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Browse the failure-mode index

20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Participants with restricted dominant shoulder internal rotation range of motion demonstrate no side-to-side difference in humeral head translation; and no difference before and after joint mobilization: a pilot study.

Hoops JF, Hooper TL, Sobczak S et al. · 2024 · Journal of physical therapy science

[Purpose] To compare humeral head translation (HHT) during shoulder elevation between dominant and non-dominant shoulders in participants with limited dominant shoulder internal rotation range of motion (ROM). To determine if joint…

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Negative / Null Result ReportOpen accessMedicine

Error-related potentials during multitasking involving sensorimotor control: an ERP and offline decoding study for brain-computer interface.

Yasuhara M, Nambu I · 2025 · Frontiers in human neuroscience

Humans achieve efficient behaviors by perceiving and responding to errors. Error-related potentials (ErrPs) are electrophysiological responses that occur upon perceiving errors. Leveraging ErrPs to improve the accuracy of brain-computer…

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Negative / Null Result ReportMedicine

The liver-heart axis in patients with severe obesity: The association between liver fibrosis and chronic myocardial injury may be explained by shared risk factors of cardiovascular disease.

Young J, Seeberg KA, Aakre KM et al. · 2024 · Clinical biochemistry

Background Severe obesity is associated with increased risk of non-alcoholic fatty liver disease and cardiovascular disease. We hypothesized that liver fibrosis as quantified by the Enhanced Liver Fibrosis (ELF) test would be predictive of…

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Negative / Null Result ReportOpen accessMedicine

Re-evaluating heart rate variability biomarkers for glucose sensing: the impact of age normalisation and subject-independent validation.

Azam MB, Singh SI · 2026 · BMC medical informatics and decision making

Background Heart rate variability (HRV) derived from electrocardiogram (ECG) signals offers a promising non-invasive window into glycemic status; however, existing studies frequently combine distinct glucose measurements and employ…

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Negative / Null Result ReportMedicine

Salsalate negatively impacts microvascular function in women with endometriosis.

Williams AC, Content VG, Alexander LM · 2025 · American journal of physiology. Heart and circulatory physiology

Women with endometriosis, an inflammatory disease, are at increased risk of cardiovascular disease and demonstrate impaired microvascular endothelial function, characterized by reduced nitric oxide (NO)-mediated vasodilation. In some…

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Negative / Null Result ReportOpen accessMedicine

Relationship between survival outcomes in patients with colorectal liver metastasis undergoing hepatectomy and significance of fibrotic markers for liver injury assessment.

Nanashima A, Hiyoshi M, Imamura N et al. · 2025 · Translational cancer research

Background Progression of chronic liver dysfunction influenced by long-term chemotherapy or repeated hepatectomy might be related to patient overall survival as well as tumor factors in colorectal liver metastasis (CLM) patients. Our aim…

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Negative / Null Result ReportOpen accessMedicine

Differences in firing patterns along the dorsal-intermediate hippocampal axis in a fixed route during a change in emotional context.

Troha R, Lee SLT, Anam M et al. · 2025 · Frontiers in systems neuroscience

The hippocampus plays a prominent role in spatial navigation and memory. However, differences exist along the hippocampus longitudinal axis in function and connectivity. The current study focuses on the dorsal and intermediate subregions…

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Negative / Null Result ReportOpen accessMedicine

Parental political engagement and self-efficacy: An exploratory study.

Randolph C, Needlman R, Hutchinson E · 2024 · American journal of community psychology

Political engagement (PE) is associated with a sense of empowerment. PE by parents affects children's lives. This study explored parents' attitudes about inclusion of political engagement discussion in well-child care. Because voting is an…

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Negative / Null Result ReportMedicine

Patterns of Symptom Change in Behaviors and Cognitions During 10-Session Cognitive Behavioral Therapy (CBT-T) for Non-Underweight Eating Disorders.

Kambanis PE, Graver H, Palmer LP et al. · 2025 · The International journal of eating disorders

Objective Little is known about the timing of behavioral versus cognitive change in 10-session cognitive-behavioral therapy for non-underweight eating disorders (CBT-T). We aimed to: (a) evaluate the magnitude of behavioral and cognitive…

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Negative / Null Result ReportOpen accessMedicine

Exosome enriched serum enhances engineered ligament mechanics and collagen content with no additional benefit of resistance exercise.

