrassment of these products has a strong negative impact on consumer buying behavior. Previous researches have exp
View details →Negative / Null Result ReportOpen accessMedicine
Hamide Abbaspour kasgari, Maria Tavakoli Ardakani, Abdollah Farhadinasab · 2019 · Journal of Mazandaran University of Medical Sciences
Background and purpose: Memantine is a medication used to treat moderate to severe Alzheimer’s disease. Memantine targeting the glutamatergic system specifically N-Methyl-D-Aspartate offer a novel approach in treatment of psychiatric disorders such as schizophrenia and schizoaffective disorder. The purpose of this study was to evaluate the efficacy and safety of memantine in combination with antipsychotics in patients with schizophrenia and schizoaffective disorder. Materials and methods: A double-blind, placebo-controlled trial was performed in patients aged 18-65 years old with confirmed dia
View details →Negative / Null Result ReportOpen accessAnesthesiology
Christian Rothe, Jørgen Lund, Morten Troels Jenstrup et al. · 2020 · BMC Anesthesiology
Abstract Background The sensory innervation of the shoulder is complex and there are variations in the branching patterns of the sensory fibres. Articular branches from the axillary nerve to the subacromial bursa are described in more than 50% of investigated shoulders but the isolated contribution of sensory input from the axillary nerve has never been investigated clinically. We hypothesized that a selective block of the axillary nerve would reduce morphine consumption and pain after arthroscopic subacromial decompression. Methods We included 60 patients in a randomized, blinded, placebo-con
View details →Negative / Null Result ReportOpen accessAnimal culture
Ya-qian LIANG, Yong-lei YANG, Lei XU et al. · 2022 · Siliao yanjiu
The experiment was to investigate the effect of adding different levels of vitamin C (VC) to parent pigeons' diets on body weight, slaughter performance, meat quality, serum biochemical indexes and blood routine of squabs. 90 pairs of parent pigeons and 270 squabs with similar body weight at one-day-old were selected, and the parent pigeons and squabs were randomly divided into five groups, with six repelicates in each group. There were three cages in each cage with one pair of baby pigeons and three squabs. Group A, group B, group C, group D and group E were supplemented with 0, 200, 400, 800
View details →Negative / Null Result ReportOpen accessGynecology and obstetrics
Yangyang Zhang, Yang Xu, Jiao Yu et al. · 2023 · Journal of Ovarian Research
Abstract Background A premature luteinizing hormone (LH) surge refers to an endogenous LH peak that occurs before follicle maturation or human chorionic gonadotropin injection in the process of controlled ovarian hyperstimulation. The effect of premature LH surge on pregnancy outcomes in fresh embryo transfer cycles is still controversial. The aim of this study was to explore the effect of a premature LH surge without elevated progesterone levels on the cumulative pregnancy rate (CPR) and cumulative live birth rate (CLBR) of patients during a flexible GnRH antagonist protocol. Methods A total
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Jia Lu, Yang Chen, Lili Shi et al. · 2023 · BioPsychoSocial Medicine
Abstract Background In Asia, the proportion of patients with irritable bowel syndrome (IBS) with abdominal discomfort alone is significantly higher than that in western countries. The purposes of this study are to understand the cognition of abdominal pain and abdominal discomfort in Chinese patients with IBS and to compare the clinical characteristics of patients with abdominal pain alone and with abdominal discomfort alone. Methods Patients with IBS with diarrhea (IBS-D) who met the Rome III diagnostic criteria and had episodes of at least one day/week were consecutively enrolled. The cognit
View details →Negative / Null Result ReportOpen accessGeriatrics
Hong-Jhe Chen, Hsun Ou, Ru-Yih Chen et al. · 2025 · BMC Geriatrics
Abstract Background This study investigated the relationship between sleep disturbance, obstructive sleep apnea (OSA), and osteoporosis in older adults. Methods This cross-sectional study involved 326 older adults (mean age: 83.46 years) in elder care institutions in Taiwan. The presence of osteoporosis was assessed using dual-energy X-ray absorptiometry, while sleep quality and OSA risk were evaluated using the Pittsburgh Sleep Quality Index and STOP-Bang questionnaire, respectively. Heart rate variability (HRV) was measured to assess autonomic function. Logistic regression models, adjusted f
