19,895 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Foster, Millist, Germaine et al. · 2026 · Epilepsia open
ES-481 is a novel potent and selective antagonist of TARP-y8-dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES-481 as an add-on anti-seizure…
View details →Ucan Gunduz, Nizam Tekcan, Erdem et al. · 2026 · Journal of pediatric ophthalmology and strabismus
To investigate microstructural alterations in the retina, choroid, and optic nerve head in children with spina bifida using optical coherence tomography. Thirty-eight children with spina bifida and 32 children without spina bifida were…
View details →Zamaniyan, Abbasi, Habibpour et al. · 2026 · International journal of reproductive biomedicine
Diminished ovarian reserve is one of the most important issues in in vitro fertilization cycles. Some authors have reported beneficial effects of dual triggering in women with poor ovarian response, whereas other investigators have…
View details →Alencar, Teles, Cunha et al. · 2026 · Revista brasileira de ortopedia
Artificial intelligence (AI) tools based on natural language, such as ChatGPT 4.1 mini (OpenAI Group PBC) and Gemini 2.5 Flash (Alphabet Inc.), are used by patients as sources of medical information. The current study aimed to evaluate and…
View details →Alencar, Teles, Cunha et al. · 2026 · Revista brasileira de ortopedia
Artificial intelligence (AI) tools based on natural language, such as ChatGPT 4.1 mini (OpenAI Group PBC) and Gemini 2.5 Flash (Alphabet Inc.), are used by patients as sources of medical information. The current study aimed to evaluate and…
View details →Petrina, Dong, Beamer et al. · 2026 · Open forum infectious diseases
Vaginal dysbiosis is associated with HIV acquisition and preterm delivery. Our objective was to evaluate prevalent vaginal infections, and changes in microbiota and cytokines among pregnant and breastfeeding women from 4 African countries…
View details →Hardika, Kurniawan, Laksmi et al. · 2026 · Journal of the ASEAN Federation of Endocrine Societies
Leukocyte telomere length (LTL) is considered a biomarker of cellular senescence. Previous studies have reported the associations between shortened telomere length and type 2 diabetes mellitus (T2DM). However, the role of underlying…
View details →Durgala, Horvath, Skrabanova et al. · 2026 · Frontiers in behavioral neuroscience
Traumatic brain injury (TBI) is a major health concern in the current population. Animal models are increasingly important for identifying early neurobehavioural changes associated with mild to severe as well as repetitive brain injuries.…
View details →Choi, Park, Song et al. · 2026 · Psychiatry investigation
Although its potential antidepressant effects have been suggested, evidence on long-term outcomes for post-delivery depression remains limited. We evaluated whether peripartum intravenous magnesium sulfate (MgSO₄) is associated with…
View details →Lamb, Akulian, Musani et al. · 2026 · Respiratory research
Single chain urokinase (LTI-01) intrapleural enzymatic therapy (IET) was safe and promising in a phase 1 clinical trial to overcome failed drainage in patients with pleural infection. The LTI-01-2001 phase 2a trial was a randomized,…
View details →Akdogan, Aydin · 2026 · BMC oral health
Data comparing the wear of 3D printed permanent resin (PR) and milled zirconia (Z) to that of primary tooth enamel are limited. This study aimed to investigate the wear behavior of two materials and their effect on antagonist primary…
View details →Güler, Kaplan, Şahan et al. · 2026 · Pain management nursing : official journal of the American Society of Pain Management Nurses
Pain during arteriovenous fistula (AVF) catheterization is a common discomfort faced by hemodialysis patients and can negatively affect treatment adherence, satisfaction, and overall quality of life. Effective pain management strategies…
View details →Russo, Comune, Di Nardo et al. · 2026 · International journal of cardiology
The shortened protocol of Nitroglycerin (NTG)-potentiated head-up tilt testing (HUTT), the so-called "fast Italian protocol," has been shown to significantly reduce test duration while maintaining diagnostic yield and safety in adults with…
View details →Yeh, Ahuja, Patel et al. · 2026 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
We conducted a target trial emulation study to examine the effect of two glucagon-like peptide-1 receptor agonists (GLP1RAs) (semaglutide and tirzepatide) on clinical outcomes in patients with inflammatory bowel diseases (IBD) with obesity…
View details →Tc, S, J et al. · 2026 · Chronic respiratory disease
BackgroundDysregulated breathing is a major cause of persisting breathlessness for many people following acute COVID-19 illness. There is little evidence to support the use of breathing interventions within this population.MethodsA…