Paulussen KJM, Hayden CMT, Griffin T et al. · 2025 · Matrix biology plus

Following resistance exercise, systemic changes foster improved functionality of tendons and ligaments. Post-exercise, muscle tissue releases exosomes that are thought to facilitate inter-tissue communication. To determine the potential…

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Negative / Null Result ReportOpen accessMedicine

Comparison of Medial Meniscus Root Repair with Two Surgical Techniques Using Medial and Lateral Tunnels: A Prospective Cohort Study.

Shahsavari Pour A, Hosseini A, Ghomashi I et al. · 2026 · The archives of bone and joint surgery

Objectives This study aimed to compare the clinical outcomes of trans-tibial pullout repair of the medial meniscus posterior root using the lateral tibial tunnel versus the conventional medial tibial tunnel. Methods In this prospective…

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Negative / Null Result ReportOpen accessMedicine

Does the change between the native and the prosthetic posterior tibial slope influence the clinical outcomes after posterior stabilized TKA? A review of 793 knees at a minimum of 5 years follow-up.

Alhamdi H, Deroche E, Shatrov J et al. · 2025 · SICOT-J

Introduction The understanding of the influence of posterior tibial slope (PTS) on knee kinematics has increased. However, the PTS influence on clinical outcomes remains unclear. The study aimed to evaluate whether a significant change…

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Negative / Null Result ReportOpen accessMedicine

Omega-3 fatty acid supplementation does not attenuate declines in skeletal muscle mitochondrial area in young, healthy females during immobilization.

Lo MM, Black MN, McGlory C et al. · 2026 · Physiological reports

Mitochondrial subcellular area influences function. Muscle disuse reduces mitochondrial content; however, its effect on mitochondrial subcellular location is unclear. Omega-3 fatty acid (n-3) attenuates declines in muscle mass and…

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Negative / Null Result ReportMedicine

Dynamic lactation responses to dietary crude protein oscillation in diets adequate and deficient in metabolizable protein in Holstein cows.

Erickson MG, Zanton GI, Wattiaux MA · 2023 · Journal of dairy science

Limited research has examined the interaction between dietary crude protein (CP) level and CP feeding pattern. We tested CP level (low protein [LP], 13.8%; high protein [HP], 15.5% CP, dry matter [DM] basis) and CP feeding pattern (OF =…

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Negative / Null Result ReportMedicine

Odor-Color Associations Are Not Mediated by Concurrent Verbalization.

Speed LJ, de Valk J, Croijmans I et al. · 2023 · Cognitive science

Odor and color are strongly associated. Numerous studies demonstrate consistent odor-color associations, as well as effects of color on odor perception and language. Yet, we know little about how these associations arise. Here, we test…

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Negative / Null Result ReportOpen accessMedicine

Do Surrogate Markers of Cardiorespiratory Fitness Predict Individual Changes in VO<sub>2peak</sub>? A Randomized Controlled Trial.

Renwick JRM, Preobrazenski N, Giudice MD et al. · 2024 · International journal of exercise science

The purpose of the current study was to test the hypothesis that individual response classification for surrogate markers of cardiorespiratory fitness (CRF) will agree with response classification for VO 2peak . Surrogate markers of CRF…

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Negative / Null Result ReportOpen accessMedicine

Relationship between the stiffness of the medial gastrocnemius and spatiotemporal variables during 100-m sprint running in collegiate sprinters.

Fujii N, Takahashi K, Kawama R et al. · 2026 · PloS one

Higher stiffness of the medial gastrocnemius (MG) has been reported to be associated with faster race time in 100-m sprint running. However, the association of muscle stiffness with spatiotemporal variables (i.e., step frequency, step…

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Negative / Null Result ReportOpen access

Association of Polygenic Risk Scores for Neurodevelopmental Traits and Psychiatric Conditions with Incontinence and Constipation in Children and Young People

Bastiani O, Dardani C, Burrows K et al. · 2024 · Preprint

Observational studies report prospective associations of neurodevelopmental and psychiatric traits with paediatric incontinence and constipation, but unmeasured and residual confounding may limit observational measures. Here, we use a…

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