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20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Effects of Inhaled Corticosteroids and Long-Acting β2-Agonists on Efferocytosis and Inflammatory Cell Survival: An In Vitro Study Relevant to COPD and Lung Cancer.

Redwan B, Biancosino C, Fischer S et al. · 2026 · International journal of molecular sciences

Efferocytosis-the tightly regulated clearance of apoptotic cells by phagocytes-maintains tissue homeostasis and is impaired in chronic obstructive pulmonary disease (COPD), where it contributes to persistent inflammation and increases the…

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Negative / Null Result ReportOpen accessMedicine

Can a Targeted Pre-Exercise Education Intervention Enhance the Exercise-Induced Hypoalgesia (EIH) Response in Individuals With Knee Osteoarthritis (OA)?

Toomey D, Lewis G, Tuck N et al. · 2026 · International journal of rheumatic diseases

Objective Recent evidence suggests that education on the pain-relieving effects of exercise may enhance exercise-induced hypoalgesia (EIH) in healthy individuals. However, its impact in populations with osteoarthritis (OA), where EIH…

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Negative / Null Result ReportMedicine

Belowground Interactions in a Barley Cultivar Mixture: Root Distribution and Arbuscular Mycorrhizal Contributions to Uptake of Heterogeneous Phosphorus

Siegwart L, Müller‐Stöver D, Dresbøll DB et al. · 2025 · Physiologia Plantarum.

Cultivar mixtures have the potential to mitigate abiotic stress and stabilize crop yields, but their belowground dynamics remain poorly understood. We evaluated phosphorus (P) uptake by two contrasting spring barley (Hordeum vulgare L.)…

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Negative / Null Result ReportMedicine

Data-Driven Techniques for Estimating Energy Expenditure in Wheelchair Users.

Doshmanziari R, Strand Aandahl H, Pettersen Reierstad H et al. · 2025 · IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

Providing feedback on energy expenditure (EE) may be an important tool to support obesity prevention among manual wheelchair users (MWU). This paper presents a data-driven approach for estimating EE based on data collected from 40…

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Negative / Null Result ReportMedicine

Responses to Hypoxia and Hyperoxia in Embryonic Tiger Keelbacks (Rhabdophis tigrinus lateralis; Colubridae).

Li XM, Su S, Zhang LW et al. · 2025 · Journal of experimental zoology. Part A, Ecological and integrative physiology

Studies examining the oxygen dependency of embryonic survival, growth, and differentiation have been conducted for decades in a diverse array of animal taxa but including only one oviparous snake, the viperine water snake Natrix maura.…

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Negative / Null Result ReportMedicine

Effect of preharvest boron spraying on the firmness and microstructure of winter-harvested frozen broccoli among maturity types.

Viriyarattanasak C, Takemura Y, Hashimoto T et al. · 2025 · Journal of the science of food and agriculture

Background Softening of winter-harvested frozen broccoli is a challenge. Application of boron (B) can improve fruit texture, but its effects on processed vegetables remain unexplored. This study is the first to investigate the impact of…

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Negative / Null Result ReportMedicine

The temporal copulatory patterns of female rat sexual behavior.

Oyem JC, Heijkoop R, Snoeren EMS · 2025 · Behavioural processes

Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulating the timing of sexual interactions is essential for optimizing mating satisfaction and…

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Negative / Null Result ReportOpen accessMedicine

Limited Utility of the CALLY Index in Enhancing Mortality Prediction for Trauma Patients in Intensive Care Units: A Retrospective Analysis.

Kuo PJ, Huang CY, Liao KH et al. · 2026 · Risk management and healthcare policy

Background Accurate prognostication for trauma patients in intensive care units (ICUs) remains challenging. This study investigated whether incorporating the C-reactive protein-albumin-lymphocyte (CALLY) index into traditional ICU scoring…

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Negative / Null Result ReportMedicine

Increasing cervical penetrability in sheep by long-acting treatments with oxytocin (Carbetocin) and/or prostaglandin E2 (Dinoprostone).