View details →Negative / Null Result ReportOpen accessSurgery
Camila Lopes Cardoso, Osny Ferreira Júnior, Paulo S. Perri de Carvalho et al. · 2011 · Acta Cirúrgica Brasileira
PURPOSE: To evaluate two treatment modalities of dry socket in rats and to discuss the first findings of the molecular analysis in this experimental model. METHODS: 84 rats underwent a tooth extraction were divided in 4 groups: I-uninfected socket (control), II-infected socket without any treatment, III-infected socket treated with irrigation of 2% sodium iodide and 3% hydrogen peroxide solution, IV-infected socket submitted to curettage, irrigation with physiological saline solution and fulfilled with metronidazole paste as base. The groups were subdivided in postoperative sacrifice periods:
View details →Negative / Null Result ReportOpen accessOrthopedic surgery
Min Zou, Xin Duan, Mufan Li et al. · 2023 · Journal of Orthopaedic Surgery and Research
Abstract Background Treating lateral compression type 1 (LC1) pelvic ring injuries in older patients is controversial. This study evaluated surgical treatments combined with ERAS for treating LC1 pelvic fractures in the elderly. Methods In this retrospective study, patients who underwent surgery with INFIX (supra-acetabular spinal pedicle screws, and a subcutaneous connecting rod; the experimental group) or superior pubic ramus cannulated screw (the control group) fixation of LC1 pelvic fracture from January 2019 to January 2022 were reviewed. Injury radiography and computed tomography were pe
View details →Negative / Null Result ReportOpen accessOils, fats, and waxes
孙玉萍，刘启东，杨亚，仇长璐，黄国栋，莫泳红，胡金华 SUN Yuping, LIU Qidong, YANG Ya, QIU Changlu, HUANG Guodong, MO Yonghong, HU Jinhua · 2023 · Zhongguo youzhi
为了对中包装的大豆油棕榈油煎炸专用调和油配方的开发和煎炸稳定性相关理化指标的选择提供参考，分别以一级大豆油、分提18 ℃棕榈油（一次精炼）及同批次的二次精炼18 ℃棕榈油为煎炸油，模拟薯条在180 ℃下高温煎炸32 h，对3种油品在煎炸过程中的酸值、过氧化值、p-茴香胺值、脂肪酸组成、极性组分含量、生育酚含量等理化指标进行了检测，并对18 ℃棕榈油中的风险因子，如PAH4、苯并（a）芘、3-氯丙醇酯（3-MCPDE）、反式脂肪酸含量进行了分析。结果表明：3种油品的酸值、过氧化值在煎炸过程中变化不明显，而p-茴香胺值、脂肪酸组成、极性组分含量在煎炸过程中变化比较明显；3种油品的生育酚氧化速度总体偏差不大；分提18 ℃棕榈油、二次精炼18 ℃棕榈油中的苯并（a）芘、反式脂肪酸含量均随煎炸时间延长呈缓慢升高的趋势；二次精炼18 ℃棕榈油的3-MCPDE在未煎炸时远高于分提18 ℃棕榈油的，3-MCPDE在煎炸初期降解剧烈，最终达到平衡；分提18 ℃棕榈油与二次精炼18 ℃棕榈油在煎炸稳定性方面没有明显区别，二次精炼不仅损失了部分有益的微量营养成分（如生育酚），还伴生出新的风险因子，如增加了3-MCPDE、反式脂肪酸。综上，酸值、过氧化值不能作为评价煎炸稳定性的敏感指标，而p-茴香胺值、脂肪酸组成、极性组分含量可作为敏感指标联合应用于评价煎炸油煎炸稳定性，另外，应倡导适度加工，以降低精炼过
View details →Negative / Null Result ReportOpen accessMedicine
Hasan M. Al-Dorzi, Abdulaziz Al-Dawood, Fahad M. Al-Hameed et al. · 2022 · Scientific Reports
Abstract There are contradictory data regarding the effect of intermittent pneumatic compression (IPC) on the incidence of deep-vein thrombosis (DVT) and heart failure (HF) decompensation in critically ill patients. This study evaluated the effect of adjunctive use of IPC on the rate of incident DVT and ventilation-free days among critically ill patients with HF. In this pre-specified secondary analysis of the PREVENT trial (N = 2003), we compared the effect of adjunctive IPC added to pharmacologic thromboprophylaxis (IPC group), with pharmacologic thromboprophylaxis alone (control group) in c
View details →Negative / Null Result ReportOpen accessOrthopedic surgery
Diego Zanolli de Solminihac MD, Emilio Wagner MD, Pablo Wagner MD et al. · 2017 · Foot & Ankle Orthopaedics
Category: Bunion Introduction/Purpose: Hallux Rigidus (HR) is characterized initially by a decrease in Hallux metatarsophalangeal joint (MTPJ) dorsiflexion, decreasing the total range of motion. To be able to study different surgical treatment options, a cadaveric model has to be developed that recreates the limited range of motion. Our objective was to develop an Hallux Rigidus cadaveric model by shortening the plantar fascia (PF). Hallux MTPJ range of motion and joint stiffness were evaluated. Methods: 8 cadaveric foot- ankle – distal tibia specimens were prepared, identifying all extensor a
View details →Negative / Null Result ReportOpen accessMedicine
Jae-Hong Kim, Chang-Su Na, Myoung-Rae Cho et al. · 2022 · PLoS ONE
This study aimed to provide preliminary evidence for the efficacy of invasive laser acupuncture (ILA) for chronic non-specific low back pain (CNLBP). This was a single-center, randomized, patient and assessor-blinded, placebo-controlled, parallel-arm, clinical trial with a 1:1:1 allocation ratio that included a full analysis set. Forty-five participants with CNLBP were randomly assigned to the control group (sham laser), 650 group (650 nm-wavelength ILA), or 830 group (830 nm-wavelength ILA) (n = 15/group). All participants received ILA for 10 min, followed by electroacupuncture for 10 min on