View details →Darwich, Yassine, Weiss et al. · 2026 · Surgical endoscopy
This prospective randomized study compared the efficacy of articulated ArtiSential® instruments with that of conventional straight laparoscopic instruments in minimally invasive left-sided colorectal resections. The primary endpoint…
View details →Xing, Hu, Liu et al. · 2026 · Medicine
Laparoscopic duodenum-preserving pancreatic head resection avoids complicated organ resection and reconstruction. In recent years, it has replaced laparoscopic pancreaticoduodenectomy as the first choice for treating benign and low-grade…
View details →Somura, Sato, Takakura et al. · 2026 · Medicine
Seizures are serious complications of awake craniotomy (AC), and generalized clonic seizures are problematic because they require pharmacologic termination and emergency airway management. Although associations between seizure onset and…
View details →Castillo Ortiz, Barrera Rodriguez · 2026 · Reumatologia clinica
Biologic therapy withdrawal in inflammatory rheumatic diseases is a frequent event with direct consequences on disease control, safety, and care costs. Real-world data from southeastern Mexico remain scarce. The objective of this study was…
View details →McShane, Olivera, Candido et al. · 2026 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
The optimal sequencing of therapy following anti-tumor necrosis factor (TNF) inhibitor failure in Crohn's disease (CD) remains uncertain. We compared the effectiveness of upadacitinib (UPA) versus risankizumab (RSZ) in patients with active…
View details →Shahzadi, Reimann, Schneider et al. · 2026 · RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
To retrospectively evaluate the diagnostic performance and confidence of photon-counting computed tomography (PCCT) for detecting bone marrow edema (BME) in trauma patients, using magnetic resonance imaging (MRI) as the reference standard.…
View details →Li, Ding, Gao · 2026 · JTCVS techniques
This study aimed to evaluate the feasibility of retrograde distal perfusion via the posterior tibial artery (PTA) in patients receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO). A retrospective single-center study was…
View details →Guo, Suo, Xue et al. · 2026 · Frontiers in physiology
This study aims to explore the effects of Velocity-Based Strength Training (VBT) on lower-limb strength, power, and muscle thickness in athletes of different sexes. It aims to identify sex-specific differences in training adaptations and…
View details →Asif, Rais, Anwar et al. · 2026 · Pakistan journal of medical sciences
To compare the efficacy of different nasal continuous positive airway pressure (NCPAP) weaning strategies in preterm infants presenting with respiratory distress syndrome (RDS). This randomized controlled trial was conducted at the…
View details →Cui, Cao · 2026 · Pakistan journal of medical sciences
To compare the predictive ability of the AIMS65, pre-endoscopic Rockall score (Pre-RS), and Glasgow-Blatchford score (GBS) for clinical outcomes in patients with non-variceal upper gastrointestinal bleeding (NVUGIB). This retrospective,…
View details →Amin, Awashra, Khan et al. · 2026 · European heart journal open
Atrial fibrillation (AF) and chronic kidney disease (CKD) often coexist, and both increase the risk of thromboembolism and bleeding. We aim to investigate the impact of CKD in patients with AF undergoing left atrial appendage occlusion…
View details →Gee Lim, Feng Ng, Fen Beh · 2026 · Turkish journal of physical medicine and rehabilitation
This study aims to assess the feasibility of this pilot study's design and implementation and to compare the effect of active and passive music therapy interventions and standard care on cognition in neurorehabilitation. Participants aged…
View details →Coellar, Keshvani, Jain et al. · 2026 · American journal of preventive cardiology
Medication non-adherence following acute coronary syndrome (ACS) is common, especially among underserved populations. The use of fixed-dose combination pills (polypills) may improve both adherence and prescription practices. This…
View details →Lazoğlu, Tekgündüz, Apay · 2026 · Scientific reports
This study aimed to compare hedonic hunger and intuitive eating status between pregnant and non-pregnant individuals. The research was conducted with 722 participants (357 pregnant and 365 non-pregnant) in different units of Kars Harakani…
View details →Jin, Xu, Wen et al. · 2026 · BMC surgery
Hypoparathyroidism (HypoPT) is the most common complication after total thyroidectomy (TT) and central lymph node dissection (CLND) for thyroid carcinoma. However, there's still no effective surgical strategy to prevent its incidence. This…
View details →