Rodríguez-Piñón M, Casuriaga D, García-Barcelo G et al. · 2025 · Domestic animal endocrinology

The aim was to study the effect of long-acting treatments with oxytocin (Carbetocin, Cb) and/or prostaglandin E2 (Dinoprostone, Dp) on cervical penetrability and collagenolysis in synchronized ewes (12 days MAP-eCG). At 42 h post eCG, ewes…

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Negative / Null Result ReportMedicine

Differential Impact of Concomitant Methotrexate and Glucocorticoids Dosages on Biologics and JAK Inhibitors: The ANSWER Cohort Study.

Ebina K, Etani Y, Okita Y et al. · 2025 · International journal of rheumatic diseases

Aim This multicenter retrospective study evaluated the differential impact of concomitant methotrexate (MTX) and glucocorticoids (GCs) administration by dosage on the effectiveness and safety of biological disease-modifying antirheumatic…

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Negative / Null Result ReportMedicine

Oral Peanut Immunotherapy With Butyrate Adjuvant (OPIA) in Children: A Randomised, Controlled Trial.

Hsu PS, Barnes EH, Barnes M et al. · 2025 · Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Background Sustained unresponsiveness (SU) remains a major challenge for peanut OIT. The short chain fatty acid (SCFA) butyrate has the potential to upregulate regulatory T cells (Tregs) to improve long term tolerance. We conducted a…

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Negative / Null Result ReportOpen accessMedicine

Acute Effects of Commercial Yerba Mate Products on Cardiometabolic Responses during Submaximal Cycling: Brewed to Perform?

Zaki S, Berkachy R, Zein Eddine R et al. · 2026 · Current developments in nutrition

Background Yerba mate ( Ilex paraguariensis ) is an herb native to South America known for its caffeine and polyphenol content, with suggested benefits for fat oxidation and energy metabolism. However, few studies have evaluated its brewed…

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Negative / Null Result ReportOpen accessMedicine

Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection.

Mazzini G, Tuerlings M, van der Stap V et al. · 2026 · Cartilage

BackgroundCell-based cartilage repair is limited by loss of chondrogenic potential during in vitro expansion. Fibronectin (FN)-based selection may enrich progenitor-like cells with better matrix-forming ability, but its long-term effect on…

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Negative / Null Result ReportMedicine

Acute metformin intake on exercise performance in healthy participants during functional fitness training.

Pinheiro AH, Silva LG, Bastos-Silva VJ · 2025 · The Journal of sports medicine and physical fitness

Background The study aimed to assess whether prior intake of metformin enhances performance in the FRAN workout, a popular Functional Fitness Training protocol. Methods Fourteen men (mean±SD: 24.2±3.5 years; height: 173.3±7.8 cm; weight:…

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Negative / Null Result ReportMedicine

Vitamin C and D do not increase the chemopreventive effect of aspirin on colon carcinogenesis in a mouse model.

Pereira M, Brandão Ostermann RA, de Fáveri W et al. · 2025 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Aspirin has significant antineoplastic effects on the colon, whereas the outcomes of Vitamin C and D supplementation have been inconsistent. This study addressed the isolated and combined effects of vitamins C and D with aspirin on…

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Negative / Null Result Report

The temporal copulatory patterns of female rat sexual behavior

Oyem JC, Heijkoop R, Snoeren EM · 2024 · Preprint

Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulating the timing of sexual interactions is essential for optimizing mating satisfaction and…

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Negative / Null Result ReportMedicine

Roles of spermary-specific carboxylesterases in Nilaparvata lugens reproduction: Opposite between insecticide-induced upregulation and resistance-associated overexpression.

Zhang H, Yang B, Xu X et al. · 2025 · International journal of biological macromolecules

Seminal fluid proteins (SFPs) in insect males are critical for reproduction, being transported into female ovary. In Nilaparvata lugens, a significant rice pest, seven spermary-specific carboxylesterases (CarEs) were found abundantly in…

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