View details →Negative / Null Result ReportOpen accessTheory and practice of education
Ali Yakar, Bilal Duman · 2022 · International Journal of Contemporary Educational Research
The purpose of the present study is to determine the effects of two multi-modal representations, the use of text and graph for learning, on problem solving, academic achievement and retention when used in a process-based instruction (PBI). The study was designed as quasi-experimental study complying with pretest-posttest control group design. The study group consists of (N=30+34=64) students from the department of classroom teacher education in the Education Faculty of a university from west of Turkey in 2015-2016 academic year. The data in the study were collected through problem solving inve
View details →Negative / Null Result ReportOpen accessBiochemistry
Alper Kucukbasmaci, Ali Sabir · 2019 · Acta Scientiarum Polonorum: Hortorum Cultus
Testing the globally popular grapevine rootstocks for affinity with new grape cultivars or tolerance potential to stress factors like drought is essential for districts where supplemental irrigation is more frequently needed due to the pressures of a global climate change. In this study, a seasonal evaluation of leaf gas exchange, leaf temperature, leaf greenness (chlorophyll content prediction) and vegetative development of Vitis vinifera L. cv. ‘Prima’ grafted to different rootstock genotypes having great variability in drought tolerance, were investigated. The experiment was conducted in a
View details →Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Tadataka Takagi, Fumikazu Koyama, Hiroyuki Kuge et al. · 2024 · Journal of the Anus, Rectum and Colon
Objectives: This study aimed to investigate the impact of the COVID-19 pandemic on the examination and treatment of colorectal cancer (CRC) and on the behaviors of patients and practitioners. Methods: This is a retrospective analysis of the CRC patients who presented to our department between April 2019 and March 2021 and underwent surgery. Clinical presentation of CRC and time from symptom onset to medical presentation were compared between the control (April 2019 to March 2020, n=124) and COVID-19 pandemic periods (April 2020 to March 2021, n=111). Results: Two hundred and thirty-five patien
View details →Negative / Null Result ReportOpen accessEcology
Imed Nouri, Khouloud Chaabane, Rym Bouzaabia · 2026 · Nature Conservation
Immersive virtual reality is increasingly being used as a tool for promoting environmental awareness, particularly to strengthen engagement with nature. However, most research has focused on the short-term effects of a single exposure, neglecting the issue of sustainability and the potential reinforcement of effects through repeated exposure. Furthermore, few studies have examined the role of affective factors such as love and care for nature in this context. The aim of this study was to examine short- and long-term differences in levels of environmental awareness and pro-conservation behavior
View details →Negative / Null Result ReportOpen accessMedicine
Sadan Soyyigit, Onur Baykara, Nur Buyru et al. · 2013 · Medicine Science
Chronic obstructive pulmonary disease (COPD) is a disease which genetic and environmental factors play an important role in COPD development. VDBP (Vitamin D Binding Protein ) gene might be responsible for COPD development. The purpose of this study to investigate the possible effect of VDBP on progression of COPD. We studied VDBP genotypes in 75 COPD patients, 36 smoker healthy subjects and 19 non-smoker healthy subjects with PCR-RFLP method to analyze the association between VDBP and COPD. In our study, the most frequently seen genotype was 1S-2 with a frequency of 32% in COPD group; and 1F-
View details →Negative / Null Result ReportOpen accessScience
Felix Willmer, Claire Reuter, Stephan Pramsohler et al. · 2023 · Life
Background: Athletes often experience poor sleep quality due to stress, altitude exposure, travel across different time zones, and pre-competition nervousness. Coaches use daytime naps to counteract the negative effects of fragmented nighttime sleep. Napping before competitions has also been used to enhance performance in athletes without sleep problems, with mixed results in previous studies, particularly for endurance performance. Thus, we investigated the effects of napping after partial sleep deprivation (PSD) on endurance performance and wakefulness in athletes. Methods: We recruited 12 h
View details →Negative / Null Result ReportOpen accessPlant culture
Simone Pietro Garofalo, Vincenzo Giannico, Beatriz Lorente et al. · 2024 · Frontiers in Plant Science
IntroductionIn the context of climate change, monitoring the spatial and temporal variability of plant physiological parameters has become increasingly important. Remote spectral imaging and GIS software have shown effectiveness in mapping field variability. Additionally, the application of machine learning techniques, essential for processing large data volumes, has seen a significant rise in agricultural applications. This research was focused on carob tree, a drought-resistant tree crop spread through the Mediterranean basin. The study aimed to develop robust models to predict the net assim
View details →Negative / Null Result ReportOpen accessDentistry
Sara Ordooei Javan, Reza Movahedian, Somayeh Hosseini Tabatabaei · 2025 · Dental Research Journal
Background: During the incremental technique of composite restorations, it is possible to be exposed to contamination of the oral environment. This study aimed to compare the effect of saliva contamination and different methods of saliva decontamination on microshear bond strength within composite surfaces. Materials and Methods: This in vitro study created 24 rectangular XT composite blocks using a silicone mold (24 mm × 10 mm × 10 mm). The blocks were divided into eight groups as follows: Group 1: Control group (without contamination); Group 2: Contaminated with saliva; Group 3: saliva + dri
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Jiagen Wen, Meizi Zeng, Zhaoqian Liu et al. · 2019 · Journal of Pharmacological Sciences
Metformin is the most widely used drug among type 2 diabetes mellitus patients. However, drug interaction on metformin will influence its glucose-lowering effect or increase its side effect of lactic acidosis. In this study, a randomized, two-stage, crossover study was conducted to unveil the potential drug interaction between metformin and the anti-hypertension drug, telmisartan. Totally, 16 healthy Chinese male volunteers were enrolled. Blood samples from various time-points after drug adminstration were analyzed for metformin quantification. Oral glucose tolerance test (OGTT) was conducted
View details →Negative / Null Result ReportOpen accessGynecology and obstetrics
Yahya Irwanto · 2012 · Indonesian Journal of Obstetrics and Gynecology
Objective: To know whether the expression of Fas Ligand has correlation with incidene of metastasis of pelvic lymph node and lymph-vascular stromal invasion (LVSI). Methods: All patients diagnosed of cervical cancer stage IB or IIA who underwent radical hysterectomy in Dr. Cipto Mangunkusumo Central General Hospital from January 2008 until December 2009 were included in analytic cross sectional study. We tested expression of Fas Ligand in cervical cancer specimen by immunohystochemistry with monoclonal antibody. The expression of Fas Ligand was compared between the group of patients with a pos
View details →Negative / Null Result ReportOpen accessScience (General)
Afsoon Motallebi, Mehdi Fathi, Fatemeh Mazhari et al. · 2024 · Heliyon
Background: This randomized clinical trial (RCT) investigated whether hypnosis would lead to favorable outcomes in reducing anxiety, enhancing cooperation, and improving physiological responses in school-aged children undergoing tooth extraction compared to nitrous oxide/oxygen (N2O/O2) and conventional behavior guidance (CBG). Methods: Sixty-six school-aged children (mean age: 7.87 ± 1.18 years) who needed one posterior primary tooth extraction were included. Children with low-to-moderate anxiety were randomly divided into three groups (n = 22 each): hypnosis, N2O/O2, and CBG. Anxiety levels
View details →Negative / Null Result ReportOpen accessMedicine
Joan Hermosura, Everett Lohman, Brenda Bartnik-Olson et al. · 2024 · PLoS ONE
Objectives The main purpose of this research study was to compare mean modified straight-leg raise test (mSLR) and hamstring muscle length (HL) between chronic non-specific low back pain (LBP) and healthy subjects to understand the possibility of neuropathic causes in LBP population as it may impact the diagnosis and treatment of LBP. Another purpose was to compare mean mSLR between those with lumbar nerve root impingement and those without as determine by magnetic resonance imaging (MRI). Methods The design of the study is cross sectional and included 32 subjects with ages ranging from 18-50
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